Midodrine (BioDeep_00000006625)
Secondary id: BioDeep_00001868229
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
(+-)-2-Amino-N-(beta-hydroxy-2,5-dimethoxyphenethyl)acetamide
化学式: C12H18N2O4 (254.1267)
中文名称: 米多君
谱图信息:
最多检出来源 Homo sapiens(blood) 11.59%
分子结构信息
SMILES: COC1=CC(=C(C=C1)OC)C(CNC(=O)CN)O
InChI: InChI=1S/C12H18N2O4/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16)
描述信息
Midodrine is only found in individuals that have used or taken this drug. It is an ethanolamine derivative that is an adrenergic alpha agonist. It is used as a vasoconstrictor agent in the treatment of hypotension. [PubChem]Midodrine forms an active metabolite, desglymidodrine, that is an alpha1-agonist, and exerts its actions via activation of the alpha-adrenergic receptors of the arteriolar and venous vasculature, producing an increase in vascular tone and elevation of blood pressure. Desglymidodrine does not stimulate cardiac beta-adrenergic receptors.
C - Cardiovascular system > C01 - Cardiac therapy > C01C - Cardiac stimulants excl. cardiac glycosides > C01CA - Adrenergic and dopaminergic agents
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013566 - Sympathomimetics
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
D002317 - Cardiovascular Agents > D014662 - Vasoconstrictor Agents
Midodrine is an α1-receptor agonist, for the treatment of dysautonomia and orthostatic hypotension.
同义名列表
29 个代谢物同义名
(+-)-2-Amino-N-(beta-hydroxy-2,5-dimethoxyphenethyl)acetamide; 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide; (+-)-2-Amino-N-(β-hydroxy-2,5-dimethoxyphenethyl)acetamide; (+-)-2-Amino-N-(b-hydroxy-2,5-dimethoxyphenethyl)acetamide; 2-Amino-N-(2,5-dimethoxy-beta-hydroxyphenethyl)acetamide; Cahill may roberts brand OF midodrine monohydrochloride; 2-Amino-N-(2,5-dimethoxy-b-hydroxyphenethyl)acetamide; DL-N1-(beta-Hydroxy-2,5-dimethoxyphenethyl)glycinamid; 2-Amino-N-(2,5-dimethoxy-β-hydroxyphenethyl)acetamide; DL-N1-(Β-hydroxy-2,5-dimethoxyphenethyl)glycinamid; DL-N1-(b-Hydroxy-2,5-dimethoxyphenethyl)glycinamid; Christiaens brand OF midodrine monohydrochloride; Nycomed brand OF midodrine monohydrochloride; 1-(2,5-Dimethoxyphenyl)-2-glycinamidoethanol; Shire brand OF midodrine monohydrochloride; Monohydrochloride, midodrine; Midodrine monohydrochloride; Midodrine hydrochloride; Midodrine HCL; ProAmatine; Midodrinum; Midodrina; midodrine; Midodrin; Amatine; Gutron; Midon; (±)-Midodrin; Midodrine
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:6933
- KEGG: C07890
- KEGGdrug: D08220
- PubChem: 4195
- HMDB: HMDB0014356
- Metlin: METLIN44344
- DrugBank: DB00211
- ChEMBL: CHEMBL1201212
- Wikipedia: Midodrine
- MeSH: Midodrine
- chemspider: 4050
- CAS: 133163-28-7
- CAS: 42794-76-3
- PMhub: MS000019694
- PubChem: 10092
- NIKKAJI: J16.460G
- RefMet: Midodrine
- medchemexpress: HY-12749
- KNApSAcK: 6933
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Praveen Sharma, Pankaj Puri, Naresh Bansal, Vikas Singla, Ashish Kumar, Anil Anikhindi ShriHari, Anil Arora. Midodrine and albumin versus albumin alone for the secondary prophylaxis of acute kidney injury in a patient with cirrhosis and ascites.
European journal of gastroenterology & hepatology.
2021 12; 33(1S Suppl 1):e499-e504. doi:
10.1097/meg.0000000000002154. [PMID: 34034268] - Xiaolan Ye, Bai Ling, Jian Wu, Shujuan Wu, Yan Ren, Hongjuan Zhang, Feifeng Song, Zixue Xuan, Maosheng Chen. Case report: severe myoclonus associated with oral midodrine treatment for hypotension.
Medicine.
2020 Oct; 99(40):e21533. doi:
10.1097/md.0000000000021533. [PMID: 33019383] - Mary J Thomson, Arthur Taylor, Pratima Sharma, Anna S Lok, Elliot B Tapper. Limited Progress in Hepatorenal Syndrome (HRS) Reversal and Survival 2002-2018: A Systematic Review and Meta-Analysis.
Digestive diseases and sciences.
2020 05; 65(5):1539-1548. doi:
10.1007/s10620-019-05858-2. [PMID: 31571102] - Amruta Tripathy, Rituparna Maiti, Monalisa Jena, Archana Mishra, Anand Srinivasan. Effect of alpha agonists on the prevention of postparacentesis circulatory dysfunction in patients with refractory or recurrent ascites: a meta-analysis.
European journal of gastroenterology & hepatology.
2020 03; 32(3):303-311. doi:
10.1097/meg.0000000000001594. [PMID: 31688312] - Yeliz Demir. The behaviour of some antihypertension drugs on human serum paraoxonase-1: an important protector enzyme against atherosclerosis.
The Journal of pharmacy and pharmacology.
2019 Oct; 71(10):1576-1583. doi:
10.1111/jphp.13144. [PMID: 31347707] - Nikhil Cordeiro, Sushilkumar Satish Gupta, Daniel Lindsay, Chanaka Seneviratne, Guy Kulbak, Yizhak Kupfer. Midodrine: Associated Bradycardia.
American journal of therapeutics.
2019 Sep; 26(5):e655-e656. doi:
10.1097/mjt.0000000000000856. [PMID: 31498780] - Victoria Treasure, Royce P Vincent, David R Taylor. Falsely elevated plasma 3-methoxytyramine in a patient receiving midodrine therapy.
Annals of clinical biochemistry.
2019 05; 56(3):415-416. doi:
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10.1007/s00467-018-4190-1. [PMID: 30734850] - Ayman Yosry, Zeinab A Soliman, Rasha Eletreby, Iman Hamza, Alaa Ismail, Mohammad A Elkady. Oral midodrine is comparable to albumin infusion in cirrhotic patients with refractory ascites undergoing large-volume paracentesis: results of a pilot study.
European journal of gastroenterology & hepatology.
2019 03; 31(3):345-351. doi:
10.1097/meg.0000000000001277. [PMID: 30312183] - Beatrice Drambarean, Paula Bielnicka, Ali Alobaidi. Midodrine treatment in a patient with treprostinil-induced hypotension receiving hemodialysis.
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Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.
2009 Apr; 41(4):298-302. doi:
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Autonomic neuroscience : basic & clinical.
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Liver international : official journal of the International Association for the Study of the Liver.
2009 Feb; 29(2):169-74. doi:
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Clinical therapeutics.
2008 Sep; 30(9):1629-38. doi:
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Liver international : official journal of the International Association for the Study of the Liver.
2008 Aug; 28(7):1019-25. doi:
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The American journal of gastroenterology.
2008 Jun; 103(6):1399-405. doi:
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Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation.
2008 Jun; 6(2):127-31. doi:
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Archives of neurology.
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2008; 30(8):808-12. doi:
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Advances in therapy.
2007 Jul; 24(4):712-20. doi:
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Journal of hepatology.
2007 Feb; 46(2):213-21. doi:
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American journal of cardiovascular drugs : drugs, devices, and other interventions.
2007; 7(6):399-411. doi:
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Best practice & research. Clinical gastroenterology.
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2006 Jul; 21(7):1988. doi:
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Journal of investigative medicine : the official publication of the American Federation for Clinical Research.
2006 May; 54(4):180-90. doi:
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Indian pacing and electrophysiology journal.
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Journal of pharmaceutical and biomedical analysis.
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
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The American journal of gastroenterology.
2005 Apr; 100(4):879-85. doi:
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The American journal of gastroenterology.
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Annales de readaptation et de medecine physique : revue scientifique de la Societe francaise de reeducation fonctionnelle de readaptation et de medecine physique.
2005 Feb; 48(1):34-40. doi:
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Hepatology (Baltimore, Md.).
2004 Jul; 40(1):55-64. doi:
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The American journal of the medical sciences.
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Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
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Hepatology (Baltimore, Md.).
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2002 Aug; 12(4):281-5. doi:
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2002 Jan; 39(1):102-7. doi:
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Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie.
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American journal of kidney diseases : the official journal of the National Kidney Foundation.
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American journal of kidney diseases : the official journal of the National Kidney Foundation.
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American journal of kidney diseases : the official journal of the National Kidney Foundation.
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Rinsho shinkeigaku = Clinical neurology.
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Drugs & aging.
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2000 Feb; 10(1):29-33. doi:
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2000 Feb; 14(1):42-7. doi:
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The Korean journal of internal medicine.
2000 Jan; 15(1):81-4. doi:
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