Pamidronate (BioDeep_00000006493)
Secondary id: BioDeep_00001868036
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
(3-amino-1-hydroxy-1-phosphonopropyl)phosphonic acid
化学式: C3H11NO7P2 (235.0011)
中文名称: 帕米膦酸
谱图信息:
最多检出来源 Homo sapiens(blood) 93.44%
分子结构信息
SMILES: C(CN)C(O)(P(=O)(O)O)P(=O)(O)O
InChI: InChI=1S/C3H11NO7P2/c4-2-1-3(5,12(6,7)8)13(9,10)11/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11)
描述信息
Pamidronate is only found in individuals that have used or taken this drug.Pamidronate, marketed as pamidronate disodium pentahydrate under the brand name Aredia, is a bisphosphonate. [Wikipedia]The mechanism of action of pamidronate is inhibition of bone resorption. Pamidronate adsorbs to calcium phosphate (hydroxyapatite) crystals in bone and may directly block dissolution of this mineral component of bone. In vitro studies also suggest that inhibition of osteoclast activity contributes to inhibition of bone resorption. Pamidronate also targets farnesyl pyrophosphate (FPP) synthase. Nitrogen-containing bisphosphonates (such as pamidronate, alendronate, risedronate, ibandronate and zoledronate) appear to act as analogues of isoprenoid diphosphate lipids, thereby inhibiting FPP synthase, an enzyme in the mevalonate pathway. Inhibition of this enzyme in osteoclasts prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are essential for the post-translational farnesylation and geranylgeranylation of small GTPase signalling proteins. This activity inhibits osteoclast activity and reduces bone resorption and turnover. In postmenopausal women, it reduces the elevated rate of bone turnover, leading to, on average, a net gain in bone mass.
M - Musculo-skeletal system > M05 - Drugs for treatment of bone diseases > M05B - Drugs affecting bone structure and mineralization > M05BA - Bisphosphonates
C78281 - Agent Affecting Musculoskeletal System > C67439 - Bone Resorption Inhibitor
D050071 - Bone Density Conservation Agents > D004164 - Diphosphonates
同义名列表
21 个代谢物同义名
(3-amino-1-hydroxy-1-phosphonopropyl)phosphonic acid; (3-Amino-1-hydroxypropylidene)-1,1-bisphosphonate; (3-Amino-1-hydroxypropylidene)-1,1-biphosphonate; 1 Hydroxy 3 aminopropane 1,1 diphosphonic acid; 1-Hydroxy-3-aminopropane-1,1-diphosphonic acid; Novartis brand OF pamidronate disodium salt; Amino 1 hydroxypropane 1,1 diphosphonate; Amino-1-hydroxypropane-1,1-diphosphonate; Aminohydroxypropylidene diphosphonate; Aminopropanehydroxydiphosphonate; Pamidronate monosodium; Pamidronate disodium; Pamidronate calcium; PAMIDRONIC ACID; Pamidronate; Amidronate; Ribodroat; Aredia; AHPrBP; APD; Pamidronate
数据库引用编号
22 个数据库交叉引用编号
- ChEBI: CHEBI:7903
- KEGG: C07395
- KEGG: C75045
- KEGGdrug: D07281
- PubChem: 4674
- HMDB: HMDB0014427
- Metlin: METLIN1692
- DrugBank: DB00282
- ChEMBL: CHEMBL834
- Wikipedia: Pamidronic acid
- MeSH: Pamidronate
- chemspider: 4512
- CAS: 1159812-33-5
- CAS: 106437-12-1
- CAS: 40391-99-9
- CAS: 57248-88-1
- PMhub: MS000019541
- PubChem: 9599
- PDB-CCD: 210
- NIKKAJI: J221.669H
- RefMet: Pamidronate
- KNApSAcK: 7903
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kun Huang, Xiao Tang, Fang Tang. Combined chemotherapy of zoledronic acid and pamidronate in the treatment of bone metastases from nonsmall cell lung cancer and the effects on pain stress and bone metabolic indices.
Drug development research.
2024 Feb; 85(1):e22147. doi:
10.1002/ddr.22147. [PMID: 38349271] - Rachel Shulman, Abdallah S Geara, Jeffrey S Berns. Pamidronate versus zoledronic acid for the treatment of multiple myeloma-related hypercalcemia.
Kidney international.
2022 05; 101(5):1086. doi:
10.1016/j.kint.2021.12.033. [PMID: 35461601] - C Tanné, J-P Pracros, F Dijoud, P-Y Mure, F Bordet, A Duncan, J Bacchetta. Severe neonatal hypercalcemia revealing congenital mesoblastic nephroma: A case report and management of neonatal hypercalcemia: Severe neonatal hypercalcemia revealing congenital mesoblastic nephroma.
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie.
2022 Feb; 29(2):153-156. doi:
10.1016/j.arcped.2021.11.013. [PMID: 35039190] - Rachel Chava Rosenblum, Orit Twito, Liat Barzilay-Yoseph, Erez Ramaty, Noa Klein, Pnina Rotman-Pikielny. Efficacy and Safety of Intravenous Pamidronate for Parathyroid Hormone-dependent Hypercalcemia in Hospitalized Patients.
The Journal of clinical endocrinology and metabolism.
2021 10; 106(11):e4593-e4602. doi:
10.1210/clinem/dgab457. [PMID: 34157125] - Camiel de Roij van Zuijdewijn, Wim van Dorp, Sandrine Florquin, Joris Roelofs, Kees Verburgh. Bisphosphonate nephropathy: A case series and review of the literature.
British journal of clinical pharmacology.
2021 09; 87(9):3485-3491. doi:
10.1111/bcp.14780. [PMID: 33595131] - Pauliina Utriainen, Tuukka T Niinimäki, Anu J Huurre, Kaisa L Vepsäläinen, Outi M Mäkitie, Riitta A Niinimäki. Bisphosphonate treatment in children with acute lymphoblastic leukemia and osteonecrosis - radiological and clinical findings in a national cohort.
Acta oncologica (Stockholm, Sweden).
2021 Sep; 60(9):1140-1145. doi:
10.1080/0284186x.2021.1950928. [PMID: 34309491] - Sarah J Norman, David J Reeves, Lindsay M Saum. Use of Pamidronate for Hypercalcemia of Malignancy in Renal Dysfunction.
Journal of pharmacy practice.
2021 Aug; 34(4):553-557. doi:
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Cell reports.
2021 04; 35(4):109040. doi:
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2021 04; 41(3):565-575. doi:
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Colombia medica (Cali, Colombia).
2018 Dec; 49(4):288-291. doi:
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The American journal of case reports.
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The Turkish journal of pediatrics.
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2017 Apr; 72(4):231-237. doi:
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Chemical communications (Cambridge, England).
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Annals of laboratory medicine.
2012 Mar; 32(2):105-12. doi:
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International journal of nanomedicine.
2012; 7(?):2307-14. doi:
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Clinical & developmental immunology.
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Journal of environmental and public health.
2012; 2012(?):835059. doi:
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Case reports in oncology.
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Journal of biological regulators and homeostatic agents.
2012 Jan; 26(1):151-5. doi:
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Archives of pharmacal research.
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2011 Dec; 28(4):1196-200. doi:
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Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
2011 Dec; 26(12):2823-6. doi:
10.1002/jbmr.530. [PMID: 21997141] - Bita Omidvar, Ali Ghorbani, Heshmatollah Shahbazian, Seyed Seifollah Beladi Mousavi, Seyed Javad Shariat Nabavi, Mohammad Alasti. Comparison of alendronate and pamidronate on bone loss in kidney transplant patients for the first 6 months of transplantation.
Iranian journal of kidney diseases.
2011 Nov; 5(6):420-4. doi:
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Annals of hematology.
2011 Oct; 90(10):1161-6. doi:
10.1007/s00277-011-1276-2. [PMID: 21698395] - Xinmin Zhao, Xiaofeng Xu, Qunling Zhang, Zhen Jia, Si Sun, Jian Zhang, Biyun Wang, Zhonghua Wang, Xichun Hu. Prognostic and predictive value of clinical and biochemical factors in breast cancer patients with bone metastases receiving 'metronomic' zoledronic acid.
BMC cancer.
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Journal of bone and mineral metabolism.
2011 Sep; 29(5):598-605. doi:
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PLoS genetics.
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Head & face medicine.
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Clinical and experimental nephrology.
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The American journal of medicine.
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BMC musculoskeletal disorders.
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Indian journal of nephrology.
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Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.
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Kidney international.
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Cancer chemotherapy and pharmacology.
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Revista brasileira de reumatologia.
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Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
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Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.
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