7a-Hydroxy-cholestene-3-one (BioDeep_00000005832)
Main id: BioDeep_00000010802
human metabolite Endogenous blood metabolite
代谢物信息卡片
(1S,2R,9R,10S,11S,14R,15R)-9-hydroxy-2,15-dimethyl-14-[(2R)-6-methylheptan-2-yl]tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-5-one
化学式: C27H44O2 (400.3341)
中文名称: 7α-羟基-4-胆固醇-3-酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)CCCC(C)C1CCC2C1(CCC3C2C(CC4=CC(=O)CCC34C)O)C
InChI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1
描述信息
7a-Hydroxy-cholestene-3-one is a metabolite in bile acid synthesis. It is derived from 7a-hydroxy-cholesterol and can be further metabolized to 7a,12a,-dihydroxy-cholest-4-en-3-one. Analysis of 7a-Hydroxycholestene-3-one (HCO) in serum may serve as a novel, simple, and sensitive method for the detection of bile acid malabsorption in patients with chronic diarrhea of unknown origin (PMID 9952217) [HMDB]
7a-Hydroxy-cholestene-3-one is a metabolite in bile acid synthesis. It is derived from 7a-hydroxy-cholesterol and can be further metabolized to 7a,12a,-dihydroxy-cholest-4-en-3-one. Analysis of 7a-Hydroxycholestene-3-one (HCO) in serum may serve as a novel, simple, and sensitive method for the detection of bile acid malabsorption in patients with chronic diarrhea of unknown origin (PMID 9952217).
同义名列表
23 个代谢物同义名
(1S,2R,9R,10S,11S,14R,15R)-9-hydroxy-2,15-dimethyl-14-[(2R)-6-methylheptan-2-yl]tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-5-one; 7a-Hydroxy-4-cholesten-3-one-12alpha; 7α-Hydroxycholest-4-en-3-one; 7 alpha-Hydroxy-4-cholesten-3-one; 7-alpha-Hydroxycholest-4-en-3-one; 7-alpha-Hydroxy-4-cholesten-3-one; 7alpha-Hydroxy-4-cholesten-3-one; 7alpha-Hydroxycholest-4-en-3-one; 7|A-Hydroxy-4-cholesten-3-one; 7-a-Hydroxycholest-4-en-3-one; Cholest-4-en-7 alpha-ol-3-one; 7-a-Hydroxy-4-cholesten-3-one; Cholest-4-en-7alpha-ol-3-one; 7a-Hydroxy-4-cholesten-3-one; 7α-Hydroxy-4-cholesten-3-one; 7-Hydroxycholest-4-en-3-one; 7-Hydroxy-4-cholesten-3-one; 7a-Hydroxy-cholestene-3-one; Cholest-4-en-7a-ol-3-one; Cholest-4-en-7α-ol-3-one; 7 alpha-3Ox-C; HCO; 7alpha-Hydroxycholest-4-en-3-one
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:17899
- KEGG: C05455
- PubChem: 123743
- PubChem: 334
- HMDB: HMDB0001993
- Metlin: METLIN43126
- ChEMBL: CHEMBL4285345
- foodb: FDB022786
- chemspider: 110306
- CAS: 3862-25-7
- PMhub: MS000018723
- PubChem: 7817
- LipidMAPS: LMST04030123
- 3DMET: B05034
- NIKKAJI: J602.383E
- RefMet: 7alpha-Hydroxy-4-cholesten-3-one
- KNApSAcK: 17899
分类词条
相关代谢途径
Reactome(11)
- Metabolism
- Biological oxidations
- Phase I - Functionalization of compounds
- Metabolism of lipids
- Metabolism of steroids
- Cytochrome P450 - arranged by substrate type
- Bile acid and bile salt metabolism
- Synthesis of bile acids and bile salts
- Endogenous sterols
- Sterols are 12-hydroxylated by CYP8B1
- Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
BioCyc(0)
PlantCyc(0)
代谢反应
169 个相关的代谢反应过程信息。
Reactome(144)
- Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism of lipids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Bile acid and bile salt metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Bile acid and bile salt metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Bile acid and bile salt metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Bile acid and bile salt metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Bile acid and bile salt metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Bile acid and bile salt metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Metabolism of lipids:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Metabolism of steroids:
17aHPROG + H+ + Oxygen + TPNH ⟶ 11-deoxycortisol + H2O + TPN - Bile acid and bile salt metabolism:
CHOL + H+ + Oxygen + TPNH ⟶ 7alpha-hydroxycholesterol + H2O + TPN - Synthesis of bile acids and bile salts:
CHOL + H+ + Oxygen + TPNH ⟶ 7alpha-hydroxycholesterol + H2O + TPN - Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol:
CHOL + H+ + Oxygen + TPNH ⟶ 7alpha-hydroxycholesterol + H2O + TPN - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Bile acid and bile salt metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Bile acid and bile salt metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of lipids:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN - Metabolism of steroids:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN - Bile acid and bile salt metabolism:
CHOL + H+ + Oxygen + TPNH ⟶ 24OH-CHOL + H2O + TPN - Synthesis of bile acids and bile salts:
CHOL + H+ + Oxygen + TPNH ⟶ 24OH-CHOL + H2O + TPN - Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol:
25(S) THCA-CoA + Oxygen ⟶ H2O2 + THCA-CoA - Sterols are 12-hydroxylated by CYP8B1:
4CHOL7aOLONE + H+ + Oxygen + TPNH ⟶ 4CHOL7a,12aDONE + H2O + TPN - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Bile acid and bile salt metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Endogenous sterols:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Sterols are 12-hydroxylated by CYP8B1:
4CHOL7aOLONE + H+ + Oxygen + TPNH ⟶ 4CHOL7a,12aDONE + H2O + TPN - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Endogenous sterols:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Sterols are 12-hydroxylated by CYP8B1:
4CHOL7aOLONE + H+ + Oxygen + TPNH ⟶ 4CHOL7a,12aDONE + H2O + TPN - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Metabolism of lipids:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Metabolism of steroids:
H+ + TPNH + estrone ⟶ EST17b + TPN - Bile acid and bile salt metabolism:
CHOL + H+ + Oxygen + TPNH ⟶ 25OH-CHOL + H2O + TPN - Synthesis of bile acids and bile salts:
CHOL + H+ + Oxygen + TPNH ⟶ 25OH-CHOL + H2O + TPN - Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol:
25(S) THCA-CoA + Oxygen ⟶ H2O2 + THCA-CoA - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of lipids:
3-oxopristanoyl-CoA + CoA-SH ⟶ 4,8,12-trimethyltridecanoyl-CoA + propionyl CoA - Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Bile acid and bile salt metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Bile acid and bile salt metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Sterols are 12-hydroxylated by CYP8B1:
4CHOL7aOLONE + H+ + Oxygen + TPNH ⟶ 4CHOL7a,12aDONE + H2O + TPN - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Endogenous sterols:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Sterols are 12-hydroxylated by CYP8B1:
4CHOL7aOLONE + H+ + Oxygen + TPNH ⟶ 4CHOL7a,12aDONE + H2O + TPN - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Endogenous sterols:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Sterols are 12-hydroxylated by CYP8B1:
4CHOL7aOLONE + H+ + Oxygen + TPNH ⟶ 4CHOL7a,12aDONE + H2O + TPN - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of lipids:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN - Metabolism of steroids:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN - Bile acid and bile salt metabolism:
CHOL + H+ + Oxygen + TPNH ⟶ 24OH-CHOL + H2O + TPN - Synthesis of bile acids and bile salts:
CHOL + H+ + Oxygen + TPNH ⟶ 24OH-CHOL + H2O + TPN - Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol:
25(S) THCA-CoA + Oxygen ⟶ H2O2 + THCA-CoA - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Endogenous sterols:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Sterols are 12-hydroxylated by CYP8B1:
4CHOL7aOLONE + H+ + Oxygen + TPNH ⟶ 4CHOL7a,12aDONE + H2O + TPN - Metabolism:
CAR + propionyl CoA ⟶ CoA-SH + Propionylcarnitine - Metabolism of lipids:
CAR + propionyl CoA ⟶ CoA-SH + Propionylcarnitine - Metabolism of steroids:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN - Bile acid and bile salt metabolism:
CHOL + H+ + Oxygen + TPNH ⟶ 25OH-CHOL + H2O + TPN - Synthesis of bile acids and bile salts:
CHOL + H+ + Oxygen + TPNH ⟶ 25OH-CHOL + H2O + TPN - Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol:
H2O + choloyl-CoA ⟶ CoA-SH + cholate - Metabolism:
GAA + SAM ⟶ CRET + H+ + SAH - Metabolism of lipids:
ACA + H+ + NADH ⟶ NAD + bHBA - Metabolism of steroids:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN - Bile acid and bile salt metabolism:
CHOL + H+ + Oxygen + TPNH ⟶ 25OH-CHOL + H2O + TPN - Synthesis of bile acids and bile salts:
CHOL + H+ + Oxygen + TPNH ⟶ 25OH-CHOL + H2O + TPN - Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol:
4CHOL7a,12aDONE + H+ + TPNH ⟶ 5beta-cholesten-7alpha, 12alpha-diol-3-one + TPN - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Endogenous sterols:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Sterols are 12-hydroxylated by CYP8B1:
4CHOL7aOLONE + H+ + Oxygen + TPNH ⟶ 4CHOL7a,12aDONE + H2O + TPN - Biological oxidations:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Phase I - Functionalization of compounds:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Cytochrome P450 - arranged by substrate type:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Endogenous sterols:
EST17b + H+ + Oxygen + TPNH ⟶ 4OH-EST17b + H2O + TPN - Sterols are 12-hydroxylated by CYP8B1:
4CHOL7aOLONE + H+ + Oxygen + TPNH ⟶ 4CHOL7a,12aDONE + H2O + TPN - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Endogenous sterols:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Sterols are 12-hydroxylated by CYP8B1:
4CHOL7aOLONE + H+ + Oxygen + TPNH ⟶ 4CHOL7a,12aDONE + H2O + TPN
BioCyc(1)
- bile acid biosynthesis, neutral pathway:
(25R)-3α,7α-dihydroxy-5-β-cholestanate + ATP + coenzyme A ⟶ (25R)-3α,7α-dihydroxy-5β-cholestanoyl-CoA + AMP + diphosphate
WikiPathways(2)
- Oxysterols derived from cholesterol:
(25R)26-HC ⟶ 3 -HCA - Disorders of bile acid synthesis and biliary transport:
Taurocholic acid ⟶ cholate
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(22)
- Bile Acid Biosynthesis:
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - Congenital Bile Acid Synthesis Defect Type II:
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - Congenital Bile Acid Synthesis Defect Type III:
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - Familial Hypercholanemia (FHCA):
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - Zellweger Syndrome:
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - Cerebrotendinous Xanthomatosis (CTX):
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - 27-Hydroxylase Deficiency:
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - Bile Acid Biosynthesis:
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - 27-Hydroxylase Deficiency:
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - Cerebrotendinous Xanthomatosis (CTX):
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - Congenital Bile Acid Synthesis Defect Type II:
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - Congenital Bile Acid Synthesis Defect Type III:
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - Familial Hypercholanemia (FHCA):
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - Zellweger Syndrome:
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - 27-Hydroxylase Deficiency:
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - Bile Acid Biosynthesis:
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - Bile Acid Biosynthesis:
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - Cerebrotendinous Xanthomatosis (CTX):
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - Congenital Bile Acid Synthesis Defect Type II:
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - Congenital Bile Acid Synthesis Defect Type III:
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - Familial Hypercholanemia (FHCA):
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid - Zellweger Syndrome:
Choloyl-CoA + Taurine ⟶ Coenzyme A + Taurocholic acid
PharmGKB(0)
4 个相关的物种来源信息
- 6058 - Haliclona oculata: 10.1021/NP0600494
- 9606 - Homo sapiens: -
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
- 5691 - Trypanosoma brucei: 10.1371/JOURNAL.PNTD.0001618
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ivan Lyutakov, Valentin Lozanov, Paulina Sugareva, Hristo Valkov, Plamen Penchev. Serum 7-alfa-hydroxy-4-cholesten-3-one and fibroblast growth factor-19 as biomarkers diagnosing bile acid malabsorption in microscopic colitis and inflammatory bowel disease.
European journal of gastroenterology & hepatology.
2021 03; 33(3):380-387. doi:
10.1097/meg.0000000000001925. [PMID: 33177381] - Ville Männistö, Dorota Kaminska, Pirjo Käkelä, Mikko Neuvonen, Mikko Niemi, Marcus Alvarez, Päivi Pajukanta, Stefano Romeo, Max Nieuwdorp, Albert K Groen, Jussi Pihlajamäki. Protein Phosphatase 1 Regulatory Subunit 3B Genotype at rs4240624 Has a Major Effect on Gallbladder Bile Composition.
Hepatology communications.
2021 02; 5(2):244-257. doi:
10.1002/hep4.1630. [PMID: 33553972] - Lauren E Hughes, Clare Ford, Matthew J Brookes, Rousseau Gama. Bile acid diarrhoea: Current and potential methods of diagnosis.
Annals of clinical biochemistry.
2021 01; 58(1):22-28. doi:
10.1177/0004563220966139. [PMID: 32998535] - Michael Camilleri, Priya Vijayvargiya. The Role of Bile Acids in Chronic Diarrhea.
The American journal of gastroenterology.
2020 10; 115(10):1596-1603. doi:
10.14309/ajg.0000000000000696. [PMID: 32558690] - Philip N Newsome, Melissa Palmer, Bradley Freilich, Muhammad Y Sheikh, Aasim Sheikh, Harry Sarles, Robert Herring, Parvez Mantry, Zeid Kayali, Tarek Hassanein, Hak-Myung Lee, Guruprasad P Aithal. Volixibat in adults with non-alcoholic steatohepatitis: 24-week interim analysis from a randomized, phase II study.
Journal of hepatology.
2020 08; 73(2):231-240. doi:
10.1016/j.jhep.2020.03.024. [PMID: 32234329] - Robert Battat, Marjolijn Duijvestein, Niels Vande Casteele, Siddharth Singh, Parambir S Dulai, Mark A Valasek, Larry Mimms, Judson McFarland, Kelly D Hester, Mark Renshaw, Anjali Jain, William J Sandborn, Brigid S Boland. Serum Concentrations of 7α-hydroxy-4-cholesten-3-one Are Associated With Bile Acid Diarrhea in Patients With Crohn's Disease.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.
2019 12; 17(13):2722-2730.e4. doi:
10.1016/j.cgh.2018.11.012. [PMID: 30448597] - Samer Al-Dury, Annika Wahlström, Katrin Panzitt, Anders Thorell, Marcus Ståhlman, Michael Trauner, Peter Fickert, Fredrik Bäckhed, Lars Fändriks, Martin Wagner, Hanns-Ulrich Marschall. Obeticholic acid may increase the risk of gallstone formation in susceptible patients.
Journal of hepatology.
2019 11; 71(5):986-991. doi:
10.1016/j.jhep.2019.06.011. [PMID: 31254596] - Mary E Rinella, James F Trotter, Manal F Abdelmalek, Angelo H Paredes, Margery A Connelly, Mark J Jaros, Lei Ling, Stephen J Rossi, Alex M DePaoli, Stephen A Harrison. Rosuvastatin improves the FGF19 analogue NGM282-associated lipid changes in patients with non-alcoholic steatohepatitis.
Journal of hepatology.
2019 04; 70(4):735-744. doi:
10.1016/j.jhep.2018.11.032. [PMID: 30529590] - Ivo P van de Peppel, Marcela Doktorova, Gitte Berkers, Hugo R de Jonge, Roderick H J Houwen, Henkjan J Verkade, Johan W Jonker, Frank A J A Bodewes. IVACAFTOR restores FGF19 regulated bile acid homeostasis in cystic fibrosis patients with an S1251N or a G551D gating mutation.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.
2019 03; 18(2):286-293. doi:
10.1016/j.jcf.2018.09.001. [PMID: 30279125] - Hiroko Ino, Akira Endo, Akira Wakamatsu, Hirofumi Ogura, Yotaro Numachi, Stuart Kendrick. Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Evaluations Following Single Oral Doses of GSK2330672 in Healthy Japanese Volunteers.
Clinical pharmacology in drug development.
2019 01; 8(1):70-77. doi:
10.1002/cpdd.576. [PMID: 29870578] - Amani Al-Khaifi, Mats Rudling, Bo Angelin. An FXR Agonist Reduces Bile Acid Synthesis Independently of Increases in FGF19 in Healthy Volunteers.
Gastroenterology.
2018 10; 155(4):1012-1016. doi:
10.1053/j.gastro.2018.06.038. [PMID: 29928896] - Yuji Kumagai, Hideki Amano, Yoshinobu Sasaki, Chie Nakagawa, Mika Maeda, Ichiro Oikawa, Hidetoshi Furuie. Effect of single and multiple doses of elobixibat, an ileal bile acid transporter inhibitor, on chronic constipation: A randomized controlled trial.
British journal of clinical pharmacology.
2018 10; 84(10):2393-2404. doi:
10.1111/bcp.13698. [PMID: 29959787] - Dana Friedrich, Hanns-Ulrich Marschall, Frank Lammert. Response of fibroblast growth factor 19 and bile acid synthesis after a body weight-adjusted oral fat tolerance test in overweight and obese NAFLD patients: a non-randomized controlled pilot trial.
BMC gastroenterology.
2018 Jun; 18(1):76. doi:
10.1186/s12876-018-0805-z. [PMID: 29866129] - Emiko Shinozawa, Yuichiro Amano, Hiroko Yamakawa, Megumi Haba, Mitsuyuki Shimada, Ryuichi Tozawa. Antidyslipidemic potential of a novel farnesoid X receptor antagonist in a hamster model of dyslipidemia: Comparative studies of other nonstatin agents.
Pharmacology research & perspectives.
2018 04; 6(2):e00390. doi:
10.1002/prp2.390. [PMID: 29541476] - Melissa Palmer, Lee Jennings, Debra G Silberg, Caleb Bliss, Patrick Martin. A randomised, double-blind, placebo-controlled phase 1 study of the safety, tolerability and pharmacodynamics of volixibat in overweight and obese but otherwise healthy adults: implications for treatment of non-alcoholic steatohepatitis.
BMC pharmacology & toxicology.
2018 03; 19(1):10. doi:
10.1186/s40360-018-0200-y. [PMID: 29548345] - Leslie J Donato, Alan Lueke, Stacy M Kenyon, Jeffrey W Meeusen, Michael Camilleri. Description of analytical method and clinical utility of measuring serum 7-alpha-hydroxy-4-cholesten-3-one (7aC4) by mass spectrometry.
Clinical biochemistry.
2018 Feb; 52(?):106-111. doi:
10.1016/j.clinbiochem.2017.10.008. [PMID: 29051033] - Renger G Tiessen, Ciara A Kennedy, Bradley T Keller, Nancy Levin, Lisette Acevedo, Bronislava Gedulin, Andre A van Vliet, Alejandro Dorenbaum, Melissa Palmer. Safety, tolerability and pharmacodynamics of apical sodium-dependent bile acid transporter inhibition with volixibat in healthy adults and patients with type 2 diabetes mellitus: a randomised placebo-controlled trial.
BMC gastroenterology.
2018 Jan; 18(1):3. doi:
10.1186/s12876-017-0736-0. [PMID: 29304731] - Yanan Wang, Scott V Harding, Sijo J Thandapilly, Susan M Tosh, Peter J H Jones, Nancy P Ames. Barley β-glucan reduces blood cholesterol levels via interrupting bile acid metabolism.
The British journal of nutrition.
2017 Nov; 118(10):822-829. doi:
10.1017/s0007114517002835. [PMID: 29115200] - Lijuan Kang, Thomas M Connolly, Naidong Weng, Wenying Jian. LC-MS/MS quantification of 7α-hydroxy-4-cholesten-3-one (C4) in rat and monkey plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Oct; 1064(?):49-55. doi:
10.1016/j.jchromb.2017.09.006. [PMID: 28915417] - Rgia A Othman, Semone B Myrie, David Mymin, Jean-Baptiste Roullet, Andrea E DeBarber, Robert D Steiner, Peter J H Jones. Thyroid Hormone Status in Sitosterolemia Is Modified by Ezetimibe.
The Journal of pediatrics.
2017 09; 188(?):198-204.e1. doi:
10.1016/j.jpeds.2017.05.049. [PMID: 28625503] - C Borup, S Wildt, J J Rumessen, P N Bouchelouche, J Graff, M Damgaard, C McQuitty, D Rainteau, L K Munck. Chenodeoxycholic acid stimulated fibroblast growth factor 19 response - a potential biochemical test for bile acid diarrhoea.
Alimentary pharmacology & therapeutics.
2017 06; 45(11):1433-1442. doi:
10.1111/apt.14056. [PMID: 28378364] - Xiaoying Liu, Anne S Henkel, Brian E LeCuyer, Susan C Hubchak, Matthew J Schipma, Eric Zhang, Richard M Green. Hepatic deletion of X-box binding protein 1 impairs bile acid metabolism in mice.
Journal of lipid research.
2017 03; 58(3):504-511. doi:
10.1194/jlr.m071266. [PMID: 28039331] - David N Assis, Osama Abdelghany, Shi-Ying Cai, Andrea A Gossard, John E Eaton, Jill C Keach, Yanhong Deng, Kenneth D R Setchell, Maria Ciarleglio, Keith D Lindor, James L Boyer. Combination Therapy of All-Trans Retinoic Acid With Ursodeoxycholic Acid in Patients With Primary Sclerosing Cholangitis: A Human Pilot Study.
Journal of clinical gastroenterology.
2017 Feb; 51(2):e11-e16. doi:
10.1097/mcg.0000000000000591. [PMID: 27428727] - Serge J Zweers, Elisabeth M de Vries, Martin Lenicek, Dagmar Tolenaars, D Rudi de Waart, Kiran V K Koelfat, Albert K Groen, Steven W M Olde Damink, Ulrich Beuers, Cyriel Ponsioen, Peter L M Jansen, Frank G Schaap. Prolonged fibroblast growth factor 19 response in patients with primary sclerosing cholangitis after an oral chenodeoxycholic acid challenge.
Hepatology international.
2017 Jan; 11(1):132-140. doi:
10.1007/s12072-016-9769-7. [PMID: 27696157] - T Blahová, L Peterková, M Leníček, M Vlachová, K Zemánková, V Adámková, L Vítek, J Kovář. The effect of colesevelam treatment on bile acid and lipid metabolism and glycemic control in healthy men.
Physiological research.
2016 12; 65(6):995-1003. doi:
10.33549/physiolres.933276. [PMID: 27539104] - Long Yuan, Yi Luo, Hamza Kandoussi, Qin C Ji. A simple, fast, sensitive and robust LC-MS/MS bioanalytical assay for evaluating 7α-hydroxy-4-cholesten-3-one biomarker in a clinical program.
Bioanalysis.
2016 Dec; 8(23):2445-2455. doi:
10.4155/bio-2016-0219. [PMID: 27855505] - Martin LeníĿek, Marek Vecka, Kateſina Žížalová, Libor Vítek. Comparison of simple extraction procedures in liquid chromatography-mass spectrometry based determination of serum 7α-hydroxy-4-cholesten-3-one, a surrogate marker of bile acid synthesis.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Oct; 1033-1034(?):317-320. doi:
10.1016/j.jchromb.2016.08.046. [PMID: 27598558] - Alex Escalona, Rodrigo Muñoz, Veronica Irribarra, Sandra Solari, Fidel Allende, Juan Francisco Miquel. Bile acids synthesis decreases after laparoscopic sleeve gastrectomy.
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery.
2016 May; 12(4):763-769. doi:
10.1016/j.soard.2015.11.015. [PMID: 26948941] - Miluše Vlachova, Tereza Blahova, Vera Lanska, Martin Leníček, Jan Pitha, Libor Vítek, Jan Kovar. Diurnal variation in cholesterol 7α-hydroxylase activity is determined by the -203A>C polymorphism of the CYP7A1 gene.
Croatian medical journal.
2016 Apr; 57(2):111-7. doi:
10.3325/cmj.2016.57.111. [PMID: 27106353] - Andrea Mignarri, Alessandro Magni, Marina Del Puppo, Gian Nicola Gallus, Ingemar Björkhem, Antonio Federico, Maria Teresa Dotti. Evaluation of cholesterol metabolism in cerebrotendinous xanthomatosis.
Journal of inherited metabolic disease.
2016 Jan; 39(1):75-83. doi:
10.1007/s10545-015-9873-1. [PMID: 26153518] - H Graffner, P-G Gillberg, L Rikner, H-U Marschall. The ileal bile acid transporter inhibitor A4250 decreases serum bile acids by interrupting the enterohepatic circulation.
Alimentary pharmacology & therapeutics.
2016 Jan; 43(2):303-10. doi:
10.1111/apt.13457. [PMID: 26527417] - Ling Zhang, Wieger Voskuijl, Marialena Mouzaki, Albert K Groen, Jennifer Alexander, Celine Bourdon, Alice Wang, Christian J Versloot, Valeria Di Giovanni, Ronald J A Wanders, Robert Bandsma. Impaired Bile Acid Homeostasis in Children with Severe Acute Malnutrition.
PloS one.
2016; 11(5):e0155143. doi:
10.1371/journal.pone.0155143. [PMID: 27163928] - Mats Rudling, Michael Camilleri, Hans Graffner, Jens Juul Holst, Leif Rikner. Specific inhibition of bile acid transport alters plasma lipids and GLP-1.
BMC cardiovascular disorders.
2015 Jul; 15(?):75. doi:
10.1186/s12872-015-0070-9. [PMID: 26197999] - Diego A Foschi, Andrea Rizzi, Igor Tubazio, Lorenzo Conti, Tarcisio Vago, Maurizio Bevilacqua, Alessandro Magni, Marina Del Puppo. Duodenal diverted sleeve gastrectomy with ileal interposition does not cause biliary salt malabsorption.
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery.
2015 Mar; 11(2):372-6. doi:
10.1016/j.soard.2014.10.025. [PMID: 25820074] - M Camilleri, A Acosta, I Busciglio, A Boldingh, R B Dyer, A R Zinsmeister, A Lueke, A Gray, L J Donato. Effect of colesevelam on faecal bile acids and bowel functions in diarrhoea-predominant irritable bowel syndrome.
Alimentary pharmacology & therapeutics.
2015 Mar; 41(5):438-48. doi:
10.1111/apt.13065. [PMID: 25594801] - Michael Camilleri, Irene Busciglio, Andres Acosta, Andrea Shin, Paula Carlson, Duane Burton, Michael Ryks, Deborah Rhoten, Jesse Lamsam, Alan Lueke, Leslie J Donato, Alan R Zinsmeister. Effect of increased bile acid synthesis or fecal excretion in irritable bowel syndrome-diarrhea.
The American journal of gastroenterology.
2014 Oct; 109(10):1621-30. doi:
10.1038/ajg.2014.215. [PMID: 25070056] - F Gothe, F Beigel, C Rust, M Hajji, S Koletzko, F Freudenberg. Bile acid malabsorption assessed by 7 alpha-hydroxy-4-cholesten-3-one in pediatric inflammatory bowel disease: correlation to clinical and laboratory findings.
Journal of Crohn's & colitis.
2014 Sep; 8(9):1072-8. doi:
10.1016/j.crohns.2014.02.027. [PMID: 24666974] - Michael Camilleri, Andrea Shin, Irene Busciglio, Paula Carlson, Andres Acosta, Adil E Bharucha, Duane Burton, Jesse Lamsam, Alan Lueke, Leslie J Donato, Alan R Zinsmeister. Genetic variation in GPBAR1 predisposes to quantitative changes in colonic transit and bile acid excretion.
American journal of physiology. Gastrointestinal and liver physiology.
2014 Sep; 307(5):G508-16. doi:
10.1152/ajpgi.00178.2014. [PMID: 25012842] - Yuichiro Amano, Eiichiro Ishikawa, Emiko Shinozawa, Mitsuyuki Shimada, Shotaro Miura, Ryutaro Adachi, Ryuichi Tozawa. Combinational effects of farnesoid X receptor antagonist and statin on plasma lipid levels and low-density lipoprotein clearance in guinea pigs.
Life sciences.
2014 Jul; 108(1):7-12. doi:
10.1016/j.lfs.2014.04.029. [PMID: 24805868] - Hester Vlaardingerbroek, Kenneth Ng, Barbara Stoll, Nancy Benight, Shaji Chacko, Leo A J Kluijtmans, Wim Kulik, E James Squires, Oluyinka Olutoye, Deborah Schady, Milton L Finegold, Johannes B van Goudoever, Douglas G Burrin. New generation lipid emulsions prevent PNALD in chronic parenterally fed preterm pigs.
Journal of lipid research.
2014 Mar; 55(3):466-77. doi:
10.1194/jlr.m044545. [PMID: 24478031] - Folke Freudenberg, Florian Gothe, Florian Beigel, Christian Rust, Sibylle Koletzko. Serum 7-alpha-hydroxy-4-cholesten-3-one as a marker for bile acid loss in children.
The Journal of pediatrics.
2013 Nov; 163(5):1367-71.e1. doi:
10.1016/j.jpeds.2013.06.083. [PMID: 23968740] - S S Pattni, W G Brydon, T Dew, I M Johnston, J D Nolan, M Srinivas, P Basumani, K D Bardhan, J R F Walters. Fibroblast growth factor 19 in patients with bile acid diarrhoea: a prospective comparison of FGF19 serum assay and SeHCAT retention.
Alimentary pharmacology & therapeutics.
2013 Oct; 38(8):967-76. doi:
10.1111/apt.12466. [PMID: 23981126] - Shoujiro Ogawa, Biao Zhou, Yusuke Kimoto, Kaoru Omura, Akiko Kobayashi, Tatsuya Higashi, Kuniko Mitamura, Shigeo Ikegawa, Lee R Hagey, Alan F Hofmann, Takashi Iida. An efficient synthesis of 7α,12α-dihydroxy-4-cholesten-3-one and its biological precursor 7α-hydroxy-4-cholesten-3-one: Key intermediates in bile acid biosynthesis.
Steroids.
2013 Sep; 78(9):927-37. doi:
10.1016/j.steroids.2013.05.011. [PMID: 23707572] - Petra Hirsova, Gabriela Karlasova, Eva Dolezelova, Jolana Cermanova, Marie Zagorova, Zuzana Kadova, Milos Hroch, Ludek Sispera, Pavel Tomsik, Martin Lenicek, Libor Vitek, Petr Pavek, Otto Kucera, Zuzana Cervinkova, Stanislav Micuda. Cholestatic effect of epigallocatechin gallate in rats is mediated via decreased expression of Mrp2.
Toxicology.
2013 Jan; 303(?):9-15. doi:
10.1016/j.tox.2012.10.018. [PMID: 23146761] - Banny S Wong, Michael Camilleri, Paula Carlson, Sanna McKinzie, Irene Busciglio, Olga Bondar, Roy B Dyer, Jesse Lamsam, Alan R Zinsmeister. Increased bile acid biosynthesis is associated with irritable bowel syndrome with diarrhea.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.
2012 Sep; 10(9):1009-15.e3. doi:
10.1016/j.cgh.2012.05.006. [PMID: 22610000] - Qing Yang, Tian Lan, Yuegang Chen, Paul A Dawson. Dietary fish oil increases fat absorption and fecal bile acid content without altering bile acid synthesis in 20-d-old weanling rats following massive ileocecal resection.
Pediatric research.
2012 Jul; 72(1):38-42. doi:
10.1038/pr.2012.41. [PMID: 22447320] - Carine Steiner, Adriaan G Holleboom, Ratna Karuna, Mohammad M Motazacker, Jan Albert Kuivenhoven, Ruth Frikke-Schmidt, Anne Tybjaerg-Hansen, Lucia Rohrer, Katharina M Rentsch, Arnold von Eckardstein. Lipoprotein distribution and serum concentrations of 7α-hydroxy-4-cholesten-3-one and bile acids: effects of monogenic disturbances in high-density lipoprotein metabolism.
Clinical science (London, England : 1979).
2012 Apr; 122(8):385-96. doi:
10.1042/cs20110482. [PMID: 22010943] - Xiaoqiang Xiang, Janne T Backman, Pertti J Neuvonen, Mikko Niemi. Gender, but not CYP7A1 or SLCO1B1 polymorphism, affects the fasting plasma concentrations of bile acids in human beings.
Basic & clinical pharmacology & toxicology.
2012 Mar; 110(3):245-52. doi:
10.1111/j.1742-7843.2011.00792.x. [PMID: 21902813] - Hanns-Ulrich Marschall, Martin Wagner, Gernot Zollner, Peter Fickert, Dagmar Silbert, Ulf Gustafsson, Staffan Sahlin, Michael Trauner. Combined rifampicin and ursodeoxycholic acid treatment does not amplify rifampicin effects on hepatic detoxification and transport systems in humans.
Digestion.
2012; 86(3):244-9. doi:
10.1159/000341420. [PMID: 22964716] - Thomas Lundåsen, Eva-Marie Andersson, Michael Snaith, Helena Lindmark, Johanna Lundberg, Ann-Margret Östlund-Lindqvist, Bo Angelin, Mats Rudling. Inhibition of intestinal bile acid transporter Slc10a2 improves triglyceride metabolism and normalizes elevated plasma glucose levels in mice.
PloS one.
2012; 7(5):e37787. doi:
10.1371/journal.pone.0037787. [PMID: 22662222] - Tiangang Li, John Y L Chiang. Bile Acid signaling in liver metabolism and diseases.
Journal of lipids.
2012; 2012(?):754067. doi:
10.1155/2012/754067. [PMID: 21991404] - C Gälman, B Angelin, M Rudling. Pronounced variation in bile acid synthesis in humans is related to gender, hypertriglyceridaemia and circulating levels of fibroblast growth factor 19.
Journal of internal medicine.
2011 Dec; 270(6):580-8. doi:
10.1111/j.1365-2796.2011.02466.x. [PMID: 22003820] - Banny S Wong, Michael Camilleri, Sanna McKinzie, Duane Burton, Hans Graffner, Alan R Zinsmeister. Effects of A3309, an ileal bile acid transporter inhibitor, on colonic transit and symptoms in females with functional constipation.
The American journal of gastroenterology.
2011 Dec; 106(12):2154-64. doi:
10.1038/ajg.2011.285. [PMID: 21876564] - Silke Matysik, Evelyn Orsó, Anne Black, Norbert Ahrens, Gerd Schmitz. Monitoring of 7α-hydroxy-4-cholesten-3-one during therapy of cerebrotendinous xanthomatosis: a case report.
Chemistry and physics of lipids.
2011 Sep; 164(6):530-4. doi:
10.1016/j.chemphyslip.2011.05.001. [PMID: 21679699] - Silke Matysik, Josefine Martin, Margarita Bala, Max Scherer, Andreas Schäffler, Gerd Schmitz. Bile acid signaling after an oral glucose tolerance test.
Chemistry and physics of lipids.
2011 Sep; 164(6):525-9. doi:
10.1016/j.chemphyslip.2011.05.003. [PMID: 21679700] - W Gordon Brydon, Pearl Culbert, Kathleen Kingstone, Ann Jarvie, Marietta Iacucci, Merel Tenhage, Subrata Ghosh. An evaluation of the use of serum 7-alpha-hydroxycholestenone as a diagnostic test of bile acid malabsorption causing watery diarrhea.
Canadian journal of gastroenterology = Journal canadien de gastroenterologie.
2011 Jun; 25(6):319-23. doi:
10.1155/2011/701287. [PMID: 21766092] - Martin Lenicek, Dana Duricova, Viktor Komarek, Bronislava Gabrysova, Milan Lukas, Zdenek Smerhovsky, Libor Vitek. Bile acid malabsorption in inflammatory bowel disease: assessment by serum markers.
Inflammatory bowel diseases.
2011 Jun; 17(6):1322-7. doi:
10.1002/ibd.21502. [PMID: 21058331] - Rima Kaddurah-Daouk, Rebecca A Baillie, Hongjie Zhu, Zhao-Bang Zeng, Michelle M Wiest, Uyen Thao Nguyen, Katie Wojnoonski, Steven M Watkins, Miles Trupp, Ronald M Krauss. Enteric microbiome metabolites correlate with response to simvastatin treatment.
PloS one.
2011; 6(10):e25482. doi:
10.1371/journal.pone.0025482. [PMID: 22022402] - Carine Steiner, Alaa Othman, Christoph H Saely, Philipp Rein, Heinz Drexel, Arnold von Eckardstein, Katharina M Rentsch. Bile acid metabolites in serum: intraindividual variation and associations with coronary heart disease, metabolic syndrome and diabetes mellitus.
PloS one.
2011; 6(11):e25006. doi:
10.1371/journal.pone.0025006. [PMID: 22110577] - Archana S Rao, Banny S Wong, Michael Camilleri, Suwebatu T Odunsi-Shiyanbade, Sanna McKinzie, Michael Ryks, Duane Burton, Paula Carlson, Jesse Lamsam, Ravinder Singh, Alan R Zinsmeister. Chenodeoxycholate in females with irritable bowel syndrome-constipation: a pharmacodynamic and pharmacogenetic analysis.
Gastroenterology.
2010 Nov; 139(5):1549-58, 1558.e1. doi:
10.1053/j.gastro.2010.07.052. [PMID: 20691689] - Carine Steiner, Arnold von Eckardstein, Katharina M Rentsch. Quantification of the 15 major human bile acids and their precursor 7α-hydroxy-4-cholesten-3-one in serum by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 Oct; 878(28):2870-80. doi:
10.1016/j.jchromb.2010.08.045. [PMID: 20869337] - Ann Båvner, Marjan Shafaati, Magnus Hansson, Maria Olin, Shoshi Shpitzen, Vardiella Meiner, Eran Leitersdorf, Ingemar Björkhem. On the mechanism of accumulation of cholestanol in the brain of mice with a disruption of sterol 27-hydroxylase.
Journal of lipid research.
2010 Sep; 51(9):2722-30. doi:
10.1194/jlr.m008326. [PMID: 20511491] - Tim C M A Schreuder, Hendrik A Marsman, Martin Lenicek, Jochem R van Werven, Aart J Nederveen, Peter L M Jansen, Frank G Schaap. The hepatic response to FGF19 is impaired in patients with nonalcoholic fatty liver disease and insulin resistance.
American journal of physiology. Gastrointestinal and liver physiology.
2010 Mar; 298(3):G440-5. doi:
10.1152/ajpgi.00322.2009. [PMID: 20093562] - Suwebatu T Odunsi-Shiyanbade, Michael Camilleri, Sanna McKinzie, Duane Burton, Paula Carlson, Irene A Busciglio, Jesse Lamsam, Ravinder Singh, Alan R Zinsmeister. Effects of chenodeoxycholate and a bile acid sequestrant, colesevelam, on intestinal transit and bowel function.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.
2010 Feb; 8(2):159-65. doi:
10.1016/j.cgh.2009.10.020. [PMID: 19879973] - Andrea E DeBarber, William E Connor, Anuradha S Pappu, Louise S Merkens, Robert D Steiner. ESI-MS/MS quantification of 7alpha-hydroxy-4-cholesten-3-one facilitates rapid, convenient diagnostic testing for cerebrotendinous xanthomatosis.
Clinica chimica acta; international journal of clinical chemistry.
2010 Jan; 411(1-2):43-8. doi:
10.1016/j.cca.2009.09.036. [PMID: 19808031] - J Kovář, M Leníček, M Zimolová, L Vítek, M Jirsa, J Pitha. Regulation of diurnal variation of cholesterol 7alpha-hydroxylase (CYP7A1) activity in healthy subjects.
Physiological research.
2010; 59(2):233-238. doi:
10.33549/physiolres.931753. [PMID: 19537927] - Jorge Herrera, Ludwig Amigo, Constanze Husche, Carlos Benítez, Silvana Zanlungo, Dieter Lütjohann, Juan Francisco Miquel, Flavio Nervi. Fecal bile acid excretion and messenger RNA expression levels of ileal transporters in high risk gallstone patients.
Lipids in health and disease.
2009 Dec; 8(?):53. doi:
10.1186/1476-511x-8-53. [PMID: 19995447] - Julian R F Walters, Ali M Tasleem, Omer S Omer, W Gordon Brydon, Tracy Dew, Carel W le Roux. A new mechanism for bile acid diarrhea: defective feedback inhibition of bile acid biosynthesis.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.
2009 Nov; 7(11):1189-94. doi:
10.1016/j.cgh.2009.04.024. [PMID: 19426836] - M Camilleri, A Nadeau, W J Tremaine, J Lamsam, D Burton, S Odunsi, S Sweetser, R Singh. Measurement of serum 7alpha-hydroxy-4-cholesten-3-one (or 7alphaC4), a surrogate test for bile acid malabsorption in health, ileal disease and irritable bowel syndrome using liquid chromatography-tandem mass spectrometry.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
2009 Jul; 21(7):734-e43. doi:
10.1111/j.1365-2982.2009.01288.x. [PMID: 19368662] - Xiaoqiang Xiang, Yi Han, Mikko Neuvonen, Marja K Pasanen, Annikka Kalliokoski, Janne T Backman, Jouko Laitila, Pertti J Neuvonen, Mikko Niemi. Effect of SLCO1B1 polymorphism on the plasma concentrations of bile acids and bile acid synthesis marker in humans.
Pharmacogenetics and genomics.
2009 Jun; 19(6):447-57. doi:
10.1097/fpc.0b013e32832bcf7b. [PMID: 19387419] - Zhao-Yan Jiang, Chong-Yi Jiang, Lei Wang, Jian-Cheng Wang, Sheng-Dao Zhang, Curt Einarsson, Mats Eriksson, Tian-Quan Han, Paolo Parini, Gösta Eggertsen. Increased NPC1L1 and ACAT2 expression in the jejunal mucosa from Chinese gallstone patients.
Biochemical and biophysical research communications.
2009 Jan; 379(1):49-54. doi:
10.1016/j.bbrc.2008.11.131. [PMID: 19071091] - Kjell-Arne Ung, Nima Mottacki, Mats Rudling, Antal Bajor. Biliary sphincterotomy does not relate to diarrhoea or major changes in bile acid synthesis or plasma lipids.
Scandinavian journal of gastroenterology.
2009; 44(9):1132-8. doi:
10.1080/00365520903131981. [PMID: 19811340] - Martin Lenícek, Viktor Komárek, Miluse Zimolová, Jan Kovár, Milan Jirsa, Milan Lukás, Libor Vítek. CYP7A1 promoter polymorphism -203A>C affects bile salt synthesis rate in patients after ileal resection.
Journal of lipid research.
2008 Dec; 49(12):2664-7. doi:
10.1194/jlr.m800364-jlr200. [PMID: 18728290] - Ariënne de Jong, Jogchum Plat, Dieter Lütjohann, Ronald P Mensink. Effects of long-term plant sterol or stanol ester consumption on lipid and lipoprotein metabolism in subjects on statin treatment.
The British journal of nutrition.
2008 Nov; 100(5):937-41. doi:
10.1017/s0007114508966113. [PMID: 18846701] - Marco Bertolotti, Marina Del Puppo, Chiara Gabbi, Federica Corna, Lucia Carulli, Elisa Pellegrini, Lisa Zambianchi, Claudia Anzivino, Matteo Ricchi, Paola Loria, Marzia Galli Kienle, Nicola Carulli. Correlation between plasma levels of 7alpha-hydroxy-4-cholesten-3-one and cholesterol 7alpha-hydroxylation rates in vivo in hyperlipidemic patients.
Steroids.
2008 Oct; 73(11):1197-202. doi:
10.1016/j.steroids.2008.05.011. [PMID: 18582481] - Martin Lenicek, Miroslava Juklova, Jaroslav Zelenka, Jan Kovar, Milan Lukas, Martin Bortlik, Libor Vitek. Improved HPLC analysis of serum 7alpha-hydroxycholest-4-en-3-one, a marker of bile acid malabsorption.
Clinical chemistry.
2008 Jun; 54(6):1087-8. doi:
10.1373/clinchem.2007.100107. [PMID: 18509016] - Anita Lövgren-Sandblom, Maura Heverin, Hanna Larsson, Eija Lundström, John Wahren, Ulf Diczfalusy, Ingemar Björkhem. Novel LC-MS/MS method for assay of 7alpha-hydroxy-4-cholesten-3-one in human plasma. Evidence for a significant extrahepatic metabolism.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Sep; 856(1-2):15-9. doi:
10.1016/j.jchromb.2007.05.019. [PMID: 17561450] - L Ellegård, H Andersson. Oat bran rapidly increases bile acid excretion and bile acid synthesis: an ileostomy study.
European journal of clinical nutrition.
2007 Aug; 61(8):938-45. doi:
10.1038/sj.ejcn.1602607. [PMID: 17251929] - M Bertolotti, C Gabbi, C Anzivino, M Crestani, N Mitro, M Del Puppo, C Godio, E De Fabiani, D Macchioni, L Carulli, A Rossi, M Ricchi, P Loria, N Carulli. Age-related changes in bile acid synthesis and hepatic nuclear receptor expression.
European journal of clinical investigation.
2007 Jun; 37(6):501-8. doi:
10.1111/j.1365-2362.2007.01808.x. [PMID: 17537158] - Juan Castro, Ludwig Amigo, Juan Francisco Miquel, Cecilia Gälman, Fernando Crovari, Alejandro Raddatz, Silvana Zanlungo, Roberto Jalil, Mats Rudling, Flavio Nervi. Increased activity of hepatic microsomal triglyceride transfer protein and bile acid synthesis in gallstone disease.
Hepatology (Baltimore, Md.).
2007 May; 45(5):1261-6. doi:
10.1002/hep.21616. [PMID: 17464999] - Ute Panzenboeck, Ulla Andersson, Magnus Hansson, Wolfgang Sattler, Steve Meaney, Ingemar Björkhem. On the mechanism of cerebral accumulation of cholestanol in patients with cerebrotendinous xanthomatosis.
Journal of lipid research.
2007 May; 48(5):1167-74. doi:
10.1194/jlr.m700027-jlr200. [PMID: 17325385] - Akira Honda, Kouwa Yamashita, Mitsuteru Numazawa, Tadashi Ikegami, Mikio Doy, Yasushi Matsuzaki, Hiroshi Miyazaki. Highly sensitive quantification of 7alpha-hydroxy-4-cholesten-3-one in human serum by LC-ESI-MS/MS.
Journal of lipid research.
2007 Feb; 48(2):458-64. doi:
10.1194/jlr.d600032-jlr200. [PMID: 17093295] - Marco Montagnani, Anna Abrahamsson, Cecilia Gälman, Gösta Eggertsen, Hanns-Ulrich Marschall, Elisa Ravaioli, Curt Einarsson, Paul A Dawson. Analysis of ileal sodium/bile acid cotransporter and related nuclear receptor genes in a family with multiple cases of idiopathic bile acid malabsorption.
World journal of gastroenterology.
2006 Dec; 12(47):7710-4. doi:
10.3748/wjg.v12.i47.7710. [PMID: 17171805] - A Bajor, A Kilander, C Gälman, M Rudling, K-A Ung. Budesonide treatment is associated with increased bile acid absorption in collagenous colitis.
Alimentary pharmacology & therapeutics.
2006 Dec; 24(11-12):1643-9. doi:
10.1111/j.1365-2036.2006.03168.x. [PMID: 17094773] - D M Klass, K Bührmann, G Sauter, M Del Puppo, J Scheibner, M Fuchs, E F Stange. Biliary lipids, cholesterol and bile synthesis: different adaptive mechanisms to dietary cholesterol in lean and obese subjects.
Alimentary pharmacology & therapeutics.
2006 Apr; 23(7):895-905. doi:
10.1111/j.1365-2036.2006.02836.x. [PMID: 16573792] - L Ellegård, H Andersson, I Bosaeus. Rapeseed oil, olive oil, plant sterols, and cholesterol metabolism: an ileostomy study.
European journal of clinical nutrition.
2005 Dec; 59(12):1374-8. doi:
10.1038/sj.ejcn.1602249. [PMID: 16091765] - Cecilia Gälman, Bo Angelin, Mats Rudling. Bile acid synthesis in humans has a rapid diurnal variation that is asynchronous with cholesterol synthesis.
Gastroenterology.
2005 Nov; 129(5):1445-53. doi:
10.1053/j.gastro.2005.09.009. [PMID: 16285946] - Manuela Matasconi, Paolo Parini, Bo Angelin, Mats Rudling. Pituitary control of cholesterol metabolism in normal and LDL receptor knock-out mice: effects of hypophysectomy and growth hormone treatment.
Biochimica et biophysica acta.
2005 Oct; 1736(3):221-7. doi:
10.1016/j.bbalip.2005.08.012. [PMID: 16185916] - Anna Abrahamsson, Sergey Krapivner, Ulf Gustafsson, Olle Muhrbeck, Gösta Eggertsen, Inger Johansson, Irene Persson, Bo Angelin, Magnus Ingelman-Sundberg, Ingemar Björkhem, Curt Einarsson, Ferdinand M van't Hooft. Common polymorphisms in the CYP7A1 gene do not contribute to variation in rates of bile acid synthesis and plasma LDL cholesterol concentration.
Atherosclerosis.
2005 Sep; 182(1):37-45. doi:
10.1016/j.atherosclerosis.2005.01.032. [PMID: 16115473] - Hanns-Ulrich Marschall, Martin Wagner, Gernot Zollner, Peter Fickert, Ulf Diczfalusy, Judith Gumhold, Dagmar Silbert, Andrea Fuchsbichler, Lisbet Benthin, Rosita Grundström, Ulf Gustafsson, Staffan Sahlin, Curt Einarsson, Michael Trauner. Complementary stimulation of hepatobiliary transport and detoxification systems by rifampicin and ursodeoxycholic acid in humans.
Gastroenterology.
2005 Aug; 129(2):476-85. doi:
10.1016/j.gastro.2005.05.009. [PMID: 16083704] - Frans H O'Neill, Tom A B Sanders, Gilbert R Thompson. Comparison of efficacy of plant stanol ester and sterol ester: short-term and longer-term studies.
The American journal of cardiology.
2005 Jul; 96(1A):29D-36D. doi:
10.1016/j.amjcard.2005.03.017. [PMID: 15992513] - L Ellegård, A Sunesson, I Bosaeus. High serum phytosterol levels in short bowel patients on parenteral nutrition support.
Clinical nutrition (Edinburgh, Scotland).
2005 Jun; 24(3):415-20. doi:
10.1016/j.clnu.2005.01.001. [PMID: 15896428] - Mark V Boekschoten, Maaike K Hofman, Rien Buytenhek, Evert G Schouten, Hans M G Princen, Martijn B Katan. Coffee oil consumption increases plasma levels of 7alpha-hydroxy-4-cholesten-3-one in humans.
The Journal of nutrition.
2005 Apr; 135(4):785-9. doi:
10.1093/jn/135.4.785. [PMID: 15795435] - Akira Honda, Gerald Salen, Yasushi Matsuzaki, Ashok K Batta, Guorong Xu, Takeshi Hirayama, G Stephen Tint, Mikio Doy, Sarah Shefer. Disrupted coordinate regulation of farnesoid X receptor target genes in a patient with cerebrotendinous xanthomatosis.
Journal of lipid research.
2005 Feb; 46(2):287-96. doi:
10.1194/jlr.m400256-jlr200. [PMID: 15576845] - D Lütjohann, C Hahn, W Prange, T Sudhop, M Axelson, T Sauerbruch, K von Bergmann, C Reichel. Influence of rifampin on serum markers of cholesterol and bile acid synthesis in men.
International journal of clinical pharmacology and therapeutics.
2004 Jun; 42(6):307-13. doi:
10.5414/cpp42307. [PMID: 15222722] - Cecilia Gälman, Juan Francisco Miquel, Rosa Maria Pérez, Curt Einarsson, Lars Ståhle, Guillermo Marshall, Flavio Nervi, Mats Rudling. Bile acid synthesis is increased in Chilean Hispanics with gallstones and in gallstone high-risk Mapuche Indians.
Gastroenterology.
2004 Mar; 126(3):741-8. doi:
10.1053/j.gastro.2003.12.009. [PMID: 14988828] - Suzanne Lind, Mats Rudling, Sverker Ericsson, Hans Olivecrona, Mats Eriksson, Birgit Borgström, Gösta Eggertsen, Lars Berglund, Bo Angelin. Growth hormone induces low-density lipoprotein clearance but not bile acid synthesis in humans.
Arteriosclerosis, thrombosis, and vascular biology.
2004 Feb; 24(2):349-56. doi:
10.1161/01.atv.0000110657.67317.90. [PMID: 14656733] - Akira Honda, Tadashi Yoshida, Guorong Xu, Yasushi Matsuzaki, Sugano Fukushima, Naomi Tanaka, Mikio Doy, Sarah Shefer, Gerald Salen. Significance of plasma 7alpha-hydroxy-4-cholesten-3-one and 27-hydroxycholesterol concentrations as markers for hepatic bile acid synthesis in cholesterol-fed rabbits.
Metabolism: clinical and experimental.
2004 Jan; 53(1):42-8. doi:
10.1016/j.metabol.2003.07.018. [PMID: 14681840] - Gerd H Sauter, Kai Thiessen, Klaus G Parhofer, Christoph Jüngst, Sven Fischer, Dieter Jüngst. Effects of ursodeoxycholic acid on synthesis of cholesterol and bile acids in healthy subjects.
Digestion.
2004; 70(2):79-83. doi:
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