4-Hydroxyaminoquinoline N-oxide (BioDeep_00000005387)

 

Secondary id: BioDeep_00000910906


代谢物信息卡片


4-Quinolinamine, N-hydroxy-, 1-oxide

化学式: C9H8N2O2 (176.0586)
中文名称: 4-(羟氨基)喹啉 N-氧化物
谱图信息: 最多检出来源 Homo sapiens(blood) 36.28%

分子结构信息

SMILES: C1=CC=C2C(=C1)C(=NO)C=CN2O
InChI: InChI=1S/C9H8N2O2/c12-10-8-5-6-11(13)9-4-2-1-3-7(8)9/h1-6,12-13H/b10-8+

描述信息

D009676 - Noxae > D002273 - Carcinogens
D009676 - Noxae > D009153 - Mutagens

同义名列表

5 个代谢物同义名

4-Quinolinamine, N-hydroxy-, 1-oxide; 4-(hydroxyamino)quinoline N-oxide; 4-Hydroxyaminoquinoline N-oxide; 4-Hydroxyaminoquinoline-1-oxide; 4-Hydroxyaminoquinoline N-oxide



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 CAT, CMPK2, HPGDS, MDM2, MIF, MYC, NME1, NQO1
Peripheral membrane protein 1 HSD17B6
Endoplasmic reticulum membrane 1 HSP90B1
Nucleus 10 FOS, HSP90B1, JUN, MDM2, MKI67, MYC, NME1, NQO1, PCNA, SERPINA3
cytosol 9 CAT, FOS, HPGDS, HSP90B1, MDM2, MIF, NGF, NME1, NQO1
dendrite 2 NGF, NQO1
nuclear body 2 MKI67, PCNA
centrosome 1 PCNA
nucleoplasm 9 CMPK2, FOS, HPGDS, JUN, MDM2, MIF, MKI67, MYC, PCNA
RNA polymerase II transcription regulator complex 2 FOS, JUN
ruffle membrane 1 NME1
Early endosome membrane 1 HSD17B6
Synapse 1 NQO1
cell surface 1 MIF
glutamatergic synapse 1 MDM2
Golgi apparatus 1 SERPINA1
Golgi membrane 1 INS
neuronal cell body 1 NQO1
smooth endoplasmic reticulum 1 HSP90B1
synaptic vesicle 1 NGF
Cytoplasm, cytosol 1 NQO1
plasma membrane 3 GCG, MDM2, MIF
Membrane 6 CAT, HSP90B1, MKI67, MYC, NME1, NQO1
axon 2 CCK, NGF
extracellular exosome 7 CAT, HSP90B1, MIF, NME1, PCNA, SERPINA1, SERPINA3
Lumenal side 1 HSD17B6
endoplasmic reticulum 4 FOS, HSD17B6, HSP90B1, SERPINA1
extracellular space 7 CCK, GCG, INS, MIF, NGF, SERPINA1, SERPINA3
perinuclear region of cytoplasm 1 HSP90B1
mitochondrion 2 CAT, CMPK2
protein-containing complex 4 CAT, HSP90B1, MDM2, MYC
intracellular membrane-bounded organelle 4 CAT, HPGDS, HSD17B6, SERPINA1
Microsome membrane 1 HSD17B6
postsynaptic density 1 MDM2
Secreted 5 CCK, GCG, INS, MIF, NGF
extracellular region 9 CAT, CCK, GCG, HSP90B1, INS, MIF, NGF, SERPINA1, SERPINA3
mitochondrial matrix 1 CAT
transcription regulator complex 1 JUN
nucleolus 3 MDM2, MKI67, MYC
midbody 1 HSP90B1
Early endosome 1 NME1
COPII-coated ER to Golgi transport vesicle 1 SERPINA1
vesicle 1 MIF
focal adhesion 2 CAT, HSP90B1
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 3 HSP90B1, SERPINA1, SERPINA3
chromatin 4 FOS, JUN, MYC, PCNA
Chromosome 1 MKI67
Nucleus, nucleolus 3 MDM2, MKI67, MYC
nuclear replication fork 1 PCNA
chromosome, telomeric region 1 PCNA
nuclear chromosome 1 JUN
blood microparticle 1 SERPINA3
nuclear envelope 1 MYC
endosome lumen 2 INS, NGF
Nucleus, nucleoplasm 2 MDM2, MYC
Melanosome 1 HSP90B1
euchromatin 1 JUN
replication fork 1 PCNA
sperm plasma membrane 1 HSP90B1
ficolin-1-rich granule lumen 3 CAT, MIF, SERPINA1
secretory granule lumen 5 CAT, GCG, INS, MIF, SERPINA3
Golgi lumen 2 INS, NGF
endoplasmic reticulum lumen 4 GCG, HSP90B1, INS, SERPINA1
nuclear matrix 1 FOS
transcription repressor complex 1 MDM2
male germ cell nucleus 1 PCNA
platelet alpha granule lumen 2 SERPINA1, SERPINA3
endocytic vesicle membrane 1 MDM2
transport vesicle 1 INS
RNA polymerase II transcription repressor complex 1 MYC
azurophil granule lumen 1 SERPINA3
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 INS, SERPINA1
nuclear lamina 1 PCNA
Sarcoplasmic reticulum lumen 1 HSP90B1
protein-DNA complex 1 FOS
Rough endoplasmic reticulum 1 MYC
cyclin-dependent protein kinase holoenzyme complex 1 PCNA
endocytic vesicle lumen 1 HSP90B1
transcription factor AP-1 complex 2 FOS, JUN
Myc-Max complex 1 MYC
[Glucagon-like peptide 1]: Secreted 1 GCG
catalase complex 1 CAT
endoplasmic reticulum chaperone complex 1 HSP90B1
PCNA complex 1 PCNA
PCNA-p21 complex 1 PCNA
replisome 1 PCNA
nucleoplasmic reticulum 1 MYC


文献列表

  • X S Qin, Y Nakatsuru, M Tada, T Ishikawa. Species and organ differences in DNA adduct formation and repair after treatment with 4-hydroxyaminoquinoline 1-oxide. Japanese journal of cancer research : Gann. 1990 Jun; 81(6-7):613-9. doi: 10.1111/j.1349-7006.1990.tb02617.x. [PMID: 2119365]
  • K Okamura. Morphological, biochemical and autoradiographic studies of pancreatic acinar cell necrosis and its regeneration induced by 4-hydroxyaminoquinoline-1-oxide in rats. Gastroenterologia Japonica. 1989 Apr; 24(2):181-94. doi: 10.1007/bf02774195. [PMID: 2501134]
  • M A Moore, T Makino, S Tsuchida, K Sato, A Ichihara, Z Amelizad, F Oesch, Y Konishi. Altered drug metabolizing potential of acinar cell lesions induced in rat pancreas by hydroxyaminoquinoline 1-oxide. Carcinogenesis. 1987 Aug; 8(8):1089-94. doi: 10.1093/carcin/8.8.1089. [PMID: 2886232]
  • Y Mii, H Maruayama, Y Miyauchi, Y Yokose, K Masuhara, Y Konishi. Experimental studies on malignant fibrous histiocytomas in rats. I. Production of malignant fibrous histiocytomas by 4-hydroxyaminoquinoline 1-oxide in bone of Fischer 344 strain rats. Cancer. 1982 Nov; 50(10):2057-65. doi: 10.1002/1097-0142(19821115)50:10<2057::aid-cncr2820501016>3.0.co;2-y. [PMID: 6290021]
  • M S Rao, M P Upton, V Subbarao, D G Scarpelli. Two populations of cells with differing proliferative capacities in atypical acinar cell foci induced by 4-hydroxyaminoquinoline-1-oxide in the rat pancreas. Laboratory investigation; a journal of technical methods and pathology. 1982 May; 46(5):527-34. doi: . [PMID: 6804715]
  • W Leon, F S Cruz, M E Vasconcellos. Toxicity of 4-nitroquinoline 1-oxide for Crithidia fasciculata. The Journal of protozoology. 1975 May; 22(2):277-80. doi: 10.1111/j.1550-7408.1975.tb05867.x. [PMID: 50443]