Dihydrolipoamide (BioDeep_00000004451)

 

Secondary id: BioDeep_00000630722

human metabolite Endogenous


代谢物信息卡片


Dihydrolipoamide, (+-)-isomer

化学式: C8H17NOS2 (207.0752)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(lipidomics) 24.57%

分子结构信息

SMILES: C(CCC(=O)N)CC(CCS)S
InChI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10)

描述信息

Dihydrolipoamide is an intermediate in glycolysis/gluconeogenesis, citrate cycle (TCA cycle), alanine, aspartate and pyruvate metabolism, and valine, leucine and isoleucine degradation (KEGG ID C00579). It is converted to lipoamide via the enzyme dihydrolipoamide dehydrogenase [EC:1.8.1.4]. Dihydrolipoamide is also a substrate of enzyme Acyltransferases [EC 2.3.1.-]. (KEGG) [HMDB]. Dihydrolipoamide is found in many foods, some of which are enokitake, mugwort, welsh onion, and tea.
Dihydrolipoamide is an intermediate in glycolysis/gluconeogenesis, citrate cycle (TCA cycle), alanine, aspartate and pyruvate metabolism, and valine, leucine and isoleucine degradation (KEGG ID C00579). It is converted to lipoamide via the enzyme dihydrolipoamide dehydrogenase [EC:1.8.1.4]. Dihydrolipoamide is also a substrate of enzyme Acyltransferases [EC 2.3.1.-]. (KEGG).

同义名列表

8 个代谢物同义名

Dihydrolipoamide, (+-)-isomer; 6,8-Bis-sulfanyloctanamide; 6,8-Dimercapto-octanamide; 6,8-Dimercaptooctanamide; 6,8-Disulfanyloctanamide; Dihydrothioctamide; dihydrolipoamide; Dihydrolipoamide



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

79 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(5)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(74)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 AKT1, ALB, CAT, CIT, MIF, TXN
Peripheral membrane protein 1 HSD17B6
Nucleus 10 AKT1, ALB, DLD, DLST, GLRX, GLRX2, PDC, PDHA1, TCF15, TXN
cytosol 10 AKT1, ALB, CAT, CIT, DLST, GLRX, GSR, MIF, PDC, TXN
dendrite 1 GLRX2
centrosome 1 ALB
nucleoplasm 6 AKT1, DLST, GLDC, GLRX2, MIF, TXN
RNA polymerase II transcription regulator complex 1 TCF15
Cell membrane 1 AKT1
lamellipodium 1 AKT1
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 1 ABCC3
cell cortex 1 AKT1
cell surface 1 MIF
glutamatergic synapse 1 AKT1
Golgi apparatus 1 ALB
Golgi membrane 1 INS
neuronal cell body 1 GLRX2
postsynapse 1 AKT1
Cytoplasm, cytosol 1 PDC
acrosomal vesicle 1 DLD
plasma membrane 4 ABCC3, AKT1, GLDC, MIF
Membrane 6 ABCC3, AKT1, CAT, CIT, DLST, EPHX4
basolateral plasma membrane 1 ABCC3
extracellular exosome 6 ALB, CAT, GLRX, GSR, MIF, TXN
Lumenal side 1 HSD17B6
endoplasmic reticulum 2 ALB, HSD17B6
extracellular space 4 ALB, INS, MIF, TST
mitochondrion 8 CAT, DLD, DLST, GLDC, GLRX2, GSR, PDHA1, TST
protein-containing complex 3 AKT1, ALB, CAT
intracellular membrane-bounded organelle 3 CAT, GLRX2, HSD17B6
Microsome membrane 1 HSD17B6
Secreted 4 ALB, INS, MIF, TXN
extracellular region 5 ALB, CAT, INS, MIF, TXN
Mitochondrion matrix 4 DLD, DLST, PDHA1, TST
mitochondrial matrix 8 CAT, DLD, DLST, GLDC, GLRX2, GSR, PDHA1, TST
anchoring junction 1 ALB
motile cilium 1 DLD
photoreceptor inner segment 1 PDC
photoreceptor outer segment 1 PDC
external side of plasma membrane 1 GSR
microtubule cytoskeleton 1 AKT1
nucleolus 1 PDHA1
cell-cell junction 1 AKT1
Single-pass type II membrane protein 1 EPHX4
vesicle 2 AKT1, MIF
focal adhesion 1 CAT
spindle 1 AKT1
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
ciliary basal body 2 AKT1, ALB
chromatin 1 TCF15
centriole 1 ALB
Cell projection, cilium, photoreceptor outer segment 1 PDC
Cytoplasmic vesicle, secretory vesicle, acrosome 1 DLD
spindle pole 1 ALB
blood microparticle 1 ALB
Cell projection, cilium, flagellum 1 DLD
Basolateral cell membrane 1 ABCC3
endosome lumen 1 INS
basal plasma membrane 1 ABCC3
ficolin-1-rich granule lumen 2 CAT, MIF
secretory granule lumen 3 CAT, INS, MIF
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 ALB, INS
platelet alpha granule lumen 1 ALB
pyruvate dehydrogenase complex 2 DLD, PDHA1
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
oxoglutarate dehydrogenase complex 2 DLD, DLST
[Isoform 2]: Nucleus 1 PDC
Basal cell membrane 1 ABCC3
oxidoreductase complex 1 DLST
catalase complex 1 CAT
acetyltransferase complex 1 DLD
acrosomal matrix 1 DLD
branched-chain alpha-ketoacid dehydrogenase complex 1 DLD
oxoadipate dehydrogenase complex 2 DLD, DLST
glycine cleavage complex 1 GLDC
ciliary transition fiber 1 ALB


文献列表

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