Dalbergin (BioDeep_00000003678)

human metabolite PANOMIX_OTCML-2023 natural product

代谢物信息卡片

6-hydroxy-7-methoxy-4-phenyl-2H-chromen-2-one

化学式: C16H12O4 (268.0736)
中文名称: 黄檀素
谱图信息: 最多检出来源 Viridiplantae(plant) 21.88%

分子结构信息

SMILES: c1(c(cc2c(c1)oc(=O)cc2c1ccccc1)O)OC
InChI: InChI=1S/C16H12O4/c1-19-15-9-14-12(7-13(15)17)11(8-16(18)20-14)10-5-3-2-4-6-10/h2-9,17H,1H3

描述信息

A polyphenol metabolite detected in biological fluids [PhenolExplorer]

同义名列表

4 个代谢物同义名

6-hydroxy-7-methoxy-4-phenyl-2H-chromen-2-one; 6-Hydroxy-7-methoxy-4-phenylcoumarin; Dalbergin; Dalbergin

数据库引用编号

17 个数据库交叉引用编号

ChEBI: CHEBI:4308
KEGG: C10414
PubChem: 442768
HMDB: HMDB0303925
Metlin: METLIN48365
ChEMBL: CHEMBL1829658
LipidMAPS: LMPK12100003
KNApSAcK: C00002519
foodb: FDB029982
chemspider: 391108
CAS: 482-83-7
PMhub: MS000010868
PubChem: 12600
3DMET: B03827
NIKKAJI: J13.175J
LOTUS: LTS0237536
KNApSAcK: 4308

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

88 个相关的物种来源信息

53862 - Dalbergia: LTS0237536
1353437 - Dalbergia baronii:
1353437 - Dalbergia baronii: 10.1016/0031-9422(73)85048-4
1353437 - Dalbergia baronii: 10.1016/S0040-4020(01)82536-9
1353437 - Dalbergia baronii: LTS0237536
1353446 - Dalbergia cearensis:
1353446 - Dalbergia cearensis: 10.1016/0031-9422(73)85048-4
1353446 - Dalbergia cearensis: 10.1016/S0031-9422(00)98663-1
1353446 - Dalbergia cearensis: LTS0237536
106130 - Dalbergia cochinchinensis:
106130 - Dalbergia cochinchinensis: 10.1016/0031-9422(73)85048-4
106130 - Dalbergia cochinchinensis: 10.1016/S0031-9422(97)80015-5
106130 - Dalbergia cochinchinensis: 10.1021/NP0300683
106130 - Dalbergia cochinchinensis: LTS0237536
862910 - Dalbergia cultrata:
862910 - Dalbergia cultrata: 10.1016/0031-9422(72)80056-6
862910 - Dalbergia cultrata: 10.1016/0031-9422(73)85048-4
862910 - Dalbergia cultrata: 10.1021/NP0300683
862910 - Dalbergia cultrata: LTS0237536
114981 - Dalbergia melanoxylon: 10.1021/NP0300683
114981 - Dalbergia melanoxylon: LTS0237536
397178 - Dalbergia miscolobium:
397178 - Dalbergia miscolobium: 10.1016/0031-9422(73)85048-4
397178 - Dalbergia miscolobium: 10.1016/S0031-9422(00)94592-8
397178 - Dalbergia miscolobium: LTS0237536
450027 - Dalbergia monetaria:
450027 - Dalbergia monetaria: 10.1016/0031-9422(73)85048-4
450027 - Dalbergia monetaria: 10.1016/0031-9422(83)80186-1
450027 - Dalbergia monetaria: 10.1016/S0031-9422(00)89103-7
450027 - Dalbergia monetaria: LTS0237536
450028 - Dalbergia nigra: 10.1016/J.PHYTOCHEM.2010.04.011
450028 - Dalbergia nigra: LTS0237536
1265830 - Dalbergia nitidula:
1265830 - Dalbergia nitidula: 10.1016/0031-9422(73)85048-4
1265830 - Dalbergia nitidula: 10.1016/S0031-9422(00)89039-1
1265830 - Dalbergia nitidula: LTS0237536
499988 - Dalbergia odorifera:
499988 - Dalbergia odorifera: 10.1002/RCM.1936
499988 - Dalbergia odorifera: 10.1016/0031-9422(73)85048-4
499988 - Dalbergia odorifera: 10.1016/S0031-9422(97)00365-8
499988 - Dalbergia odorifera: 10.1021/NP0300683
499988 - Dalbergia odorifera: 10.1055/S-2006-957394
499988 - Dalbergia odorifera: 10.1248/CPB.56.1722
499988 - Dalbergia odorifera: LTS0237536
1889010 - Dalbergia riparia:
1889010 - Dalbergia riparia: 10.1016/0031-9422(73)85048-4
1889010 - Dalbergia riparia: 10.1021/NP0300683
1889010 - Dalbergia riparia: LTS0237536
2507847 - Dalbergia sissoides:
2507847 - Dalbergia sissoides: 10.1016/0031-9422(73)85048-4
2507847 - Dalbergia sissoides: LTS0237536
107308 - Dalbergia sissoo:
107308 - Dalbergia sissoo: 10.1016/0031-9422(73)85048-4
107308 - Dalbergia sissoo: 10.1021/NP0300683
107308 - Dalbergia sissoo: LTS0237536
1353472 - Dalbergia spruceana:
1353472 - Dalbergia spruceana: 10.1016/0031-9422(73)85048-4
1353472 - Dalbergia spruceana: 10.1016/J.PHYTOCHEM.2010.04.011
1353472 - Dalbergia spruceana: 10.1016/S0031-9422(00)94601-6
1353472 - Dalbergia spruceana: LTS0237536
1966414 - Dalbergia stevensonii:
1966414 - Dalbergia stevensonii: 10.1016/0031-9422(73)85048-4
1966414 - Dalbergia stevensonii: 10.1021/NP0300683
1966414 - Dalbergia stevensonii: 10.1039/P19730001737
1966414 - Dalbergia stevensonii: LTS0237536
1544813 - Dalbergia volubilis:
1544813 - Dalbergia volubilis: 10.1016/0031-9422(73)85048-4
1544813 - Dalbergia volubilis: 10.1016/0031-9422(83)80186-1
1544813 - Dalbergia volubilis: 10.1016/S0031-9422(00)89103-7
1544813 - Dalbergia volubilis: LTS0237536
2759 - Eukaryota: LTS0237536
3803 - Fabaceae: LTS0237536
9606 - Homo sapiens: -
53897 - Machaerium: LTS0237536
1954621 - Machaerium pedicellatum:
1954621 - Machaerium pedicellatum: 10.1016/0031-9422(73)80478-9
1954621 - Machaerium pedicellatum: LTS0237536
225113 - Machaerium scleroxylon:
3398 - Magnoliopsida: LTS0237536
100169 - Pterocarpus: LTS0237536
1071199 - Pterocarpus santalinus: 10.1016/J.BMCL.2011.06.036
1071199 - Pterocarpus santalinus: LTS0237536
53922 - Senna: LTS0237536
53923 - Senna alata: 10.1016/0031-9422(93)85192-T
53923 - Senna alata: LTS0237536
35493 - Streptophyta: LTS0237536
58023 - Tracheophyta: LTS0237536
33090 - Viridiplantae: LTS0237536

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位		关联基因列表
Cytoplasm	11	CASP3, CAT, ELANE, GAPDH, MAPK14, MAPK8, MTOR, PTGS2, RUNX2, SRARP, TYR
Peripheral membrane protein	3	GORASP1, MTOR, PTGS2
Endoplasmic reticulum membrane	3	HMOX1, MTOR, PTGS2
Nucleus	9	CASP3, GABPA, GAPDH, HMOX1, MAPK14, MAPK8, MTOR, RUNX2, SRARP
cytosol	9	CASP3, CAT, ELANE, GAPDH, HMOX1, MAPK14, MAPK8, MTOR, RUNX2
dendrite	1	MTOR
phagocytic vesicle	2	ELANE, MTOR
nucleoplasm	7	CASP3, GABPA, HMOX1, MAPK14, MAPK8, MTOR, RUNX2
Cell membrane	1	TNF
Cytoplasmic side	3	GORASP1, HMOX1, MTOR
Golgi apparatus membrane	2	GORASP1, MTOR
Synapse	1	MAPK8
cell surface	2	ELANE, TNF
glutamatergic synapse	2	CASP3, MAPK14
Golgi apparatus	1	GORASP1
Golgi membrane	2	GORASP1, MTOR
lysosomal membrane	2	GAA, MTOR
neuronal cell body	2	CASP3, TNF
Cytoplasm, cytosol	1	GAPDH
Lysosome	3	GAA, MTOR, TYR
plasma membrane	4	GAA, GAPDH, TNF, TNFRSF11B
Membrane	5	CAT, GAA, GAPDH, HMOX1, MTOR
axon	1	MAPK8
caveola	1	PTGS2
extracellular exosome	5	BMP3, CAT, ELANE, GAA, GAPDH
Lysosome membrane	2	GAA, MTOR
endoplasmic reticulum	2	HMOX1, PTGS2
extracellular space	6	BMP3, ELANE, HMOX1, IL6, TNF, TNFRSF11B
lysosomal lumen	1	GAA
perinuclear region of cytoplasm	3	GAPDH, HMOX1, TYR
mitochondrion	2	CAT, MAPK14
protein-containing complex	2	CAT, PTGS2
intracellular membrane-bounded organelle	4	CAT, GAA, GAPDH, TYR
Microsome membrane	2	MTOR, PTGS2
postsynaptic density	1	CASP3
TORC1 complex	1	MTOR
TORC2 complex	1	MTOR
Single-pass type I membrane protein	1	TYR
Secreted	4	BMP3, GAA, IL6, TNFRSF11B
extracellular region	9	BMP3, CAT, DNAH9, ELANE, GAA, IL6, MAPK14, TNF, TNFRSF11B
Mitochondrion outer membrane	1	MTOR
mitochondrial outer membrane	2	HMOX1, MTOR
mitochondrial matrix	1	CAT
transcription regulator complex	1	RUNX2
motile cilium	1	DNAH9
nuclear membrane	1	GAPDH
external side of plasma membrane	1	TNF
microtubule cytoskeleton	1	GAPDH
Melanosome membrane	1	TYR
Golgi-associated vesicle	1	TYR
recycling endosome	1	TNF
Single-pass type II membrane protein	1	TNF
vesicle	1	GAPDH
Cytoplasm, perinuclear region	1	GAPDH
Membrane raft	1	TNF
Cytoplasm, cytoskeleton	1	GAPDH
focal adhesion	1	CAT
microtubule	1	DNAH9
cis-Golgi network	1	GORASP1
extracellular matrix	1	TNFRSF11B
Peroxisome	1	CAT
Peroxisome matrix	1	CAT
peroxisomal matrix	1	CAT
peroxisomal membrane	1	CAT
Nucleus, PML body	1	MTOR
PML body	1	MTOR
collagen-containing extracellular matrix	1	ELANE
secretory granule	1	ELANE
axoneme	1	DNAH9
nuclear speck	1	MAPK14
Nucleus inner membrane	1	PTGS2
Nucleus outer membrane	1	PTGS2
nuclear inner membrane	1	PTGS2
nuclear outer membrane	1	PTGS2
receptor complex	1	TNFRSF11B
neuron projection	1	PTGS2
chromatin	2	GABPA, RUNX2
phagocytic cup	1	TNF
cytoskeleton	1	GAPDH
spindle pole	1	MAPK14
Cytoplasm, cytoskeleton, cilium axoneme	1	DNAH9
nuclear envelope	1	MTOR
Endomembrane system	1	MTOR
Lipid droplet	1	GAPDH
tertiary granule membrane	1	GAA
Melanosome	1	TYR
ficolin-1-rich granule lumen	2	CAT, MAPK14
secretory granule lumen	2	CAT, MAPK14
endoplasmic reticulum lumen	2	IL6, PTGS2
transcription repressor complex	1	ELANE
specific granule lumen	1	ELANE
azurophil granule membrane	1	GAA
azurophil granule lumen	1	ELANE
Endoplasmic reticulum-Golgi intermediate compartment membrane	1	GORASP1
9+2 motile cilium	1	DNAH9
dynein complex	1	DNAH9
Golgi apparatus, cis-Golgi network membrane	1	GORASP1
Single-pass type IV membrane protein	1	HMOX1
ribonucleoprotein complex	1	GAPDH
ficolin-1-rich granule membrane	1	GAA
basal dendrite	1	MAPK8
death-inducing signaling complex	1	CASP3
Cytoplasmic vesicle, phagosome	2	ELANE, MTOR
GAIT complex	1	GAPDH
[Tumor necrosis factor, soluble form]: Secreted	1	TNF
catalase complex	1	CAT
interleukin-6 receptor complex	1	IL6
autolysosome lumen	1	GAA
outer dynein arm	1	DNAH9
[C-domain 2]: Secreted	1	TNF
[Tumor necrosis factor, membrane form]: Membrane	1	TNF
[C-domain 1]: Secreted	1	TNF
distal portion of axoneme	1	DNAH9

文献列表

Dharmendra Choudhary, Priyanka Kushwaha, Jyoti Gautam, Padam Kumar, Ashwani Verma, Avinash Kumar, Saransh Wales Maurya, Ibadur Rahman Siddiqui, Prabhat Ranjan Mishra, Rakesh Maurya, Ritu Trivedi. Fast and long acting neoflavonoids dalbergin isolated from Dalbergia sissoo heartwood is osteoprotective in ovariectomized model of osteoporosis: Osteoprotective effect of Dalbergin. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2016 Oct; 83(?):942-957. doi: 10.1016/j.biopha.2016.08.010. [PMID: 27522257]
Padam Kumar, Priyanka Kushwaha, Vikram Khedgikar, Jyoti Gautam, Dharmendra Choudhary, Divya Singh, Ritu Trivedi, Rakesh Maurya. Neoflavonoids as potential osteogenic agents from Dalbergia sissoo heartwood. Bioorganic & medicinal chemistry letters. 2014 Jun; 24(12):2664-8. doi: 10.1016/j.bmcl.2014.04.056. [PMID: 24803361]
Shou-Fang Wu, Tsong-Long Hwang, Shu-Li Chen, Chin-Chung Wu, Emika Ohkoshi, Kuo-Hsiung Lee, Fang-Rong Chang, Yang-Chang Wu. Bioactive components from the heartwood of Pterocarpus santalinus. Bioorganic & medicinal chemistry letters. 2011 Sep; 21(18):5630-2. doi: 10.1016/j.bmcl.2011.06.036. [PMID: 21784631]
Mohammad Asif, Arun Kumar. Phytochemical investigation and evaluation of antinociceptive activity of ethanolic extract of Dalbergia sissoo (Roxb.) bark. Journal of natural science, biology, and medicine. 2011 Jan; 2(1):76-9. doi: 10.4103/0976-9668.82315. [PMID: 22470239]
Rong Tsao. Chemistry and biochemistry of dietary polyphenols. Nutrients. 2010 12; 2(12):1231-46. doi: 10.3390/nu2121231. [PMID: 22254006]
Andreas Daugsch, Cleber S Moraes, Patricia Fort, Yong K Park. Brazilian red propolis--chemical composition and botanical origin. Evidence-based complementary and alternative medicine : eCAM. 2008 Dec; 5(4):435-41. doi: 10.1093/ecam/nem057. [PMID: 18955226]
Shu-ying Yao, Yun-bao Ma, Ya Tang, Ji-jun Chen, Xue-mei Zhang. [Chemical constituents of Oxytropis falcate]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2008 Jun; 33(12):1418-21. doi: . [PMID: 18837346]
Rong-Xia Liu, Qiao Wang, Hong-Zhu Guo, Li Li, Kai-Shun Bi, De-An Guo. Simultaneous determination of 10 major flavonoids in Dalbergia odorifera by high performance liquid chromatography. Journal of pharmaceutical and biomedical analysis. 2005 Sep; 39(3-4):469-76. doi: 10.1016/j.jpba.2005.04.007. [PMID: 15935596]
Osamu Shirota, Vibha Pathak, Setsuko Sekita, Motoyoshi Satake, Yoshio Nagashima, Yutaka Hirayama, Yusuke Hakamata, Tatsuo Hayashi. Phenolic constituents from Dalbergia cochinchinensis. Journal of natural products. 2003 Aug; 66(8):1128-31. doi: 10.1021/np0300683. [PMID: 12932142]