MET-enkephalin (BioDeep_00000003590)

 

Secondary id: BioDeep_00000015403

Volatile Flavor Compounds


代谢物信息卡片


Met-Enkephalin acetate salt

化学式: C27H35N5O7S (573.225708)
中文名称: 蛋氨酸脑啡肽三氟乙酸盐
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CSCCC(C(=O)O)NC(=O)C(CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)C(CC2=CC=C(C=C2)O)N
InChI: InChI=1S/C27H35N5O7S/c1-40-12-11-21(27(38)39)32-26(37)22(14-17-5-3-2-4-6-17)31-24(35)16-29-23(34)15-30-25(36)20(28)13-18-7-9-19(33)10-8-18/h2-10,20-22,33H,11-16,28H2,1H3,(H,29,34)(H,30,36)(H,31,35)(H,32,37)(H,38,39)/t20-,21-,22-/m0/s1

描述信息

A pentapeptide comprising L-tyrosine, glycine, glycine, L-phenylalanine and L-methionine residues joined in sequence by peptide linkages. It is an endogenous opioid peptide with antitumor, analgesic, and immune-boosting properties.
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials, DrugBank
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist
D018377 - Neurotransmitter Agents > D018847 - Opioid Peptides
D018377 - Neurotransmitter Agents > D004745 - Enkephalins
C308 - Immunotherapeutic Agent
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Tyr-Gly-Gly-Phe-Met-OH regulates human immune function and inhibits tumor growth via binding to the opioid receptor.
Tyr-Gly-Gly-Phe-Met-OH regulates human immune function and inhibits tumor growth via binding to the opioid receptor.

同义名列表

6 个代谢物同义名

Met-Enkephalin acetate salt; Methionine enkephalin; MET-enkephalin; Metenkefalin; Tyr-Gly-Gly-Phe-Met-OH; MET-enkephalin



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Chaowei Li, Qi Chen, Yanrong Liu, Zhuwen Sun, Zhentong Shen, Shuhan Li, Dingrui Cha, Chao Sun. Methionine enkephalin promotes white fat browning through cAMP/PKA pathway. Life sciences. 2023 Jan; 312(?):121189. doi: 10.1016/j.lfs.2022.121189. [PMID: 36396109]
  • Chirag Patel, Ian S Zagon, Mason Pearce-Clawson, Patricia J McLaughlin. Timing of treatment with an endogenous opioid alters immune response and spinal cord pathology in female mice with experimental autoimmune encephalomyelitis. Journal of neuroscience research. 2022 02; 100(2):551-563. doi: 10.1002/jnr.24983. [PMID: 34821408]
  • Ian S Zagon, Joseph W Sassani, Indira Purushothaman, Patricia J McLaughlin. Blockade of OGFr delays the onset and reduces the severity of diabetic ocular surface complications. Experimental biology and medicine (Maywood, N.J.). 2021 03; 246(5):629-636. doi: 10.1177/1535370220972060. [PMID: 33203224]
  • Chirag Patel, Mark D Meadowcroft, Ian S Zagon, Patricia J McLaughlin. [Met5]-enkephalin preserves diffusion metrics in EAE mice. Brain research bulletin. 2020 12; 165(?):246-252. doi: 10.1016/j.brainresbull.2020.10.015. [PMID: 33141073]
  • Qun Wang, Jianyin Miao, Konglong Feng, Jianhua Liu, Wei Li, Jun Li, Zhijie Yang, Yong Cao. Antibacterial action of peptide F1 against colistin resistance E. coli SHP45 (mcr-1). Food & function. 2020 Nov; 11(11):10231-10241. doi: 10.1039/d0fo01923b. [PMID: 33169751]
  • Fubo Tian, Wuzhong Cheng, Jianying Hu, Shaoqiang Huang, Shen Sun. Effects of botulinum toxin A on endometriosis‑associated pain and its related mechanism. Molecular medicine reports. 2020 Nov; 22(5):4351-4359. doi: 10.3892/mmr.2020.11501. [PMID: 33000241]
  • Robert Root-Bernstein, Beth Churchill, Miah Turke. Glutathione and Glutathione-Like Sequences of Opioid and Aminergic Receptors Bind Ascorbic Acid, Adrenergic and Opioid Drugs Mediating Antioxidant Function: Relevance for Anesthesia and Abuse. International journal of molecular sciences. 2020 Aug; 21(17):. doi: 10.3390/ijms21176230. [PMID: 32872204]
  • Yali Tuo, Zijun Zhang, Cheng Tian, Qinyu Hu, Rui Xie, Jian Yang, Hong Zhou, Lili Lu, Ming Xiang. Anti-inflammatory and metabolic reprogramming effects of MENK produce antitumor response in CT26 tumor-bearing mice. Journal of leukocyte biology. 2020 07; 108(1):215-228. doi: 10.1002/jlb.3ma0120-578r. [PMID: 31994797]
  • Michał Dyaczyński, Marek Drożdż, Leontyna Wylężek, Colin G Scanes, Anna Rzepa, Andrzej Cieśla, Krystyna Pierzchała-Koziec. Opioid-like peptides and ghrelin mitigation of bariatric results depends on obesity level. Endokrynologia Polska. 2020; 71(1):27-33. doi: 10.5603/ep.a2019.0044. [PMID: 31681979]
  • Michelle W Ng, Julie Angerosa, Igor E Konstantinov, Michael M Cheung, Salvatore Pepe. Remote ischaemic preconditioning modifies serum apolipoprotein D, met-enkephalin, adenosine, and nitric oxide in healthy young adults. Clinical and experimental pharmacology & physiology. 2019 11; 46(11):995-1000. doi: 10.1111/1440-1681.13150. [PMID: 31361911]
  • Małgorzata Sobocińska, Artur Giełdoń, Jakub Fichna, Elżbieta Kamysz. 1-Substituted sialorphin analogues-synthesis, molecular modelling and in vitro effect on enkephalins degradation by NEP. Amino acids. 2019 Aug; 51(8):1201-1207. doi: 10.1007/s00726-019-02760-z. [PMID: 31302778]
  • Keying Zhang, Jing Yang, Na Ao, Shi Jin, Ruiqun Qi, Fengping Shan, Jian Du. Methionine enkephalin (MENK) regulates the immune pathogenesis of type 2 diabetes mellitus via the IL-33/ST2 pathway. International immunopharmacology. 2019 Aug; 73(?):23-40. doi: 10.1016/j.intimp.2019.04.054. [PMID: 31078923]
  • Mario García-Domínguez, Ana Lastra, Alicia R Folgueras, Rafael Cernuda-Cernuda, María Teresa Fernández-García, Agustín Hidalgo, Luis Menéndez, Ana Baamonde. The Chemokine CCL4 (MIP-1β) Evokes Antinociceptive Effects in Mice: a Role for CD4+ Lymphocytes and Met-Enkephalin. Molecular neurobiology. 2019 Mar; 56(3):1578-1595. doi: 10.1007/s12035-018-1176-8. [PMID: 29907903]
  • Beata Wilenska, Dagmara Tymecka, Marcin Włodarczyk, Aleksandra Sobolewska-Włodarczyk, Maria Wiśniewska-Jarosińska, Jolanta Dyniewicz, Árpád Somogyi, Jakub Fichna, Aleksandra Misicka. Enkephalin degradation in serum of patients with inflammatory bowel diseases. Pharmacological reports : PR. 2019 Feb; 71(1):42-47. doi: 10.1016/j.pharep.2018.08.001. [PMID: 30391790]
  • Aliye Ozalp, Begona Barroso, John Meijer, Cas van den Beld. Determination of methionine-enkephalin and leucine-enkephalin by LC-MS in human plasma: Study of pre-analytical stability. Analytical biochemistry. 2018 10; 559(?):24-29. doi: 10.1016/j.ab.2018.07.001. [PMID: 29981318]
  • Michael D Ludwig, Ian S Zagon, Patricia J McLaughlin. Featured Article: Modulation of the OGF-OGFr pathway alters cytokine profiles in experimental autoimmune encephalomyelitis and multiple sclerosis. Experimental biology and medicine (Maywood, N.J.). 2018 02; 243(4):361-369. doi: 10.1177/1535370217749830. [PMID: 29307283]
  • Marília Carneiro Machado, João Moreira da Costa-Neto, Ricardo Dias Portela, Mário Jorge Melhor Heine D'Assis, Olindo Assis Martins-Filho, Stella Maria Barrouin-Melo, Natalie Ferreira Borges, Fabiana Lessa Silva, Alessandra Estrela-Lima. The effect of naltrexone as a carboplatin chemotherapy-associated drug on the immune response, quality of life and survival of dogs with mammary carcinoma. PloS one. 2018; 13(10):e0204830. doi: 10.1371/journal.pone.0204830. [PMID: 30286124]
  • Dong-Mei Wang, Xue Jiao, Nicolas P Plotnikoff, Noreen Griffin, Rui-Qun Qi, Xing-Hua Gao, Feng-Ping Shan. Killing effect of methionine enkephalin on melanoma in vivo and in vitro. Oncology reports. 2017 Oct; 38(4):2132-2140. doi: 10.3892/or.2017.5918. [PMID: 28849104]
  • Michael D Ludwig, Ian S Zagon, Patricia J McLaughlin. Elevated serum [Met5]-enkephalin levels correlate with improved clinical and behavioral outcomes in experimental autoimmune encephalomyelitis. Brain research bulletin. 2017 Sep; 134(?):1-9. doi: 10.1016/j.brainresbull.2017.06.015. [PMID: 28647454]
  • Michael D Ludwig, Ian S Zagon, Patricia J McLaughlin. Featured Article: Serum [Met5]-enkephalin levels are reduced in multiple sclerosis and restored by low-dose naltrexone. Experimental biology and medicine (Maywood, N.J.). 2017 09; 242(15):1524-1533. doi: 10.1177/1535370217724791. [PMID: 28766982]
  • William H DuPont, William J Kraemer, Bradley C Nindl, Elaine C Lee, Maren S Fragala, Disa L Hatfield, Lydia K Caldwell, Emily M Post, Matthew K Beeler, Jeff S Volek, Carl M Maresh. The effects of different exercise training modalities on plasma proenkephalin Peptide F in women. Peptides. 2017 05; 91(?):26-32. doi: 10.1016/j.peptides.2017.02.006. [PMID: 28263851]
  • Yiming Meng, Xinghua Gao, Wenna Chen, Nicolas P Plotnikoff, Noreen Griffin, Guirong Zhang, Fengping Shan. Methionine enkephalin (MENK) mounts antitumor effect via regulating dendritic cells (DCs). International immunopharmacology. 2017 Mar; 44(?):61-71. doi: 10.1016/j.intimp.2017.01.004. [PMID: 28088065]
  • Saurabh Shukla, Zahra Shamsi, Alexander S Moffett, Balaji Selvam, Diwakar Shukla. Application of Hidden Markov Models in Biomolecular Simulations. Methods in molecular biology (Clifton, N.J.). 2017; 1552(?):29-41. doi: 10.1007/978-1-4939-6753-7_3. [PMID: 28224489]
  • Aswini Kumar Giri, Christopher R Apostol, Yue Wang, Brittany L Forte, Tally M Largent-Milnes, Peg Davis, David Rankin, Gabriella Molnar, Keith M Olson, Frank Porreca, Todd W Vanderah, Victor J Hruby. Discovery of Novel Multifunctional Ligands with μ/δ Opioid Agonist/Neurokinin-1 (NK1) Antagonist Activities for the Treatment of Pain. Journal of medicinal chemistry. 2015 Nov; 58(21):8573-83. doi: 10.1021/acs.jmedchem.5b01170. [PMID: 26465170]
  • Zhaoqun Liu, Zhi Zhou, Lingling Wang, Shuai Jiang, Weilin Wang, Ran Zhang, Linsheng Song. The immunomodulation mediated by a delta-opioid receptor for [Met(5)]-enkephalin in oyster Crassostrea gigas. Developmental and comparative immunology. 2015 Apr; 49(2):217-24. doi: 10.1016/j.dci.2014.11.017. [PMID: 25475959]
  • William J Kraemer, Scott E Gordon, Maren S Fragala, Jill A Bush, Tunde K Szivak, Shawn D Flanagan, David R Hooper, David P Looney, N Travis Triplett, William H DuPont, Joseph E Dziados, Louis J Marchitelli, John F Patton. The effects of exercise training programs on plasma concentrations of proenkephalin Peptide F and catecholamines. Peptides. 2015 Feb; 64(?):74-81. doi: 10.1016/j.peptides.2015.01.001. [PMID: 25582563]
  • L Granholm, E Roman, I Nylander. Single housing during early adolescence causes time-, area- and peptide-specific alterations in endogenous opioids of rat brain. British journal of pharmacology. 2015 Jan; 172(2):606-14. doi: 10.1111/bph.12753. [PMID: 24821004]
  • Roko Martinić, Hrvoje Sošić, Petra Turčić, Paško Konjevoda, Aleksandra Fučić, Ranko Stojković, Gorana Aralica, Mario Gabričević, Tin Weitner, Nikola Stambuk. Hepatoprotective effects of Met-enkephalin on acetaminophen-induced liver lesions in male CBA mice. Molecules (Basel, Switzerland). 2014 Aug; 19(8):11833-45. doi: 10.3390/molecules190811833. [PMID: 25105920]
  • Z Benyhe, G Toth, M Wollemann, A Borsodi, Z Helyes, C Rougeot, S Benyhe. Effects of synthetic analogues of human opiorphin on rat brain opioid receptors. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2014 Aug; 65(4):525-30. doi: . [PMID: 25179084]
  • Kun-Ming Tao, Yong Tao, Cai-Yang Chen, Li-Qun Yang, Zhi-Jie Lu, Yu-Ming Sun, Sheng-Dong Huang, Wei-Feng Yu. Proteinase-activated receptor 1 contributed to up-regulation of enkephalin in keratinocytes of patients with obstructive jaundice. Anesthesiology. 2014 Jul; 121(1):127-39. doi: 10.1097/aln.0000000000000210. [PMID: 24614324]
  • A Tsanova, A Jordanova, T Dzimbova, T Pajpanova, E Golovinsky, Z Lalchev. Interaction of methionine-enkephalins with raft-forming lipids: monolayers and BAM experiments. Amino acids. 2014 May; 46(5):1159-68. doi: 10.1007/s00726-013-1647-1. [PMID: 24357114]
  • Weiwei Li, Wenna Chen, Ronald B Herberman, Nicolas P Plotnikoff, Gene Youkilis, Noreen Griffin, Enhua Wang, Changlong Lu, Fengping Shan. Immunotherapy of cancer via mediation of cytotoxic T lymphocytes by methionine enkephalin (MENK). Cancer letters. 2014 Mar; 344(2):212-22. doi: 10.1016/j.canlet.2013.10.029. [PMID: 24291668]
  • Nicole C Victoria, Mary C Karom, Hila Eichenbaum, Anne Z Murphy. Neonatal injury rapidly alters markers of pain and stress in rat pups. Developmental neurobiology. 2014 Jan; 74(1):42-51. doi: 10.1002/dneu.22129. [PMID: 24022912]
  • Yajing Feng, Yongyu Li, Chunqiu Chen, Xuhong Lin, Yuehua Yang, Haidong Cai, Zhongwei Lv, Minghua Cao, Kun Li, Jing Xu, Sainan Li, Yijun Jia. Inhibiting roles of berberine in gut movement of rodents are related to activation of the endogenous opioid system. Phytotherapy research : PTR. 2013 Oct; 27(10):1564-71. doi: 10.1002/ptr.4926. [PMID: 23339028]
  • Leonid N Maslov, Natalia V Naryzhnaia, Sergey Yu Tsibulnikov, Frantisek Kolar, Yi Zhang, Hongxin Wang, Anna M Gusakova, Yury B Lishmanov. Role of endogenous opioid peptides in the infarct size-limiting effect of adaptation to chronic continuous hypoxia. Life sciences. 2013 Sep; 93(9-11):373-9. doi: 10.1016/j.lfs.2013.07.018. [PMID: 23891777]
  • Aron D Mosnaim, Patricio Maturana, Owen H Callaghan, Marion E Wolf. Changes in plasma methionine-enkephalin levels associated with a cluster headache episode. American journal of therapeutics. 2013 Sep; 20(5):463-8. doi: 10.1097/mjt.0b013e31826fc1cf. [PMID: 23353772]
  • Moshe Rogosnitzky, Milton J Finegold, Patricia J McLaughlin, Ian S Zagon. Opioid growth factor (OGF) for hepatoblastoma: a novel non-toxic treatment. Investigational new drugs. 2013 Aug; 31(4):1066-70. doi: 10.1007/s10637-012-9918-3. [PMID: 23275062]
  • William J Kraemer, Maren S Fragala, Wendy R H Beijersbergen van Henegouwen, Scott E Gordon, Jill A Bush, Jeff S Volek, N Travis Triplett, Courtenay Dunn-Lewis, Brett A Comstock, Tunde K Szivak, Shawn D Flanagan, David R Hooper, Hui-Ying Luk, Andrea M Mastro. Responses of proenkephalin Peptide F to aerobic exercise stress in the plasma and white blood cell biocompartments. Peptides. 2013 Apr; 42(?):118-24. doi: 10.1016/j.peptides.2013.01.013. [PMID: 23395721]
  • V M Pickel, E T Shobin, D A Lane, K Mackie. Cannabinoid-1 receptors in the mouse ventral pallidum are targeted to axonal profiles expressing functionally opposed opioid peptides and contacting N-acylphosphatidylethanolamine-hydrolyzing phospholipase D terminals. Neuroscience. 2012 Dec; 227(?):10-21. doi: 10.1016/j.neuroscience.2012.07.050. [PMID: 22863674]
  • Aron D Mosnaim, Patricio Maturana, Javier Puente, Marion E Wolf. Decreased plasma methionine-enkephalin levels in cluster headache patients. American journal of therapeutics. 2012 May; 19(3):174-9. doi: 10.1097/mjt.0b013e3182456a61. [PMID: 22487772]
  • Krisztina Csabafi, Miklós Jászberényi, Zsolt Bagosi, Géza Tóth, Mária Wollemann, Gyula Telegdy. The action of a synthetic derivative of Met5-enkephalin-Arg6-Phe7 on behavioral and endocrine responses. Peptides. 2011 Aug; 32(8):1656-60. doi: 10.1016/j.peptides.2011.05.029. [PMID: 21722680]
  • D Owczarek, D Cibor, T Mach, A Cieśla, K Pierzchała-Koziec, K Sałapa, B Kuśnierz-Cabała. Met-enkephalins in patients with inflammatory bowel diseases. Advances in medical sciences. 2011; 56(2):158-64. doi: 10.2478/v10039-011-0051-x. [PMID: 22112433]
  • Fan Cheng, Patricia J McLaughlin, William A Banks, Ian S Zagon. Internalization of the opioid growth factor, [Met5]-enkephalin, is dependent on clathrin-mediated endocytosis for downregulation of cell proliferation. American journal of physiology. Regulatory, integrative and comparative physiology. 2010 Sep; 299(3):R774-85. doi: 10.1152/ajpregu.00318.2010. [PMID: 20592180]
  • Yoram Shechter, Eli Heldman, Keren Sasson, Tzach Bachar, Mary Popov, Matityahu Fridkin. Delivery of neuropeptides from the periphery to the brain: studies with enkephalin. ACS chemical neuroscience. 2010 May; 1(5):399-406. doi: 10.1021/cn100001j. [PMID: 22778833]
  • Terry A McNearney, K A Sluka, C Ahn, J D Reveille, Michael Fischbach, Maureen D Mayes. Plasma endogenous enkephalin levels in early systemic sclerosis: clinical and laboratory associations. Clinical and experimental rheumatology. 2010 Mar; 28(2 Suppl 58):S7-11. doi: NULL. [PMID: 20576209]
  • Faye A Bradbury, Jennifer C Zelnik, John R Traynor. G protein independent phosphorylation and internalization of the delta-opioid receptor. Journal of neurochemistry. 2009 Jun; 109(5):1526-35. doi: 10.1111/j.1471-4159.2009.06082.x. [PMID: 19344370]
  • Craig Bolte, Gilbert Newman, Jo El J Schultz. Hypertensive state, independent of hypertrophy, exhibits an attenuated decrease in systolic function on cardiac kappa-opioid receptor stimulation. American journal of physiology. Heart and circulatory physiology. 2009 Apr; 296(4):H967-75. doi: 10.1152/ajpheart.00909.2008. [PMID: 19181965]
  • Vladana Vukojević, Yu Ming, Claudio D'Addario, Mats Hansen, Ulo Langel, Rüdiger Schulz, Björn Johansson, Rudolf Rigler, Lars Terenius. Mu-opioid receptor activation in live cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2008 Oct; 22(10):3537-48. doi: 10.1096/fj.08-108894. [PMID: 18587007]
  • Isseki Yu, Yoichi Jindo, Masataka Nagaoka. Microscopic understanding of preferential exclusion of compatible solute ectoine: direct interaction and hydration alteration. The journal of physical chemistry. B. 2007 Aug; 111(34):10231-8. doi: 10.1021/jp068367z. [PMID: 17676787]
  • Shaaban A Mousa, Rainer H Straub, Michael Schäfer, Christoph Stein. Beta-endorphin, Met-enkephalin and corresponding opioid receptors within synovium of patients with joint trauma, osteoarthritis and rheumatoid arthritis. Annals of the rheumatic diseases. 2007 Jul; 66(7):871-9. doi: 10.1136/ard.2006.067066. [PMID: 17324971]
  • L Kamel, A Saleh, A Morsy, A Ghali, H El Khayat. Plasma met-enkephalin, beta-endorphin and leu-enkephalin levels in human hepatic encephalopathy. Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit. 2007 Mar; 13(2):257-65. doi: NULL. [PMID: 17684846]
  • Olivier Mozziconacci, Krzysztof Bobrowski, Carla Ferreri, Chryssostomos Chatgilialoglu. Reactions of hydrogen atoms with met-enkephalin and related peptides. Chemistry (Weinheim an der Bergstrasse, Germany). 2007; 13(7):2029-33. doi: 10.1002/chem.200600828. [PMID: 17124712]
  • Tomohiro Kimura. Human opioid peptide Met-enkephalin binds to anionic phosphatidylserine in high preference to zwitterionic phosphatidylcholine: natural-abundance 13C NMR study on the binding state in large unilamellar vesicles. Biochemistry. 2006 Dec; 45(51):15601-9. doi: 10.1021/bi061641v. [PMID: 17176081]
  • Shi-zhong Zhang, Ning-fu Wang, Jian Xu, Qin Gao, Guo-hua Lin, Iain C Bruce, Qiang Xia. Kappa-opioid receptors mediate cardioprotection by remote preconditioning. Anesthesiology. 2006 Sep; 105(3):550-6. doi: 10.1097/00000542-200609000-00019. [PMID: 16931988]
  • Akihiko Urayama, Kevin King, Frederich S Gaskin, Susan A Farr, William A Banks. Effects of chronic ethanol administration on brain interstitial fluid levels of Methionine-enkephalin as measured by microdialysis in vivo. Peptides. 2006 Sep; 27(9):2201-6. doi: 10.1016/j.peptides.2006.03.024. [PMID: 16672169]
  • Ian S Zagon, Patricia J McLaughlin. Opioid growth factor receptor is unaltered with the progression of human pancreatic and colon cancers. International journal of oncology. 2006 Aug; 29(2):489-94. doi: . [PMID: 16820893]
  • Andreas Breit, Khatuna Gagnidze, Lakshmi A Devi, Monique Lagacé, Michel Bouvier. Simultaneous activation of the delta opioid receptor (deltaOR)/sensory neuron-specific receptor-4 (SNSR-4) hetero-oligomer by the mixed bivalent agonist bovine adrenal medulla peptide 22 activates SNSR-4 but inhibits deltaOR signaling. Molecular pharmacology. 2006 Aug; 70(2):686-96. doi: 10.1124/mol.106.022897. [PMID: 16682504]
  • Jill A Bush, Andrea M Mastro, William J Kraemer. Proenkephalin peptide F immunoreactivity in different circulatory biocompartments after exercise. Peptides. 2006 Jun; 27(6):1498-506. doi: 10.1016/j.peptides.2005.11.023. [PMID: 16406203]
  • William A Banks, Laura B Jaeger, Akihiko Urayama, Vijaya B Kumar, Stanley M Hileman, Frederich S Gaskin, Nancy V Llanza, Susan A Farr, John E Morley. Preproenkephalin targeted antisenses cross the blood-brain barrier to reduce brain methionine enkephalin levels and increase voluntary ethanol drinking. Peptides. 2006 Apr; 27(4):784-96. doi: 10.1016/j.peptides.2005.09.001. [PMID: 16229925]
  • Arndt Psurek, Frank-Michael Matysik, Gerhard K E Scriba. Determination of enkephalin peptides by nonaqueous capillary electrophoresis with electrochemical detection. Electrophoresis. 2006 Mar; 27(5-6):1199-208. doi: 10.1002/elps.200500499. [PMID: 16523458]
  • William J Kraemer, Sang K Kim, Jill A Bush, Bradley C Nindl, Jeff S Volek, Barry A Spiering, Disa L Hatfield, Maren S Fragala, Margo Putukian, Wayne J Sebastianelli. Influence of the menstrual cycle on proenkephalin peptide F responses to maximal cycle exercise. European journal of applied physiology. 2006 Mar; 96(5):581-6. doi: 10.1007/s00421-005-0114-4. [PMID: 16408233]
  • Sandra Sobocanec, Borka Kusić, Visnja Sverko, Tihomir Balog, Tatjana Marotti. Methionine-enkephalin modulated regulation of oxidant/antioxidant status in liver of CBA mice. Biogerontology. 2006 Feb; 7(1):53-62. doi: 10.1007/s10522-005-6040-3. [PMID: 16518720]
  • Anna Wójcik-Gładysz, Krzysztof W Nowak, Krystyna Pierzchała-Koziec, Marta Wańkowska, Tomasz Misztal, Jolanta Polkowska, Magdalena Nowak, Przemysław Kaczmarek, Tatiana Górska, Dawid Szczepankiewicz, Joanna Zubel. Aspects of central and peripheral regulation of reproduction in mammals. Reproductive biology. 2006; 6 Suppl 1(?):89-103. doi: . [PMID: 16967091]
  • Yuzuru Kato. [Methionine-enkephalin (Met-Enk) and leucine-enkephalin (Leu-Enk)]. Nihon rinsho. Japanese journal of clinical medicine. 2005 Aug; 63 Suppl 8(?):211-2. doi: NULL. [PMID: 16149492]
  • Ljubica Glavas-Obrovac, Andreja Jakas, Saska Marczi, Stefica Horvat. The influence of cell growth media on the stability and antitumour activity of methionine enkephalin. Journal of peptide science : an official publication of the European Peptide Society. 2005 Jul; 11(8):506-11. doi: 10.1002/psc.643. [PMID: 15685713]
  • Maria Korak-Leiter, Rudolf Likar, Michael Oher, Ernst Trampitsch, Gerda Ziervogel, Joseph V Levy, Enno C Freye. Withdrawal following sufentanil/propofol and sufentanil/midazolam. Sedation in surgical ICU patients: correlation with central nervous parameters and endogenous opioids. Intensive care medicine. 2005 Mar; 31(3):380-7. doi: 10.1007/s00134-005-2579-3. [PMID: 15714323]
  • Maarit Marmendal, Erika Roman, C J Peter Eriksson, Ingrid Nylander, Claudia Fahlke. Maternal separation alters maternal care, but has minor effects on behavior and brain opioid peptides in adult offspring. Developmental psychobiology. 2004 Nov; 45(3):140-52. doi: 10.1002/dev.20027. [PMID: 15505796]
  • Tihomir Balog, Sandra Sobocanec, Visnja Sverko, Tatjana Marotti. Met-enkephalin modulates resistance to oxidative stress in mouse brain. Neuropeptides. 2004 Oct; 38(5):298-303. doi: 10.1016/j.npep.2004.05.010. [PMID: 15464195]
  • William A Banks, Vijaya B Kumar, John E Morley. Influence of ethanol dependence and methionine enkephalin antisense on serum endomorphin-1 and methionine enkephalin levels. Alcoholism, clinical and experimental research. 2004 May; 28(5):792-6. doi: 10.1097/01.alc.0000125357.54776.41. [PMID: 15166656]
  • Isabelle Marcotte, Frances Separovic, Michèle Auger, Stéphane M Gagné. A multidimensional 1H NMR investigation of the conformation of methionine-enkephalin in fast-tumbling bicelles. Biophysical journal. 2004 Mar; 86(3):1587-600. doi: 10.1016/s0006-3495(04)74226-5. [PMID: 14990485]
  • William J Kraemer, Andrea M Mastro, Scott E Gordon, L Perry Koziris, Jill A Bush, Jeff S Volek, Robert S Staron, Duncan N French, Matthew J Sharman, Bonzena Jemiolo, Michael R Deschenes, Wesley C Hymer. Responses of plasma proenkephalin peptide F in rats following 14 days of spaceflight. Aviation, space, and environmental medicine. 2004 Feb; 75(2):114-7. doi: NULL. [PMID: 14960045]
  • Isabelle Marcotte, Marise Ouellet, Michèle Auger. Insights on the interaction of met-enkephalin with negatively charged membranes--an infrared and solid-state NMR spectroscopic study. Chemistry and physics of lipids. 2004 Feb; 127(2):175-87. doi: 10.1016/j.chemphyslip.2003.10.012. [PMID: 14726000]
  • Patricia J McLaughlin, Brendan C Stack, Kristi M Braine, James D Ruda, Ian S Zagon. Opioid growth factor inhibition of a human squamous cell carcinoma of the head and neck in nude mice: dependency on the route of administration. International journal of oncology. 2004 Jan; 24(1):227-32. doi: NULL. [PMID: 14654962]
  • Robert C Sizemore, Marta Piva, LeeTerry Moore, Natalia Gordonov, Edward Heilman, Henry P Godfrey. Modulation of delayed-type hypersensitivity responses in hairless guinea pigs by peptides derived from enkephalin. Neuroimmunomodulation. 2004; 11(3):141-8. doi: 10.1159/000076763. [PMID: 15067205]
  • Stanislava Stanojević, Mirjana Dimitrijević, Vesna Kovacević-Jovanović, Tatjana Miletić, Vesna Vujić, Jelena Radulović. Stress applied during primary immunization affects the secondary humoral immune response in the rat: involvement of opioid peptides. Stress (Amsterdam, Netherlands). 2003 Dec; 6(4):247-58. doi: 10.1080/1025389032000114515. [PMID: 14660057]
  • William A Banks, Kathleen M Wolf, Michael L Niehoff. Effects of chronic ethanol on brain and serum level of methionine enkephalin. Peptides. 2003 Dec; 24(12):1935-40. doi: 10.1016/j.peptides.2003.10.001. [PMID: 15127945]
  • Cui Weina, Wang Chao, Zhao Ming, Peng Shiqi. Effect of synthetic oligopeptides on osteoporosis. Preparative biochemistry & biotechnology. 2003 Aug; 33(3):217-31. doi: 10.1081/pb-120022990. [PMID: 12916813]
  • Catherine Rougeot, Michaël Messaoudi, Véronique Hermitte, Anne Gaëlle Rigault, Thierry Blisnick, Christophe Dugave, Didier Desor, François Rougeon. Sialorphin, a natural inhibitor of rat membrane-bound neutral endopeptidase that displays analgesic activity. Proceedings of the National Academy of Sciences of the United States of America. 2003 Jul; 100(14):8549-54. doi: 10.1073/pnas.1431850100. [PMID: 12835417]
  • R Gulati, D K Agarwal, M M Hossain, R Ali, U Srivastava. Study of serum lipid profile changes in Met-enkephalin treated rats. Indian journal of physiology and pharmacology. 2003 Jul; 47(3):357-60. doi: NULL. [PMID: 14723325]
  • Isabelle Marcotte, Erick J Dufourc, Marise Ouellet, Michèle Auger. Interaction of the neuropeptide met-enkephalin with zwitterionic and negatively charged bicelles as viewed by 31P and 2H solid-state NMR. Biophysical journal. 2003 Jul; 85(1):328-39. doi: 10.1016/s0006-3495(03)74477-4. [PMID: 12829487]
  • Y Ohmori, M Suzuki, K Fukuta. Anatomical relationship between enkephalin-containing neurones and caecum-projecting neurones in the chicken intestinal nerve. Anatomia, histologia, embryologia. 2003 Jun; 32(3):179-82. doi: 10.1046/j.1439-0264.2003.00457.x. [PMID: 12823105]
  • Ian S Zagon, Torre B Ruth, Alphonse E Leure-duPree, Joseph W Sassani, Patricia J McLaughlin. Immunoelectron microscopic localization of the opioid growth factor receptor (OGFr) and OGF in the cornea. Brain research. 2003 Mar; 967(1-2):37-47. doi: 10.1016/s0006-8993(02)04172-0. [PMID: 12650964]
  • E Bujdosó, M Jászberényi, J Farkas, G Tóth, M Wollemann, G Telegdy. Behavioral and neuroendocrine actions of the Met-enkephalin-related peptide MERF. Hormones and behavior. 2003 Feb; 43(2):302-11. doi: 10.1016/s0018-506x(03)00004-7. [PMID: 12694640]
  • Tihomir Balog, Tatjana Marotti, Visnja Sverko, Miljenko Marotti, Ivan Krolo, Boris Rocic, Nikola Karapanda. Enkephalin degradating enzymes in pheochromocytoma patients. Oncology reports. 2003 Jan; 10(1):253-8. doi: 10.3892/or.10.1.253. [PMID: 12469178]
  • Aron D Mosnaim, Javier Puente, Rolando Saavedra, Seymour Diamond, Marion E Wolf. In vitro human plasma leucine(5)-enkephalin degradation is inhibited by a select number of drugs with the phenothiazine molecule in their chemical structure. Pharmacology. 2003 Jan; 67(1):6-13. doi: 10.1159/000066781. [PMID: 12444298]
  • Danuta Owczarek, Magdalena Garlicka, Krystyna Pierzchała-Koziec, Dariusz Skulina, Paweł Szulewski. [Met-enkephalin plasma concentration and content in liver tissue in patients with primary biliary cirrhosis]. Przeglad lekarski. 2003; 60(7):461-6. doi: . [PMID: 14750419]
  • T Gambichler, A Bader, M Vojvodic, A Avermaete, M Schenk, P Altmeyer, K Hoffmann. Plasma levels of opioid peptides after sunbed exposures. The British journal of dermatology. 2002 Dec; 147(6):1207-11. doi: 10.1046/j.1365-2133.2002.04859.x. [PMID: 12452872]
  • Visnja Sverko, Sandra Sobocanec, Tihomir Balog, Tatjana Marotti. Met-enkephalin modulates lipid peroxidation and total sialic acid level in CBA mice in age- and sex-dependent manners. Experimental gerontology. 2002 Dec; 37(12):1413-21. doi: 10.1016/s0531-5565(02)00118-3. [PMID: 12559410]
  • Eric Bonneil, Jianjun Li, T-L Tremblay, John J Bergeron, Pierre Thibault. Integration of solid-phase extraction membranes for sample multiplexing: application to rapid protein identification from gel-isolated protein extracts. Electrophoresis. 2002 Oct; 23(20):3589-98. doi: 10.1002/1522-2683(200210)23:20<3589::aid-elps3589>3.0.co;2-o. [PMID: 12412129]
  • Weina Cui, Chao Wang, Ming Zhao, Shiqi Peng. Effect of synthetic oligopeptides on osteoporosis. Preparative biochemistry & biotechnology. 2002 Aug; 32(3):253-68. doi: 10.1081/pb-120013472. [PMID: 12375813]
  • Po Chang Lee, Yu Chuan Tsai, Chung Jye Hung, Yih Jyh Lin, Huan Yao Lei, Jih Ing Chuang, Kuei Sen Hsu. Induction of antinociception and increased met-enkephalin plasma levels by cyclosporine and morphine in rats: implications of the combined use of cyclosporine and morphine and acute posttransplant neuropsychosis. The Journal of surgical research. 2002 Jul; 106(1):1-6. doi: 10.1006/jsre.2002.6392. [PMID: 12127800]
  • Fiorella Fontana, Pasquale Bernardi, Santi Spampinato, Rosanna Di Toro, Raffaele Bugiardini. beta-Endorphin modulation of pressor response to hyperventilation in hypertensive patients. Peptides. 2002 May; 23(5):911-8. doi: 10.1016/s0196-9781(02)00018-9. [PMID: 12084522]
  • M Dziedzicka-Wasylewska, D Dlaboga, K Pierzchała-Koziec, Z Rogóz. Effect of tianeptine and fluoxetine on the levels of Met-enkephalin and mRNA encoding proenkephalin in the rat. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2002 Mar; 53(1):117-25. doi: NULL. [PMID: 11939714]
  • A Tirelli, S Guastafierro, S Annunziata, R Guariglia, L Coppola. Effects of beta-endorphin and met-enkephalin on platelet activity. American journal of hematology. 2001 Sep; 68(1):1-3. doi: 10.1002/ajh.1140. [PMID: 11559929]
  • I S Zagon, J D Wylie, W J Hurst, P J McLaughlin. Transplacental transfer of the opioid growth factor, [Met(5)]-enkephalin, in rats. Brain research bulletin. 2001 Jun; 55(3):341-6. doi: 10.1016/s0361-9230(01)00518-4. [PMID: 11489341]
  • J P Li, K Y Lee, T M Chang, W Y Chey. MEK inhibits secretin release and pancreatic secretion: roles of secretin-releasing peptide and somatostatin. American journal of physiology. Gastrointestinal and liver physiology. 2001 May; 280(5):G890-6. doi: 10.1152/ajpgi.2001.280.5.g890. [PMID: 11292597]
  • C Parlapiano, M C Borgia, G Tonnarini, E Campana, G Giancaspro, P Pantone, T Giovanniello, G Cardarelli, G M Vincentelli, F Alegiani, M Negri. The role of met-enkephalin in silent myocardial ischemia in diabetic patients. Journal of medicine. 2001; 32(5-6):267-70. doi: NULL. [PMID: 11958273]
  • S R Bornstein, H Tian, A Haidan, A Böttner, N Hiroi, G Eisenhofer, S M McCann, G P Chrousos, S Roffler-Tarlov. Deletion of tyrosine hydroxylase gene reveals functional interdependence of adrenocortical and chromaffin cell system in vivo. Proceedings of the National Academy of Sciences of the United States of America. 2000 Dec; 97(26):14742-7. doi: 10.1073/pnas.97.26.14742. [PMID: 11121073]
  • R D Egleton, S A Mitchell, J D Huber, J Janders, D Stropova, R Polt, H I Yamamura, V J Hruby, T P Davis. Improved bioavailability to the brain of glycosylated Met-enkephalin analogs. Brain research. 2000 Oct; 881(1):37-46. doi: 10.1016/s0006-8993(00)02794-3. [PMID: 11033091]