N-Nitrosopiperidine (BioDeep_00000002976)
Secondary id: BioDeep_00001867941
human metabolite blood metabolite
代谢物信息卡片
N-Nitrosopentamethyleneimine
化学式: C5H10N2O (114.0793)
中文名称: N-亚硝基哌啶
谱图信息:
最多检出来源 Homo sapiens(blood) 80.84%
分子结构信息
SMILES: C1CCN(CC1)N=O
InChI: InChI=1S/C5H10N2O/c8-6-7-4-2-1-3-5-7/h1-5H2
描述信息
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3453
D009676 - Noxae > D002273 - Carcinogens
D009676 - Noxae > D009153 - Mutagens
同义名列表
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:76324
- KEGG: C19284
- KEGGdrug: D92816
- PubChem: 7526
- HMDB: HMDB0243970
- Metlin: METLIN73002
- ChEMBL: CHEMBL165244
- chemspider: 7245
- CAS: 100-75-4
- MoNA: EQ345306
- MoNA: EQ345301
- MoNA: EQ345303
- MoNA: EQ345302
- MoNA: EQ345304
- MoNA: EQ345305
- PMhub: MS000007585
- PubChem: 124489956
- KNApSAcK: 76324
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 3039 - Euglena gracilis: 10.3389/FBIOE.2021.662655
- 9606 - Homo sapiens: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Chao Zhao, Qiang Lu, Yun Gu, Enchun Pan, Zhongming Sun, Hu Zhang, Jingjing Zhou, Ying Du, Ying Zhang, Yuanmei Feng, Ran Liu, Yuepu Pu, Lihong Yin. Distribution of N-nitrosamines in drinking water and human urinary excretions in high incidence area of esophageal cancer in Huai'an, China.
Chemosphere.
2019 Nov; 235(?):288-296. doi:
10.1016/j.chemosphere.2019.06.124. [PMID: 31260869] - Youngmin Hong, Kyung Hwan Kim, Byoung-In Sang, Hyunook Kim. Simple quantification method for N-nitrosamines in atmospheric particulates based on facile pretreatment and GC-MS/MS.
Environmental pollution (Barking, Essex : 1987).
2017 Jul; 226(?):324-334. doi:
10.1016/j.envpol.2017.04.017. [PMID: 28412030] - James A Hodgson, Tiffany H Seyler, Lanqing Wang. Long-Term Stability of Volatile Nitrosamines in Human Urine.
Journal of analytical toxicology.
2016 Jul; 40(6):414-8. doi:
10.1093/jat/bkw038. [PMID: 27274026] - Abdulrahman L Al-Malki, Elie K Barbour, Huwait Ea, Said S Moselhy, Hani Choudhry. MODULATION OF CARCINOGEN-METABOLIZING ENZYME BY MADINAH MINT (Mentha spp) IN RAT LIVER.
African journal of traditional, complementary, and alternative medicines : AJTCAM.
2016; 13(6):32-37. doi:
10.21010/ajtcam.v13i6.7. [PMID: 28480358] - Minju Lee, Yunho Lee, Fabian Soltermann, Urs von Gunten. Analysis of N-nitrosamines and other nitro(so) compounds in water by high-performance liquid chromatography with post-column UV photolysis/Griess reaction.
Water research.
2013 Sep; 47(14):4893-903. doi:
10.1016/j.watres.2013.05.031. [PMID: 23891540] - Tiffany H Seyler, Jenny G Kim, James A Hodgson, Elizabeth A Cowan, Benjamin C Blount, Lanqing Wang. Quantitation of urinary volatile nitrosamines from exposure to tobacco smoke.
Journal of analytical toxicology.
2013 May; 37(4):195-202. doi:
10.1093/jat/bkt020. [PMID: 23508653] - Emilie Combet, Tom Preston, Kenneth E L McColl. Development of an in vitro system combining aqueous and lipid phases as a tool to understand gastric nitrosation.
Rapid communications in mass spectrometry : RCM.
2010 Mar; 24(5):529-34. doi:
10.1002/rcm.4388. [PMID: 20112267] - Megan H Plumlee, Montserrat López-Mesas, Andy Heidlberger, Kenneth P Ishida, Martin Reinhard. N-nitrosodimethylamine (NDMA) removal by reverse osmosis and UV treatment and analysis via LC-MS/MS.
Water research.
2008 Jan; 42(1-2):347-55. doi:
10.1016/j.watres.2007.07.022. [PMID: 17697696] - E Combet, S Paterson, K Iijima, J Winter, W Mullen, A Crozier, T Preston, K E L McColl. Fat transforms ascorbic acid from inhibiting to promoting acid-catalysed N-nitrosation.
Gut.
2007 Dec; 56(12):1678-84. doi:
10.1136/gut.2007.128587. [PMID: 17785370] - Yuan-Yuan Zhao, Jessica Boyd, Steve E Hrudey, Xing-Fang Li. Characterization of new nitrosamines in drinking water using liquid chromatography tandem mass spectrometry.
Environmental science & technology.
2006 Dec; 40(24):7636-41. doi:
10.1021/es061332s. [PMID: 17256506] - Kun Lin, Wenying Shen, Zhongying Shen, Yongning Wu, Shihhsin Lu. Dietary exposure and urinary excretion of total N-nitroso compounds, nitrosamino acids and volatile nitrosamine in inhabitants of high- and low-risk areas for esophageal cancer in southern China.
International journal of cancer.
2002 Nov; 102(3):207-11. doi:
10.1002/ijc.10698. [PMID: 12397637] - P Levallois, P Ayotte, J M Van Maanen, T Desrosiers, S Gingras, J W Dallinga, I T Vermeer, J Zee, G Poirier. Excretion of volatile nitrosamines in a rural population in relation to food and drinking water consumption.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2000 Nov; 38(11):1013-9. doi:
10.1016/s0278-6915(00)00089-2. [PMID: 11038239] - I T Vermeer, E J Moonen, J W Dallinga, J C Kleinjans, J M van Maanen. Effect of ascorbic acid and green tea on endogenous formation of N-nitrosodimethylamine and N-nitrosopiperidine in humans.
Mutation research.
1999 Jul; 428(1-2):353-61. doi:
10.1016/s1383-5742(99)00061-7. [PMID: 10518007] - K T Kitchin, J L Brown, W Lijinsky. Biochemical studies of six nitrogen-containing heterocycles in rat tissues.
Biochemical pharmacology.
1989 Aug; 38(16):2733-8. doi:
10.1016/0006-2952(89)90561-3. [PMID: 2764994] - T Shirai, H Tsuda, T Ogiso, M Hirose, N Ito. Organ specific modifying potential of ethinyl estradiol on carcinogenesis initiated with different carcinogens.
Carcinogenesis.
1987 Jan; 8(1):115-9. doi:
10.1093/carcin/8.1.115. [PMID: 3802386] - M Nakamura, Y Osada, Y Horiguchi, T Nakaoka, K Ito, T Kawabata. Effect of ascorbic acid on the metabolism of N-nitrosopiperidine.
IARC scientific publications.
1987; ?(84):173-4. doi:
. [PMID: 3679363] - M Vollrath, M Altmannsberger, K Weber, M Osborn. Chemically induced tumors of rat olfactory epithelium: a model for human esthesioneuroepithelioma.
Journal of the National Cancer Institute.
1986 Jun; 76(6):1205-16. doi:
. [PMID: 2423738] - G M Singer, W A MacIntosh. Urinary metabolites of some alicyclic nitrosamines.
IARC scientific publications.
1984; ?(57):459-63. doi:
. [PMID: 6533037] - C Marlowe, W J Waddell. Affinity of [14C]nitrosopiperidine and metabolites for mouse epithelial tissues.
Toxicology and applied pharmacology.
1983 Jan; 67(1):110-6. doi:
10.1016/0041-008x(83)90249-1. [PMID: 6845351] - R Kupper, M D Reuber, B N Blackwell, W Lijinsky, S R Koepke, C J Michejda. Carcinogenicity of the isomeric, N-nitroso-delta3-and N-nitroso-delta2-piperidines in rats and the in vivo isomerization of the delta3-to the delta2-isomer.
Carcinogenesis.
1980 Sep; 1(9):753-7. doi:
10.1093/carcin/1.9.753. [PMID: 11219865] - G L Princler, K R McIntire, R H Adamson. In vitro alpha-fetoprotein synthesis by monkey hepatocellular carcinoma.
Journal of the National Cancer Institute.
1978 Mar; 60(3):643-8. doi:
10.1093/jnci/60.3.643. [PMID: 75269]
