4-Fluoro-L-phenylalanine (BioDeep_00000002902)

 

Secondary id: BioDeep_00001871908

human metabolite blood metabolite


代谢物信息卡片


2-amino-3-(4-fluorophenyl)propanoic acid

化学式: C9H10FNO2 (183.0696)
中文名称: 4-氟-DL-苯丙氨酸, 对氟苯丙氨酸, 4-氟苯丙氨酸
谱图信息: 最多检出来源 Homo sapiens(blood) 97.48%

分子结构信息

SMILES: C1=CC(=CC=C1CC(C(=O)O)N)F
InChI: InChI=1S/C9H10FNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 AZIN2, DHFR, FANCA, GAK, ODC1, PTH1R, S100A9, SNCA
Peripheral membrane protein 1 S100A9
Nucleus 5 AZIN2, FANCA, PTH1R, S100A9, SNCA
cytosol 11 AMD1, AZIN2, DHFR, FANCA, GAK, HBB, ODC1, PAH, PRF1, S100A9, SNCA
dendrite 1 AZIN2
trans-Golgi network 1 AZIN2
nucleoplasm 1 FANCA
Cell membrane 4 GCGR, PRF1, PTH1R, S100A9
Cell projection, axon 1 SNCA
Multi-pass membrane protein 3 GCGR, PRF1, PTH1R
Synapse 1 SNCA
cell cortex 1 SNCA
Golgi apparatus 1 GAK
growth cone 1 SNCA
neuronal cell body 1 SNCA
postsynapse 1 SNCA
Lysosome 1 SNCA
Presynapse 1 GAK
endosome 1 GCGR
plasma membrane 8 GCGR, IFNLR1, NMUR1, NMUR2, PRF1, PTH1R, S100A9, SNCA
synaptic vesicle membrane 1 SNCA
terminal bouton 1 NMU
Membrane 9 AZIN2, GAK, GCGR, HBB, IFNLR1, NMUR1, NMUR2, PRF1, SNCA
apical plasma membrane 1 PTH1R
axon 2 AZIN2, SNCA
basolateral plasma membrane 1 PTH1R
extracellular exosome 2 HBB, S100A9
extracellular space 4 HBB, PRSS1, S100A9, SNCA
perinuclear region of cytoplasm 3 AZIN2, GAK, SNCA
mitochondrion 3 AZIN2, DHFR, SNCA
protein-containing complex 1 SNCA
intracellular membrane-bounded organelle 1 GAK
Single-pass type I membrane protein 1 IFNLR1
Secreted 3 NMU, PRF1, SNCA
extracellular region 7 ELN, HBB, NMU, PRF1, PRSS1, S100A9, SNCA
Secreted, extracellular space, extracellular matrix 1 ELN
actin cytoskeleton 1 SNCA
perikaryon 1 AZIN2
cytoplasmic vesicle 1 AZIN2
vesicle 1 GAK
Cytoplasm, perinuclear region 1 GAK
Cell junction, focal adhesion 1 GAK
Cytoplasm, cytoskeleton 1 S100A9
focal adhesion 1 GAK
cis-Golgi network 1 AZIN2
extracellular matrix 1 ELN
collagen-containing extracellular matrix 3 ELN, PRSS1, S100A9
receptor complex 1 PTH1R
cilium 1 NMUR1
chromatin 1 FANCA
supramolecular fiber 1 SNCA
cytoskeleton 1 S100A9
Golgi apparatus, trans-Golgi network 1 GAK
blood microparticle 2 HBB, PRSS1
endosome lumen 1 PRF1
Fanconi anaemia nuclear complex 1 FANCA
clathrin-coated vesicle 1 GAK
ficolin-1-rich granule lumen 1 HBB
secretory granule lumen 1 S100A9
axon terminus 1 SNCA
tertiary granule lumen 1 HBB
Cytoplasmic vesicle, clathrin-coated vesicle 1 GAK
transport vesicle 1 AZIN2
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 AZIN2
immunological synapse 1 PRF1
endoplasmic reticulum-Golgi intermediate compartment 1 AZIN2
Golgi apparatus, cis-Golgi network 1 AZIN2
elastic fiber 1 ELN
hemoglobin complex 1 HBB
endocytic vesicle lumen 1 HBB
haptoglobin-hemoglobin complex 1 HBB
inclusion body 1 SNCA
calprotectin complex 1 S100A9
S100A9 complex 1 S100A9
Cytolytic granule 1 PRF1
cytolytic granule lumen 1 PRF1
interleukin-28 receptor complex 1 IFNLR1
granular vesicle 1 AZIN2


文献列表

  • Bryan J Leong, Andrew D Hanson. Continuous Directed Evolution of a Feedback-Resistant Arabidopsis Arogenate Dehydratase in Plantized Escherichia coli. ACS synthetic biology. 2023 01; 12(1):43-50. doi: 10.1021/acssynbio.2c00511. [PMID: 36534785]
  • O V Zimina, M F Parii, O G Alkhimova. Title Not Available. TSitologiia i genetika. 2016 Sep; 50(5):17-24. doi: ". [PMID: 30480912]
  • Karen M E Dierickx, Renato Morandini, Thi Hien Nguyen, François Salès, Jean-Michel Kauffmann, Ghanem E Ghanem. A novel transport and delivery mechanism underpins the effectiveness of prolyl-m-sarcolysyl-p-fluorophenylalanine (PSF) in a human melanoma xenograft nude-mouse model. Pigment cell & melanoma research. 2008 Aug; 21(4):439-50. doi: 10.1111/j.1755-148x.2008.00471.x. [PMID: 18627526]
  • K V Kiselev, A S Dubrovina, M V Veselova, V P Bulgakov, S A Fedoreyev, Y N Zhuravlev. The rolB gene-induced overproduction of resveratrol in Vitis amurensis transformed cells. Journal of biotechnology. 2007 Feb; 128(3):681-92. doi: 10.1016/j.jbiotec.2006.11.008. [PMID: 17166613]
  • H Kloosterman, G I Hessels, J W Vrijbloed, G J Euverink, L Dijkhuizen. (De)regulation of key enzyme steps in the shikimate pathway and phenylalanine-specific pathway of the actinomycete Amycolatopsis methanolica. Microbiology (Reading, England). 2003 Nov; 149(Pt 11):3321-3330. doi: 10.1099/mic.0.26494-0. [PMID: 14600244]
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  • N Babudri, G Morpurgo. Frequency of spontaneous and induced recessive mutations in a diploid strain of Aspergillus nidulans. Mutation research. 1990 Jun; 230(2):187-95. doi: 10.1016/0027-5107(90)90056-a. [PMID: 2197553]
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