Hydralazine (BioDeep_00000002898)
Secondary id: BioDeep_00001867821
human metabolite blood metabolite Chemicals and Drugs Volatile Flavor Compounds
代谢物信息卡片
(1Z)-1(2H)-Phthalazinone hydrazone
化学式: C8H8N4 (160.0748928)
中文名称: 1(2H)-酞嗪酮腙, 肼苯哒嗪, 肼酞嗪
谱图信息:
最多检出来源 Homo sapiens(blood) 4.66%
分子结构信息
SMILES: C1=CC=C2C(=C1)C=NN=C2NN
InChI: InChI=1S/C8H8N4/c9-11-8-7-4-2-1-3-6(7)5-10-12-8/h1-5H,9H2,(H,11,12)
描述信息
Hydralazine is only found in individuals that have used or taken this drug. It is a direct-acting vasodilator that is used as an antihypertensive agent. [PubChem]Although the precise mechanism of action of hydralazine is not fully understood, the major effects are on the cardiovascular system. Hydralazine apparently lowers blood pressure by exerting a peripheral vasodilating effect through a direct relaxation of vascular smooth muscle. It has also been suggested that cyclic 3,5-adenosine monophosphate (cyclic AMP) mediates, at least partly, the relaxation of arterial smooth muscle by altering cellular calcium metabolism, which interferes with the calcium movements within the vascular smooth muscle that are responsible for initiating or maintaining the contractile state. In hypertensive patients, the hydralazine-induced decrease in blood pressure is accompanied by increased heart rate, cardiac output, and stroke volume, probably because of a reflex response to decreased peripheral resistance. The drug has no direct effect on the heart. Hydralazine may increase pulmonary arterial pressure, as well as coronary, splanchnic, cerebral, and renal blood flow. The preferential dilatation of arterioles, as compared to veins, minimizes postural hypotension and promotes the increase in cardiac output. Hydralazine usually increases renin activity in plasma, presumably as a result of increased secretion of renin by the renal juxtaglomerular cells in response to reflex sympathetic discharge. This increase in renin activity leads to the production of angiotensin II, which then causes stimulation of aldosterone and consequent sodium reabsorption. Tolerance to the antihypertensive effect of the drug develops during prolonged therapy, especially if a diuretic is not administered concurrently. In patients with CHF, hydralazine decreases systemic vascular resistance and increases cardiac output.
C - Cardiovascular system > C02 - Antihypertensives > C02D - Arteriolar smooth muscle, agents acting on > C02DB - Hydrazinophthalazine derivatives
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
同义名列表
30 个代谢物同义名
(1Z)-1(2H)-Phthalazinone hydrazone; mono-Hydrochloride, hydralazine; Hydralazine mono hydrochloride; Hydralazine mono-hydrochloride; Hydrazone 1(2H)-phthalazinone; (2H)-Phthalazinone hydrazone; Hydrochloride, hydralazine; Hydralazine hydrochloride; Phthalazin-1-ylhydrazine; 1-Hydrazino-phthalazine; 1-Phthalazinylhydrazine; 1-hydrazinylphthalazine; 1-Hydrazinophthalazine; Hydrazinophthalazine; 6-Hydralazine; Hypophthalin; Hydrallazine; Hydralazinum; hydralazine; Hydrallazin; Apressoline; Hidralazina; Idralazina; Hydralazin; Apresoline; Apressin; Nepresol; Hidral; Hydralazine; Hydralazine
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:5775
- KEGG: C07040
- KEGGdrug: D08044
- PubChem: 3637
- HMDB: HMDB0015400
- Metlin: METLIN3163
- DrugBank: DB01275
- ChEMBL: CHEMBL276832
- Wikipedia: Hydralazine
- MeSH: Hydralazine
- chemspider: 3511
- CAS: 59275-69-3
- CAS: 86-54-4
- PMhub: MS000006842
- PubChem: 9252
- PDB-CCD: HLZ
- NIKKAJI: J4.262E
- RefMet: Hydralazine
- KNApSAcK: 5775
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 282760 - Achillea pseudopectinata: 10.1080/14786410310001643849
- 9606 - Homo sapiens: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xin Quan, Caiyong Yu, Zhongmin Fan, Tong Wu, Chuchu Qi, Haoying Zhang, Shengxi Wu, Xi Wang. Hydralazine plays an immunomodulation role of pro-regeneration in a mouse model of spinal cord injury.
Experimental neurology.
2023 Feb; ?(?):114367. doi:
10.1016/j.expneurol.2023.114367. [PMID: 36858281] - Ting-Ting Chang, Chih-Hung Chiang, Ching Chen, Su-Chu Lin, Hsin-Jou Lee, Jaw-Wen Chen. Antioxidation and Nrf2-mediated heme oxygenase-1 activation contribute to renal protective effects of hydralazine in diabetic nephropathy.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Jul; 151(?):113139. doi:
10.1016/j.biopha.2022.113139. [PMID: 35623171] - Seth A Herr, Spencer S Gardeen, Philip S Low, Riyi Shi. Targeted delivery of acrolein scavenger hydralazine in spinal cord injury using folate-linker-drug conjugation.
Free radical biology & medicine.
2022 05; 184(?):66-73. doi:
10.1016/j.freeradbiomed.2022.04.003. [PMID: 35398493] - Fumihiko Takeuchi, Yi-Qiang Liang, Masato Isono, Mia Yang Ang, Kotaro Mori, Norihiro Kato. Transcriptomic Response in the Heart and Kidney to Different Types of Antihypertensive Drug Administration.
Hypertension (Dallas, Tex. : 1979).
2022 02; 79(2):413-423. doi:
10.1161/hypertensionaha.121.18026. [PMID: 34879704] - Jyh-Gang Leu, Wei-Hsiang Su, Yu-Cheng Chen, Yao-Jen Liang. Hydralazine attenuates renal inflammation in diabetic rats with ischemia/reperfusion acute kidney injury.
European journal of pharmacology.
2021 Nov; 910(?):174468. doi:
10.1016/j.ejphar.2021.174468. [PMID: 34478692] - Danillo Menezes Dos Santos, Eric Aian Pereira Da Silva, Jeferson Yuri Santos Oliveira, Yandra Yssa de Menezes Marinho, Izabel Rodrigues de Santana, Luana Heimfarth, Erik Willyame Menezes Pereira, Lucindo José Quintans Júnior, Jamil Assreuy, Igor Alexandre Cortes Menezes, Márcio Roberto Viana Dos Santos. The Therapeutic Value of Hydralazine in Reducing Inflammatory Response, Oxidative Stress, and Mortality in Animal Sepsis: Involvement of the PI3K/AKT Pathway.
Shock (Augusta, Ga.).
2021 11; 56(5):782-792. doi:
10.1097/shk.0000000000001746. [PMID: 33555842] - Mohamed Amar, Simon W Lam, Kathleen Faulkenberg, Antonio Perez, W H Wilson Tang, J Bradley Williams. Captopril Versus Hydralazine-Isosorbide Dinitrate Vasodilator Protocols in Patients With Acute Decompensated Heart Failure Transitioning From Sodium Nitroprusside.
Journal of cardiac failure.
2021 10; 27(10):1053-1060. doi:
10.1016/j.cardfail.2021.05.007. [PMID: 34051349] - Dominick Santoriello, Andrew S Bomback, Satoru Kudose, Ibrahim Batal, M Barry Stokes, Pietro A Canetta, Jai Radhakrishnan, Gerald B Appel, Vivette D D'Agati, Glen S Markowitz. Anti-neutrophil cytoplasmic antibody associated glomerulonephritis complicating treatment with hydralazine.
Kidney international.
2021 08; 100(2):440-446. doi:
10.1016/j.kint.2021.03.029. [PMID: 33857570] - Weiwei Tang, Andrew Gordon, Fang Wang, Yanwen Chen, Bin Li. Hydralazine as a Versatile and Universal Matrix for High-Molecular Coverage and Dual-Polarity Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging.
Analytical chemistry.
2021 07; 93(26):9083-9093. doi:
10.1021/acs.analchem.1c00498. [PMID: 34152727] - Takashi Matsuyama, Naro Ohashi, Taro Aoki, Sayaka Ishigaki, Shinsuke Isobe, Taichi Sato, Tomoyuki Fujikura, Akihiko Kato, Hiroaki Miyajima, Hideo Yasuda. Circadian rhythm of the intrarenal renin-angiotensin system is caused by glomerular filtration of liver-derived angiotensinogen depending on glomerular capillary pressure in adriamycin nephropathy rats.
Hypertension research : official journal of the Japanese Society of Hypertension.
2021 Jun; 44(6):618-627. doi:
10.1038/s41440-021-00620-6. [PMID: 33558668] - Wan Tu, Barry Fayman, Stephen C Ward, Yusufal Mamoon, Sabiha S Bandagi. Hydralazine-Induced Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: Asymptomatic and Renal-Restricted Presentation.
The American journal of case reports.
2021 May; 22(?):e931263. doi:
10.12659/ajcr.931263. [PMID: 33993184] - Mae Xintong Huo, Alzira Rocheteau M Avelino, Gurpreet Singh. Severe cutaneous presentation of hydralazine-induced ANCA vasculitis without renal or pulmonary involvement, complicated by DIC.
BMJ case reports.
2021 May; 14(5):. doi:
10.1136/bcr-2020-238609. [PMID: 33975832] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Yoko Fujita, Daisuke Ichikawa, Takeshi Sugaya, Keiichi Ohata, Jun Tanabe, Kazuho Inoue, Seiko Hoshino, Tatsuru Togo, Minoru Watanabe, Kenjiro Kimura, Yugo Shibagaki, Atsuko Kamijo-Ikemori. Angiotensin II type 1a receptor loss ameliorates chronic tubulointerstitial damage after renal ischemia reperfusion.
Scientific reports.
2021 01; 11(1):982. doi:
10.1038/s41598-020-80209-0. [PMID: 33441837] - Chie Yokouchi, Yukari Nishimura, Hirohiko Goto, Makoto Sato, Yuya Hidoh, Kenji Takeuchi, Yuji Ishii. Reduction of fatty liver in rats by nicotinamide via the regeneration of the methionine cycle and the inhibition of aldehyde oxidase.
The Journal of toxicological sciences.
2021; 46(1):31-42. doi:
10.2131/jts.46.31. [PMID: 33408299] - Wei Xu, Lei Qian, Xiaoyan Yuan, Yong Lu. Combined effects of hydralazine and nitrate on serum biochemistry and left ventricular remodeling in chronic heart failure patients.
Pakistan journal of pharmaceutical sciences.
2021 Jan; 34(1(Special)):381-386. doi:
. [PMID: 34275783] - Kohei Hayashi, Takaomi Shimokawa, Masayo Yamagata, Kozo Yoneda. Inhibition of α2-adrenoceptor is renoprotective in 5/6 nephrectomy-induced chronic kidney injury rats.
Journal of pharmacological sciences.
2021 Jan; 145(1):79-87. doi:
10.1016/j.jphs.2020.11.001. [PMID: 33357783] - Benjamin P Larkin, Sonia Saad, Sarah J Glastras, Long T Nguyen, Miao Hou, Hui Chen, Rosy Wang, Carol A Pollock. Low-dose hydralazine during gestation reduces renal fibrosis in rodent offspring exposed to maternal high fat diet.
PloS one.
2021; 16(3):e0248854. doi:
10.1371/journal.pone.0248854. [PMID: 33735324] - David M Charytan, Jesse Y Hsu, Finnian R Mc Causland, Sushrut S Waikar, T Alp Ikizler, Dominic S Raj, J Richard Landis, Rajnish Mehrotra, Mark Williams, Marcelo DiCarli, Hicham Skali, Paul L Kimmel, Alan S Kliger, Laura M Dember. Combination Hydralazine and Isosorbide Dinitrate in Dialysis-Dependent ESRD (HIDE): A Randomized, Placebo-Controlled, Pilot Trial.
Kidney360.
2020 12; 1(12):1380-1389. doi:
10.34067/kid.0004342020. [PMID: 35372900] - Pattraporn Chera-Aree, Pimrapat Tengtrakulcharoen, Jarunee Leetheeragul, Urai Sampaojarean, Supitchaya Surasereewong, Tuangsit Wataganara. Clinical Experiences of Intravenous Hydralazine and Labetalol for Acute Treatment of Severe Hypertension in Pregnant Thai Women.
Journal of clinical pharmacology.
2020 12; 60(12):1662-1670. doi:
10.1002/jcph.1685. [PMID: 32598488] - Hsieh-Chou Huang, Tsan-Seng Hsiao, Mei-Hui Liao, Cheng-Ming Tsao, Chih-Chin Shih, Chin-Chen Wu. Low-dose hydralazine improves endotoxin-induced coagulopathy and multiple organ dysfunction via its anti-inflammatory and anti-oxidative/nitrosative properties.
European journal of pharmacology.
2020 Sep; 882(?):173279. doi:
10.1016/j.ejphar.2020.173279. [PMID: 32561290] - Ahmad Al-Abdouh, Abdul Muhaymin Siyal, Hanan Seid, Ammer Bekele, Pablo Garcia. Hydralazine-induced antineutrophil cytoplasmic antibody-associated vasculitis with pulmonary-renal syndrome: a case report.
Journal of medical case reports.
2020 Apr; 14(1):47. doi:
10.1186/s13256-020-02378-w. [PMID: 32290867] - Qingjun Pan, Yun Guo, Linjie Guo, Shuzhen Liao, Chunfei Zhao, Sijie Wang, Hua-Feng Liu. Mechanistic Insights of Chemicals and Drugs as Risk Factors for Systemic Lupus Erythematosus.
Current medicinal chemistry.
2020; 27(31):5175-5188. doi:
10.2174/0929867326666190404140658. [PMID: 30947650] - Yuan Yuan, Hisao Naito, Kazuya Kitamori, Sayuki Hashimoto, Tomomi Asano, Tamie Nakajima. The antihypertensive agent hydralazine reduced extracellular matrix synthesis and liver fibrosis in nonalcoholic steatohepatitis exacerbated by hypertension.
PloS one.
2020; 15(12):e0243846. doi:
10.1371/journal.pone.0243846. [PMID: 33315911] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Lena R Thurner, Klaus Höcherl. Role of protease-activated receptor 2 in regulation of renin synthesis and secretion in mice.
Naunyn-Schmiedeberg's archives of pharmacology.
2019 11; 392(11):1401-1410. doi:
10.1007/s00210-019-01677-4. [PMID: 31243492] - Amrita V Pai, Crystal A West, Aline M Arlindo de Souza, Parnika S Kadam, Emma J Pollner, David A West, Jia Li, Hong Ji, Xie Wu, Michelle J Zhu, Chris Baylis, Kathryn Sandberg. Renal T cell infiltration occurs despite attenuation of development of hypertension with hydralazine in Envigo's female Dahl rat maintained on a low-Na+ diet.
American journal of physiology. Renal physiology.
2019 09; 317(3):F572-F583. doi:
10.1152/ajprenal.00512.2018. [PMID: 31241996] - Erika E Nishi, Nathalia R Lopes, Guiomar N Gomes, Juliana C Perry, Alex Y S Sato, Maria G Naffah-Mazzacoratti, Cássia T Bergamaschi, Ruy R Campos. Renal denervation reduces sympathetic overactivation, brain oxidative stress, and renal injury in rats with renovascular hypertension independent of its effects on reducing blood pressure.
Hypertension research : official journal of the Japanese Society of Hypertension.
2019 05; 42(5):628-640. doi:
10.1038/s41440-018-0171-9. [PMID: 30573809] - Michelle C Starr, Joseph T Flynn. Neonatal hypertension: cases, causes, and clinical approach.
Pediatric nephrology (Berlin, Germany).
2019 05; 34(5):787-799. doi:
10.1007/s00467-018-3977-4. [PMID: 29808264] - Yong Li, Daorong Hou, Xuguan Chen, Jingfeng Zhu, Ruyi Zhang, Wei Sun, Peng Li, Yunfan Tian, Xiangqing Kong. Hydralazine protects against renal ischemia-reperfusion injury in rats.
European journal of pharmacology.
2019 Jan; 843(?):199-209. doi:
10.1016/j.ejphar.2018.11.015. [PMID: 30472201] - Michael A Paley, Fahad Edrees, Satoru Kudose, Joseph P Gaut, Prabha Ranganathan, Anitha Vijayan. Successful use of rituximab for hydralazine-induced anti-neutrophil cytoplasmic antibodies-associated vasculitis.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia.
2019 Jan; 30(1):226-230. doi:
10.4103/1319-2442.252915. [PMID: 30804286] - Kenji Takeuchi, Chie Yokouchi, Hirohiko Goto, Ken Umehara, Hideyuki Yamada, Yuji Ishii. Alleviation of fatty liver in a rat model by enhancing N1-methylnicotinamide bioavailability through aldehyde oxidase inhibition.
Biochemical and biophysical research communications.
2018 12; 507(1-4):203-210. doi:
10.1016/j.bbrc.2018.11.008. [PMID: 30446221] - Narothama Reddy Aeddula, Samata Pathireddy, Asif Ansari, Peter J Juran. Hydralazine-associated antineutrophil cytoplasmic antibody vasculitis with pulmonary-renal syndrome.
BMJ case reports.
2018 Nov; 2018(?):. doi:
10.1136/bcr-2018-227161. [PMID: 30413463] - Noor Ul-Ain Baloch, Adaeze N Ibeabuchi. Hydralazine-induced MPO-ANCA Renal-Limited Vasculitis Masquerading as Lupus Nephritis.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.
2018 Nov; 28(11):896-897. doi:
10.29271/jcpsp.2018.11.896. [PMID: 30369391] - Bharat Kumar, Jennifer Strouse, Melissa Swee, Petar Lenert, Manish Suneja. Hydralazine-associated vasculitis: Overlapping features of drug-induced lupus and vasculitis.
Seminars in arthritis and rheumatism.
2018 10; 48(2):283-287. doi:
10.1016/j.semarthrit.2018.01.005. [PMID: 29519741] - Kwadwo A Yeboah, Amy Allspaw, Akram Al-Makki, Brian M Shepler. Hydralazine-associated Amenorrhea in a Premenopausal Patient With Chronic Kidney Disease: A Case Report and Review of Literature.
Clinical therapeutics.
2018 09; 40(9):1592-1595. doi:
10.1016/j.clinthera.2018.07.022. [PMID: 30166053] - Philip C Burcham. Carbonyl scavengers as pharmacotherapies in degenerative disease: Hydralazine repurposing and challenges in clinical translation.
Biochemical pharmacology.
2018 08; 154(?):397-406. doi:
10.1016/j.bcp.2018.06.006. [PMID: 29883705] - Waseem Amjad, Geevarghese John, Sharifova Gulru. Hydralazine-Induced Autoimmune Hepatitis Precipitated by the Blood Transfusion.
American journal of therapeutics.
2018 Jul; 25(4):e514-e516. doi:
10.1097/mjt.0000000000000605. [PMID: 29045246] - Roman Zuckerman, Mayurkumar Patel, Eric J Costanzo, Harry Dounis, Rany Al Haj, Seyedehsara Seyedali, Arif Asif. Hydralazine-associated adverse events: a report of two cases of hydralazine-induced ANCA vasculitis.
Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia.
2018 Apr; 40(2):193-197. doi:
10.1590/2175-8239-jbn-3858. [PMID: 29738027] - Jorge A Irizarry-Caro, Carmelo Carmona-Rivera, Daniella M Schwartz, Sami S Khaznadar, Mariana J Kaplan, Peter C Grayson. Brief Report: Drugs Implicated in Systemic Autoimmunity Modulate Neutrophil Extracellular Trap Formation.
Arthritis & rheumatology (Hoboken, N.J.).
2018 03; 70(3):468-474. doi:
10.1002/art.40372. [PMID: 29121457] - Yuji Sogawa, Hajime Nagasu, Seiji Itano, Kengo Kidokoro, Shun'ichiro Taniguchi, Masafumi Takahashi, Hiroyuki Kadoya, Minoru Satoh, Tamaki Sasaki, Naoki Kashihara. The eNOS-NO pathway attenuates kidney dysfunction via suppression of inflammasome activation in aldosterone-induced renal injury model mice.
PloS one.
2018; 13(10):e0203823. doi:
10.1371/journal.pone.0203823. [PMID: 30281670] - Lu Yao, Yun-Tao Wu, Guo-Xiang Tian, Chang-Quan Xia, Feng Zhang, Wei Zhang. Acrolein Scavenger Hydralazine Prevents Streptozotocin-Induced Painful Diabetic Neuropathy and Spinal Neuroinflammation in Rats.
Anatomical record (Hoboken, N.J. : 2007).
2017 Oct; 300(10):1858-1864. doi:
10.1002/ar.23618. [PMID: 28598552] - Lindsay M Parker, Sheng Le, Travis A Wearne, Kate Hardwick, Natasha N Kumar, Katherine J Robinson, Simon McMullan, Ann K Goodchild. Neurochemistry of neurons in the ventrolateral medulla activated by hypotension: Are the same neurons activated by glucoprivation?.
The Journal of comparative neurology.
2017 Jun; 525(9):2249-2264. doi:
10.1002/cne.24203. [PMID: 28295336] - Andrew S Bomback. An Elderly Man with Fatigue, Dyspnea, and Kidney Failure.
Clinical journal of the American Society of Nephrology : CJASN.
2017 05; 12(5):836-838. doi:
10.2215/cjn.13311216. [PMID: 28274994] - Masaaki Nishihara, Ko Takesue, Yoshitaka Hirooka. Renal denervation enhances GABA-ergic input into the PVN leading to blood pressure lowering in chronic kidney disease.
Autonomic neuroscience : basic & clinical.
2017 05; 204(?):88-97. doi:
10.1016/j.autneu.2016.09.018. [PMID: 27729205] - Björn Tampe, Ulrike Steinle, Désirée Tampe, Julienne L Carstens, Peter Korsten, Elisabeth M Zeisberg, Gerhard A Müller, Raghu Kalluri, Michael Zeisberg. Low-dose hydralazine prevents fibrosis in a murine model of acute kidney injury-to-chronic kidney disease progression.
Kidney international.
2017 01; 91(1):157-176. doi:
10.1016/j.kint.2016.07.042. [PMID: 27692563] - Caroline Camaré, Corinne Vanucci-Bacqué, Nathalie Augé, Mélanie Pucelle, Corinne Bernis, Audrey Swiader, Michel Baltas, Florence Bedos-Belval, Robert Salvayre, Anne Nègre-Salvayre. 4-Hydroxynonenal Contributes to Angiogenesis through a Redox-Dependent Sphingolipid Pathway: Prevention by Hydralazine Derivatives.
Oxidative medicine and cellular longevity.
2017; 2017(?):9172741. doi:
10.1155/2017/9172741. [PMID: 28479957] - Somwail Rasla, Amr El Meligy, Dragos F Cucu. Hydralazine-Induced ANCA Vasculitis in the Setting of Acute Clostridium Difficile Infection.
Rhode Island medical journal (2013).
2016 Nov; 99(11):41-43. doi:
. [PMID: 27801920] - Jordan W Squair, Aaron A Phillips, Mark Harmon, Andrei V Krassioukov. Emergency management of autonomic dysreflexia with neurologic complications.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.
2016 Oct; 188(15):1100-1103. doi:
10.1503/cmaj.151311. [PMID: 27221275] - Neil P Jerome, Jessica K R Boult, Matthew R Orton, James d'Arcy, David J Collins, Martin O Leach, Dow-Mu Koh, Simon P Robinson. Modulation of renal oxygenation and perfusion in rat kidney monitored by quantitative diffusion and blood oxygen level dependent magnetic resonance imaging on a clinical 1.5T platform.
BMC nephrology.
2016 10; 17(1):142. doi:
10.1186/s12882-016-0356-x. [PMID: 27716094] - Wei-Yang Chen, Jingwen Zhang, Smita Ghare, Shirish Barve, Craig McClain, Swati Joshi-Barve. Acrolein Is a Pathogenic Mediator of Alcoholic Liver Disease and the Scavenger Hydralazine Is Protective in Mice.
Cellular and molecular gastroenterology and hepatology.
2016 Sep; 2(5):685-700. doi:
10.1016/j.jcmgh.2016.05.010. [PMID: 28119953] - Zhe Chen, Jonghyuck Park, Breanne Butler, Glen Acosta, Sasha Vega-Alvarez, Lingxing Zheng, Jonathan Tang, Robyn McCain, Wenpeng Zhang, Zheng Ouyang, Peng Cao, Riyi Shi. Mitigation of sensory and motor deficits by acrolein scavenger phenelzine in a rat model of spinal cord contusive injury.
Journal of neurochemistry.
2016 07; 138(2):328-38. doi:
10.1111/jnc.13639. [PMID: 27060873] - Mallavva B Bolattin, Sharanappa T Nandibewoor, Shivamurti A Chimatadar. Biomolecular interaction study of hydralazine with bovine serum albumin and effect of β-cyclodextrin on binding by fluorescence, 3D, synchronous, CD, and Raman spectroscopic methods.
Journal of molecular recognition : JMR.
2016 07; 29(7):308-17. doi:
10.1002/jmr.2532. [PMID: 26785703] - Shinsuke Isobe, Naro Ohashi, Sayaka Ishigaki, Takayuki Tsuji, Yukitoshi Sakao, Akihiko Kato, Hiroaki Miyajima, Yoshihide Fujigaki, Akira Nishiyama, Hideo Yasuda. Augmented circadian rhythm of the intrarenal renin-angiotensin systems in anti-thymocyte serum nephritis rats.
Hypertension research : official journal of the Japanese Society of Hypertension.
2016 May; 39(5):312-20. doi:
10.1038/hr.2015.151. [PMID: 26739872] - Zhengrong Guan, Sean T Singletary, Haword Cha, Justin P Van Beusecum, Anthony K Cook, Jennifer S Pollock, David M Pollock, Edward W Inscho. Pentosan polysulfate preserves renal microvascular P2X1 receptor reactivity and autoregulatory behavior in DOCA-salt hypertensive rats.
American journal of physiology. Renal physiology.
2016 Mar; 310(6):F456-65. doi:
10.1152/ajprenal.00110.2015. [PMID: 26697978] - Jerry Yee. PGX: Pharmacogenomics During Generation X.
Advances in chronic kidney disease.
2016 Mar; 23(2):57-60. doi:
10.1053/j.ackd.2016.01.012. [PMID: 26979142] - Chih-Chin Shih, Hiong-Ping Hii, Cheng-Ming Tsao, Shiu-Jen Chen, Shuk-Man Ka, Mei-Hui Liao, Chin-Chen Wu. Therapeutic Effects of Procainamide on Endotoxin-Induced Rhabdomyolysis in Rats.
PloS one.
2016; 11(2):e0150319. doi:
10.1371/journal.pone.0150319. [PMID: 26918767] - Jonghyuck Park, Lingxing Zheng, Glen Acosta, Sasha Vega-Alvarez, Zhe Chen, Breanne Muratori, Peng Cao, Riyi Shi. Acrolein contributes to TRPA1 up-regulation in peripheral and central sensory hypersensitivity following spinal cord injury.
Journal of neurochemistry.
2015 Dec; 135(5):987-97. doi:
10.1111/jnc.13352. [PMID: 26365991] - Md Sanaullah Biswas, Jun'ichi Mano. Lipid Peroxide-Derived Short-Chain Carbonyls Mediate Hydrogen Peroxide-Induced and Salt-Induced Programmed Cell Death in Plants.
Plant physiology.
2015 Jul; 168(3):885-98. doi:
10.1104/pp.115.256834. [PMID: 26025050] - Wei Cao, Aiqing Li, Liangliang Wang, Zhanmei Zhou, Zhengxiu Su, Wei Bin, Christopher S Wilcox, Fan Fan Hou. A Salt-Induced Reno-Cerebral Reflex Activates Renin-Angiotensin Systems and Promotes CKD Progression.
Journal of the American Society of Nephrology : JASN.
2015 Jul; 26(7):1619-33. doi:
10.1681/asn.2014050518. [PMID: 25635129] - Tomomi Nagayama, Yoshitaka Hirooka, Takuya Kishi, Yasushi Mukai, Shujiro Inoue, Susumu Takase, Masao Takemoto, Akiko Chishaki, Kenji Sunagawa. Blockade of brain angiotensin II type 1 receptor inhibits the development of atrial fibrillation in hypertensive rats.
American journal of hypertension.
2015 Apr; 28(4):444-51. doi:
10.1093/ajh/hpu196. [PMID: 25352232] - Fumiki Yoshihara, Takeshi Tokudome, Ichiro Kishimoto, Kentaro Otani, Atsunori Kuwabara, Takeshi Horio, Yuhei Kawano, Kenji Kangawa. Aggravated renal tubular damage and interstitial fibrosis in mice lacking guanylyl cyclase-A (GC-A), a receptor for atrial and B-type natriuretic peptides.
Clinical and experimental nephrology.
2015 Apr; 19(2):197-207. doi:
10.1007/s10157-014-0982-1. [PMID: 24845230] - Mahesha H Gangadhariah, James M Luther, Victor Garcia, Paisit Paueksakon, Ming-Zhi Zhang, Simon W Hayward, Harold D Love, John R Falck, Vijaya L Manthati, John D Imig, Michal L Schwartzman, Roy Zent, Jorge H Capdevila, Ambra Pozzi. Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy.
Journal of the American Society of Nephrology : JASN.
2015 Mar; 26(3):597-610. doi:
10.1681/asn.2013090980. [PMID: 25071086] - Ting-Ting Chang, Tao-Cheng Wu, Po-Hsun Huang, Chih-Pei Lin, Jia-Shiong Chen, Liang-Yu Lin, Shing-Jong Lin, Jaw-Wen Chen. Direct Renin Inhibition with Aliskiren Improves Ischemia-Induced Neovasculogenesis in Diabetic Animals via the SDF-1 Related Mechanism.
PloS one.
2015; 10(8):e0136627. doi:
10.1371/journal.pone.0136627. [PMID: 26305217] - Yang Wang, Bing-Qing Xie, Wei-Hua Gao, Ding-Yi Yan, Wen-Ling Zheng, Yong-Bo Lv, Yu-Meng Cao, Jia-Wen Hu, Zu-Yi Yuan, Jian-Jun Mu. Effects of Renin-Angiotensin System Inhibitors on Renal Expression of Renalase in Sprague-Dawley Rats Fed With High Salt Diet.
Kidney & blood pressure research.
2015; 40(6):605-13. doi:
10.1159/000368536. [PMID: 26619289] - Miki Ueda, Kohei Uchimura, Yuki Narita, Yoshikazu Miyasato, Teruhiko Mizumoto, Jun Morinaga, Manabu Hayata, Yutaka Kakizoe, Masataka Adachi, Taku Miyoshi, Naoki Shiraishi, Daisuke Kadowaki, Yoshiki Sakai, Masashi Mukoyama, Kenichiro Kitamura. The serine protease inhibitor camostat mesilate attenuates the progression of chronic kidney disease through its antioxidant effects.
Nephron.
2015; 129(3):223-32. doi:
10.1159/000375308. [PMID: 25766432] - Hongxian Wu, Xian Wu Cheng, Lina Hu, Chang-Ning Hao, Mutsuharu Hayashi, Kyosuke Takeshita, Mohammad Shoaib Hamrah, Guo-Ping Shi, Masafumi Kuzuya, Toyoaki Murohara. Renin inhibition reduces atherosclerotic plaque neovessel formation and regresses advanced atherosclerotic plaques.
Atherosclerosis.
2014 Dec; 237(2):739-47. doi:
10.1016/j.atherosclerosis.2014.10.098. [PMID: 25463114] - Isis A Katayama, Rafael C Pereira, Ellen P B Dopona, Maria H M Shimizu, Luzia N S Furukawa, Ivone B Oliveira, Joel C Heimann. High-salt intake induces cardiomyocyte hypertrophy in rats in response to local angiotensin II type 1 receptor activation.
The Journal of nutrition.
2014 Oct; 144(10):1571-8. doi:
10.3945/jn.114.192054. [PMID: 25122644] - Karen A Griffin, Aaron Polichnowski, Natalia Litbarg, Maria Picken, Manjeri A Venkatachalam, Anil K Bidani. Critical blood pressure threshold dependence of hypertensive injury and repair in a malignant nephrosclerosis model.
Hypertension (Dallas, Tex. : 1979).
2014 Oct; 64(4):801-7. doi:
10.1161/hypertensionaha.114.03609. [PMID: 24958497] - Shigetaka Yoshida, Kenichi Ishizawa, Nobuhiro Ayuzawa, Kohei Ueda, Maki Takeuchi, Wakako Kawarazaki, Toshiro Fujita, Miki Nagase. Renin inhibition ameliorates renal damage through prominent suppression of both angiotensin I and II in human renin angiotensinogen transgenic mice with high salt loading.
Clinical and experimental nephrology.
2014 Aug; 18(4):593-9. doi:
10.1007/s10157-013-0893-6. [PMID: 24154707] - J C Chan, D Y Yap, C K Yeung. Hydralazine-induced toxic epidermal necrolysis in a patient on continuous ambulatory peritoneal dialysis.
Journal of clinical pharmacy and therapeutics.
2014 Jun; 39(3):322-4. doi:
10.1111/jcpt.12141. [PMID: 24588409] - Andrew S deLemos, David M Foureau, Carl Jacobs, Will Ahrens, Mark W Russo, Herbert L Bonkovsky. Drug-induced liver injury with autoimmune features.
Seminars in liver disease.
2014 May; 34(2):194-204. doi:
10.1055/s-0034-1375959. [PMID: 24879983] - Alok Sharma, Monica Colvin-Adams, Clyde W Yancy. Heart failure in African Americans: disparities can be overcome.
Cleveland Clinic journal of medicine.
2014 May; 81(5):301-11. doi:
10.3949/ccjm.81a.13045. [PMID: 24789589] - Daniel F Arruda-Junior, Stephannie G Virgulino, Adriana C C Girardi. Reduced tubular proteinuria in hypertensive rats treated with losartan is associated with higher renal cortical megalin expression.
Hormone molecular biology and clinical investigation.
2014 May; 18(2):105-12. doi:
10.1515/hmbci-2013-0061. [PMID: 25390006] - Jonghyuck Park, Lingxing Zheng, Andrew Marquis, Michael Walls, Brad Duerstock, Amber Pond, Sasha Vega-Alvarez, He Wang, Zheng Ouyang, Riyi Shi. Neuroprotective role of hydralazine in rat spinal cord injury-attenuation of acrolein-mediated damage.
Journal of neurochemistry.
2014 Apr; 129(2):339-49. doi:
10.1111/jnc.12628. [PMID: 24286176] - Manish Suneja, Shalanki Baiswar, Scott A Vogelgesang. Hydralazine associated pauci-immune glomerulonephritis.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases.
2014 Mar; 20(2):99-102. doi:
10.1097/rhu.0000000000000049. [PMID: 24561415] - Snežana Trifunović, Anđelka M Isaković, Aleksandra Isaković, Ivan Vučković, Boris Mandić, Miroslav Novaković, Vlatka Vajs, Slobodan Milosavljević, Vladimir Trajković. Isolation, characterization, and in vitro cytotoxicity of new sesquiterpenoids from Achillea clavennae.
Planta medica.
2014 Mar; 80(4):297-305. doi:
10.1055/s-0033-1360312. [PMID: 24510367] - Ikuko Sugama, Kentaro Kohagura, Masanobu Yamazato, Takuto Nakamura, Tomoko Shinzato, Yusuke Ohya. Superoxide dismutase mimetic, tempol, aggravates renal injury in advanced-stage stroke-prone spontaneously hypertensive rats.
Journal of hypertension.
2014 Mar; 32(3):534-41. doi:
10.1097/hjh.0000000000000064. [PMID: 24309490] - Michael R Due, Jonghyuck Park, Lingxing Zheng, Michael Walls, Yohance M Allette, Fletcher A White, Riyi Shi. Acrolein involvement in sensory and behavioral hypersensitivity following spinal cord injury in the rat.
Journal of neurochemistry.
2014 Mar; 128(5):776-786. doi:
10.1111/jnc.12500. [PMID: 24147766] - William F Pendergraft, John L Niles. Trojan horses: drug culprits associated with antineutrophil cytoplasmic autoantibody (ANCA) vasculitis.
Current opinion in rheumatology.
2014 Jan; 26(1):42-9. doi:
10.1097/bor.0000000000000014. [PMID: 24276086] - Yao-Ko Wen, Kai-I Wen. An unusual cause of non-infectious peritonitis in a peritoneal dialysis patient.
International urology and nephrology.
2014 Jan; 46(1):265-8. doi:
10.1007/s11255-012-0312-z. [PMID: 23054326] - Shuhei Kobuchi, Ryosuke Tanaka, Asami Funai, Rie Suzuki, Maki Yazawa, Hidenobu Tsutsui, Mamoru Ohkita, Kazuhide Ayajiki, Yasuo Matsumura. Involvement of renal sympathetic nerve overactivation in the progression of chronic kidney disease in rats.
Journal of cardiovascular pharmacology.
2014 Jan; 63(1):9-15. doi:
10.1097/fjc.0000000000000016. [PMID: 24084211] - N Arulkumaran, L Lightstone. Severe pre-eclampsia and hypertensive crises.
Best practice & research. Clinical obstetrics & gynaecology.
2013 Dec; 27(6):877-84. doi:
10.1016/j.bpobgyn.2013.07.003. [PMID: 23962474] - Suresh K Kesavan, Shweta Bhat, Sandeep B Golegaonkar, Mashanipalya G Jagadeeshaprasad, Arati B Deshmukh, Harshal S Patil, Santosh D Bhosale, Mahemud L Shaikh, Hirekodathakallu V Thulasiram, Ramanamurthy Boppana, Mahesh J Kulkarni. Proteome wide reduction in AGE modification in streptozotocin induced diabetic mice by hydralazine mediated transglycation.
Scientific reports.
2013 Oct; 3(?):2941. doi:
10.1038/srep02941. [PMID: 24126953] - Fumihiro Sugiyama, Naohiko Kobayashi, Mayuko Ishikawa, Sho Onoda, Toshihiko Ishimitsu. Renoprotective mechanisms of telmisartan on renal injury and inflammation in SHRSP.Z-Leprfa/IzmDmcr rats.
Clinical and experimental nephrology.
2013 Aug; 17(4):515-24. doi:
10.1007/s10157-012-0759-3. [PMID: 23268284] - J Verdú Solans, I Ojeda Cuchillero, M Soler Costa. [Pharmacological iatrogenesis in a cardiac-renal patient: presentation of a case].
Semergen.
2013 May; 39(4):226-30. doi:
10.1016/j.semerg.2012.02.009. [PMID: 23726736] - Urmila P Kodavanti, Ronald F Thomas, Allen D Ledbetter, Mette C Schladweiler, Virginia Bass, Q Todd Krantz, Charly King, Abraham Nyska, Judy E Richards, Debora Andrews, M Ian Gilmour. Diesel exhaust induced pulmonary and cardiovascular impairment: the role of hypertension intervention.
Toxicology and applied pharmacology.
2013 Apr; 268(2):232-40. doi:
10.1016/j.taap.2013.02.002. [PMID: 23415681] - Yu Cao, Jian-Jun Mu, Yuan Fang, Zu-Yi Yuan, Fu-Qiang Liu. Impact of high salt independent of blood pressure on PRMT/ADMA/DDAH pathway in the aorta of Dahl salt-sensitive rats.
International journal of molecular sciences.
2013 Apr; 14(4):8062-72. doi:
10.3390/ijms14048062. [PMID: 23584024] - Jianping Li, Kevin A Carnevale, Donald J Dipette, Scott C Supowit. Renal protective effects of α-calcitonin gene-related peptide in deoxycorticosterone-salt hypertension.
American journal of physiology. Renal physiology.
2013 Apr; 304(7):F1000-8. doi:
10.1152/ajprenal.00434.2012. [PMID: 23389451] - Luigi Villa, Peter Boor, Andrzej Konieczny, Uta Kunter, Claudia R C van Roeyen, Bernd Denecke, Lin Gan, Matthias A Neusser, Clemens D Cohen, Frank Eitner, Thomas Scholl, Tammo Ostendorf, Jürgen Floege. Late angiotensin II receptor blockade in progressive rat mesangioproliferative glomerulonephritis: new insights into mechanisms.
The Journal of pathology.
2013 Apr; 229(5):672-84. doi:
10.1002/path.4151. [PMID: 23192593] - James M Alexander, Karen L Wilson. Hypertensive emergencies of pregnancy.
Obstetrics and gynecology clinics of North America.
2013 Mar; 40(1):89-101. doi:
10.1016/j.ogc.2012.11.008. [PMID: 23466139] - Stephanie L MacAllister, Nicolas Martin-Brisac, Vincent Lau, Kai Yang, Peter J O'Brien. Acrolein and chloroacetaldehyde: an examination of the cell and cell-free biomarkers of toxicity.
Chemico-biological interactions.
2013 Feb; 202(1-3):259-66. doi:
10.1016/j.cbi.2012.11.017. [PMID: 23220588] - Mahboob Rahman, Tom Greene, Robert A Phillips, Lawrence Y Agodoa, George L Bakris, Jeanne Charleston, Gabriel Contreras, Francis Gabbai, Leena Hiremath, Kenneth Jamerson, Cynthia Kendrick, John W Kusek, James P Lash, Janice Lea, Edgar R Miller, Stephen Rostand, Robert Toto, Xulei Wang, Jackson T Wright, Lawrence J Appel. A trial of 2 strategies to reduce nocturnal blood pressure in blacks with chronic kidney disease.
Hypertension (Dallas, Tex. : 1979).
2013 Jan; 61(1):82-8. doi:
10.1161/hypertensionaha.112.200477. [PMID: 23172931] - Nina Queisser, Kerstin Amann, Valentin Hey, Samy L Habib, Nicole Schupp. Blood pressure has only minor influence on aldosterone-induced oxidative stress and DNA damage in vivo.
Free radical biology & medicine.
2013 Jan; 54(?):17-25. doi:
10.1016/j.freeradbiomed.2012.10.549. [PMID: 23104102] - Shinji Kosaka, Nicolas Pelisch, Matlubur Rahman, Daisuke Nakano, Hirofumi Hitomi, Hiroyuki Kobori, Noriyasu Fukuoka, Hideki Kobara, Hirohito Mori, Tsutomu Masaki, Ludek Cervenka, Yasuo Matsumura, Hitoshi Houchi, Akira Nishiyama. Effects of angiotensin II AT₁-receptor blockade on high fat diet-induced vascular oxidative stress and endothelial dysfunction in Dahl salt-sensitive rats.
Journal of pharmacological sciences.
2013; 121(2):95-102. doi:
10.1254/jphs.12169fp. [PMID: 23337436] - Bart F J Heijnen, Jelly Nelissen, Helma van Essen, Gregorio E Fazzi, Jan W Cohen Tervaert, Carine J Peutz-Kootstra, John J Mullins, Casper G Schalkwijk, Ben J A Janssen, Harry A J Struijker-Boudier. Irreversible renal damage after transient renin-angiotensin system stimulation: involvement of an AT1-receptor mediated immune response.
PloS one.
2013; 8(2):e57815. doi:
10.1371/journal.pone.0057815. [PMID: 23469072] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - Haibo Xu, Elizabeth B Oliveira-Sales, Fiona McBride, Beihui Liu, James Hewinson, Marie Toward, Emma B Hendy, Delyth Graham, Anna F Dominiczak, Monica Giannotta, Hidefumi Waki, Raimondo Ascione, Julian F R Paton, Sergey Kasparov. Upregulation of junctional adhesion molecule-A is a putative prognostic marker of hypertension.
Cardiovascular research.
2012 Dec; 96(3):552-60. doi:
10.1093/cvr/cvs273. [PMID: 22918977] - Chi-Ming Wong, Ioana R Preston, Nicholas S Hill, Yuichiro J Suzuki. Iron chelation inhibits the development of pulmonary vascular remodeling.
Free radical biology & medicine.
2012 Nov; 53(9):1738-47. doi:
10.1016/j.freeradbiomed.2012.08.576. [PMID: 22974762]