Lopinavir (BioDeep_00000002766)

human metabolite blood metabolite Chemicals and Drugs

代谢物信息卡片

N-(4-(((2,6-Dimethylphenoxy)acetyl)amino)-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl)tetrahydro-alpha-(1-methylethyl)-2-oxo-1(2H)-pydrimidineacetamide

化学式: C37H48N4O5 (628.3624517999999)
中文名称: 洛匹那韦
谱图信息: 最多检出来源 Homo sapiens(blood) 43%

分子结构信息

SMILES: CC(C)[C@H](N1CCCNC1=O)C(=O)N[C@H](C[C@H](O)[C@H](CC1=CC=CC=C1)NC(=O)COC1=C(C)C=CC=C1C)CC1=CC=CC=C1
InChI: InChI=1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31-,32-,34-/m0/s1

描述信息

Lopinavir is only found in individuals that have used or taken this drug. It is an antiretroviral of the protease inhibitor class. It is marketed by Abbott as Kaletra, a co-formulation with a sub-therapeutic dose of ritonavir, as a component of combination therapy to treat HIV/AIDS.Lopinavir inhibits the HIV viral protease enzyme. This prevents cleavage of the gag-pol polyprotein and, therefore, improper viral assembly results. This subsequently results in non-infectious, immature viral particles.
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors > D065692 - Cytochrome P-450 CYP3A Inhibitors
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D000084762 - Viral Protease Inhibitors
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D044966 - Anti-Retroviral Agents
COVID info from DrugBank, clinicaltrial, clinicaltrials, clinical trial, clinical trials
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor > C97366 - HIV Protease Inhibitor
C254 - Anti-Infective Agent > C281 - Antiviral Agent > C1660 - Anti-HIV Agent
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors
CONFIDENCE standard compound; INTERNAL_ID 2288
Same as: D01425
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

11 个代谢物同义名

N-(4-(((2,6-Dimethylphenoxy)acetyl)amino)-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl)tetrahydro-alpha-(1-methylethyl)-2-oxo-1(2H)-pydrimidineacetamide; (2S)-N-[(2S,4S,5S)-5-[2-(2,6-dimethylphenoxy)acetamido]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide; N-[5-[[2-(2,6-dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide; ABT-378a-157378-0a-157378.0; Lopinavir; 378, ABT; Kaletra; ABT 378; ABT-378; LPV; Lopinavir

数据库引用编号

23 个数据库交叉引用编号

ChEBI: CHEBI:31781
KEGG: C12871
PubChem: 92727
PubChem: 3817
HMDB: HMDB0015539
Metlin: METLIN69502
DrugBank: DB01601
ChEMBL: CHEMBL729
Wikipedia: Lopinavir
MeSH: Lopinavir
chemspider: 83706
CAS: 192725-17-0
MoNA: AU228804
MoNA: AU228806
MoNA: AU228802
MoNA: AU228805
MoNA: AU228801
MoNA: AU228803
PMhub: MS000004806
PubChem: 583260
PDB-CCD: AB1
NIKKAJI: J1.543.461I
KNApSAcK: 31781

分类词条

Valine and derivatives

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 - Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Abdurezak Ahmed Abdela, Helen Yifter, Ahmed Reja, Aster Shewaamare, Ighovwerha Ofotokun, Wondwossen Amogne Degu. Prevalence and risk factors of metabolic syndrome in Ethiopia: describing an emerging outbreak in HIV clinics of the sub-Saharan Africa - a cross-sectional study. BMJ open. 2023 12; 13(12):e069637. doi: 10.1136/bmjopen-2022-069637. [PMID: 38070936]
V Krishnaraju, Y Alghazwani, S Durgaramani, Y I Asiri, K Prabahar, K Kalpana, V Rajalakshimi, A K Noohu, P Premalatha, S A Sirajudeen, V Kumar, V Vinoth Prabhu. Beneficial effects of Naringin against lopinavir/ ritonavir-induced hyperlipidemia and reproductive toxicity in male albino rats. European review for medical and pharmacological sciences. 2023 May; 27(9):4221-4231. doi: 10.26355/eurrev_202305_32332. [PMID: 37203848]
Malinda Salim, Gisela Ramirez, Andrew J Clulow, Adrian Hawley, Ben J Boyd. Implications of the Digestion of Milk-Based Formulations for the Solubilization of Lopinavir/Ritonavir in a Combination Therapy. Molecular pharmaceutics. 2023 Apr; 20(4):2256-2265. doi: 10.1021/acs.molpharmaceut.3c00072. [PMID: 36919249]
He Xu, Ge Liu, Jixing Gong, Ying Zhang, Shanshan Gu, Zhongjun Wan, Pengcheng Yang, Yage Nie, Yinghan Wang, Zhan-Peng Huang, Guanzheng Luo, Zhongyan Chen, Donghui Zhang, Nan Cao. Investigating and Resolving Cardiotoxicity Induced by COVID-19 Treatments using Human Pluripotent Stem Cell-Derived Cardiomyocytes and Engineered Heart Tissues. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2022 10; 9(30):e2203388. doi: 10.1002/advs.202203388. [PMID: 36055796]
Piyush Kashyap, Mamta Thakur, Nidhi Singh, Deep Shikha, Shiv Kumar, Poonam Baniwal, Yogender Singh Yadav, Minaxi Sharma, Kandi Sridhar, Baskaran Stephen Inbaraj. In Silico Evaluation of Natural Flavonoids as a Potential Inhibitor of Coronavirus Disease. Molecules (Basel, Switzerland). 2022 Sep; 27(19):. doi: 10.3390/molecules27196374. [PMID: 36234910]
Akshay Narula, Rayan Sabra, Na Li. Mechanisms and Extent of Enhanced Passive Permeation by Colloidal Drug Particles. Molecular pharmaceutics. 2022 09; 19(9):3085-3099. doi: 10.1021/acs.molpharmaceut.2c00124. [PMID: 35998304]
Bin Su, Cheng Yao, Qing-Xia Zhao, Wei-Ping Cai, Min Wang, Hong-Zhou Lu, Ting-Ting Mu, Yuan-Yuan Chen, Li Liu, Hui Wang, Yun He, Yu-Huang Zheng, Ling-Hua Li, Jin-Feng Chen, Jian-Hua Yu, Biao Zhu, Min Zhao, Yong-Tao Sun, Wen-Hui Lun, Yi-Hang Zhang, Hu Wang, Wei Xia, Li-Jun Sun, Li-Li Dai, Tai-Yi Jiang, Mei-Xia Wang, Qing-Shan Zheng, Hai-Yan Peng, Yao Wang, Min Hu, Xia Liu, Rong-Jian Lu, Jian-Hua Hu, Cheng-Chen Sun, Hui Xing, Yi-Ming Shao, Dong Xie, Tong Zhang, Fu-Jie Zhang, Hao Wu. Long-acting HIV fusion inhibitor albuvirtide combined with ritonavir-boosted lopinavir for HIV-1-infected patients after failing the first-line antiretroviral therapy: 48-week randomized, controlled, phase 3 non-inferiority TALENT study. The Journal of infection. 2022 09; 85(3):334-363. doi: 10.1016/j.jinf.2022.05.034. [PMID: 35659547]
Mehdi Hassaniazad, Hossein Farshidi, Abdollah Gharibzadeh, Ali Bazram, Elham Khalili, Afsaneh Noormandi, Mohammad Fathalipour. Efficacy and safety of favipiravir plus interferon-beta versus lopinavir/ritonavir plus interferon-beta in moderately ill patients with COVID-19: A randomized clinical trial. Journal of medical virology. 2022 Jul; 94(7):3184-3191. doi: 10.1002/jmv.27724. [PMID: 35292989]
Md Sorwer Alam Parvez, Manash Kumar Saha, Md Ibrahim, Yusha Araf, Md Taufiqul Islam, Gen Ohtsuki, Mohammad Jakir Hosen. Insights from a computational analysis of the SARS-CoV-2 Omicron variant: Host-pathogen interaction, pathogenicity, and possible drug therapeutics. Immunity, inflammation and disease. 2022 07; 10(7):e639. doi: 10.1002/iid3.639. [PMID: 35759231]
Bożena Czech, Agnieszka Krzyszczak, Anna Boguszewska-Czubara, Grzegorz Opielak, Izabela Jośko, Mirabbos Hojamberdiev. Revealing the toxicity of lopinavir- and ritonavir-containing water and wastewater treated by photo-induced processes to Danio rerio and Allivibrio fischeri. The Science of the total environment. 2022 Jun; 824(?):153967. doi: 10.1016/j.scitotenv.2022.153967. [PMID: 35182634]
Rajesh Ghosh, Ayon Chakraborty, Ashis Biswas, Snehasis Chowdhuri. Depicting the inhibitory potential of polyphenols from Isatis indigotica root against the main protease of SARS CoV-2 using computational approaches. Journal of biomolecular structure & dynamics. 2022 06; 40(9):4110-4121. doi: 10.1080/07391102.2020.1858164. [PMID: 33292085]
Caroline S Foo, Rana Abdelnabi, Suzanne J F Kaptein, Xin Zhang, Sebastiaan Ter Horst, Raf Mols, Leen Delang, Joana Rocha-Pereira, Lotte Coelmont, Pieter Leyssen, Kai Dallmeier, Valentijn Vergote, Elisabeth Heylen, Laura Vangeel, Arnab K Chatterjee, Pieter P Annaert, Patrick F Augustijns, Steven De Jonghe, Dirk Jochmans, Mieke Gouwy, Seppe Cambier, Jennifer Vandooren, Paul Proost, Christine van Laer, Birgit Weynand, Johan Neyts. HIV protease inhibitors Nelfinavir and Lopinavir/Ritonavir markedly improve lung pathology in SARS-CoV-2-infected Syrian hamsters despite lack of an antiviral effect. Antiviral research. 2022 06; 202(?):105311. doi: 10.1016/j.antiviral.2022.105311. [PMID: 35390430]
. Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses. Lancet (London, England). 2022 05; 399(10339):1941-1953. doi: 10.1016/s0140-6736(22)00519-0. [PMID: 35512728]
Anne Caufriez, Andrés Tabernilla, Raf Van Campenhout, Axelle Cooreman, Kaat Leroy, Julen Sanz Serrano, Prashant Kadam, Bruna Dos Santos Rodrigues, Arthur Lamouroux, Steven Ballet, Mathieu Vinken. Effects of Drugs Formerly Suggested for COVID-19 Repurposing on Pannexin1 Channels. International journal of molecular sciences. 2022 May; 23(10):. doi: 10.3390/ijms23105664. [PMID: 35628472]
Osman Moneer, Garrison Daly, Joshua J Skydel, Kate Nyhan, Peter Lurie, Joseph S Ross, Joshua D Wallach. Agreement of treatment effects from observational studies and randomized controlled trials evaluating hydroxychloroquine, lopinavir-ritonavir, or dexamethasone for covid-19: meta-epidemiological study. BMJ (Clinical research ed.). 2022 05; 377(?):e069400. doi: 10.1136/bmj-2021-069400. [PMID: 35537738]
Mei Nee Chiu, Maitry Bhardwaj, Sangeeta Pilkhwal Sah. Safety profile of COVID-19 drugs in a real clinical setting. European journal of clinical pharmacology. 2022 May; 78(5):733-753. doi: 10.1007/s00228-021-03270-2. [PMID: 35088108]
Elettra Fallani, Fabio Cevenini, Pietro Enea Lazzerini, Annalisa Verdini, Simona Saponara. Off-Label Use of Hydroxychloroquine in COVID-19: Analysis of Reports of Suspected Adverse Reactions From the Italian National Network of Pharmacovigilance. Journal of clinical pharmacology. 2022 05; 62(5):646-655. doi: 10.1002/jcph.2006. [PMID: 34802170]
Adewale Oluwaseun Fadaka, Raphael Taiwo Aruleba, Nicole Remaliah Samantha Sibuyi, Ashwil Klein, Abram Madimabe Madiehe, Mervin Meyer. Inhibitory potential of repurposed drugs against the SARS-CoV-2 main protease: a computational-aided approach. Journal of biomolecular structure & dynamics. 2022 05; 40(8):3416-3427. doi: 10.1080/07391102.2020.1847197. [PMID: 33200673]
Carlos K H Wong, Marshall C H Low, Ashley C Y Kwok, Angel Y C Lui, Kristy T K Lau, Ivan C H Au, Xi Xiong, Matthew S H Chung, Mike Y W Kwan, Eric H Y Lau, Benjamin J Cowling. Slower Recovery with Early Lopinavir/Ritonavir use in Pediatric COVID-19 Patients: A Retrospective Observational Study. Paediatric drugs. 2022 May; 24(3):269-280. doi: 10.1007/s40272-022-00500-7. [PMID: 35428969]
Alasdair MacGowan, Fergus Hamilton, Mark Bayliss, Liam Read, Marie Attwood, Alan Noel, Maha Albur, Sally Grier, Anna Morley, David Arnold, Nicholas Maskell. Letter to the Editor: Pharmacokinetics of Lopinavir/Ritonavir in Hospitalized Patients with COVID-19 Not Requiring Critical Care. Microbial drug resistance (Larchmont, N.Y.). 2022 05; 28(5):611-612. doi: 10.1089/mdr.2021.0259. [PMID: 35099290]
Md Oliullah Rafi, Gourab Bhattacharje, Khattab Al-Khafaji, Tugba Taskin-Tok, Md Almujaddade Alfasane, Amit Kumar Das, Md Anowar Khasru Parvez, Md Shahedur Rahman. Combination of QSAR, molecular docking, molecular dynamic simulation and MM-PBSA: analogues of lopinavir and favipiravir as potential drug candidates against COVID-19. Journal of biomolecular structure & dynamics. 2022 05; 40(8):3711-3730. doi: 10.1080/07391102.2020.1850355. [PMID: 33251975]
P-H Secretan, O Thirion, V Vieillard, J Saunier, K Razazi, M Paul, B Do. Hospital compounding to face shortage: A case study of the development of a lopinavir-ritonavir oral suspension during the first wave of SARS-COV-2 in France. Annales pharmaceutiques francaises. 2022 May; 80(3):273-279. doi: 10.1016/j.pharma.2021.09.002. [PMID: 34563517]
Axelle Cooreman, Anne Caufriez, Andrés Tabernilla, Raf Van Campenhout, Kaat Leroy, Prashant Kadam, Julen Sanz Serrano, Bruna Dos Santos Rodrigues, Pieter Annaert, Mathieu Vinken. Effects of Drugs Formerly Proposed for COVID-19 Treatment on Connexin43 Hemichannels. International journal of molecular sciences. 2022 Apr; 23(9):. doi: 10.3390/ijms23095018. [PMID: 35563409]
Laura Waters, Fiona Marra, Anton Pozniak, James Cockburn, Marta Boffito. Ritonavir and COVID-19: pragmatic guidance is important. Lancet (London, England). 2022 04; 399(10334):1464-1465. doi: 10.1016/s0140-6736(22)00280-x. [PMID: 35334211]
Á Estella, J L Garcia Garmendia, C de la Fuente, J F Machado Casas, M E Yuste, R Amaya Villar, M A Estecha, L Yaguez Mateos, M L Cantón Bulnes, A Loza, J Mora, L Fernández Ruiz, B Díez Del Corral Fernández, M Rojas Amezcua, M I Rodriguez Higueras, I Díaz Torres, M Recuerda Núñez, M Zaheri Beryanaki, F Rivera Espinar, D F Matallana Zapata, S G Moreno Cano, B Gimenez Beltrán, N Muñoz, A Sainz de Baranda Piñero, P Bustelo Bueno, E Moreno Barriga, J J Rios Toro, M Pérez Ruiz, C Gómez González, A Breval Flores, A de San José Bermejo Gómez, M A Ruiz Cabello Jimenez, M Guerrero Marín, A Ortega Ordiales, J Tejero-Aranguren, C Rodriguez Mejías, J Gomez de Oña, C de la Hoz, D Ocaña Fernández, S Ibañez Cuadros, J Garnacho Montero. Predictive factors of six-week mortality in critically ill patients with SARS-CoV-2: A multicenter prospective study. Medicina intensiva. 2022 04; 46(4):179-191. doi: 10.1016/j.medine.2021.02.008. [PMID: 35461665]
Rahman Abdizadeh, Farzin Hadizadeh, Tooba Abdizadeh. In silico analysis and identification of antiviral coumarin derivatives against 3-chymotrypsin-like main protease of the novel coronavirus SARS-CoV-2. Molecular diversity. 2022 Apr; 26(2):1053-1076. doi: 10.1007/s11030-021-10230-6. [PMID: 34213728]
Miao Yu, Deng-Chao Wang, Sheng Li, Yue-Hua Lei, Jian Wei, Li-Yan Huang. Meta-analysis of arbidol versus lopinavir/ritonavir in the treatment of coronavirus disease 2019. Journal of medical virology. 2022 04; 94(4):1513-1522. doi: 10.1002/jmv.27481. [PMID: 34837230]
Ariel Izcovich, Reed Alexander Siemieniuk, Jessica Julia Bartoszko, Long Ge, Dena Zeraatkar, Elena Kum, Anila Qasim, Assem M Khamis, Bram Rochwerg, Thomas Agoritsas, Derek K Chu, Shelley L McLeod, Reem A Mustafa, Per Vandvik, Romina Brignardello-Petersen. Adverse effects of remdesivir, hydroxychloroquine and lopinavir/ritonavir when used for COVID-19: systematic review and meta-analysis of randomised trials. BMJ open. 2022 03; 12(3):e048502. doi: 10.1136/bmjopen-2020-048502. [PMID: 35236729]
Felix Stader, Manuel Battegay, Parham Sendi, Catia Marzolini. Physiologically Based Pharmacokinetic Modelling to Investigate the Impact of the Cytokine Storm on CYP3A Drug Pharmacokinetics in COVID-19 Patients. Clinical pharmacology and therapeutics. 2022 03; 111(3):579-584. doi: 10.1002/cpt.2402. [PMID: 34496043]
Simone Perazzolo, Danny D Shen, Rodney J Y Ho. Physiologically Based Pharmacokinetic Modeling of 3 HIV Drugs in Combination and the Role of Lymphatic System after Subcutaneous Dosing. Part 2: Model for the Drug-combination Nanoparticles. Journal of pharmaceutical sciences. 2022 03; 111(3):825-837. doi: 10.1016/j.xphs.2021.10.009. [PMID: 34673094]
Pinky Kotecha, Alexander Light, Enrico Checcucci, Daniele Amparore, Cristian Fiori, Francesco Porpiglia, Prokar Dasgupta, Oussama Elhage. Repurposing of drugs for COVID-19: a systematic review and meta-analysis. Panminerva medica. 2022 Mar; 64(1):96-114. doi: 10.23736/s0031-0808.20.04024-0. [PMID: 33073552]
A Oyefabi, S Musa, H Kambai, I Usman, J Gwamna, J Sheyin, O Ige, M Abdullahi, J Sunday, H N Kera, A Atiku, H Dauda, G C Umeh, T Olasinde, A Abdullahi. Comparison of the Ivermectin and Lopinavir/Ritonavir Treatment Outcomes among COVID-19 Mild to Moderate Cases in Kaduna State. West African journal of medicine. 2022 Feb; 39(2):140-146. doi: NULL. [PMID: 35278050]
Giusy Tiseo, Dafna Yahav, Mical Paul, Marco Tinelli, Gaetan Gavazzi, Cristina Mussini, Virginie Prendki, Marco Falcone. What have we learned from the first to the second wave of COVID-19 pandemic? An international survey from the ESCMID Study Group for Infection in the Elderly (ESGIE) group. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2022 Feb; 41(2):281-288. doi: 10.1007/s10096-021-04377-1. [PMID: 34775534]
Manisha Choudhury, Anantha K Dhanabalan, Nabajyoti Goswami. Understanding the binding mechanism for potential inhibition of SARS-CoV-2 Mpro and exploring the modes of ACE2 inhibition by hydroxychloroquine. Journal of cellular biochemistry. 2022 02; 123(2):347-358. doi: 10.1002/jcb.30174. [PMID: 34741481]
Caroline E Dunk, Lena Serghides. Protease inhibitor-based antiretroviral therapy in pregnancy: effects on hormones, placenta, and decidua. The lancet. HIV. 2022 02; 9(2):e120-e129. doi: 10.1016/s2352-3018(21)00249-6. [PMID: 34863352]
Eman Zeyad I Elmekaty, Rim Alibrahim, Rania Hassanin, Sitelbanat Eltaib, Ahmed Elsayed, Fatima Rustom, Mohamed Izham Mohamed Ibrahim, Mohammed Abu Khattab, Hussam Al Soub, Muna Al Maslamani, Abdullatif Al-Khal. Darunavir-cobicistat versus lopinavir-ritonavir in the treatment of COVID-19 infection (DOLCI): A multicenter observational study. PloS one. 2022; 17(5):e0267884. doi: 10.1371/journal.pone.0267884. [PMID: 35507606]
Elif Sargin Altunok, Celal Satici, Veysel Dinc, Sadettin Kamat, Mustafa Alkan, Mustafa Asim Demirkol, Ilkim Deniz Toprak, Muhammed Emin Kostek, Semih Yazla, Sinem Nihal Esatoglu. Comparison of demographic and clinical characteristics of hospitalized COVID-19 patients with severe/critical illness in the first wave versus the second wave. Journal of medical virology. 2022 01; 94(1):291-297. doi: 10.1002/jmv.27319. [PMID: 34491575]
Rayssa Barbary Pedroza Moura, Lígia Marquez Andrade, Lais Alonso, Antonio Alonso, Ricardo Neves Marreto, Stephânia Fleury Taveira. Combination of lipid nanoparticles and iontophoresis for enhanced lopinavir skin permeation: Impact of electric current on lipid dynamics. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2022 Jan; 168(?):106048. doi: 10.1016/j.ejps.2021.106048. [PMID: 34699938]
Subhradip Kundu, Debayan Sarkar. Synthetic Attempts Towards Eminent Anti-viral Candidates of SARS-CoV. Mini reviews in medicinal chemistry. 2022; 22(2):232-247. doi: 10.2174/1389557521666210712205655. [PMID: 34254915]
Hossein Mazaherpour, Masoomeh Sofian, Elham Farahani, Alireza Abdi, Sakine Mazaherpour, Anahita Bavand, Amitis Ramezani. Comparing Outcomes of Two Antiviral Therapy Combinations among COVID-19 Patients. BioMed research international. 2022; 2022(?):1522426. doi: 10.1155/2022/1522426. [PMID: 35013710]
Wooyoung Hong, Yu-Kyung Park, Bong-Ok Kim, Sung Kyu Park, Jiin Shin, Soon-Pyo Jang, Hea-Woon Park, Wonjong Yang, Joonyoung Jang, Soon-Woo Jang, Tae-Ho Hwang. Use of combined treatment of 3rd-generation cephalosporin, azithromycin and antiviral agents on moderate SARs-CoV-2 patients in South Korea: A retrospective cohort study. PloS one. 2022; 17(5):e0267645. doi: 10.1371/journal.pone.0267645. [PMID: 35507600]
Wissam H Faour, Ali Choaib, Elio Issa, Francesca El Choueiry, Khodor Shbaklo, Maryline Alhajj, Ramy Touma Sawaya, Zeina Harhous, Eman Alefishat, Moni Nader. Mechanisms of COVID-19-induced kidney injury and current pharmacotherapies. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2022 Jan; 71(1):39-56. doi: 10.1007/s00011-021-01520-8. [PMID: 34802072]
Hesham Salem, Ebtihal Samir, Amany Abdelaziz, Mahmoud Alaa El-Din, Mahmoud Abdelgaleel, Dina Zein, Hoda Madian. Combining subsidiary and synchronous approaches for concurrent spectrofluorimetric assurance of lopinavir and ritonavir in tablets utilized in convention for treatment of coronavirus infection (COVID-19) and biological fluids. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2021 Dec; 262(?):120066. doi: 10.1016/j.saa.2021.120066. [PMID: 34175754]
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Ilad Alavi Darazam, Shervin Shokouhi, Masoud Mardani, Mohamad Amin Pourhoseingholi, Mohammad Mahdi Rabiei, Firouze Hatami, Minoosh Shabani, Omid Moradi, Farid Javandoust Gharehbagh, Seyed Sina Naghibi Irvani, Mahdi Amirdosara, Mohammadreza Hajiesmaeili, Omidvar Rezaei, Ali Khoshkar, Legha Lotfollahi, Latif Gachkar, Hadiseh Shabanpour Dehbsneh, Negar Khalili, Azam Soleymaninia, Akram Hoseyni Kusha, Maryam Taleb Shoushtari, Parham Torabinavid. Umifenovir in hospitalized moderate to severe COVID-19 patients: A randomized clinical trial. International immunopharmacology. 2021 Oct; 99(?):107969. doi: 10.1016/j.intimp.2021.107969. [PMID: 34273635]
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Thanawat Vongchaiudomchoke, Vittawin Sawangduan, Tosapon Sinpanee, Nipon Chalermphunchai, Kumtorn Lelamali, Kajohnsak Noppakun. Modification of immunosuppressive agents in a kidney transplant recipient with COVID-19 and acute kidney injury. Journal of infection in developing countries. 2021 09; 15(9):1273-1276. doi: 10.3855/jidc.13176. [PMID: 34669595]
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Bilal Ahmad, Maria Batool, Qurat Ul Ain, Moon Suk Kim, Sangdun Choi. Exploring the Binding Mechanism of PF-07321332 SARS-CoV-2 Protease Inhibitor through Molecular Dynamics and Binding Free Energy Simulations. International journal of molecular sciences. 2021 Aug; 22(17):. doi: 10.3390/ijms22179124. [PMID: 34502033]
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Tanakorn Apornpong, Beatriz Grinsztejn, Michael Hughes, Justin Ritz, Stephen J Kerr, Courtney V Fletcher, Kiat Ruxrungtham, Catherine Godfrey, Robert Gross, Evelyn Hogg, Carole L Wallis, Sharlaa Badal-Faesen, Mina C Hosseinipour, Rosie Mngqbisa, Breno R Santos, Sarita Shah, Laura J Hovind, Sajeeda Mawlana, Marije Van Schalkwyk, Nuntisa Chotirosniramit, Cecilia Kanyama, Nagalingeswaran Kumarasamy, Robert Salata, Ann C Collier, Monica Gandhi. Antiretroviral hair levels, self-reported adherence, and virologic failure in second-line regimen patients in resource-limited settings. AIDS (London, England). 2021 07; 35(9):1439-1449. doi: 10.1097/qad.0000000000002901. [PMID: 33831905]
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Yunzhen Hu, Minjuan Zuo, Xiaojuan Wang, Rongrong Wang, Lu Li, Xiaoyang Lu, Saiping Jiang. Pharmacokinetic interactions between the potential COVID-19 treatment drugs lopinavir/ritonavir and arbidol in rats. Journal of Zhejiang University. Science. B. 2021 Jul; 22(7):599-602. doi: 10.1631/jzus.b2000728. [PMID: 34269012]
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Seyed Majid Mousavi Movahed, Hamed Akhavizadegan, Fatemeh Dolatkhani, Seyed Aria Nejadghaderi, Faezeh Aghajani, Monireh Faghir Gangi, Zahra Ghazi, Hoomaan Ghasemi. Different incidences of acute kidney injury (AKI) and outcomes in COVID-19 patients with and without non-azithromycin antibiotics: A retrospective study. Journal of medical virology. 2021 Jul; 93(7):4411-4419. doi: 10.1002/jmv.26992. [PMID: 33792956]
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Raissa Virgy Rianda, Mohammad Subkhan, Aditya Doni Pradana, Fahrun Nisa'i Fatimah, Rama Azalix Rianda, Muhammad Perdana Airlangga, Muhammad Miftahussurur. The Challenging Anticoagulant Therapy in COVID19 Patient with Associated Coagulopathy. Acta medica Indonesiana. 2021 Jul; 53(3):308-314. doi: NULL. [PMID: 34611070]
M D Cantudo-Cuenca, Antonio Gutiérrez-Pizarraya, Ana Pinilla-Fernández, Enrique Contreras-Macías, M Fernández-Fuertes, F A Lao-Domínguez, Pilar Rincón, Juan Antonio Pineda, Juan Macías, Ramón Morillo-Verdugo. Drug-drug interactions between treatment specific pharmacotherapy and concomitant medication in patients with COVID-19 in the first wave in Spain. Scientific reports. 2021 06; 11(1):12414. doi: 10.1038/s41598-021-91953-2. [PMID: 34127740]
Carlos Minguito-Carazo, Julio Echarte-Morales, Tomás Benito-González, Samuel Del Castillo-García, Miguel Rodríguez-Santamarta, Enrique Sánchez-Muñoz, Clea González Maniega, Rubén García-Bergel, Paula Menéndez-Suárez, Silvia Prieto-González, Carmen Palacios-Echavarren, Javier Borrego-Rodríguez, Guisela Flores-Vergara, Ignacio Iglesias-Garriz, Felipe Fernández-Vázquez. QT Interval Monitoring with Handheld Heart Rhythm ECG Device in COVID-19 Patients. Global heart. 2021 06; 16(1):42. doi: 10.5334/gh.916. [PMID: 34211828]
Betsy Ann Joseph, Mahmoud Dibas, Kirk W Evanson, Geeta Paranjape, Charan Thej Reddy Vegivinti, Pragadeesh Thamarai Selvan, Kavitha Saravu, Nitin Gupta, Yashwitha Sai Pulakurthi, Praneeth Reddy Keesari, Sriram Varsha, Spandana Chittajallu, Adam A Dmytriw, Natalie L Reierson, Nick Mikoff, Shelby Kamrowski, Megan Schmidt, Amber R Davis, John M Pederson, Hemant K Mishra, Jillienne C Touchette, Kevin Kallmes. Efficacy and safety of lopinavir/ritonavir in the treatment of COVID-19: A systematic review. Expert review of anti-infective therapy. 2021 06; 19(6):679-687. doi: 10.1080/14787210.2021.1848545. [PMID: 33187459]
Jian Wang, Li Zhu, Leyang Xue, Longgen Liu, Xuebing Yan, Xiaomin Yan, Songping Huang, Biao Zhang, Tianmin Xu, Chunyang Li, Fang Ji, Fang Ming, Yun Zhao, Juan Cheng, Huaping Shao, Kang Chen, Xiang-An Zhao, Dawen Sang, Haiyan Zhao, Xinying Guan, Xiaobing Chen, Yuxin Chen, Jiacheng Liu, Rui Huang, Chuanwu Zhu, Chao Wu. Risk factors of liver injury in patients with coronavirus disease 2019 in Jiangsu, China: A retrospective, multi-center study. Journal of medical virology. 2021 06; 93(6):3305-3311. doi: 10.1002/jmv.26663. [PMID: 33174624]
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Jaime Lora-Tamayo, Guillermo Maestro, Antonio Lalueza, Manuel Rubio-Rivas, Gracia Villarreal Paul, Francisco Arnalich Fernández, José Luis Beato Pérez, Juan Antonio Vargas Núñez, Mónica Llorente Barrio, Carlos Lumbreras Bermejo. Early Lopinavir/ritonavir does not reduce mortality in COVID-19 patients: Results of a large multicenter study. The Journal of infection. 2021 06; 82(6):276-316. doi: 10.1016/j.jinf.2021.02.011. [PMID: 33582204]
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Masoud Solaymani-Dodaran, Mostafa Ghanei, Mehdi Bagheri, Ali Qazvini, Ensieh Vahedi, Seyed Hassan Saadat, Seyed Amin Setarehdan, Akram Ansarifar, Hossein Biganeh, Arash Mohazzab, Davood Khalili, Amir Hosein Ghazale, Mohammad Reza Heidari, Ali Taheri, Maliheh Khoramdad, Mohammad Mahdi Asadi, Masoud Nazemieh, Mojtaba Varshochi, Samaneh Abbasian, Ali Bakhtiari, Reza Mosaed, Seyyed-Javad Hosseini-Shokouh, Masoume Shahrokhi, Zeynab Yassin, Mohammad Ali Zohal, Maryam Qaraati, Nafiseh Rastgoo, Ramin Sami, Mohammad Javad Eslami, Akram Asghari, Mansoor Namazi, Shadi Ziaie, Raana Jafari-Moghaddam, Saeid Kalantari, Mohammad Memarian, Javad Khodadadi, Mohammad Hossein Afshari, Mansooreh Momen-Heravi, Niusha Behzadseresht, Ahmad Reza Mobayen, Abolfazl Mozafari, Fatemeh Movasaghi, Maryam Haddadzadeh Shoushtari, Javad Moazen. Safety and efficacy of Favipiravir in moderate to severe SARS-CoV-2 pneumonia. International immunopharmacology. 2021 Jun; 95(?):107522. doi: 10.1016/j.intimp.2021.107522. [PMID: 33735712]
Yasemin Cag, Haluk Vahaboglu. A novel approach to managing COVID-19 patients: results of lopinavir plus doxycycline cohort-authors' reply. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2021 06; 40(6):1351-1352. doi: 10.1007/s10096-020-04099-w. [PMID: 33439342]
Falasca Katia, Di Penta Myriam, Claudio Ucciferri, Antonio Auricchio, Marta Di Nicola, Michele Marchioni, Celletti Eleonora, Sabatini Emanuela, Francesco Cipollone, Jacopo Vecchiet. Efficacy of canakinumab in mild or severe COVID-19 pneumonia. Immunity, inflammation and disease. 2021 06; 9(2):399-405. doi: 10.1002/iid3.400. [PMID: 33465283]
Carlos Diaz-Arocutipa, Ana Brañez-Condorena, Adrian V Hernandez. QTc prolongation in COVID-19 patients treated with hydroxychloroquine, chloroquine, azithromycin, or lopinavir/ritonavir: A systematic review and meta-analysis. Pharmacoepidemiology and drug safety. 2021 06; 30(6):694-706. doi: 10.1002/pds.5234. [PMID: 33772933]
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