Flurbiprofen (BioDeep_00000002723)

 

Secondary id: BioDeep_00000398947

human metabolite blood metabolite


代谢物信息卡片


(±)-2-fluoro-α-methyl-[1,1-biphenyl]-4-acetic acid

化学式: C15H13FO2 (244.089953)
中文名称: 氟比洛芬, 2-氟-α-甲基-4-联苯甲酸
谱图信息: 最多检出来源 Homo sapiens(blood) 16.48%

分子结构信息

SMILES: CC(C(=O)O)c1ccc(-c2ccccc2)c(F)c1
InChI: InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)

描述信息

Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically prior to ocular surgery to prevent or reduce intraoperative miosis. Flurbiprofen is structurally and pharmacologically related to fenoprofen, ibuprofen, and ketoprofen.
M - Musculo-skeletal system > M02 - Topical products for joint and muscular pain > M02A - Topical products for joint and muscular pain > M02AA - Antiinflammatory preparations, non-steroids for topical use
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AE - Propionic acid derivatives
S - Sensory organs > S01 - Ophthalmologicals > S01B - Antiinflammatory agents > S01BC - Antiinflammatory agents, non-steroids
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
R - Respiratory system > R02 - Throat preparations > R02A - Throat preparations
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C471 - Enzyme Inhibitor > C29577 - Carbonic Anhydrase Inhibitor
D002491 - Central Nervous System Agents > D000700 - Analgesics
C471 - Enzyme Inhibitor > C1323 - Cyclooxygenase Inhibitor
D000893 - Anti-Inflammatory Agents
D004791 - Enzyme Inhibitors

同义名列表

62 个代谢物同义名

(±)-2-fluoro-α-methyl-[1,1-biphenyl]-4-acetic acid; 2-Fluoro-alpha-methyl-(1,1-biphenyl)-4-acetic acid; (+-)-2-Fluoro-alpha-methyl-4-biphenylacetic acid; 2-{2-fluoro-[1,1-biphenyl]-4-yl}propanoic acid; 2-Fluoro-α-methyl-(1,1-biphenyl)-4-acetic acid; 2-Fluoro-a-methyl-(1,1-biphenyl)-4-acetic acid; 2-Fluoro-alpha-methyl-(1,1-biphenyl)-4-acetate; (+-)-2-Fluoro-alpha-methyl-4-biphenylacetate; (+-)-2-Fluoro-α-methyl-4-biphenylacetic acid; (+-)-2-Fluoro-a-methyl-4-biphenylacetic acid; Pharm allergan brand OF flurbiprofen sodium; Pharm-allergan brand OF flurbiprofen sodium; 2-Fluoro-a-methyl-(1,1-biphenyl)-4-acetate; 2-Fluoro-α-methyl-(1,1-biphenyl)-4-acetate; (+-)-2-Fluoro-α-methyl-4-biphenylacetate; (+-)-2-Fluoro-a-methyl-4-biphenylacetate; 2-Fluoro-α-methyl-4-biphenylacetic Acid; 2-(2-Fluorobiphenyl-4-yl)propanoic acid; Allergan brand OF flurbiprofen sodium; 2-(2-Fluorobiphenyl-4-yl)propanoate; Klosterfrau brand OF flurbiprofen; 3-Fluoro-4-phenylhydratropic acid; Ratiopharm brand OF flurbiprofen; Novopharm brand OF flurbiprofen; Recordati brand OF flurbiprofen; Cantabria brand OF flurbiprofen; Nu-pharm brand OF flurbiprofen; Nu pharm brand OF flurbiprofen; Crookes brand OF flurbiprofen; 3-Fluoro-4-phenylhydratropate; Apotex brand OF flurbiprofen; Pfizer brand OF flurbiprofen; Abbott brand OF flurbiprofen; Shire brand OF flurbiprofen; Knoll brand OF flurbiprofen; Flurbiprofen pfizer brand; (±)-Flurbiprofen; Sodium, flurbiprofen; Flurbiprofen sodium; ratio Flurbiprofen; ratio-Flurbiprofen; apo Flurbiprofen; apo-Flurbiprofen; Nu flurbiprofen; novo Flurprofen; novo-Flurprofen; Nu-flurbiprofen; flurbiprofen; Fluriproben; Flubiprofen; neo Artrol; Froben SR; Dobrofen; Flugalin; Strefen; Ocuflur; Cebutid; Froben; Ansaid; Ocufen; FLP; Flurbiprofen



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Bushra Arooj, Sajid Asghar, Mohammad Saleem, Syed Haroon Khalid, Muhammad Asif, Tahir Chohan, Ikram Ullah Khan, Hafiz Muhammad Zubair, Hafiza Sidra Yaseen. Anti-inflammatory mechanisms of eucalyptol rich Eucalyptus globulus essential oil alone and in combination with flurbiprofen. Inflammopharmacology. 2023 May; ?(?):. doi: 10.1007/s10787-023-01237-6. [PMID: 37179510]
  • Ivana Predarska, Mohamad Saoud, Ibrahim Morgan, Peter Lönnecke, Goran N Kaluđerović, Evamarie Hey-Hawkins. Triphenyltin(IV) Carboxylates with Exceptionally High Cytotoxicity against Different Breast Cancer Cell Lines. Biomolecules. 2023 Mar; 13(4):. doi: 10.3390/biom13040595. [PMID: 37189343]
  • Arvind Bagde, Emmanual Kouagou, Mandip Singh. Formulation of Topical Flurbiprofen Solid Lipid Nanoparticle Gel Formulation Using Hot Melt Extrusion Technique. AAPS PharmSciTech. 2022 Sep; 23(7):257. doi: 10.1208/s12249-022-02410-w. [PMID: 36114430]
  • Urs Duthaler, Fabio Bachmann, Claudia Suenderhauf, Tanja Grandinetti, Florian Pfefferkorn, Manuel Haschke, Petr Hruz, Jamal Bouitbir, Stephan Krähenbühl. Liver Cirrhosis Affects the Pharmacokinetics of the Six Substrates of the Basel Phenotyping Cocktail Differently. Clinical pharmacokinetics. 2022 07; 61(7):1039-1055. doi: 10.1007/s40262-022-01119-0. [PMID: 35570253]
  • Bianca-Maria Ţuchiu, Raluca-Ioana Stefan-van Staden, Marius Bădulescu, Jacobus Frederick van Staden. Disposable stochastic sensors for fast analysis of ibuprofen, ketoprofen, and flurbiprofen in their topical pharmaceutical formulations. Journal of pharmaceutical and biomedical analysis. 2022 Jun; 215(?):114758. doi: 10.1016/j.jpba.2022.114758. [PMID: 35421777]
  • Natasja de Bruin, Ann-Kathrin Schneider, Philipp Reus, Sonja Talmon, Sandra Ciesek, Denisa Bojkova, Jindrich Cinatl, Imran Lodhi, Bruce Charlesworth, Simon Sinclair, Graham Pennick, William F Laughey, Philip Gribbon, Aimo Kannt, Susanne Schiffmann. Ibuprofen, Flurbiprofen, Etoricoxib or Paracetamol Do Not Influence ACE2 Expression and Activity In Vitro or in Mice and Do Not Exacerbate In-Vitro SARS-CoV-2 Infection. International journal of molecular sciences. 2022 Jan; 23(3):. doi: 10.3390/ijms23031049. [PMID: 35162972]
  • Ivana Predarska, Mohamad Saoud, Ibrahim Morgan, Thomas Eichhorn, Goran N Kaluđerović, Evamarie Hey-Hawkins. Cisplatin-cyclooxygenase inhibitor conjugates, free and immobilised in mesoporous silica SBA-15, prove highly potent against triple-negative MDA-MB-468 breast cancer cell line. Dalton transactions (Cambridge, England : 2003). 2022 Jan; 51(3):857-869. doi: 10.1039/d1dt03265h. [PMID: 34877948]
  • Haruki Hirakawa, Kei Taguchi, Seiya Murakawa, Masaya Asano, Soma Noguchi, Satoshi Kikkawa, Kana Harada, Naoko Adachi, Takehiko Ueyama, Izumi Hide, Shigeru Tanaka, Norio Sakai. Effects of flurbiprofen on the functional regulation of serotonin transporter and its misfolded mutant. Journal of pharmacological sciences. 2022 Jan; 148(1):187-195. doi: 10.1016/j.jphs.2021.11.006. [PMID: 34924125]
  • Fabio Bachmann, Urs Duthaler, Stephan Krähenbühl. Effect of deglucuronidation on the results of the Basel phenotyping cocktail. British journal of clinical pharmacology. 2021 12; 87(12):4608-4618. doi: 10.1111/bcp.14874. [PMID: 33890704]
  • Masaki Amemiya, Yusuke Nakagawa, Hideya Yoshimura, Toru Takahashi, Kei Inomata, Tsuyoshi Nagase, Young-Jin Ju, Masayuki Shimaya, Sachiyuki Tsukada, Naoyuki Hirasawa, Hideyuki Koga. Comparison of tissue pharmacokinetics of esflurbiprofen plaster with flurbiprofen tablets in patients with knee osteoarthritis: A multicenter randomized controlled trial. Biopharmaceutics & drug disposition. 2021 Nov; 42(9):418-426. doi: 10.1002/bdd.2302. [PMID: 34529839]
  • Laura Tiozzo Fasiolo, Michele Dario Manniello, Sabrina Banella, Laura Napoli, Fabrizio Bortolotti, Eride Quarta, Paolo Colombo, Evangelos Balafas, Nikolaos Kostomitsopoulos, Dimitrios M Rekkas, Georgia Valsami, Paraskevi Papakyriakopoulou, Gaia Colombo, Paola Russo. Flurbiprofen sodium microparticles and soft pellets for nose-to-brain delivery: Serum and brain levels in rats after nasal insufflation. International journal of pharmaceutics. 2021 Aug; 605(?):120827. doi: 10.1016/j.ijpharm.2021.120827. [PMID: 34171428]
  • Xiaoshu Dai, Michael D Karol, Matthew Hitron, Marjie L Hard, Matthew T Goulet, Colleen F McLaughlin, Scott J Brantley. Napabucasin Drug-Drug Interaction Potential, Safety, Tolerability, and Pharmacokinetics Following Oral Dosing in Healthy Adult Volunteers. Clinical pharmacology in drug development. 2021 08; 10(8):824-839. doi: 10.1002/cpdd.961. [PMID: 34107166]
  • Ayse Nur Oktay, Sibel Ilbasmis-Tamer, Orhan Uludag, Nevin Celebi. Enhanced Dermal Delivery of Flurbiprofen Nanosuspension Based Gel: Development and Ex Vivo Permeation, Pharmacokinetic Evaluations. Pharmaceutical research. 2021 Jun; 38(6):991-1009. doi: 10.1007/s11095-021-03060-6. [PMID: 34086139]
  • Mehmet Emrah Yaman, Alptug Atila, Tugrul Cagri Akman, Mevlut Albayrak, Yucel Kadioglu, Zekai Halici. A Sensitive UPLC-MS/MS Method for the Determination of Flurbiprofen in Rat Plasma: Application to Real Sample. Journal of chromatographic science. 2021 May; 59(6):502-509. doi: 10.1093/chromsci/bmab047. [PMID: 33884406]
  • Jin Wang, Liuhan Dong, Rui Wang, Yun Cai. Evaluation of bioequivalence of two flurbiprofen axetil injections: A randomized, open-label, double-cycle, and crossover study. Clinical and experimental pharmacology & physiology. 2021 05; 48(5):660-667. doi: 10.1111/1440-1681.13479. [PMID: 33609057]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Zhengzuo Wan, Chunhua Chu, Rong Zhou, Bin Que. Effects of Oxycodone Combined With Flurbiprofen Axetil on Postoperative Analgesia and Immune Function in Patients Undergoing Radical Resection of Colorectal Cancer. Clinical pharmacology in drug development. 2021 03; 10(3):251-259. doi: 10.1002/cpdd.818. [PMID: 32567233]
  • Sandhyarani Guggilla, Middela Karthik, Boini Shylendra. Sensitive and Stereospecific High-Performance Liquid Chromatographic Method for Flurbiprofen in Human Plasma. Advances in experimental medicine and biology. 2021; 1339(?):59-63. doi: 10.1007/978-3-030-78787-5_9. [PMID: 35023091]
  • Hana Nevídalová, Lenka Michalcová, Zdeněk Glatz. Applicability of capillary electrophoresis-frontal analysis for displacement studies: Effect of several drugs on l-tryptophan and lidocaine binding to human serum albumin. Journal of separation science. 2020 Nov; 43(22):4225-4233. doi: 10.1002/jssc.202000594. [PMID: 32966669]
  • Keisuke Okamoto, Yoshitaka Saito, Katsuya Narumi, Ayako Furugen, Ken Iseki, Masaki Kobayashi. Comparison of the nephroprotective effects of non-steroidal anti-inflammatory drugs on cisplatin-induced nephrotoxicity in vitro and in vivo. European journal of pharmacology. 2020 Oct; 884(?):173339. doi: 10.1016/j.ejphar.2020.173339. [PMID: 32726655]
  • Zara Khizer, Jorabar Singh Nirwan, Barbara R Conway, Muhammad Usman Ghori. Okra (Hibiscus esculentus) gum based hydrophilic matrices for controlled drug delivery applications: Estimation of percolation threshold. International journal of biological macromolecules. 2020 Jul; 155(?):835-845. doi: 10.1016/j.ijbiomac.2020.03.227. [PMID: 32240737]
  • Ziyi Yang, Qing Song, Zhongcheng Cao, Guangjun Yu, Zhuoling Liu, Zhenghuai Tan, Yong Deng. Design, synthesis and evaluation of flurbiprofen-clioquinol hybrids as multitarget-directed ligands against Alzheimer's disease. Bioorganic & medicinal chemistry. 2020 04; 28(7):115374. doi: 10.1016/j.bmc.2020.115374. [PMID: 32089390]
  • S Blazaki, K Pachis, M Tzatzarakis, M Tsilimbaris, S G Antimisiaris. Novel Liposome Aggregate Platform (LAP) system for sustained retention of drugs in the posterior ocular segment following intravitreal injection. International journal of pharmaceutics. 2020 Feb; 576(?):118987. doi: 10.1016/j.ijpharm.2019.118987. [PMID: 31870961]
  • Dong Wang, Shi-Kun Yang, Meng-Xi Zhao, Yong-Zhong Tang, Wen Ou-Yang, Hao Zhang, Qin Liao. Low dose of flurbiprofen axetil decrease the rate of acute kidney injury after operation: a retrospective clinical data analysis of 9915 cases. BMC nephrology. 2020 02; 21(1):52. doi: 10.1186/s12882-020-1711-5. [PMID: 32059699]
  • Wenqian Wu, Feng Lin, Xiaohan Yang, Bin Wang, Xin Lu, Qiuxia Chen, Fanggui Ye, Shulin Zhao. Facile synthesis of magnetic carbon nanotubes derived from ZIF-67 and application to magnetic solid-phase extraction of profens from human serum. Talanta. 2020 Jan; 207(?):120284. doi: 10.1016/j.talanta.2019.120284. [PMID: 31594616]
  • Chaoquan Tian, Xiaoming Qiang, Qing Song, Zhongcheng Cao, Chanyuan Ye, Yuxi He, Yong Deng, Li Zhang. Flurbiprofen-chalcone hybrid Mannich base derivatives as balanced multifunctional agents against Alzheimer's disease: Design, synthesis and biological evaluation. Bioorganic chemistry. 2020 01; 94(?):103477. doi: 10.1016/j.bioorg.2019.103477. [PMID: 31818478]
  • Myrthe Giesbers, Enrique Javier Carrasco-Correa, Ernesto F Simó-Alfonso, José Manuel Herrero-Martínez. Hybrid monoliths with metal-organic frameworks in spin columns for extraction of non-steroidal drugs prior to their quantitation by reversed-phase HPLC. Mikrochimica acta. 2019 11; 186(12):759. doi: 10.1007/s00604-019-3923-6. [PMID: 31712934]
  • Valentina Loconte, Ilaria Menozzi, Alberto Ferrari, Claudia Folli, Bruno P Imbimbo, Giuseppe Zanotti, Rodolfo Berni. Structure-activity relationships of flurbiprofen analogues as stabilizers of the amyloidogenic protein transthyretin. Journal of structural biology. 2019 11; 208(2):165-173. doi: 10.1016/j.jsb.2019.08.011. [PMID: 31473362]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Malek Hassan, Usama Alshana. Switchable-hydrophilicity solvent liquid-liquid microextraction of non-steroidal anti-inflammatory drugs from biological fluids prior to HPLC-DAD determination. Journal of pharmaceutical and biomedical analysis. 2019 Sep; 174(?):509-517. doi: 10.1016/j.jpba.2019.06.023. [PMID: 31238298]
  • X F Ding, Y Luan, S M Lu, T B Huang, F Yan, J N Xu, Y Q Zhou, F Wang, Y Z Xu. [Effect of multimodal analgesia using periprostatic nerve block anesthesia combined with flurbiprofen in transperineal template-guided prostate biopsy]. Zhonghua wai ke za zhi [Chinese journal of surgery]. 2019 Jun; 57(6):428-433. doi: 10.3760/cma.j.issn.0529-5815.2019.06.007. [PMID: 31142067]
  • Jovana Maric, Avinash Ravindran, Luca Mazzurana, Aline Van Acker, Anna Rao, Efthymia Kokkinou, Maria Ekoff, Dominique Thomas, Alexander Fauland, Gunnar Nilsson, Craig E Wheelock, Sven-Erik Dahlén, Nerea Ferreirós, Gerd Geisslinger, Danielle Friberg, Akos Heinemann, Viktoria Konya, Jenny Mjösberg. Cytokine-induced endogenous production of prostaglandin D2 is essential for human group 2 innate lymphoid cell activation. The Journal of allergy and clinical immunology. 2019 06; 143(6):2202-2214.e5. doi: 10.1016/j.jaci.2018.10.069. [PMID: 30578872]
  • Hongyan Liu, Xiaoming Qiang, Qing Song, Wei Li, Yuxi He, Chanyuan Ye, Zhenghuai Tan, Yong Deng. Discovery of 4'-OH-flurbiprofen Mannich base derivatives as potential Alzheimer's disease treatment with multiple inhibitory activities. Bioorganic & medicinal chemistry. 2019 03; 27(6):991-1001. doi: 10.1016/j.bmc.2019.01.040. [PMID: 30772129]
  • Lisa Nothnagel, Fabian Jung, Tanja Rossmanith, Manuela Thurn, Mukul Ashtikar, Gerd Geisslinger, Michael J Parnham, Matthias G Wacker. Predictive PBPK modeling as a tool in the formulation of the drug candidate TMP-001. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2019 Jan; 134(?):144-152. doi: 10.1016/j.ejpb.2018.11.012. [PMID: 30453024]
  • Nahla E El-Ashmawy, Ghada M Al-Ashmawy, Asmaa A Kamel. Docosahexaenoic acid-flurbiprofen combination ameliorates metaflammation in rats fed on high-carbohydrate high-fat diet. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Jan; 109(?):233-241. doi: 10.1016/j.biopha.2018.10.049. [PMID: 30396081]
  • Qing Song, Yan Li, Zhongcheng Cao, Hongyan Liu, Chaoquan Tian, Ziyi Yang, Xiaoming Qiang, Zhenghuai Tan, Yong Deng. Discovery of novel 2,5-dihydroxyterephthalamide derivatives as multifunctional agents for the treatment of Alzheimer's disease. Bioorganic & medicinal chemistry. 2018 12; 26(23-24):6115-6127. doi: 10.1016/j.bmc.2018.11.015. [PMID: 30470598]
  • Xiaodong Zhao, Leting Ji. Flurbiprofen axetil: Analgesic effect and adverse reaction. Pakistan journal of pharmaceutical sciences. 2018 May; 31(3(Special)):1163-1167. doi: ". [PMID: 29735468]
  • Zhongcheng Cao, Jie Yang, Rui Xu, Qin Song, Xiaoyu Zhang, Hongyan Liu, Xiaoming Qiang, Yan Li, Zhenghuai Tan, Yong Deng. Design, synthesis and evaluation of 4'-OH-flurbiprofen-chalcone hybrids as potential multifunctional agents for Alzheimer's disease treatment. Bioorganic & medicinal chemistry. 2018 03; 26(5):1102-1115. doi: 10.1016/j.bmc.2018.01.030. [PMID: 29409707]
  • Hiroaki Todo, Mai Tamura, Takashi Uchida, Miyuki Kurumada, Anzu Motoki, Tomohiko Sano, Yoshinori Onuki, Kozo Takayama, Kenji Sugibayashi. Prediction of Skin Permeation of Flurbiprofen from Neat Ester Oils and Their O/W Emulsions. Chemical & pharmaceutical bulletin. 2018; 66(10):959-966. doi: 10.1248/cpb.c18-00384. [PMID: 30270242]
  • Ling Rong Wong, Paul C Ho. Role of serum albumin as a nanoparticulate carrier for nose-to-brain delivery of R-flurbiprofen: implications for the treatment of Alzheimer's disease. The Journal of pharmacy and pharmacology. 2018 Jan; 70(1):59-69. doi: 10.1111/jphp.12836. [PMID: 29034965]
  • Noboru Otsuka, Ikuko Yataba, Isao Matsushita, Hideo Matsumoto, Yuichi Hoshino, Yoshio Terada. A minimal impact of long-term S-flurbiprofen plaster application on kidney function in osteoarthritis patients. Clinical and experimental nephrology. 2017 Dec; 21(6):1060-1067. doi: 10.1007/s10157-017-1406-9. [PMID: 28378068]
  • Hong Zhang, Jian Gu, Yi Feng, Haiyan An. Absorption kinetics of flurbiprofen axetil microspheres in cerebrospinal fluid: A pilot study
. International journal of clinical pharmacology and therapeutics. 2017 Nov; 55(11):875-880. doi: 10.5414/cp203092. [PMID: 28956529]
  • Hriday Bera, Jhansirani Nadimpalli, Sanoj Kumar, Pavani Vengala. Kondogogu gum-Zn+2-pectinate emulgel matrices reinforced with mesoporous silica for intragastric furbiprofen delivery. International journal of biological macromolecules. 2017 Nov; 104(Pt A):1229-1237. doi: 10.1016/j.ijbiomac.2017.07.027. [PMID: 28688948]
  • Elizabeth M Yi, Elizabeth Leech. Topical flurbiprofen toxicosis in a cat. Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001). 2017 Nov; 27(6):707-712. doi: 10.1111/vec.12638. [PMID: 28834579]
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  • Hriday Bera, Sohitha Reddy Ippagunta, Sanoj Kumar, Pavani Vangala. Core-shell alginate-ghatti gum modified montmorillonite composite matrices for stomach-specific flurbiprofen delivery. Materials science & engineering. C, Materials for biological applications. 2017 Jul; 76(?):715-726. doi: 10.1016/j.msec.2017.03.074. [PMID: 28482582]
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  • Silvana Pinheiro, Carles Curutchet. Can Förster Theory Describe Stereoselective Energy Transfer Dynamics in a Protein-Ligand Complex?. The journal of physical chemistry. B. 2017 03; 121(10):2265-2278. doi: 10.1021/acs.jpcb.7b00217. [PMID: 28235382]
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  • Lixia Qiang, Yanxia Guan, Xiangshun Li, Li Liu, Yanshuang Mu, Aki Sugano, Yutaka Takaoka, Toshiyuki Sakaeda, Bruno P Imbimbo, Ken-Ichi Yamamura, Shoude Jin, Zhenghua Li. CSP-1103 (CHF5074) stabilizes human transthyretin in healthy human subjects. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. 2017 Mar; 24(1):42-51. doi: 10.1080/13506129.2017.1308348. [PMID: 28393633]
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