Clotrimazole (BioDeep_00000002336)
Secondary id: BioDeep_00000229725, BioDeep_00000398929
human metabolite Chemicals and Drugs
代谢物信息卡片
化学式: C22H17ClN2 (344.1080192)
中文名称: 克霉唑
谱图信息:
最多检出来源 Mentha canadensis(plant) 90.32%
分子结构信息
SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4
InChI: InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
描述信息
Clotrimazole is an imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane. -- Pubchem; There is the potential for drug interactions with Clotrimazole if taken orally, as it is a potent, specific inhibitor of cytochrome P450 oxidase enzymes and so may alter the metabolism of other drugs.; Clotrimazole is an antifungal medication commonly used in the treatment of fungal infections of both humans and animals such as vaginal yeast infections and ringworm. -- Wikipedia; An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane.; Clotrimazole is a potent, specific inhibitor of cytochrome P450 oxidase enzymes. Hence, it may alter the metabolism of other drugs particularly if taken orally. -- Wikipedia; Clotrimazole is an antifungal medication commonly used in the treatment of fungal infections of both humans and animals such as vaginal yeast infections and ringworm. It also used to treat athletes foot and jock itch. [HMDB]
Clotrimazole is an imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane. -- Pubchem; There is the potential for drug interactions with Clotrimazole if taken orally, as it is a potent, specific inhibitor of cytochrome P450 oxidase enzymes and so may alter the metabolism of other drugs. Clotrimazole is an antifungal medication commonly used in the treatment of fungal infections of both humans and animals such as vaginal yeast infections and ringworm. -- Wikipedia; An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane. Clotrimazole is a potent, specific inhibitor of cytochrome P450 oxidase enzymes. Hence, it may alter the metabolism of other drugs particularly if taken orally. -- Wikipedia; Clotrimazole is an antifungal medication commonly used in the treatment of fungal infections of both humans and animals such as vaginal yeast infections and ringworm. It also used to treat athletes foot and jock itch.
G - Genito urinary system and sex hormones > G01 - Gynecological antiinfectives and antiseptics > G01A - Antiinfectives and antiseptics, excl. combinations with corticosteroids > G01AF - Imidazole derivatives
A - Alimentary tract and metabolism > A01 - Stomatological preparations > A01A - Stomatological preparations > A01AB - Antiinfectives and antiseptics for local oral treatment
D - Dermatologicals > D01 - Antifungals for dermatological use > D01A - Antifungals for topical use > D01AC - Imidazole and triazole derivatives
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D065088 - Steroid Synthesis Inhibitors
D004791 - Enzyme Inhibitors > D065088 - Steroid Synthesis Inhibitors > D058888 - 14-alpha Demethylase Inhibitors
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
C254 - Anti-Infective Agent > C514 - Antifungal Agent
同义名列表
88 个代谢物同义名
1-(O-Chloro-alpha,alpha-diphenylbenzyl)imidazole; 1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole; 1-[(2-chlorophenyl)diphenylmethyl]-1H-imidazole; 1-(alpha-(2-Chlorophenyl)benzhydryl)imidazole; 1-(a-(2-Chlorophenyl)benzhydryl)imidazole; 1-(Α-(2-chlorophenyl)benzhydryl)imidazole; 1-(O-Chloro-a,a-diphenylbenzyl)imidazole; 1-(O-Chloro-α,α-diphenylbenzyl)imidazole; Gyne-lotrimin 3 combination pack; Canesten combi-pak 3-day therapy; Canesten combi-pak 1-day therapy; Gyne-lotrimin3 combination pack; Gyne-lotrimin combination pack; Schering brand OF clotrimazole; Canesten 1-day cream combi-pak; Bayer brand 1 OF clotrimazole; Bayer brand 2 OF clotrimazole; Clotrimazole schering brand; 1-(O-Chlorotrityl)imidazole; Mycelex: mycosporinrimazole; Lotrimin af jock-itch cream; Mycelex-7 combination pack; (Chlorotrityl)imidazole; Canesten 1-day therapy; Canesten 6-day therapy; Canesten 3-day therapy; Myclo spray solution; Lotrimin af solution; Clotrimaderm cream; Lotrimin af lotion; Canesten solution; Mycelex twin pack; Lotrimin solution; Lotrimin af cream; Mycelex solution; Lotrimin lotion; Gyne-lotrimin 3; Mycelex troches; Lotrimin cream; Myclo solution; Canesten cream; Gyne-lotrimin3; mono-Baycuten; Trivagizole 3; Chlotrimazole; Gyne-lotrimin; Mycelex cream; Clotrimazolum; Neo-zol cream; Gyne lotrimin; Prestwick_120; Klotrimazole; clotrimazole; Lopac-C-6019; Clotrimaderm; Monobaycuten; Mycelex otc; Myclo cream; Lotrimin af; Clotrimazol; Mycosporin; Myclo-gyne; Mykosporin; Bay b 5097; Mycelex g; FB b 5097; Canestine; Mycelex-g; Mycelex 7; Mycelex-7; Trimysten; Desamix F; Lotrisone; Kanesten; Pedisafe; Lotrimax; Canesten; Fem care; Rimazole; Lotrimin; Empecid; Tibatin; FemCare; Mycelex; Veltrim; Mycelax; Otomax; Gynix
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:3764
- KEGG: C06922
- KEGGdrug: D00282
- PubChem: 2812
- HMDB: HMDB0001922
- Metlin: METLIN1897
- DrugBank: DB00257
- ChEMBL: CHEMBL104
- Wikipedia: Clotrimazole
- MeSH: Clotrimazole
- foodb: FDB022740
- chemspider: 2710
- CAS: 117829-71-7
- CAS: 23593-75-1
- PMhub: MS000002378
- PubChem: 9139
- PDB-CCD: CL6
- NIKKAJI: J3.156I
分类词条
相关代谢途径
Reactome(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Vasile-Ion Iancu, Laura-Florentina Chiriac, Iuliana Paun, Florinela Pirvu, Cristina Dinu, Lidia Kim, Luoana Florentina Pascu, Marcela Niculescu. Occurrence and distribution of azole antifungal agents in eight urban Romanian waste water treatment plants.
The Science of the total environment.
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Molecular and cellular endocrinology.
2023 Mar; 564(?):111883. doi:
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Journal of natural products.
2022 04; 85(4):927-935. doi:
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. [PMID: 35271771] - Temitope Dadewura Melefa, Christopher Didigwu Nwani. Imidazole antifungal drug clotrimazole alters the behavior, brain acetylcholinesterase and oxidative stress biomarkers in African catfish Clarias gariepinus (Burchell 1822).
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2021 Oct; 248(?):109108. doi:
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. [PMID: 34126252] - Alessio Ausili, Illya Yakymenko, José A Teruel, Juan C Gómez-Fernández. Clotrimazole Fluidizes Phospholipid Membranes and Localizes at the Hydrophobic Part near the Polar Part of the Membrane.
Biomolecules.
2021 09; 11(9):. doi:
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. [PMID: 34572517] - Monica Kam Draskau, Anna Kjerstine Rosenmai, Martin Scholze, Mikael Pedersen, Julie Boberg, Sofie Christiansen, Terje Svingen. Human-relevant concentrations of the antifungal drug clotrimazole disrupt maternal and fetal steroid hormone profiles in rats.
Toxicology and applied pharmacology.
2021 07; 422(?):115554. doi:
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Polish journal of veterinary sciences.
2019 Mar; 22(1):173-175. doi:
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Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology.
2018 Oct; 38(7):985-988. doi:
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2018 10; 161(?):676-682. doi:
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The American journal of case reports.
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Bioorganic & medicinal chemistry.
2018 02; 26(3):786-790. doi:
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2017 Nov; 66(11):1573-1580. doi:
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The journal of physical chemistry. B.
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Phytotherapy research : PTR.
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. [PMID: 28299831] - Katarzyna Sosnowska, Emilia Szymanska, Katarzyna Winnicka. NANOEMULSION WITH CLOTRIMAZOLE - DESIGN AND OPTIMALIZATION OF MEAN DROPLET SIZE USING MICROFLUIDIZATION TECHNIQUE.
Acta poloniae pharmaceutica.
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"
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Hematology/oncology and stem cell therapy.
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. [PMID: 26684920] - Eva Iniguez, Armando Varela-Ramirez, Alberto Martínez, Caresse L Torres, Roberto A Sánchez-Delgado, Rosa A Maldonado. Ruthenium-Clotrimazole complex has significant efficacy in the murine model of cutaneous leishmaniasis.
Acta tropica.
2016 Dec; 164(?):402-410. doi:
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Anais da Academia Brasileira de Ciencias.
2016 Oct; 88(4):2303-2317. doi:
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Journal of inorganic biochemistry.
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Chemosphere.
2016 Sep; 159(?):10-22. doi:
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Scientific reports.
2016 06; 6(?):27690. doi:
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FEMS yeast research.
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