Deoxycorticosterone (BioDeep_00000002275)

 

Secondary id: BioDeep_00000405184, BioDeep_00000410538

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite natural product


代谢物信息卡片


(1S,2R,10S,11S,14S,15S)-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one

化学式: C21H30O3 (330.2195)
中文名称: 11-脱氧皮质酮, 11-去氧皮质酮
谱图信息: 最多检出来源 Homo sapiens(blood) 24.01%

分子结构信息

SMILES: CC12CCC(=O)C=C1CCC1C2CCC2(C)C(C(=O)CO)CCC12
InChI: InChI=1S/C21H30O3/c1-20-9-7-14(23)11-13(20)3-4-15-16-5-6-18(19(24)12-22)21(16,2)10-8-17(15)20/h11,15-18,22H,3-10,12H2,1-2H3

描述信息

11-Deoxycorticosterone (also called desoxycortone, 21-hydroxyprogesterone, DOC, or simply deoxycorticosterone) is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as a precursor to aldosterone. It is classified as a member of the 21-hydroxysteroids. 21-hydroxysteroids are steroids carrying a hydroxyl group at the 21-position of the steroid backbone. Deoxycorticosterone is very hydrophobic, practically insoluble (in water), and relatively neutral. Deoxycorticosterone can be synthesized from progesterone by 21-beta-hydroxylase and is then converted to corticosterone by 11-beta-hydroxylase. Corticosterone is then converted to aldosterone by aldosterone synthase. Deoxycorticosterone stimulates the collecting tubules in the kidney to continue to excrete potassium in much the same way that aldosterone does. Deoxycorticosterone has about 1/20 of the sodium retaining power of aldosterone and about 1/5 the potassium excreting power of aldosterone (Wikipedia). Deoxycorticosterone can be found throughout all human tissues and has been detected in amniotic fluid and blood. When present in sufficiently high levels, deoxycorticosterone can act as a hypertensive agent and a metabotoxin. A hypertensive agent increases blood pressure and causes the production of more urine. A metabotoxin is an endogenously produced metabolite that causes adverse health effects at chronically high levels. Chronically high levels of deoxycorticosterone are associated with congenital adrenal hyperplasia (CAH) and with adrenal tumors producing deoxycorticosterone (PMID: 20671982). High levels of this mineralocorticoid are associated with resistant hypertension, which can result in polyuria, polydipsia, increased blood volume, edema, and cardiac enlargement. Deoxycorticosterone can be used to treat adrenal insufficiency. In particular, desoxycorticosterone acetate (DOCA) is used as replacement therapy in Addisons disease.
Desoxycorticosterol, also known as 21-hydroxy-4-pregnene-3,20-dione or 21-hydroxyprogesterone, is a member of the class of compounds known as 21-hydroxysteroids. 21-hydroxysteroids are steroids carrying a hydroxyl group at the 21-position of the steroid backbone. Thus, desoxycorticosterol is considered to be a steroid lipid molecule. Desoxycorticosterol is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Desoxycorticosterol can be synthesized from progesterone. Desoxycorticosterol can also be synthesized into 11-deoxycorticosterone-21-hemisuccinate and 5beta-dihydrodeoxycorticosterone. Desoxycorticosterol can be found in rice, which makes desoxycorticosterol a potential biomarker for the consumption of this food product. Desoxycorticosterol can be found primarily in amniotic fluid and blood, as well as throughout all human tissues. In humans, desoxycorticosterol is involved in the steroidogenesis. Desoxycorticosterol is also involved in several metabolic disorders, some of which include corticosterone methyl oxidase I deficiency (CMO I), 21-hydroxylase deficiency (CYP21), corticosterone methyl oxidase II deficiency - CMO II, and 11-beta-hydroxylase deficiency (CYP11B1). Desoxycorticosterol is a non-carcinogenic (not listed by IARC) potentially toxic compound.
CONFIDENCE standard compound; INTERNAL_ID 793; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9334; ORIGINAL_PRECURSOR_SCAN_NO 9329
CONFIDENCE standard compound; INTERNAL_ID 793; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9427; ORIGINAL_PRECURSOR_SCAN_NO 9423
CONFIDENCE standard compound; INTERNAL_ID 793; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9386; ORIGINAL_PRECURSOR_SCAN_NO 9384
CONFIDENCE standard compound; INTERNAL_ID 793; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9356; ORIGINAL_PRECURSOR_SCAN_NO 9353
CONFIDENCE standard compound; INTERNAL_ID 793; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9399; ORIGINAL_PRECURSOR_SCAN_NO 9396
CONFIDENCE standard compound; INTERNAL_ID 793; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9378; ORIGINAL_PRECURSOR_SCAN_NO 9376
H - Systemic hormonal preparations, excl. sex hormones and insulins > H02 - Corticosteroids for systemic use > H02A - Corticosteroids for systemic use, plain > H02AA - Mineralocorticoids
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D008901 - Mineralocorticoids
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
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Deoxycorticosterone is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as an aldosterone precursor.
Deoxycorticosterone is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as an aldosterone precursor.

同义名列表

33 个代谢物同义名

(1S,2R,10S,11S,14S,15S)-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one; 17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one; 21-Hydroxy-pregn-4-ene-3,20-dione; 21-Hydroxy-D4-pregnene-3,20-dione; 21-Hydroxy-D4-pregnane-3,20-dione; 21 Hydroxy 4 pregnene 3,20 dione; 21-Hydroxy-3,20-dioxopregn-4-ene; 21-Hydroxy-4-pregnene-3,20-dione; 21-hydroxypregn-4-ene-3,20-dione; D4-Pregnene-21-ol-3,20-dione; Kendalls desoxy compound b; 4-Pregnen-21-ol-3,20-dione; 11-Dehydroxycorticosterone; Reichsteins substance Q; 11-Deoxy-corticosterone; 21-Hydroxy-progesterone; 11-Desoxycorticosterone; 21-hydroxyProgesterone; 11-deoxycorticosterone; 21 Hydroxyprogesterone; Desoxycorticosterone; 11-Decorticosterone; 11 Decorticosterone; Desoxycorticosterol; Deoxycorticosterone; Desoxycortone; Deoxycortone; Reichstein Q; ST 21:3;O3; Cortexone; Doca; DOC; 11-Deoxycorticosterone



数据库引用编号

31 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(13)

BioCyc(0)

PlantCyc(0)

代谢反应

122 个相关的代谢反应过程信息。

Reactome(81)

BioCyc(0)

WikiPathways(6)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(35)

PharmGKB(0)

12 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 ACE, NR3C1, NR3C2, POMC
Peripheral membrane protein 4 CYP11A1, CYP11B1, CYP21A2, FDXR
Endoplasmic reticulum membrane 5 CYP11B1, CYP17A1, CYP19A1, CYP21A2, NR3C2
Mitochondrion membrane 1 CYP11A1
Nucleus 2 NR3C1, NR3C2
cytosol 4 AVP, COMT, NR3C1, NR3C2
dendrite 2 AVP, COMT
centrosome 1 NR3C1
nucleoplasm 3 ATP2B1, NR3C1, NR3C2
Cell membrane 3 ACE, ATP2B1, COMT
Multi-pass membrane protein 2 ATP2B1, CYP19A1
Synapse 4 ATP2B1, COMT, CRH, NR3C1
glutamatergic synapse 1 ATP2B1
Golgi apparatus 1 CCN2
Golgi membrane 1 INS
mitochondrial inner membrane 3 CYP11A1, CYP11B1, FDXR
neuronal cell body 1 CYP17A1
presynaptic membrane 1 ATP2B1
Lysosome 1 ACE
endosome 1 ACE
plasma membrane 6 ACE, ATP2B1, CCN2, COMT, KNG1, REN
synaptic vesicle membrane 1 ATP2B1
Membrane 8 ACE, ATP2B1, COMT, CYP11A1, CYP19A1, CYP21A2, NR3C1, REN
axon 2 COMT, CYP17A1
basolateral plasma membrane 1 ATP2B1
extracellular exosome 5 ACE, ATP2B1, COMT, KNG1, SERPINA6
endoplasmic reticulum 2 CYP17A1, CYP19A1
extracellular space 9 ACE, AVP, CCN2, CRH, INS, KNG1, POMC, REN, SERPINA6
mitochondrion 5 CYP11A1, CYP11B1, FDX1, FDXR, NR3C1
protein-containing complex 1 NR3C1
intracellular membrane-bounded organelle 3 ATP2B1, CCN2, COMT
Microsome membrane 3 CYP17A1, CYP19A1, CYP21A2
Single-pass type I membrane protein 1 ACE
Secreted 7 ACE, AVP, CCN2, CRH, INS, POMC, REN
extracellular region 9 ACE, AVP, CCN2, CRH, INS, KNG1, POMC, REN, SERPINA6
Single-pass membrane protein 1 CYP21A2
Mitochondrion matrix 1 FDX1
mitochondrial matrix 4 CYP11A1, FDX1, FDXR, NR3C1
Extracellular side 1 COMT
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 NR3C1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
external side of plasma membrane 1 ACE
varicosity 1 CRH
Secreted, extracellular space, extracellular matrix 1 CCN2
neuronal dense core vesicle lumen 1 CRH
perikaryon 1 CRH
apical part of cell 1 REN
Single-pass type II membrane protein 1 COMT
Mitochondrion inner membrane 3 CYP11A1, CYP11B1, FDXR
Cytoplasm, cytoskeleton, spindle 1 NR3C1
spindle 1 NR3C1
extracellular matrix 1 CCN2
collagen-containing extracellular matrix 1 KNG1
secretory granule 2 AVP, POMC
lateral plasma membrane 1 ATP2B1
nuclear speck 1 NR3C1
receptor complex 1 NR3C2
chromatin 2 NR3C1, NR3C2
cell projection 1 ATP2B1
Chromosome 1 NR3C1
Secreted, extracellular space 1 KNG1
brush border membrane 1 ACE
blood microparticle 1 KNG1
sperm midpiece 1 ACE
Basolateral cell membrane 1 ATP2B1
endosome lumen 1 INS
Nucleus, nucleoplasm 1 NR3C1
Presynaptic cell membrane 1 ATP2B1
basal plasma membrane 1 ACE
secretory granule lumen 2 INS, POMC
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 INS, KNG1
platelet alpha granule lumen 1 KNG1
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 ATP2B1
neuronal dense core vesicle 1 AVP
clathrin-coated endocytic vesicle membrane 1 AVP
[Isoform Alpha]: Cytoplasm 1 NR3C1
[Isoform Beta]: Nucleus 1 NR3C1
[Isoform Alpha-B]: Nucleus 1 NR3C1
photoreceptor ribbon synapse 1 ATP2B1
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
[Isoform Soluble]: Cytoplasm 1 COMT
[Isoform Membrane-bound]: Cell membrane 1 COMT


文献列表

  • Karla Vagnerová, Michal Jágr, Chahrazed Mekadim, Peter Ergang, Hana Sechovcová, Martin Vodička, Kateřina Olša Fliegerová, Václav Dvořáček, Jakub Mrázek, Jiří Pácha. Profiling of adrenal corticosteroids in blood and local tissues of mice during chronic stress. Scientific reports. 2023 May; 13(1):7278. doi: 10.1038/s41598-023-34395-2. [PMID: 37142643]
  • Chetan N Patil, McKenzie L Ritter, Kelsey K Wackman, Vanessa Oliveira, Kirthikaa Balapattabi, Connie C Grobe, Daniel T Brozoski, John J Reho, Pablo Nakagawa, Gary C Mouradian, Alison J Kriegel, Anne E Kwitek, Matthew R Hodges, Jeffrey L Segar, Curt D Sigmund, Justin L Grobe. Cardiometabolic effects of DOCA-salt in male C57BL/6J mice are variably dependent on sodium and nonsodium components of diet. American journal of physiology. Regulatory, integrative and comparative physiology. 2022 06; 322(6):R467-R485. doi: 10.1152/ajpregu.00017.2022. [PMID: 35348007]
  • Vadim Tseilikman, Maria Komelkova, Marina V Kondashevskaya, Eugenia Manukhina, H Fred Downey, Valerii Chereshnev, Margarita Chereshneva, Pavel Platkovskii, Anna Goryacheva, Anton Pashkov, Julia Fedotova, Olga Tseilikman, Natalya Maltseva, Olga Cherkasova, Charlotte Steenblock, Stefan R Bornstein, Barbara Ettrich, George P Chrousos, Enrico Ullmann. A Rat Model of Post-Traumatic Stress Syndrome Causes Phenotype-Associated Morphological Changes and Hypofunction of the Adrenal Gland. International journal of molecular sciences. 2021 Dec; 22(24):. doi: 10.3390/ijms222413235. [PMID: 34948031]
  • Osaze Edosuyi, Myung Choi, Ighodaro Igbe, Adebayo Oyekan. Fumarate exerted an antihypertensive effect and reduced kidney injury molecule (KIM)-1 expression in deoxycorticosterone acetate-salt hypertension. Clinical and experimental hypertension (New York, N.Y. : 1993). 2021 Aug; 43(6):555-564. doi: 10.1080/10641963.2021.1916943. [PMID: 33879002]
  • Gaizun Hu, Qing Zhu, Weili Wang, Dengpiao Xie, Chaoling Chen, Pin-Lan Li, Joseph K Ritter, Ningjun Li. Collecting duct-specific knockout of sphingosine-1-phosphate receptor 1 aggravates DOCA-salt hypertension in mice. Journal of hypertension. 2021 08; 39(8):1559-1566. doi: 10.1097/hjh.0000000000002809. [PMID: 33534341]
  • Nadeem Irshad, Arif-Ullah Khan, Alamgeer, Salah-Ud-Din Khan, Muhammad Shahid Iqbal. Antihypertensive potential of selected pyrimidine derivatives: Explanation of underlying mechanistic pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Jul; 139(?):111567. doi: 10.1016/j.biopha.2021.111567. [PMID: 33848773]
  • Alysha M Vincent, Linda K Okonkowski, Jean M Brudvig, Kent R Refsal, Nora Berghoff, N Bari Olivier, Daniel K Langlois. Low-dose desoxycorticosterone pivalate treatment of hypoadrenocorticism in dogs: A randomized controlled clinical trial. Journal of veterinary internal medicine. 2021 Jul; 35(4):1720-1728. doi: 10.1111/jvim.16195. [PMID: 34114259]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Yifang Li, Matthew Shen, Dorota Ferens, Brad R S Broughton, Padma Murthi, Sheetal Saini, Robert E Widdop, Sharon D Ricardo, Anita A Pinar, Chrishan S Samuel. Combining mesenchymal stem cells with serelaxin provides enhanced renoprotection against 1K/DOCA/salt-induced hypertension. British journal of pharmacology. 2021 03; 178(5):1164-1181. doi: 10.1111/bph.15361. [PMID: 33450051]
  • Kristina M Deligiannidis, Aimee R Kroll-Desrosiers, Yanglan Tan, Michelle L Dubuke, Scott A Shaffer. Longitudinal proneuroactive and neuroactive steroid profiles in medication-free women with, without and at-risk for perinatal depression: A liquid chromatography-tandem mass spectrometry analysis. Psychoneuroendocrinology. 2020 11; 121(?):104827. doi: 10.1016/j.psyneuen.2020.104827. [PMID: 32828068]
  • Yasunori Nio, Mitsugi Ookawara, Midori Yamasaki, Guido Hanauer, Kimio Tohyama, Sachio Shibata, Tomoya Sano, Fumi Shimizu, Hisashi Anayama, Masatoshi Hazama, Takanori Matsuo. Ameliorative effect of phosphodiesterase 4 and 5 inhibitors in deoxycorticosterone acetate-salt hypertensive uni-nephrectomized KKAy mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020 11; 34(11):14997-15014. doi: 10.1096/fj.202001084r. [PMID: 32939821]
  • Zhida Chen, Chunying Wu, Yuting Liu, Haonan Li, Yeyan Zhu, Cailing Huang, Huangbo Lin, Qiao Qiao, Mengming Huang, Qing Zhu, Lei Wang. ELABELA attenuates deoxycorticosterone acetate/salt-induced hypertension and renal injury by inhibition of NADPH oxidase/ROS/NLRP3 inflammasome pathway. Cell death & disease. 2020 08; 11(8):698. doi: 10.1038/s41419-020-02912-0. [PMID: 32829380]
  • Dandan Wei, Xue Liu, Jingjing Jiang, Runqi Tu, Dou Qiao, Ruiying Li, Yikang Wang, Mengying Fan, Xiu Yang, Jinyu Zhang, Jian Hou, Wenqian Huo, Songcheng Yu, Linlin Li, Chongjian Wang, Zhenxing Mao. Mineralocorticoids, glucose homeostasis and type 2 diabetes mellitus: The Henan Rural Cohort study. Journal of diabetes and its complications. 2020 05; 34(5):107558. doi: 10.1016/j.jdiacomp.2020.107558. [PMID: 32075751]
  • Sheung-Fat Ko, Hon-Kan Yip, Yen-Yi Zhen, Chi-Chih Hung, Chen-Chang Lee, Chung-Cheng Huang, Shu-Hang Ng, Yi-Ling Chen, Jui-Wei Lin. Renal Damages in Deoxycorticosterone Acetate-Salt Hypertensive Rats: Assessment with Diffusion Tensor Imaging and T2-mapping. Molecular imaging and biology. 2020 02; 22(1):94-104. doi: 10.1007/s11307-019-01364-z. [PMID: 31065896]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Monica Aleman, Patrick M McCue, Munashe Chigerwe, John E Madigan. Plasma concentrations of steroid precursors, steroids, neuroactive steroids, and neurosteroids in healthy neonatal foals from birth to 7 days of age. Journal of veterinary internal medicine. 2019 Sep; 33(5):2286-2293. doi: 10.1111/jvim.15618. [PMID: 31489708]
  • Nadia S Sieber-Ruckstuhl, Claudia E Reusch, Nathalie Hofer-Inteeworn, Claudia Kuemmerle-Fraune, Claudia Müller, Regina Hofmann-Lehmann, Felicitas S Boretti. Evaluation of a low-dose desoxycorticosterone pivalate treatment protocol for long-term management of dogs with primary hypoadrenocorticism. Journal of veterinary internal medicine. 2019 May; 33(3):1266-1271. doi: 10.1111/jvim.15475. [PMID: 30865322]
  • Marzieh Kafami, Mahmoud Hosseini, Saeed Niazmand, Esmaeil Farrokhi, Mosa Al-Reza Hajzadeh, Samad Nazemi. The effects of estradiol and testosterone on renal tissues oxidative after central injection of angiotensin II in female doca - salt treated rats. Hormone molecular biology and clinical investigation. 2018 Nov; 37(3):. doi: 10.1515/hmbci-2018-0044. [PMID: 30398970]
  • Leticia Gonzalez, Ulises Novoa, Jackeline Moya, Luigi Gabrielli, Jorge E Jalil, Lorena García, Mario Chiong, Sergio Lavandero, María Paz Ocaranza. Angiotensin-(1-9) reduces cardiovascular and renal inflammation in experimental renin-independent hypertension. Biochemical pharmacology. 2018 10; 156(?):357-370. doi: 10.1016/j.bcp.2018.08.045. [PMID: 30179588]
  • Pia Kiilerich, Arianna Servili, Sandrine Péron, Claudiane Valotaire, Lionel Goardon, Isabelle Leguen, Patrick Prunet. Regulation of the corticosteroid signalling system in rainbow trout HPI axis during confinement stress. General and comparative endocrinology. 2018 03; 258(?):184-193. doi: 10.1016/j.ygcen.2017.08.013. [PMID: 28837788]
  • Sylvain Milla, Sophie Massart, Cédric Mathieu, Neil Wang, Caroline Douny, Jessica Douxfils, Marie-Louise Scippo, Edwin De Pauw, Marc Dieu, Frédéric Silvestre, Patrick Kestemont. Physiological and proteomic responses to corticosteroid treatments in Eurasian perch, Perca fluviatilis: Investigation of immune-related parameters. Comparative biochemistry and physiology. Part D, Genomics & proteomics. 2018 03; 25(?):86-98. doi: 10.1016/j.cbd.2017.11.005. [PMID: 29223774]
  • Congcong Chen, Chaosheng Lu, Yan Qian, Haiyan Li, Yi Tan, Lu Cai, Huachun Weng. Urinary miR-21 as a potential biomarker of hypertensive kidney injury and fibrosis. Scientific reports. 2017 12; 7(1):17737. doi: 10.1038/s41598-017-18175-3. [PMID: 29255279]
  • J A Jaffey, P Nurre, A B Cannon, A E DeClue. Desoxycorticosterone Pivalate Duration of Action and Individualized Dosing Intervals in Dogs with Primary Hypoadrenocorticism. Journal of veterinary internal medicine. 2017 Nov; 31(6):1649-1657. doi: 10.1111/jvim.14828. [PMID: 28892205]
  • Tomoaki Tochitani, Akihito Yamashita, Izumi Matsumoto, Mami Kouchi, Yuta Fujii, Izuru Miyawaki, Toru Yamada, Kiyoko Bando. Usefulness of Simultaneous Measurement of Plasma Steroids, Including Precursors, for the Evaluation of Drug Effects on Adrenal Steroidogenesis in Rats. Toxicologic pathology. 2017 08; 45(6):756-763. doi: 10.1177/0192623317730416. [PMID: 29046138]
  • Wenzheng Han, Weiyi Fang, Qian Gan, Shaofeng Guan, Yanjie Li, Ming Wang, Kaizheng Gong, Xinkai Qu. Low-dose sustained-release deoxycorticosterone acetate-induced hypertension in Bama miniature pigs for renal sympathetic nerve denervation. Journal of the American Society of Hypertension : JASH. 2017 May; 11(5):314-320. doi: 10.1016/j.jash.2017.02.006. [PMID: 28411074]
  • Anja Hofmann, Mirko Peitzsch, Coy Brunssen, Jennifer Mittag, Annett Jannasch, Annika Frenzel, Nicholas Brown, Steven M Weldon, Graeme Eisenhofer, Stefan R Bornstein, Henning Morawietz. Elevated Steroid Hormone Production in the db/db Mouse Model of Obesity and Type 2 Diabetes. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2017 Jan; 49(1):43-49. doi: 10.1055/s-0042-116157. [PMID: 27813053]
  • Mikako Hisamichi, Atsuko Kamijo-Ikemori, Takeshi Sugaya, Daisuke Ichikawa, Takayuki Natsuki, Seiko Hoshino, Kenjiro Kimura, Yugo Shibagaki. Role of angiotensin II type 1a receptor in renal injury induced by deoxycorticosterone acetate-salt hypertension. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2017 01; 31(1):72-84. doi: 10.1096/fj.201600684rr. [PMID: 27663860]
  • Rastafa I Geddes, Kentaro Hayashi, Quinn Bongers, Marlyse Wehber, Icelle M Anderson, Alex D Jansen, Chase Nier, Emily Fares, Gabrielle Farquhar, Amita Kapoor, Toni E Ziegler, Sivan VadakkadathMeethal, Ian M Bird, Craig S Atwood. Conjugated Linoleic Acid Administration Induces Amnesia in Male Sprague Dawley Rats and Exacerbates Recovery from Functional Deficits Induced by a Controlled Cortical Impact Injury. PloS one. 2017; 12(1):e0169494. doi: 10.1371/journal.pone.0169494. [PMID: 28125600]
  • Kristina M Deligiannidis, Aimee R Kroll-Desrosiers, Shunyan Mo, Hien P Nguyen, Abby Svenson, Nina Jaitly, Janet E Hall, Bruce A Barton, Anthony J Rothschild, Scott A Shaffer. Peripartum neuroactive steroid and γ-aminobutyric acid profiles in women at-risk for postpartum depression. Psychoneuroendocrinology. 2016 08; 70(?):98-107. doi: 10.1016/j.psyneuen.2016.05.010. [PMID: 27209438]
  • Hua Liang, Zhiheng Ma, Hui Peng, Liqun He, Zhaoyong Hu, Yanlin Wang. CXCL16 Deficiency Attenuates Renal Injury and Fibrosis in Salt-Sensitive Hypertension. Scientific reports. 2016 06; 6(?):28715. doi: 10.1038/srep28715. [PMID: 27353044]
  • Grazielle C Silva, Fernão C Braga, Virgínia S Lemos, Steyner F Cortes. Potent antihypertensive effect of Hancornia speciosa leaves extract. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2016 Feb; 23(2):214-9. doi: 10.1016/j.phymed.2015.12.010. [PMID: 26926183]
  • S M Krishnan, J K Dowling, Y H Ling, H Diep, C T Chan, D Ferens, M M Kett, A Pinar, C S Samuel, A Vinh, T V Arumugam, T D Hewitson, B K Kemp-Harper, A A B Robertson, M A Cooper, E Latz, A Mansell, C G Sobey, G R Drummond. Inflammasome activity is essential for one kidney/deoxycorticosterone acetate/salt-induced hypertension in mice. British journal of pharmacology. 2016 Feb; 173(4):752-65. doi: 10.1111/bph.13230. [PMID: 26103560]
  • Tomoaki Tochitani, Akihito Yamashita, Mami Kouchi, Yuta Fujii, Izumi Matsumoto, Izuru Miyawaki, Toru Yamada, Hitoshi Funabashi. Changes in plasma concentrations of corticosterone and its precursors after ketoconazole administration in rats: An application of simultaneous measurement of multiple steroids using LC-MS/MS. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 2016 Feb; 68(2-3):125-31. doi: 10.1016/j.etp.2015.11.004. [PMID: 26610754]
  • A E Kulle, F G Riepe, J Hedderich, W G Sippell, J Schmitz, L Niermeyer, P M Holterhus. LC-MS/MS based determination of basal- and ACTH-stimulated plasma concentrations of 11 steroid hormones: implications for detecting heterozygote CYP21A2 mutation carriers. European journal of endocrinology. 2015 Oct; 173(4):517-24. doi: 10.1530/eje-14-1084. [PMID: 26315375]
  • Christopher D Schmoutz, Glenn F Guerin, Scott P Runyon, Suraj Dhungana, Nicholas E Goeders. A therapeutic combination of metyrapone and oxazepam increases brain levels of GABA-active neurosteroids and decreases cocaine self-administration in male rats. Behavioural brain research. 2015 Sep; 291(?):108-111. doi: 10.1016/j.bbr.2015.05.019. [PMID: 26003946]
  • Jefferson H Amaral, Graziele C Ferreira, Lucas C Pinheiro, Marcelo F Montenegro, Jose E Tanus-Santos. Consistent antioxidant and antihypertensive effects of oral sodium nitrite in DOCA-salt hypertension. Redox biology. 2015 Aug; 5(?):340-346. doi: 10.1016/j.redox.2015.06.009. [PMID: 26119848]
  • Yi Zhu, Fang Xie, Liang Ding, Xiaoyu Fan, Xinxin Ding, Qing-Yu Zhang. Intestinal epithelium-specific knockout of the cytochrome P450 reductase gene exacerbates dextran sulfate sodium-induced colitis. The Journal of pharmacology and experimental therapeutics. 2015 Jul; 354(1):10-7. doi: 10.1124/jpet.115.223263. [PMID: 25926522]
  • Vivien Zell, Pierre-Éric Juif, Ulrike Hanesch, Pierrick Poisbeau, Fernand Anton, Pascal Darbon. Corticosterone analgesia is mediated by the spinal production of neuroactive metabolites that enhance GABAergic inhibitory transmission on dorsal horn rat neurons. The European journal of neuroscience. 2015 Feb; 41(3):390-7. doi: 10.1111/ejn.12796. [PMID: 25427854]
  • Julie A Ray, Mark M Kushnir, Richard A Yost, Alan L Rockwood, A Wayne Meikle. Performance enhancement in the measurement of 5 endogenous steroids by LC-MS/MS combined with differential ion mobility spectrometry. Clinica chimica acta; international journal of clinical chemistry. 2015 Jan; 438(?):330-6. doi: 10.1016/j.cca.2014.07.036. [PMID: 25110813]
  • Qi Zhang, Yingying Tan. [Effect of inhibiting brain reactive oxygen species on sympathetic nerve activity in DOCA-salt hypertensive rats]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2014 Nov; 34(11):1632-6. doi: NULL. [PMID: 25413063]
  • M E Baumstark, J Nussberger, F S Boretti, M W Baumstark, B Riond, C E Reusch, N S Sieber-Ruckstuhl. Use of plasma renin activity to monitor mineralocorticoid treatment in dogs with primary hypoadrenocorticism: desoxycorticosterone versus fludrocortisone. Journal of veterinary internal medicine. 2014 Sep; 28(5):1471-8. doi: 10.1111/jvim.12426. [PMID: 25274440]
  • Richard J Auchus, Elizabeth O Buschur, Alice Y Chang, Gary D Hammer, Carole Ramm, David Madrigal, George Wang, Martha Gonzalez, Xu Steven Xu, Johan W Smit, James Jiao, Margaret K Yu. Abiraterone acetate to lower androgens in women with classic 21-hydroxylase deficiency. The Journal of clinical endocrinology and metabolism. 2014 Aug; 99(8):2763-70. doi: 10.1210/jc.2014-1258. [PMID: 24780050]
  • David J Morris, Syed A Latif, Andrew S Brem. An alternative explanation of hypertension associated with 17α-hydroxylase deficiency syndrome. Steroids. 2014 Jan; 79(?):44-8. doi: 10.1016/j.steroids.2013.10.006. [PMID: 24176792]
  • Cédric Mathieu, Sylvain Milla, S N M Mandiki, Jessica Douxfils, Patrick Kestemont. In vivo response of some immune and endocrine variables to LPS in Eurasian perch (Perca fluviatilis, L.) and modulation of this response by two corticosteroids, cortisol and 11-deoxycorticosterone. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 2014 Jan; 167(?):25-34. doi: 10.1016/j.cbpa.2013.09.006. [PMID: 24041989]
  • Pierre R Provost, Eric Boucher, Yves Tremblay. Glucocorticoid metabolism in the developing lung: adrenal-like synthesis pathway. The Journal of steroid biochemistry and molecular biology. 2013 Nov; 138(?):72-80. doi: 10.1016/j.jsbmb.2013.03.004. [PMID: 23537622]
  • Sri N Batchu, Angie Hughson, Janice Gerloff, Deborah J Fowell, Vyacheslav A Korshunov. Role of Axl in early kidney inflammation and progression of salt-dependent hypertension. Hypertension (Dallas, Tex. : 1979). 2013 Aug; 62(2):302-9. doi: 10.1161/hypertensionaha.113.01382. [PMID: 23774230]
  • Shu Liu, Zhongwen Xie, Alan Daugherty, Lisa A Cassis, Kevin J Pearson, Ming C Gong, Zhenheng Guo. Mineralocorticoid receptor agonists induce mouse aortic aneurysm formation and rupture in the presence of high salt. Arteriosclerosis, thrombosis, and vascular biology. 2013 Jul; 33(7):1568-79. doi: 10.1161/atvbaha.112.300820. [PMID: 23661677]
  • Sandra Schordan, Olaf Grisk, Eric Schordan, Bärbel Miehe, Elisabeth Rumpel, Karlhans Endlich, Jürgen Giebel, Nicole Endlich. OPN deficiency results in severe glomerulosclerosis in uninephrectomized mice. American journal of physiology. Renal physiology. 2013 Jun; 304(12):F1458-70. doi: 10.1152/ajprenal.00615.2012. [PMID: 23552865]
  • Xing-hui Wang, Ling-ling Huang, Ting-ting Yu, Jin-hang Zhu, Bing Shen, Ye Zhang, Hong-zhi Wang, Shan Gao. Effects of oligomeric grape seed proanthocyanidins on heart, aorta, kidney in DOCA-salt mice: role of oxidative stress. Phytotherapy research : PTR. 2013 Jun; 27(6):869-76. doi: 10.1002/ptr.4793. [PMID: 22903376]
  • Cédric Mathieu, Sylvain Milla, S N M Mandiki, Jessica Douxfils, Caroline Douny, Marie-Louise Scippo, Edwin De Pauw, Patrick Kestemont. First evidence of the possible implication of the 11-deoxycorticosterone (DOC) in immune activity of Eurasian perch (Perca fluviatilis, L.): comparison with cortisol. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 2013 Jun; 165(2):149-58. doi: 10.1016/j.cbpa.2013.02.025. [PMID: 23458843]
  • L Kyriakopoulou, M Yazdanpanah, D A Colantonio, M K Chan, C H Daly, K Adeli. A sensitive and rapid mass spectrometric method for the simultaneous measurement of eight steroid hormones and CALIPER pediatric reference intervals. Clinical biochemistry. 2013 May; 46(7-8):642-51. doi: 10.1016/j.clinbiochem.2013.01.002. [PMID: 23337690]
  • Jianping Li, Kevin A Carnevale, Donald J Dipette, Scott C Supowit. Renal protective effects of α-calcitonin gene-related peptide in deoxycorticosterone-salt hypertension. American journal of physiology. Renal physiology. 2013 Apr; 304(7):F1000-8. doi: 10.1152/ajprenal.00434.2012. [PMID: 23389451]
  • Aline M Hilzendeger, Martin D Cassell, Deborah R Davis, Harald M Stauss, Allyn L Mark, Justin L Grobe, Curt D Sigmund. Angiotensin type 1a receptors in the subfornical organ are required for deoxycorticosterone acetate-salt hypertension. Hypertension (Dallas, Tex. : 1979). 2013 Mar; 61(3):716-22. doi: 10.1161/hypertensionaha.111.00356. [PMID: 23266541]
  • J A Bates, S Shott, W D Schall. Lower initial dose desoxycorticosterone pivalate for treatment of canine primary hypoadrenocorticism. Australian veterinary journal. 2013 Mar; 91(3):77-82; discussion 81. doi: 10.1111/avj.12019. [PMID: 23438457]
  • Robert Patrick Davis, Theodora Szasz, Hannah Garver, Robert Burnett, Nathan R Tykocki, Stephanie W Watts. One-month serotonin infusion results in a prolonged fall in blood pressure in the deoxycorticosterone acetate (DOCA) salt hypertensive rat. ACS chemical neuroscience. 2013 Jan; 4(1):141-8. doi: 10.1021/cn300114a. [PMID: 23336053]
  • Britta Veitenheimer, John W Osborn. Effects of intrathecal kynurenate on arterial pressure during chronic osmotic stress in conscious rats. American journal of physiology. Heart and circulatory physiology. 2013 Jan; 304(2):H303-10. doi: 10.1152/ajpheart.00629.2012. [PMID: 23161878]
  • Nilufar Mohebbi, Angelica Perna, Jenny van der Wijst, Helen M Becker, Giovambattista Capasso, Carsten A Wagner. Regulation of two renal chloride transporters, AE1 and pendrin, by electrolytes and aldosterone. PloS one. 2013; 8(1):e55286. doi: 10.1371/journal.pone.0055286. [PMID: 23383138]
  • Theodora Szasz, Robert Patrick Davis, Hannah S Garver, Robert J Burnett, Gregory D Fink, Stephanie W Watts. Long-term inhibition of xanthine oxidase by febuxostat does not decrease blood pressure in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. PloS one. 2013; 8(2):e56046. doi: 10.1371/journal.pone.0056046. [PMID: 23393607]
  • Alexandra E Kulle, Maik Welzel, Paul-Martin Holterhus, Felix G Riepe. Implementation of a liquid chromatography tandem mass spectrometry assay for eight adrenal C-21 steroids and pediatric reference data. Hormone research in paediatrics. 2013; 79(1):22-31. doi: 10.1159/000346406. [PMID: 23328487]
  • Youping Wang, Donna H Wang. Role of substance P in renal injury during DOCA-salt hypertension. Endocrinology. 2012 Dec; 153(12):5972-9. doi: 10.1210/en.2012-1284. [PMID: 23024265]
  • Brett L Jennings, Anne M Estes, Larry J Anderson, Xiao R Fang, Fariborz A Yaghini, Zheng Fan, Frank J Gonzalez, William B Campbell, Kafait U Malik. Cytochrome P450 1B1 gene disruption minimizes deoxycorticosterone acetate-salt-induced hypertension and associated cardiac dysfunction and renal damage in mice. Hypertension (Dallas, Tex. : 1979). 2012 Dec; 60(6):1510-6. doi: 10.1161/hypertensionaha.112.202606. [PMID: 23108654]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Christina S Bartlett, Kelli L Boyd, Raymond C Harris, Roy Zent, Richard M Breyer. EP1 disruption attenuates end-organ damage in a mouse model of hypertension. Hypertension (Dallas, Tex. : 1979). 2012 Nov; 60(5):1184-91. doi: 10.1161/hypertensionaha.112.199026. [PMID: 23006735]
  • Rodrigo Maia de Pádua, Nadine Meitinger, José Dias de Souza Filho, Reiner Waibel, Peter Gmeiner, Fernão Castro Braga, Wolfgang Kreis. Biotransformation of 21-O-acetyl-deoxycorticosterone by cell suspension cultures of Digitalis lanata (strain W.1.4). Steroids. 2012 Nov; 77(13):1373-80. doi: 10.1016/j.steroids.2012.07.016. [PMID: 22917633]
  • Yuying Liu, Grant Bledsoe, Makato Hagiwara, Bo Shen, Lee Chao, Julie Chao. Depletion of endogenous kallistatin exacerbates renal and cardiovascular oxidative stress, inflammation, and organ remodeling. American journal of physiology. Renal physiology. 2012 Oct; 303(8):F1230-8. doi: 10.1152/ajprenal.00257.2012. [PMID: 22811485]
  • J Nelissen, P Lemkens, H Sann, M Bindl, F Bassissi, D Jasserand, J G R De Mey, B J A Janssen. Pharmacokinetic and pharmacodynamic properties of SOL1: a novel dual inhibitor of neutral endopeptidase and endothelin converting enzyme. Life sciences. 2012 Oct; 91(13-14):587-92. doi: 10.1016/j.lfs.2012.01.015. [PMID: 22365954]
  • Xu Ji, Yukiko Naito, Huachun Weng, Kosuke Endo, Xiao Ma, Naoharu Iwai. P2X7 deficiency attenuates hypertension and renal injury in deoxycorticosterone acetate-salt hypertension. American journal of physiology. Renal physiology. 2012 Oct; 303(8):F1207-15. doi: 10.1152/ajprenal.00051.2012. [PMID: 22859404]
  • Kimihiro Kimura, Mamoru Ohkita, Maki Koyama, Yasuo Matsumura. Reduced NO production rapidly aggravates renal function through the NF-κB/ET-1/ETA receptor pathway in DOCA-salt-induced hypertensive rats. Life sciences. 2012 Oct; 91(13-14):644-50. doi: 10.1016/j.lfs.2012.04.022. [PMID: 22569294]
  • Bhupesh Sharma, Nirmal Singh. Defensive effect of natrium diethyldithiocarbamate trihydrate (NDDCT) and lisinopril in DOCA-salt hypertension-induced vascular dementia in rats. Psychopharmacology. 2012 Oct; 223(3):307-17. doi: 10.1007/s00213-012-2718-9. [PMID: 22526544]
  • Emily P McQuarrie, E Marie Freel, Patrick B Mark, Robert Fraser, Rajan K Patel, Henry G Dargie, John M C Connell, Alan G Jardine. Urinary corticosteroid excretion predicts left ventricular mass and proteinuria in chronic kidney disease. Clinical science (London, England : 1979). 2012 Sep; 123(5):285-94. doi: 10.1042/cs20120015. [PMID: 22397469]
  • Kafait U Malik, Brett L Jennings, Fariborz A Yaghini, Seyhan Sahan-Firat, Chi Young Song, Anne M Estes, Xiao R Fang. Contribution of cytochrome P450 1B1 to hypertension and associated pathophysiology: a novel target for antihypertensive agents. Prostaglandins & other lipid mediators. 2012 Aug; 98(3-4):69-74. doi: 10.1016/j.prostaglandins.2011.12.003. [PMID: 22210049]
  • Krishna M Boini, Min Xia, Jing Xiong, Caixia Li, Lori P Payne, Pin-Lan Li. Implication of CD38 gene in podocyte epithelial-to-mesenchymal transition and glomerular sclerosis. Journal of cellular and molecular medicine. 2012 Aug; 16(8):1674-85. doi: 10.1111/j.1582-4934.2011.01462.x. [PMID: 21992601]
  • Pichavaram Prahalathan, Subramanian Kumar, Boobalan Raja. Morin attenuates blood pressure and oxidative stress in deoxycorticosterone acetate-salt hypertensive rats: a biochemical and histopathological evaluation. Metabolism: clinical and experimental. 2012 Aug; 61(8):1087-99. doi: 10.1016/j.metabol.2011.12.012. [PMID: 22386933]
  • Priscila S Guimaraes, Nivia M Santiago, Carlos H Xavier, Elizabeth P P Velloso, Marco A P Fontes, Robson A S Santos, Maria Jose Campagnole-Santos. Chronic infusion of angiotensin-(1-7) into the lateral ventricle of the brain attenuates hypertension in DOCA-salt rats. American journal of physiology. Heart and circulatory physiology. 2012 Aug; 303(3):H393-400. doi: 10.1152/ajpheart.00075.2012. [PMID: 22661512]
  • Chinnadurai Veeramani, Khalid S Al-Numair, Govindasamy Chandramohan, Mohammed A Alsaif, Kodukkur Viswanathan Pugalendi. Protective effect of Melothria maderaspatana leaf fraction on electrolytes, catecholamines, endothelial nitric oxide synthase and endothelin-1 peptide in uninephrectomized deoxycorticosterone acetate-salt hypertensive rats. Journal of natural medicines. 2012 Jul; 66(3):535-43. doi: 10.1007/s11418-011-0621-z. [PMID: 22246664]
  • Bhupesh Sharma, Nirmal Singh. Experimental hypertension induced vascular dementia: pharmacological, biochemical and behavioral recuperation by angiotensin receptor blocker and acetylcholinesterase inhibitor. Pharmacology, biochemistry, and behavior. 2012 Jul; 102(1):101-8. doi: 10.1016/j.pbb.2012.03.029. [PMID: 22507914]
  • Sandeep Tyagi, Saurabh Sharma, Ramji Dass Budhiraja. Effect of phosphatidylinositol 3-kinase-γ inhibitor CAY10505 in hypertension, and its associated vascular endothelium dysfunction in rats. Canadian journal of physiology and pharmacology. 2012 Jul; 90(7):881-5. doi: 10.1139/y2012-089. [PMID: 22731503]
  • Mee-Hwa Lee, Seok Won Park, Tae Ki Yoon, Sung Han Shim. Homozygous CYP17A1 mutation (H373L) identified in a 46,XX female with combined 17α-hydroxylase/17,20-lyase deficiency. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 2012 Jul; 28(7):573-6. doi: 10.3109/09513590.2011.650743. [PMID: 22452398]
  • Yasuhiro Nakamura, Juilee Rege, Fumitoshi Satoh, Ryo Morimoto, Michael R Kennedy, Clarence N Ahlem, Seijiro Honma, Hironobu Sasano, William E Rainey. Liquid chromatography-tandem mass spectrometry analysis of human adrenal vein corticosteroids before and after adrenocorticotropic hormone stimulation. Clinical endocrinology. 2012 Jun; 76(6):778-84. doi: 10.1111/j.1365-2265.2011.04316.x. [PMID: 22150161]
  • Chinnadurai Veeramani, Khalid S Al-Numair, Govindasamy Chandramohan, Mohammed A Alsaif, Kodukkur Viswanathan Pugalendi. Antihyperlipidemic effect of Melothria maderaspatana leaf extracts on DOCA-salt induced hypertensive rats. Asian Pacific journal of tropical medicine. 2012 Jun; 5(6):434-9. doi: 10.1016/s1995-7645(12)60074-1. [PMID: 22575974]
  • Masashi Asanoma, Nobuhiko Tachibana, Motohiko Hirotsuka, Mitsutaka Kohno, Yasuo Watanabe. Effects of soy protein isolate feeding on severe kidney damage in DOCA salt-treated obese Zucker rats. Journal of agricultural and food chemistry. 2012 May; 60(21):5367-72. doi: 10.1021/jf300598a. [PMID: 22553937]
  • Likun Ma, Jinsheng Hua, Lifeng He, Qian Li, Junling Zhou, Jiangtao Yu. Anti-fibrotic effect of Aliskiren in rats with deoxycorticosterone induced myocardial fibrosis and its potential mechanism. Bosnian journal of basic medical sciences. 2012 May; 12(2):69-73. doi: 10.17305/bjbms.2012.2498. [PMID: 22642589]
  • Dan-Dan Chen, Yu-Gang Dong, Hong Yuan, Alex F Chen. Endothelin 1 activation of endothelin A receptor/NADPH oxidase pathway and diminished antioxidants critically contribute to endothelial progenitor cell reduction and dysfunction in salt-sensitive hypertension. Hypertension (Dallas, Tex. : 1979). 2012 May; 59(5):1037-43. doi: 10.1161/hypertensionaha.111.183368. [PMID: 22431579]
  • Therese Koal, Diane Schmiederer, Hai Pham-Tuan, Cornelia Röhring, Manfred Rauh. Standardized LC-MS/MS based steroid hormone profile-analysis. The Journal of steroid biochemistry and molecular biology. 2012 Apr; 129(3-5):129-38. doi: 10.1016/j.jsbmb.2011.12.001. [PMID: 22210511]
  • Chinnadurai Veeramani, Khalid S Al-Numair, Govindasamy Chandramohan, Mohammed A Alsaif, Adel A Alhamdan, Kodukkur Viswanathan Pugalendi. Antihypertensive effect of Melothria maderaspatana leaf fractions on DOCA-salt-induced hypertensive rats and identification of compounds by GC-MS analysis. Journal of natural medicines. 2012 Apr; 66(2):302-10. doi: 10.1007/s11418-011-0590-2. [PMID: 21964566]
  • John N Lorenz, Naomi Oshiro, Elizabeth L Loreaux, Jerry B Lingrel. DOCA-salt hypertension does not require the ouabain-sensitive binding site of the α2 Na,K-ATPase. American journal of hypertension. 2012 Apr; 25(4):421-9. doi: 10.1038/ajh.2011.255. [PMID: 22258333]
  • Susan S Girdler, Monica Lindgren, Patrizia Porcu, David R Rubinow, Jacqueline L Johnson, A Leslie Morrow. A history of depression in women is associated with an altered GABAergic neuroactive steroid profile. Psychoneuroendocrinology. 2012 Apr; 37(4):543-53. doi: 10.1016/j.psyneuen.2011.08.004. [PMID: 21890277]
  • Christian Krebs, Christoph Fraune, Robin Schmidt-Haupt, Jan-Eric Turner, Ulf Panzer, Michael N Quang, Andrea Tannapfel, Joachim Velden, Rolf A Stahl, Ulrich O Wenzel. CCR5 deficiency does not reduce hypertensive end-organ damage in mice. American journal of hypertension. 2012 Apr; 25(4):479-86. doi: 10.1038/ajh.2011.243. [PMID: 22258337]
  • Thangarasu Silambarasan, Boobalan Raja. Diosmin, a bioflavonoid reverses alterations in blood pressure, nitric oxide, lipid peroxides and antioxidant status in DOCA-salt induced hypertensive rats. European journal of pharmacology. 2012 Mar; 679(1-3):81-9. doi: 10.1016/j.ejphar.2011.12.040. [PMID: 22266490]
  • Simon Trent, Alison Dennehy, Heather Richardson, Obah A Ojarikre, Paul S Burgoyne, Trevor Humby, William Davies. Steroid sulfatase-deficient mice exhibit endophenotypes relevant to attention deficit hyperactivity disorder. Psychoneuroendocrinology. 2012 Feb; 37(2):221-9. doi: 10.1016/j.psyneuen.2011.06.006. [PMID: 21723668]
  • María Paz Ocaranza, Jorge E Jalil. Protective Role of the ACE2/Ang-(1-9) Axis in Cardiovascular Remodeling. International journal of hypertension. 2012; 2012(?):594361. doi: 10.1155/2012/594361. [PMID: 22315665]
  • Nadav Ben-Dov, Rafi Korenstein. Enhancement of cell membrane invaginations, vesiculation and uptake of macromolecules by protonation of the cell surface. PloS one. 2012; 7(4):e35204. doi: 10.1371/journal.pone.0035204. [PMID: 22558127]
  • Wolfram Kessler, Stephan Diedrich, Pia Menges, Tobias Ebker, Michael Nielson, Lars Ivo Partecke, Tobias Traeger, Katharina Cziupka, Julia van der Linde, Ralf Puls, Alexandra Busemann, Claus-Dieter Heidecke, Stefan Maier. The role of the vagus nerve: modulation of the inflammatory reaction in murine polymicrobial sepsis. Mediators of inflammation. 2012; 2012(?):467620. doi: 10.1155/2012/467620. [PMID: 22547905]
  • Eun Hui Bae, In Jin Kim, Soo Yeon Joo, Eun Young Kim, Chang Seong Kim, Joon Seok Choi, Seong Kwon Ma, Suhn Hee Kim, Jong Un Lee, Soo Wan Kim. Renoprotective effects of sildenafil in DOCA-salt hypertensive rats. Kidney & blood pressure research. 2012; 36(1):248-57. doi: 10.1159/000343414. [PMID: 23171857]
  • Pichavaram Prahalathan, Murugesan Saravanakumar, Boobalan Raja. The flavonoid morin restores blood pressure and lipid metabolism in DOCA-salt hypertensive rats. Redox report : communications in free radical research. 2012; 17(4):167-75. doi: 10.1179/1351000212y.0000000015. [PMID: 22781105]
  • Lisann Pelzl, Tatsiana Pakladok, Ganesh Pathare, Hajar Fakhri, Diana Michael, Carsten A Wagner, Markus Paulmichl, Florian Lang. DOCA sensitive pendrin expression in kidney, heart, lung and thyroid tissues. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2012; 30(6):1491-501. doi: 10.1159/000343337. [PMID: 23235354]
  • Carrie A Northcott, Jeremy P Glenn, Robert E Shade, Candace M Kammerer, Carmen Hinojosa-Laborde, Gregory D Fink, Joseph R Haywood, Laura A Cox. A custom rat and baboon hypertension gene array to compare experimental models. Experimental biology and medicine (Maywood, N.J.). 2012 Jan; 237(1):99-110. doi: 10.1258/ebm.2011.011188. [PMID: 22228705]
  • Caitlin W Hicks, Daniel A Sweeney, Robert L Danner, Peter Q Eichacker, Anthony F Suffredini, Jing Feng, Junfeng Sun, Ellen N Behrend, Steven B Solomon, Charles Natanson. Efficacy of selective mineralocorticoid and glucocorticoid agonists in canine septic shock. Critical care medicine. 2012 Jan; 40(1):199-207. doi: 10.1097/ccm.0b013e31822efa14. [PMID: 21926575]
  • Zhigang Song, Lei Liu, Ardashir Sheikhahmadi, Hongchao Jiao, Hai Lin. Effect of heat exposure on gene expression of feed intake regulatory peptides in laying hens. Journal of biomedicine & biotechnology. 2012; 2012(?):484869. doi: 10.1155/2012/484869. [PMID: 22619495]