Pyridaben (BioDeep_00000002050)

 

Secondary id: BioDeep_00001867814

human metabolite blood metabolite


代谢物信息卡片


4-Chloro-2-(1,1-dimethylethyl)-5-(((4-(1,1-dimethylethyl)phenyl)methyl)thio)-3(2H)-pyridazinone

化学式: C19H25ClN2OS (364.1376)
中文名称: 哒螨灵
谱图信息: 最多检出来源 Viridiplantae(plant) 20.38%

分子结构信息

SMILES: CC(C)(C)C1=CC=C(C=C1)CSC2=C(C(=O)N(N=C2)C(C)(C)C)Cl
InChI: InChI=1S/C19H25ClN2OS/c1-18(2,3)14-9-7-13(8-10-14)12-24-15-11-21-22(19(4,5)6)17(23)16(15)20/h7-11H,12H2,1-6H3

描述信息

CONFIDENCE standard compound; INTERNAL_ID 331; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 10598; ORIGINAL_PRECURSOR_SCAN_NO 10596
CONFIDENCE standard compound; INTERNAL_ID 331; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 10636; ORIGINAL_PRECURSOR_SCAN_NO 10634
CONFIDENCE standard compound; INTERNAL_ID 331; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 10546; ORIGINAL_PRECURSOR_SCAN_NO 10544
CONFIDENCE standard compound; INTERNAL_ID 331; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 10660; ORIGINAL_PRECURSOR_SCAN_NO 10659
CONFIDENCE standard compound; INTERNAL_ID 331; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 10708; ORIGINAL_PRECURSOR_SCAN_NO 10707
CONFIDENCE standard compound; INTERNAL_ID 331; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 10670; ORIGINAL_PRECURSOR_SCAN_NO 10667
CONFIDENCE standard compound; INTERNAL_ID 2632

同义名列表

7 个代谢物同义名

4-Chloro-2-(1,1-dimethylethyl)-5-(((4-(1,1-dimethylethyl)phenyl)methyl)thio)-3(2H)-pyridazinone; 2-tert-butyl-5-{[(4-tert-butylphenyl)methyl]sulfanyl}-4-chloro-2,3-dihydropyridazin-3-one; 2-Tert-butyl-5-(4-tert-butyl-benzylthio)-4-chloropyridazin-3(2H)-one; Pyridaben; Sanmite; Pyridaben; dADP



数据库引用编号

28 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 AIMP2, ARHGAP45, CAT, CRYZ, CTNNB1, GAD1, HPGDS, MAPK8, ODC1, PIK3CA
Peripheral membrane protein 2 CYP1B1, NDUFS8
Endoplasmic reticulum membrane 1 CYP1B1
Nucleus 6 AIMP2, CTNNB1, MAPK8, PDXK, PPARA, PPARD
cytosol 10 AIMP2, ARHGAP45, CAT, CRYZ, CTNNB1, HPGDS, MAPK8, ODC1, PDXK, PIK3CA
centrosome 1 CTNNB1
nucleoplasm 7 ATP2B1, CTNNB1, HPGDS, MAPK8, PDXK, PPARA, PPARD
Cell membrane 3 ATP2B1, CTNNB1, GPRC5A
lamellipodium 2 CTNNB1, PIK3CA
ruffle membrane 1 ARHGAP45
Multi-pass membrane protein 4 ATP2B1, ATP4A, GPRC5A, MT-CYB
Synapse 3 ATP2B1, CTNNB1, MAPK8
cell cortex 2 CTNNB1, GAD1
cell junction 1 CTNNB1
glutamatergic synapse 2 ATP2B1, CTNNB1
mitochondrial inner membrane 2 MT-CYB, NDUFS8
presynaptic membrane 2 ATP2B1, CTNNB1
Cytoplasm, cytosol 2 AIMP2, PDXK
plasma membrane 7 ARHGAP45, ATP2B1, ATP4A, CTNNB1, GAD1, GPRC5A, PIK3CA
presynaptic active zone 1 GAD1
synaptic vesicle membrane 1 ATP2B1
Membrane 9 AIMP2, ARHGAP45, ATP2B1, ATP4A, CAT, CTNNB1, CYP1B1, MT-CYB, NDUFS8
apical plasma membrane 1 ATP4A
axon 1 MAPK8
basolateral plasma membrane 2 ATP2B1, CTNNB1
extracellular exosome 7 ATP2B1, CAT, CRYZ, CTNNB1, GPRC5A, PDXK, SERPING1
extracellular space 2 ATP4A, SERPING1
perinuclear region of cytoplasm 3 CTNNB1, GAD1, PIK3CA
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 1 CTNNB1
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 1 CTNNB1
intercalated disc 1 PIK3CA
mitochondrion 5 CAT, CRYZ, CYP1B1, MT-CYB, NDUFS8
protein-containing complex 2 CAT, CTNNB1
intracellular membrane-bounded organelle 5 ATP2B1, CAT, CYP1B1, GPRC5A, HPGDS
Microsome membrane 1 CYP1B1
extracellular region 4 ARHGAP45, CAT, PDXK, SERPING1
mitochondrial matrix 2 CAT, NDUFS8
transcription regulator complex 1 CTNNB1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
nucleolus 1 GPRC5A
Wnt signalosome 1 CTNNB1
apical part of cell 1 CTNNB1
cell-cell junction 1 CTNNB1
vesicle 1 GPRC5A
postsynaptic membrane 1 CTNNB1
Apical cell membrane 1 ATP4A
Cell projection, ruffle membrane 1 ARHGAP45
Mitochondrion inner membrane 2 MT-CYB, NDUFS8
Matrix side 1 NDUFS8
Cytoplasm, cytoskeleton 1 CTNNB1
focal adhesion 2 CAT, CTNNB1
GABA-ergic synapse 1 GAD1
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 SERPING1
fascia adherens 1 CTNNB1
lateral plasma membrane 2 ATP2B1, CTNNB1
receptor complex 1 GPRC5A
chromatin 2 PPARA, PPARD
cell projection 1 ATP2B1
cell periphery 1 CTNNB1
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
spindle pole 1 CTNNB1
blood microparticle 1 SERPING1
postsynaptic density, intracellular component 1 CTNNB1
Basolateral cell membrane 1 ATP2B1
microvillus membrane 1 CTNNB1
Endomembrane system 1 CTNNB1
Cytoplasmic vesicle membrane 1 GPRC5A
euchromatin 1 CTNNB1
Presynaptic cell membrane 1 ATP2B1
respiratory chain complex I 1 NDUFS8
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 3 ARHGAP45, CAT, PDXK
endoplasmic reticulum lumen 1 SERPING1
platelet alpha granule lumen 1 SERPING1
axon terminus 1 GAD1
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
specific granule lumen 1 PDXK
beta-catenin-TCF complex 1 CTNNB1
azurophil granule lumen 1 ARHGAP45
immunological synapse 1 ATP2B1
presynaptic active zone cytoplasmic component 1 CTNNB1
vesicle membrane 1 GAD1
respiratory chain complex III 1 MT-CYB
protein-DNA complex 1 CTNNB1
basal dendrite 1 MAPK8
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
catenin complex 1 CTNNB1
inhibitory synapse 1 GAD1
catalase complex 1 CAT
clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane 1 GAD1
photoreceptor ribbon synapse 1 ATP2B1
beta-catenin-TCF7L2 complex 1 CTNNB1
potassium:proton exchanging ATPase complex 1 ATP4A
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA


文献列表

  • Liwen Song, Wenhua Fu, Wenliang Li, Lei Liu, Senshan Wang. The influence of high-temperature frequency variation on the life-history traits of pyridaben-sensitive and -resistant strains of Tetranychus truncatus. Experimental & applied acarology. 2024 Jan; 92(1):109-122. doi: 10.1007/s10493-023-00873-5. [PMID: 38172470]
  • Deng Pan, Menghao Xia, Chuanzhen Li, Xunyan Liu, Lewis Archdeacon, Andrias O O'Reilly, Guorui Yuan, Jinjun Wang, Wei Dou. CYP4CL2 Confers Metabolic Resistance to Pyridaben in the Citrus Pest Mite Panonychus citri. Journal of agricultural and food chemistry. 2023 Dec; 71(49):19465-19474. doi: 10.1021/acs.jafc.3c06921. [PMID: 38048568]
  • Deng Pan, Menghao Xia, Qiujuan Luo, Chuanzhen Li, Guorui Yuan, Jinjun Wang, Wei Dou. Sublethal and transgenerational effects of pyridaben exposure on the fitness and gene expression of Panonychus citri. Pest management science. 2023 Sep; 79(9):3250-3261. doi: 10.1002/ps.7506. [PMID: 37071486]
  • He Chen, Hao Liu, Yanran Ji, Zekun Sha, Li An, Meng Li, Di Zhang, Xujin Wu, Xiude Hua. Monoclonal Antibody-Based Colorimetric Lateral Flow Immunoassay for the Detection of Pyridaben in the Environment. Biosensors. 2023 May; 13(5):. doi: 10.3390/bios13050545. [PMID: 37232906]
  • Deng Pan, Meng-Hao Xia, Qiu-Juan Luo, Xun-Yan Liu, Chuan-Zhen Li, Guo-Rui Yuan, Jin-Jun Wang, Wei Dou. Resistance of Panonychus citri (McGregor) (Acari: Tetranychidae) to pyridaben in China: monitoring and fitness costs. Pest management science. 2023 Mar; 79(3):996-1004. doi: 10.1002/ps.7270. [PMID: 36318043]
  • Yusuke Itoh, Yushi Shimotsuma, Akiya Jouraku, Wannes Dermauw, Thomas Van Leeuwen, Masahiro Osakabe. Combination of target site mutation and associated CYPs confers high-level resistance to pyridaben in Tetranychus urticae. Pesticide biochemistry and physiology. 2022 Feb; 181(?):105000. doi: 10.1016/j.pestbp.2021.105000. [PMID: 35082027]
  • İsmail Döker, Cengiz Kazak. Toxicity and risk assessment of acaricides on the predatory mite, Euseius scutalis (Athias-Henriot) (Acari: Phytoseiidae) under laboratory conditions. Chemosphere. 2020 Dec; 261(?):127760. doi: 10.1016/j.chemosphere.2020.127760. [PMID: 32731029]
  • Mozhgan Hedayati, Amin Sadeghi, Mostafa Maroufpoor, Hamed Ghobari, Ali Güncan. Transgenerational sublethal effects of abamectin and pyridaben on demographic traits of Phytonemus pallidus (Banks) (Acari: Tarsonemidae). Ecotoxicology (London, England). 2019 May; 28(4):467-477. doi: 10.1007/s10646-019-02040-2. [PMID: 30982944]
  • Xiuping Wang, Haicui Xie, Zhenying Wang, Kanglai He. Graphene oxide as a pesticide delivery vector for enhancing acaricidal activity against spider mites. Colloids and surfaces. B, Biointerfaces. 2019 Jan; 173(?):632-638. doi: 10.1016/j.colsurfb.2018.10.010. [PMID: 30368210]
  • Moosa Saber, Zeinab Ahmadi, Gholamreza Mahdavinia. Sublethal effects of spirodiclofen, abamectin and pyridaben on life-history traits and life-table parameters of two-spotted spider mite, Tetranychus urticae (Acari: Tetranychidae). Experimental & applied acarology. 2018 May; 75(1):55-67. doi: 10.1007/s10493-018-0226-2. [PMID: 29520527]
  • Sung-Woo Kim, A M Abd El-Aty, Md Musfiqur Rahman, Jeong-Heui Choi, Ok-Ja Choi, Gyu-Seek Rhee, Moon-Ik Chang, Heejung Kim, Morad D N Abid, Sung Chul Shin, Jae-Han Shim. Detection of pyridaben residue levels in hot pepper fruit and leaves by liquid chromatography-tandem mass spectrometry: effect of household processes. Biomedical chromatography : BMC. 2015 Jul; 29(7):990-7. doi: 10.1002/bmc.3383. [PMID: 25402259]
  • Chong-Yu Liao, Kun Zhang, Jin-Zhi Niu, Tian-Bo Ding, Rui Zhong, Wen-Kai Xia, Wei Dou, Jin-Jun Wang. Identification and characterization of seven glutathione S-transferase genes from citrus red mite, Panonychus citri (McGregor). International journal of molecular sciences. 2013 Dec; 14(12):24255-70. doi: 10.3390/ijms141224255. [PMID: 24351815]
  • Changpeng Zhang, Hua Zhao, Min Wu, Xiuqing Hu, Xiaoming Cai, Lifeng Ping, Zhen Li. Simultaneous determination of procymidone, pyridaben and beta-cypermethrin residues in tea solution by GC-ECD. Journal of chromatographic science. 2012 Nov; 50(10):940-4. doi: 10.1093/chromsci/bms094. [PMID: 22689906]
  • J-Z Niu, W Dou, T-B Ding, G-M Shen, K Zhang, G Smagghe, J-J Wang. Transcriptome analysis of the citrus red mite, Panonychus citri, and its gene expression by exposure to insecticide/acaricide. Insect molecular biology. 2012 Aug; 21(4):422-36. doi: 10.1111/j.1365-2583.2012.01148.x. [PMID: 22676046]
  • Jin-Zhi Niu, Wei Dou, Bao-Jun Wang, Guo-Na Zhang, Rui Zhang, Yi Yin, Jin-Jun Wang. Purification and partial characterization of glutathione S-transferases from three field populations of Panonychus citri (Acari: Tetranychidae). Experimental & applied acarology. 2012 Feb; 56(2):99-111. doi: 10.1007/s10493-011-9498-5. [PMID: 21979304]
  • Song-Hwa Chae, Soon-Il Kim, Seong-Hum Yeon, Si-Woo Lee, Young-Joon Ahn. Adulticidal activity of phthalides identified in Cnidium officinale rhizome to B- and Q-biotypes of Bemisia tabaci. Journal of agricultural and food chemistry. 2011 Aug; 59(15):8193-8. doi: 10.1021/jf201927t. [PMID: 21728333]
  • Qodratollah Sabahi, Arash Rasekh, J P Michaud. Toxicity of three insecticides to Lysiphlebus fabarum, a parasitoid of the black bean aphid, Aphis fabae. Journal of insect science (Online). 2011; 11(?):104. doi: 10.1673/031.011.10401. [PMID: 22221255]
  • Ming-Long Yuan, Dan-Dan Wei, Bao-Jun Wang, Wei Dou, Jin-Jun Wang. The complete mitochondrial genome of the citrus red mite Panonychus citri (Acari: Tetranychidae): high genome rearrangement and extremely truncated tRNAs. BMC genomics. 2010 Oct; 11(?):597. doi: 10.1186/1471-2164-11-597. [PMID: 20969792]
  • Jinfeng Hu, Changfang Wang, Jun Wang, Yong You, Feng Chen. Monitoring of resistance to spirodiclofen and five other acaricides in Panonychus citri collected from Chinese citrus orchards. Pest management science. 2010 Sep; 66(9):1025-30. doi: 10.1002/ps.1978. [PMID: 20540074]
  • Jun Han, Byeoung-Ryeol Choi, Sang-Gyeu Lee, Soon Il Kim, Young-Joon Ahn. Toxicity of plant essential oils to acaricide-susceptible and -resistant Tetranychus urticae (Acari: Tetranychidae) and Neoseiulus californicus (Acari: Phytoseiidae). Journal of economic entomology. 2010 Aug; 103(4):1293-8. doi: 10.1603/ec09222. [PMID: 20857739]
  • Tiantian Mou, Huihui Jing, Wenjiang Yang, Wei Fang, Cheng Peng, Feng Guo, Xianzhong Zhang, Yan Pang, Yunchuan Ma. Preparation and biodistribution of [18F]FP2OP as myocardial perfusion imaging agent for positron emission tomography. Bioorganic & medicinal chemistry. 2010 Feb; 18(3):1312-20. doi: 10.1016/j.bmc.2009.12.022. [PMID: 20056551]
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  • Joachim Audenaert, Marc Vissers, Bart Haleydt, Ruth Verhoeven, Frans Goossens, Bruno Gobin. Acaricides and predatory mites against the begonia mite, Polyphagotarsonemus latus (Acari: Tarsonemidae), on Hedera helix. Communications in agricultural and applied biological sciences. 2009; 74(1):217-24. doi: . [PMID: 20218530]
  • Heike Radeke, Kelley Hanson, Padmaja Yalamanchili, Megan Hayes, Zhi-Qin Zhang, Michael Azure, Ming Yu, Mary Guaraldi, Mikhail Kagan, Simon Robinson, David Casebier. Synthesis and biological evaluation of the mitochondrial complex 1 inhibitor 2-[4-(4-fluorobutyl)benzylsulfanyl]-3-methylchromene-4-one as a potential cardiac positron emission tomography tracer. Journal of medicinal chemistry. 2007 Sep; 50(18):4304-15. doi: 10.1021/jm0701831. [PMID: 17696417]
  • Eunho Suh, Sang-Hyun Koh, Joon-Ho Lee, Key-Il Shin, Kijong Cho. Evaluation of resistance pattern to fenpyroximate and pyridaben in Tetranychus urticae collected from greenhouses and apple orchards using lethal concentration-slope relationship. Experimental & applied acarology. 2006; 38(2-3):151-65. doi: 10.1007/s10493-006-0009-z. [PMID: 16596349]
  • Yijing Cen, Xiongfei Pang, Changbao Xu, Qiaosheng Deng. [Control effects of Mikania micrantha alcohol extract on citrus red mite Panonychus citri]. Ying yong sheng tai xue bao = The journal of applied ecology. 2005 Apr; 16(4):754-7. doi: ". [PMID: 16011182]
  • Gennady Cherednichenko, Aleksey V Zima, Wei Feng, Saul Schaefer, Lothar A Blatter, Isaac N Pessah. NADH oxidase activity of rat cardiac sarcoplasmic reticulum regulates calcium-induced calcium release. Circulation research. 2004 Mar; 94(4):478-86. doi: 10.1161/01.res.0000115554.65513.7c. [PMID: 14699012]