Pyridazine-3,6-diol (BioDeep_00000001803)

 

Secondary id: BioDeep_00001868074

human metabolite blood metabolite


代谢物信息卡片


1,2,3,6-tetrahydropyridazine-3,6-dione

化学式: C4H4N2O2 (112.0273)
中文名称: 甲醇中抑芽丹溶液, 马来酰肼
谱图信息: 最多检出来源 Homo sapiens(blood) 79.27%

分子结构信息

SMILES: C1=CC(=O)NNC1=O
InChI: InChI=1S/C4H4N2O2/c7-3-1-2-4(8)6-5-3/h1-2H,(H,5,7)(H,6,8)

描述信息

D006133 - Growth Substances > D010937 - Plant Growth Regulators
D010575 - Pesticides > D006540 - Herbicides
D016573 - Agrochemicals

同义名列表

10 个代谢物同义名

1,2,3,6-tetrahydropyridazine-3,6-dione; Acid hydrazide, maleic; Hydrazide, maleic acid; Maleic acid hydrazide; Pyridazine-3,6-diol; Hydrazide, maleic; MALEIC HYDRAZIDE; stuntman; Maleic hydrazide; Maleic hydrazide



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ARHGAP45, CAT, NOTCH2, TCHP, TLR2, TLR4
Endosome membrane 1 TLR4
Endoplasmic reticulum membrane 2 NOTCH2, WDR83OS
Nucleus 1 NOTCH2
cytosol 3 ARHGAP45, CAT, TCHP
centrosome 1 TCHP
nucleoplasm 1 NOTCH2
Cell membrane 3 TCHP, TLR4, TNF
ruffle membrane 1 ARHGAP45
Multi-pass membrane protein 2 KCNA3, WDR83OS
cell surface 4 NOTCH2, TLR2, TLR4, TNF
glutamatergic synapse 1 KCNA3
Golgi apparatus 1 TLR2
Golgi membrane 1 NOTCH2
lysosomal membrane 1 CP
neuronal cell body 1 TNF
presynaptic membrane 1 KCNA3
sarcolemma 1 SYNM
plasma membrane 8 ARHGAP45, CP, KCNA3, NOTCH2, TCHP, TLR2, TLR4, TNF
Membrane 7 ARHGAP45, CAT, KCNA3, NOTCH2, TLR2, TLR4, WDR83OS
axon 1 KCNA3
extracellular exosome 3 CAT, CP, VWF
endoplasmic reticulum 1 VWF
extracellular space 3 CP, TNF, VWF
perinuclear region of cytoplasm 2 KCNA3, TLR4
adherens junction 1 SYNM
mitochondrion 2 CAT, TCHP
protein-containing complex 1 CAT
intracellular membrane-bounded organelle 1 CAT
Single-pass type I membrane protein 3 NOTCH2, TLR2, TLR4
Secreted 2 CP, VWF
extracellular region 6 ARHGAP45, CAT, CP, NOTCH2, TNF, VWF
mitochondrial matrix 1 CAT
external side of plasma membrane 2 TLR4, TNF
Secreted, extracellular space, extracellular matrix 1 VWF
Early endosome 1 TLR4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
postsynaptic membrane 1 KCNA3
Cell projection, ruffle membrane 1 ARHGAP45
Membrane raft 3 KCNA3, TLR2, TNF
Cytoplasm, cytoskeleton 1 TCHP
focal adhesion 1 CAT
extracellular matrix 1 VWF
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 VWF
intermediate filament 1 SYNM
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 3 NOTCH2, TLR2, TLR4
cilium 1 NOTCH2
Cytoplasmic vesicle, phagosome membrane 1 TLR2
cell projection 1 TLR2
phagocytic cup 2 TLR4, TNF
phagocytic vesicle membrane 1 TLR2
blood microparticle 1 CP
[Isoform 2]: Cell membrane 1 KCNA3
cell body 1 TLR2
intermediate filament cytoskeleton 1 SYNM
voltage-gated potassium channel complex 1 KCNA3
platelet alpha granule 1 VWF
lipopolysaccharide receptor complex 1 TLR4
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 ARHGAP45, CAT
secretory granule membrane 1 TLR2
endoplasmic reticulum lumen 1 CP
platelet alpha granule lumen 1 VWF
azurophil granule lumen 1 ARHGAP45
calyx of Held 1 KCNA3
costamere 1 SYNM
neurofilament cytoskeleton 1 SYNM
protein folding chaperone complex 1 WDR83OS
[Isoform 1]: Cell membrane 1 KCNA3
keratin filament 1 TCHP
Cell junction, desmosome 1 TCHP
desmosome 1 TCHP
Toll-like receptor 1-Toll-like receptor 2 protein complex 1 TLR2
Toll-like receptor 2-Toll-like receptor 6 protein complex 1 TLR2
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
Weibel-Palade body 1 VWF
apical cortex 1 TCHP
[Isoform 3]: Cytoplasm, perinuclear region 1 KCNA3
multi-pass translocon complex 1 WDR83OS
[Notch 2 extracellular truncation]: Cell membrane 1 NOTCH2
[Notch 2 intracellular domain]: Nucleus 1 NOTCH2
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Dounia Elfadil, Kawtar Saidi, Aziz Amine. Selective extraction of maleic hydrazide in foods using magnetic molecularly imprinted polymers and colorimetric detection via smartphone. Talanta. 2024 Mar; 269(?):125488. doi: 10.1016/j.talanta.2023.125488. [PMID: 38071768]
  • Shaorong Luan, Danni Cai, Dandan Zhang, Chang Hou, Lingling Meng, Jialin Xu, Dongmei Yan, Hongguo Zheng, Qingchun Huang. Real-Time Monitoring of Translocation, Dissipation, and Cumulative Risk of Maleic Hydrazide in Potato Plants and Tubers by Ion Exclusion Chromatography. Journal of agricultural and food chemistry. 2023 Oct; ?(?):. doi: 10.1021/acs.jafc.3c04713. [PMID: 37831971]
  • Jiahuan Wang, Tianyu Gao, Hong Hu, Ling Sun, Shaoqiang Ban, Xiaoyu Tan, Xiaoxue Li, Mingyue Zhu, Yana Tong, Yerong Zhu, Yong Wang. Maleic hydrazide prompting growth and delaying senescence of mother frond in S. Polyrriza 7498. Journal of plant physiology. 2023 May; 284(?):153966. doi: 10.1016/j.jplph.2023.153966. [PMID: 36965290]
  • Adrianna W Bara-Halama, Dominika Idziak-Helmcke, Jolanta Kwasniewska. Unraveling the DNA Methylation in the rDNA Foci in Mutagen-Induced Brachypodium distachyon Micronuclei. International journal of molecular sciences. 2022 Jun; 23(12):. doi: 10.3390/ijms23126797. [PMID: 35743241]
  • Joanna Jaskowiak, Jolanta Kwasniewska, Miriam Szurman-Zubrzycka, Magdalena Rojek-Jelonek, Paul B Larsen, Iwona Szarejko. Al-Tolerant Barley Mutant hvatr.g Shows the ATR-Regulated DNA Damage Response to Maleic Acid Hydrazide. International journal of molecular sciences. 2020 Nov; 21(22):. doi: 10.3390/ijms21228500. [PMID: 33198069]
  • Sanjay K Singh, Mitchell D Richmond, Robert C Pearce, William A Bailey, Xin Hou, Sitakanta Pattanaik, Ling Yuan. Maleic hydrazide elicits global transcriptomic changes in chemically topped tobacco to influence shoot bud development. Planta. 2020 Sep; 252(4):64. doi: 10.1007/s00425-020-03460-9. [PMID: 32968874]
  • Huimin Deng, Zhaoyang Bian, Fei Yang, Shanshan Liu, Zhonghao Li, Ziyan Fan, Ying Wang, Gangling Tang. Use of autoclave extraction and liquid chromatography with tandem mass spectrometry for determination of maleic hydrazide residues in tobacco. Journal of separation science. 2019 Jul; 42(14):2390-2397. doi: 10.1002/jssc.201900250. [PMID: 31038270]
  • Arita Kus, Jolanta Kwasniewska, Joanna Szymanowska-Pulka, Robert Hasterok. Dissecting the chromosomal composition of mutagen-induced micronuclei in Brachypodium distachyon using multicolour FISH. Annals of botany. 2018 12; 122(7):1161-1171. doi: 10.1093/aob/mcy115. [PMID: 29982446]
  • Sonia Sharma, Sushant Sharma, Adarsh Pal Vig. Antigenotoxic potential of plant leaf extracts of Parkinsonia aculeata L. using Allium cepa assay. Plant physiology and biochemistry : PPB. 2018 Sep; 130(?):314-323. doi: 10.1016/j.plaphy.2018.07.017. [PMID: 30036860]
  • Tao Pang, Qian Lin, Yong Li, Junli Shi, Xiaopeng Deng, Guanghui Kong, Xiuping Lu, Yan Jin. [Determination of maleic hydrazide and its glucosides in tobacco leaves using hydrophilic interaction liquid chromatography-tandem mass spectrometry]. Se pu = Chinese journal of chromatography. 2018 Jul; 36(7):651-658. doi: 10.3724/sp.j.1123.2018.01050. [PMID: 30136537]
  • Arita Kus, Jolanta Kwasniewska, Robert Hasterok. Brachypodium distachyon - A Useful Model in the Qualification of Mutagen-Induced Micronuclei Using Multicolor FISH. PloS one. 2017; 12(1):e0170618. doi: 10.1371/journal.pone.0170618. [PMID: 28118403]
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  • Agnieszka Braszewska-Zalewska, Marta Tylikowska, Jolanta Kwasniewska, Joanna Szymanowska-Pulka. Epigenetic chromatin modifications in barley after mutagenic treatment. Journal of applied genetics. 2014 Nov; 55(4):449-56. doi: 10.1007/s13353-014-0226-9. [PMID: 24939040]
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  • Kai Hou, Jun-Wen Chen, Juan-Yuan Zhai, Hao Shen, Li Chen, Wei Wu. [Effect of different plant growth regulators on yield and quality of Angelica dahurica var. formosana development]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2013 Jul; 38(13):2082-5. doi: . [PMID: 24079230]
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  • Claudia Mamani Moreno, Teodoro Stadler, Antônio Alberto da Silva, Luiz C A Barbosa, Maria Eliana L R de Queiroz. Determination of maleic hydrazide residues in garlic bulbs by HPLC. Talanta. 2012 Jan; 89(?):369-76. doi: 10.1016/j.talanta.2011.12.045. [PMID: 22284504]
  • V De Blauwer, K Demeulemeester, A Demeyere, E Hofmans. Maleic hydrazide: sprout suppression of potatoes in the field. Communications in agricultural and applied biological sciences. 2012; 77(3):343-51. doi: . [PMID: 23878989]
  • Anne-Sophie Foltête, Adrien Dhyèvre, Jean-François Férard, Sylvie Cotelle. Improvement of Vicia-micronucleus test for assessment of soil quality: a proposal for international standardization. Chemosphere. 2011 Nov; 85(10):1624-9. doi: 10.1016/j.chemosphere.2011.08.026. [PMID: 21906776]
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  • Anthony S Riggs, David M Borth, David G Tutty, Wan S Yu. Determination of hydrazine in maleic hydrazide technical and pesticide formulations by gas chromatography: collaborative study. Journal of AOAC International. 2008 Jan; 91(1):5-12. doi: . [PMID: 18376580]
  • Jolanta Juchimiuk, Barbara Hering, Jolanta Maluszynska. Multicolour FISH in an analysis of chromosome aberrations induced by N-nitroso-N-methylurea and maleic hydrazide in barley cells. Journal of applied genetics. 2007; 48(2):99-106. doi: 10.1007/bf03194666. [PMID: 17495342]
  • Xi Wang, Long-Xing Tao, Hui-Juan Tan, Xiao-Lin Huang, Chang-Deng Yang. [Inhibitory effects of exogenous abscisic acid and maleic hydrazide on panicle sprouting in hybrid rice F1]. Zhi wu sheng li yu fen zi sheng wu xue xue bao = Journal of plant physiology and molecular biology. 2005 Aug; 31(4):396-402. doi: ". [PMID: 16121011]
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