Trimethoprim (BioDeep_00000001590)

 

Secondary id: BioDeep_00000398393

human metabolite blood metabolite


代谢物信息卡片


5-[(3,4,5-Trimethoxyphenyl)methyl]-2,4-pyrimidinediamine

化学式: C14H18N4O3 (290.1378838)
中文名称: 甲氧苄氨嘧啶, 甲氧苄啶
谱图信息: 最多检出来源 Homo sapiens(blood) 0.35%

Reviewed

Last reviewed on 2024-07-09.

Cite this Page

Trimethoprim. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/trimethoprim (retrieved 2024-11-05) (BioDeep RN: BioDeep_00000001590). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: c1(Cc2c(nc(N)nc2)N)cc(c(OC)c(c1)OC)OC
InChI: InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)

描述信息

A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to pyrimethamine. The interference with folic acid metabolism may cause a depression of hematopoiesis. It is potentiated by sulfonamides and the trimethoprim-sulfamethoxazole combination is the form most often used. It is sometimes used alone as an antimalarial. Trimethoprim resistance has been reported. [PubChem]

Trimethoprim. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=738-70-5 (retrieved 2024-07-09) (CAS RN: 738-70-5). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

同义名列表

7 个代谢物同义名

5-[(3,4,5-Trimethoxyphenyl)methyl]-2,4-pyrimidinediamine; 5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine; 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine; CO-Trimoxazole; trimethoprim; Proloprim; Trimpex



数据库引用编号

42 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(5)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Érika M L Sousa, Marta Otero, María V Gil, Paula Ferreira, Valdemar I Esteves, Vânia Calisto. Evaluation of different functionalization methodologies for improving the removal of three target antibiotics from wastewater by a brewery waste activated carbon. The Science of the total environment. 2024 Feb; 912(?):169437. doi: 10.1016/j.scitotenv.2023.169437. [PMID: 38128671]
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  • Taiwo J Erinle, Martine Boulianne, Deborah Adewole. Red osier dogwood extract vs. trimethoprim-sulfadiazine (Part 2). Pharmacodynamic effects on ileal and cecal microbiota of broiler chickens challenged orally with Salmonella Enteritidis. Poultry science. 2023 Feb; 102(4):102550. doi: 10.1016/j.psj.2023.102550. [PMID: 36854216]
  • Junge Xu, Ziwei Zhang, Junxian Hong, Dong Wang, Gongduan Fan, Jian Zhou, Yingmu Wang. Co-doped Fe3O4/α-FeOOH for highly efficient peroxymonosulfate activation to degrade trimethoprim: Occurrence of hybrid non-radical and radical pathways. Journal of environmental management. 2023 Jan; 325(Pt A):116459. doi: 10.1016/j.jenvman.2022.116459. [PMID: 36244291]
  • Vincenzo Cunsolo, Antonella Di Francesco, Maria Gaetana Giovanna Pittalà, Rosaria Saletti, Salvatore Foti. The TriMet_DB: A Manually Curated Database of the Metabolic Proteins of Triticum aestivum. Nutrients. 2022 Dec; 14(24):. doi: 10.3390/nu14245377. [PMID: 36558536]
  • Klaudia Stando, Aleksandra Czyż, Magdalena Gajda, Ewa Felis, Sylwia Bajkacz. Study of the Phytoextraction and Phytodegradation of Sulfamethoxazole and Trimethoprim from Water by Limnobium laevigatum. International journal of environmental research and public health. 2022 12; 19(24):. doi: 10.3390/ijerph192416994. [PMID: 36554877]
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  • Ronield Fernandez, Nieves R Colás-Ruiz, Gonzalo Martínez-Rodríguez, Pablo A Lara-Martín, Juan Miguel Mancera, Chiara Trombini, Julián Blasco, Miriam Hampel. The antibacterials ciprofloxacin, trimethoprim and sulfadiazine modulate gene expression, biomarkers and metabolites associated with stress and growth in gilthead sea bream (Sparus aurata). Aquatic toxicology (Amsterdam, Netherlands). 2022 Sep; 250(?):106243. doi: 10.1016/j.aquatox.2022.106243. [PMID: 35872527]
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  • Robert T Tessman, Whitney Nolte, Paul Toren, Kim Gibson, Linda Vu, Jennifer Goldman. Simultaneous quantification of trimethoprim metabolites in pediatric plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2022 May; 1198(?):123232. doi: 10.1016/j.jchromb.2022.123232. [PMID: 35428009]
  • Chris Harding, Thomas Chadwick, Tara Homer, Jan Lecouturier, Helen Mossop, Sonya Carnell, Will King, Alaa Abouhajar, Luke Vale, Gillian Watson, Rebecca Forbes, Stephanie Currer, Robert Pickard, Ian Eardley, Ian Pearce, Nikesh Thiruchelvam, Karen Guerrero, Katherine Walton, Zahid Hussain, Henry Lazarowicz, Ased Ali. Methenamine hippurate compared with antibiotic prophylaxis to prevent recurrent urinary tract infections in women: the ALTAR non-inferiority RCT. Health technology assessment (Winchester, England). 2022 05; 26(23):1-172. doi: 10.3310/qoiz6538. [PMID: 35535708]
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  • Đorđe Tadić, Michal Gramblicka, Robert Mistrik, Josep Maria Bayona. Systematic identification of trimethoprim metabolites in lettuce. Analytical and bioanalytical chemistry. 2022 Apr; 414(9):3121-3135. doi: 10.1007/s00216-022-03943-6. [PMID: 35141763]
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  • Duangrudee Tanramluk, Danaya Pakotiprapha, Sakao Phoochaijaroen, Pattra Chantravisut, Sirikanya Thampradid, Jarunee Vanichtanankul, Lalita Narupiyakul, Ruj Akavipat, Jirundon Yuvaniyama. MANORAA: A machine learning platform to guide protein-ligand design by anchors and influential distances. Structure (London, England : 1993). 2022 01; 30(1):181-189.e5. doi: 10.1016/j.str.2021.09.004. [PMID: 34614393]
  • Toshiyuki Murase, Patchara Phuektes, Hiroichi Ozaki, Sunpetch Angkititrakul. Prevalence of qnrS-positive Escherichia coli from chicken in Thailand and possible co-selection of isolates with plasmids carrying qnrS and trimethoprim-resistance genes under farm use of trimethoprim. Poultry science. 2022 Jan; 101(1):101538. doi: 10.1016/j.psj.2021.101538. [PMID: 34788713]
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  • Fahimeh Nematollahi, Tahoora Shomali, Bahman Abdi-Hachesoo, Azizollah Khodakaram-Tafti. Effect of prophylactic vitamin C administration on the efficiency of florfenicol or sulfadiazine-trimethoprim antimicrobial therapy in chickens with staphylococcal arthritis. Tropical animal health and production. 2021 Dec; 54(1):25. doi: 10.1007/s11250-021-03033-2. [PMID: 34957533]
  • Eduardo D Tecuapa-Flores, José Guadalupe Hernández, Pedro Roquero-Tejeda, Jesús A Arenas-Alatorre, Pandiyan Thangarasu. Rapid electrochemical recognition of trimethoprim in human urine samples using new modified electrodes (CPE/Ag/Au NPs) analysing tunable electrode properties: experimental and theoretical studies. The Analyst. 2021 Dec; 146(24):7653-7669. doi: 10.1039/d1an01408k. [PMID: 34806723]
  • Tatsuyuki Yoshii, Choji Oki, Rei Watahiki, Akinobu Nakamura, Kai Tahara, Keiko Kuwata, Toshiaki Furuta, Shinya Tsukiji. Chemo-optogenetic Protein Translocation System Using a Photoactivatable Self-Localizing Ligand. ACS chemical biology. 2021 08; 16(8):1557-1565. doi: 10.1021/acschembio.1c00416. [PMID: 34339163]
  • Erica Memoli, Pietro B Faré, Pietro Camozzi, Giacomo D Simonetti, Mario G Bianchetti, Sebastiano A Lava, Gregorio P Milani. Trimethoprim-associated electrolyte and acid-base abnormalities. Minerva medica. 2021 Aug; 112(4):500-505. doi: 10.23736/s0026-4806.20.06660-4. [PMID: 32697061]
  • Fikret Aydin, Aleksander E P Durumeric, Gabriel C A da Hora, John D M Nguyen, Myong In Oh, Jessica M J Swanson. Improving the accuracy and convergence of drug permeation simulations via machine-learned collective variables. The Journal of chemical physics. 2021 Jul; 155(4):045101. doi: 10.1063/5.0055489. [PMID: 34340389]
  • You Ma, Pei-Kun Yuan, Yu Wu, Xin-Ying Cheng, Han Meng, Huan He, Guo-Xiang Wang, Xue-Ming Chen, Wen-Ming Xie, Li-Min Zhang. The inhibitory effect of in situ extracellular polymeric substances on trimethoprim adsorption by activated sludge. Chemosphere. 2021 Jul; 274(?):129798. doi: 10.1016/j.chemosphere.2021.129798. [PMID: 33540314]
  • U M C Nibamureke, G M Wagenaar. Histopathological changes in Oreochromis mossambicus (Peters, 1852) ovaries after a chronic exposure to a mixture of the HIV drug nevirapine and the antibiotics sulfamethoxazole and trimethoprim. Chemosphere. 2021 Jul; 274(?):129900. doi: 10.1016/j.chemosphere.2021.129900. [PMID: 33979944]
  • Magdi H El Habbal. Combination therapy of zinc and trimethoprim inhibits infection of influenza A virus in chick embryo. Virology journal. 2021 06; 18(1):113. doi: 10.1186/s12985-021-01585-1. [PMID: 34082750]
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  • Jian-Ping Liang, Xiong-Feng Zhou, Zi-Lu Zhao, De-Zheng Yang, Wen-Chun Wang. Degradation of trimethoprim in aqueous by persulfate activated with nanosecond pulsed gas-liquid discharge plasma. Journal of environmental management. 2021 Jan; 278(Pt 2):111539. doi: 10.1016/j.jenvman.2020.111539. [PMID: 33157465]
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