Trimethoprim (BioDeep_00000001590)
Secondary id: BioDeep_00000398393
human metabolite blood metabolite
代谢物信息卡片
5-[(3,4,5-Trimethoxyphenyl)methyl]-2,4-pyrimidinediamine
化学式: C14H18N4O3 (290.1379)
中文名称: 甲氧苄氨嘧啶, 甲氧苄啶
谱图信息:
最多检出来源 Homo sapiens(plant) 24.83%
Reviewed
Last reviewed on 2024-07-09.
Cite this Page
Trimethoprim. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/trimethoprim (retrieved
2024-12-22) (BioDeep RN: BioDeep_00000001590). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: c1(Cc2c(nc(N)nc2)N)cc(c(OC)c(c1)OC)OC
InChI: InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)
描述信息
A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to pyrimethamine. The interference with folic acid metabolism may cause a depression of hematopoiesis. It is potentiated by sulfonamides and the trimethoprim-sulfamethoxazole combination is the form most often used. It is sometimes used alone as an antimalarial. Trimethoprim resistance has been reported. [PubChem]
Trimethoprim. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=738-70-5 (retrieved 2024-07-09) (CAS RN: 738-70-5). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
同义名列表
数据库引用编号
44 个数据库交叉引用编号
- ChEBI: CHEBI:45924
- KEGG: C01965
- KEGGdrug: D00145
- PubChem: 5578
- HMDB: HMDB0014583
- Metlin: METLIN2956
- DrugBank: DB00440
- ChEMBL: CHEMBL22
- Wikipedia: Trimethoprim
- MeSH: Trimethoprim
- chemspider: 5376
- CAS: 738-70-5
- MoNA: EA019914
- MoNA: KO004153
- MoNA: EA019906
- MoNA: EA019911
- MoNA: KO004156
- MoNA: EA019912
- MoNA: KO009282
- MoNA: KO009279
- MoNA: KO004154
- MoNA: KO009281
- MoNA: EA019909
- MoNA: EA019913
- MoNA: KO009278
- MoNA: EA019901
- MoNA: EA019902
- MoNA: EA019908
- MoNA: EA019910
- MoNA: KO004152
- MoNA: KO004155
- MoNA: EA019905
- MoNA: KO009280
- MoNA: EA019907
- MoNA: KO009277
- MoNA: EA019903
- MoNA: EA019904
- PMhub: MS000000813
- PDB-CCD: TOP
- PDB-CCD: TRR
- NIKKAJI: J9.454D
- RefMet: Trimethoprim
- PubChem: 5066
- KNApSAcK: 45924
分类词条
相关代谢途径
Reactome(0)
BioCyc(5)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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Journal of environmental management.
2023 Jan; 325(Pt A):116459. doi:
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American journal of obstetrics and gynecology.
2019 11; 221(5):505.e1-505.e7. doi:
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Journal of medicinal chemistry.
2019 02; 62(3):1562-1576. doi:
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Drug metabolism and pharmacokinetics.
2019 Feb; 34(1):87-94. doi:
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BMJ evidence-based medicine.
2018 12; 23(6):233-234. doi:
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Environmental pollution (Barking, Essex : 1987).
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PLoS medicine.
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The Journal of chemical physics.
2018 Aug; 149(7):072310. doi:
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Pharmacoepidemiology and drug safety.
2018 08; 27(8):949-951. doi:
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Proceedings of the National Academy of Sciences of the United States of America.
2018 06; 115(25):E5726-E5735. doi:
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The Journal of antimicrobial chemotherapy.
2018 06; 73(6):1700-1707. doi:
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Scientific reports.
2018 05; 8(1):8321. doi:
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Bioconjugate chemistry.
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Annals of internal medicine.
2018 05; 168(10):JC58. doi:
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Health technology assessment (Winchester, England).
2018 05; 22(24):1-102. doi:
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Pharmacology research & perspectives.
2018 04; 6(2):e00327. doi:
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Veterinary parasitology.
2018 Mar; 252(?):17-21. doi:
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Drug metabolism and pharmacokinetics.
2018 Feb; 33(1):103-110. doi:
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Journal of agricultural and food chemistry.
2018 Jan; 66(4):822-830. doi:
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Antimicrobial resistance and infection control.
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British journal of biomedical science.
2018 Jan; 75(1):24-29. doi:
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The Journal of antimicrobial chemotherapy.
2018 Jan; 73(1):223-230. doi:
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PloS one.
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International journal of antimicrobial agents.
2018 Jan; 51(1):123-127. doi:
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Microbial drug resistance (Larchmont, N.Y.).
2018 Jan; 24(1):40-47. doi:
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International journal of antimicrobial agents.
2017 Dec; 50(6):707-714. doi:
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Pharmacology research & perspectives.
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British journal of clinical pharmacology.
2017 08; 83(8):1643-1653. doi:
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Food microbiology.
2017 Aug; 65(?):19-24. doi:
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Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria.
2017 May; 41(3):423-424. doi:
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The Science of the total environment.
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PloS one.
2017; 12(6):e0178541. doi:
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Journal of chemical theory and computation.
2016 Oct; 12(10):5157-5169. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
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Journal of veterinary pharmacology and therapeutics.
2016 Oct; 39(5):504-13. doi:
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BMC veterinary research.
2016 Sep; 12(?):209. doi:
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Analytica chimica acta.
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Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.
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Zoonoses and public health.
2016 May; 63(3):241-50. doi:
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British poultry science.
2016 Apr; 57(2):179-84. doi:
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The Journal of pediatrics.
2016 Apr; 171(?):116-21. doi:
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Environmental science & technology.
2016 Mar; 50(5):2573-83. doi:
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American journal of therapeutics.
2016 Mar; 23(2):e382-7. doi:
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Scientific reports.
2016 Feb; 6(?):20370. doi:
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Molecular pharmaceutics.
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
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