Thymidine-5'-monophosphoric acid (BioDeep_00000001465)

 

Secondary id: BioDeep_00000399973

natural product human metabolite PANOMIX_OTCML-2023 Endogenous BioNovoGene_Lab2019


代谢物信息卡片


{[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methoxy}phosphonic acid

化学式: C10H15N2O8P (322.0566)
中文名称: 胸苷-单磷酸, 脱氧胸苷酸, 胸腺嘧啶脱氧核苷酸
谱图信息: 最多检出来源 Homo sapiens(feces) 15.09%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

Thymidine-5'-monophosphoric acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/thymidine-5_-monophosphoric_acid (retrieved 2024-12-23) (BioDeep RN: BioDeep_00000001465). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CC1=CN(C(=O)NC1=O)C2CC(C(O2)COP(=O)(O)O)O
InChI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/t6-,7+,8+/m0/s1

描述信息

5-Thymidylic acid (conjugate base thymidylate), also known as thymidine monophosphate (TMP), deoxythymidine monophosphate (dTMP), or deoxythymidylic acid (conjugate base deoxythymidylate), is a nucleotide that is used as a monomer in DNA. It is an ester of phosphoric acid with the nucleoside thymidine. dTMP consists of a phosphate group, the pentose sugar deoxyribose, and the nucleobase thymine. Unlike the other deoxyribonucleotides, thymidine monophosphate often does not contain the "deoxy" prefix in its name; nevertheless, its symbol often includes a "d" ("dTMP"). 5-Thymidylic acid belongs to the class of organic compounds known as pyrimidine 2-deoxyribonucleoside monophosphates. These are pyrimidine nucleotides with a monophosphate group linked to the ribose moiety lacking a hydroxyl group at position 2. The neutral species of 5-Thymidylic acid (2-deoxythymidine 5-monophosphate). 5-Thymidylic acid exists in all living species, ranging from bacteria to humans. Within humans, 5-thymidylic acid participates in a number of enzymatic reactions. In particular, 5-thymidylic acid and dihydrofolic acid can be biosynthesized from dUMP and 5,10-methylene-THF by the enzyme thymidylate synthase. In addition, 5-thymidylic acid can be converted into dTDP; which is catalyzed by the enzyme thymidylate synthase. In humans, 5-thymidylic acid is involved in pyrimidine metabolism. Outside of the human body, 5-Thymidylic acid has been detected, but not quantified in several different foods, such as common buckwheats, corn salad, garden cress, squashberries, and star fruits.
5-thymidylic acid, also known as thymidylate or thymidine 5-phosphate, is a member of the class of compounds known as pyrimidine 2-deoxyribonucleoside monophosphates. Pyrimidine 2-deoxyribonucleoside monophosphates are pyrimidine nucleotides with a monophosphate group linked to the ribose moiety lacking a hydroxyl group at position 2. 5-thymidylic acid is slightly soluble (in water) and a moderately acidic compound (based on its pKa). 5-thymidylic acid can be found in a number of food items such as burbot, enokitake, scarlet bean, and garland chrysanthemum, which makes 5-thymidylic acid a potential biomarker for the consumption of these food products. 5-thymidylic acid can be found primarily in feces, as well as in human fibroblasts tissue. 5-thymidylic acid exists in all living species, ranging from bacteria to humans. In humans, 5-thymidylic acid is involved in the pyrimidine metabolism. 5-thymidylic acid is also involved in few metabolic disorders, which include beta ureidopropionase deficiency, dihydropyrimidinase deficiency, MNGIE (mitochondrial neurogastrointestinal encephalopathy), and UMP synthase deficiency (orotic aciduria).
Acquisition and generation of the data is financially supported in part by CREST/JST.

同义名列表

48 个代谢物同义名

{[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methoxy}phosphonic acid; Thymidine 5-(dihydrogen phosphoric acid); Deoxyribosylthymine monophosphoric acid; Ribothymidine 5-monophosphoric acid; Thymidine 5-(dihydrogen phosphate); Deoxyribosylthymine monophosphate; 2-Deoxythymidine 5-monophosphate; Deoxythymidine 5-phosphoric acid; Thymidine-5-monophosphoric acid; Deoxythymidine 5-monophosphate; Thymidine monophosphoric acid; Ribothymidine 5-monophosphate; Deoxythymidine monophosphate; Thymidine 5-phosphoric acid; THYMIDINE-5-phosphoric acid; Thymidine-5-monophosphorate; Deoxythymidine 5-phosphate; THYMIDINE 5-MONOPHOSPHATE; Thymidine-5-monophosphate; monoPhosphate, thymidine; Thymidine mononucleotide; Thymidine 5-phosphorate; Thymidine monophosphate; THYMIDINE-5-phosphATE; Thymidine 5-phosphate; Deoxythymidylic acid; Deoxythymydilic acid; Thymidine phosphate; 5-Thymidylic acid; Acids, thymidylic; Deoxythymydilate; Deoxythymidylate; Acid, thymidylic; Thymidylic acids; Thymidylic acid; 5-Methyl-dUMP; 5-Thymidylate; Thymidine 5MP; Thymidylate; Deoxy TMP; 5-dTMP; (DT)1; 5-TMP; dTMP; TMP; Thymidine 5'-monophosphate; Thymideine-monophosphate(dTMP); dTMP



数据库引用编号

34 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(4)

PlantCyc(0)

代谢反应

60 个相关的代谢反应过程信息。

Reactome(15)

BioCyc(11)

WikiPathways(4)

Plant Reactome(0)

INOH(3)

PlantCyc(0)

COVID-19 Disease Map(1)

PathBank(26)

PharmGKB(0)

5 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 CMPK2, DCTD, DTYMK, MTHFD1, MTR, POLB, SHMT1, SHMT2, TK2, TP53, TYMS
Nucleus 9 DTYMK, DUT, POLB, SHMT1, SHMT2, TP53, TRIM33, TYMS, UNG
cytosol 11 CDA, DCTD, DTYMK, MTHFD1, MTHFR, MTR, NT5E, SHMT1, TP53, TYMP, TYMS
dendrite 1 THY1
centrosome 1 TP53
nucleoplasm 8 CMPK2, DUT, NT5E, POLB, SHMT1, TP53, TRIM33, UNG
Cell membrane 2 NT5E, THY1
cell surface 2 NT5E, THY1
glutamatergic synapse 1 THY1
growth cone 1 THY1
mitochondrial inner membrane 2 SHMT2, TYMS
postsynapse 1 THY1
Presynapse 1 THY1
plasma membrane 2 NT5E, THY1
Membrane 3 MTHFD1, NT5E, TP53
apical plasma membrane 1 THY1
extracellular exosome 6 DUT, MTHFD1, NT5E, SHMT1, SHMT2, THY1
endoplasmic reticulum 2 THY1, TP53
extracellular space 1 THPO
mitochondrion 10 CMPK2, DTYMK, DUT, MTHFD1, SHMT1, SHMT2, TK2, TP53, TYMS, UNG
protein-containing complex 2 POLB, TP53
Secreted 1 THPO
extracellular region 3 CDA, THPO, THY1
neuronal cell body membrane 1 THY1
Mitochondrion matrix 2 TP53, TYMS
mitochondrial matrix 5 DTYMK, SHMT2, TK2, TP53, TYMS
transcription regulator complex 1 TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
external side of plasma membrane 2 NT5E, THY1
microtubule cytoskeleton 1 SHMT2
nucleolus 1 TP53
Mitochondrion inner membrane 2 SHMT2, TYMS
Membrane raft 1 THY1
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 1 THY1
microtubule 1 POLB
axolemma 1 THY1
mitochondrial nucleoid 1 SHMT2
Nucleus, PML body 1 TP53
PML body 1 TP53
chromatin 2 TP53, TRIM33
Lipid-anchor, GPI-anchor 2 NT5E, THY1
site of double-strand break 1 TP53
side of membrane 2 NT5E, THY1
germ cell nucleus 1 TP53
replication fork 1 TP53
ficolin-1-rich granule lumen 1 CDA
secretory granule lumen 1 CDA
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
tertiary granule lumen 1 CDA
[Isoform 2]: Nucleus 1 DUT
[Isoform 1]: Nucleus 1 TP53
spindle microtubule 1 POLB
dendrite membrane 1 THY1
[Isoform 3]: Mitochondrion 1 DUT
Mitochondrion matrix, mitochondrion nucleoid 1 SHMT2
BRISC complex 1 SHMT2


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