N-Methylhydantoin (BioDeep_00000001190)

 

Secondary id: BioDeep_00001868378

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


1-Methylimidazolidine-2,4-dione

化学式: C4H6N2O2 (114.0429)
中文名称: 1-甲基乙内酰脲
谱图信息: 最多检出来源 Homo sapiens(blood) 25.28%

分子结构信息

SMILES: CN1CC(=O)NC1=O
InChI: InChI=1S/C4H6N2O2/c1-6-2-3(7)5-4(6)8/h2H2,1H3,(H,5,7,8)

描述信息

N-methylhydantoin is a imidazolidine-2,4-dione that is the N-methyl-derivative of hydantoin. It has a role as a bacterial metabolite. It derives from a hydantoin. N-Methylhydantoin is a small molecular weight polar substance, the product of degradation of creatinine by bacteria (hydrolyzed by creatinine iminohydrolase, EC 3.5.4.21 to ammonia and N-methylhydantoin). In mammals, the metabolism of 1-methylhydantoin occurs via 5-hydroxy-1-methylhydantoin. In a reported human case, 1-Methylhydantoin was found as an unexpected metabolite of the intelligence-affecting substance dupracetam (PMID:15533691, 8287520, 3196760, 7294979).
N-Methylhydantoin is a small molecular weight polar substance, the product of degradation of creatinine by bacteria (hydrolyzed by creatinine iminohydrolase, EC 3.5.4.21 to ammonia and N-methylhydantoin). In mammals, the metabolism of 1-methylhydantoin occurs via 5-hydroxy-1-methylhydantoin. In a reported human case, 1-Methylhydantoin was found as an unexpected metabolite of the intelligence-affecting substance dupracetam. (PMID: 15533691, 8287520, 3196760, 7294979) [HMDB]
KEIO_ID M016
N-Methylhydantoin is a product of degradation of creatinine by bacteria.
N-Methylhydantoin is a product of degradation of creatinine by bacteria.

同义名列表

9 个代谢物同义名

1-Methylimidazolidine-2,4-dione; 1-Methyl-2,4-imidazolidinedione; N-Methylimidazolidine-2,4-dione; 1-Methyldiazolidine-2,4-dione; 1-Methyl-hydantoin; N-Methylhydantoin; 1-Methylhydantoin; Dioxy-creatinine; 1-Methylhydantoin



数据库引用编号

23 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

5 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(5)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ABCB1, ALB, ANXA5, ITPR3, PTGS1, PTGS2, SARDH, TLR2, ZG16B
Peripheral membrane protein 3 ANXA5, PTGS1, PTGS2
Endoplasmic reticulum membrane 3 ITPR3, PTGS1, PTGS2
Nucleus 2 ALB, UNG
cytosol 2 ALB, ANXA5
centrosome 1 ALB
nucleoplasm 2 ITPR3, UNG
Cell membrane 3 ABCB1, TNF, ZG16B
Multi-pass membrane protein 2 ABCB1, ITPR3
Synapse 2 ALDH5A1, TAC1
cell surface 3 ABCB1, TLR2, TNF
Golgi apparatus 3 ALB, PTGS1, TLR2
Golgi membrane 1 INS
neuronal cell body 3 ITPR3, TAC1, TNF
sarcolemma 1 ANXA5
plasma membrane 6 ABCB1, ITPR3, MUC7, TLR2, TNF, ZG16B
Membrane 4 ABCB1, ANXA5, ITPR3, TLR2
apical plasma membrane 1 ABCB1
axon 2 CCK, TAC1
brush border 1 ITPR3
caveola 1 PTGS2
extracellular exosome 6 ABCB1, ALB, ANXA5, MUC7, PTGS1, ZG16B
endoplasmic reticulum 3 ALB, ITPR3, PTGS2
extracellular space 6 ALB, CCK, INS, TAC1, TNF, ZG16B
apicolateral plasma membrane 1 ZG16B
mitochondrion 4 ABAT, ALDH5A1, SARDH, UNG
protein-containing complex 2 ALB, PTGS2
intracellular membrane-bounded organelle 1 PTGS1
Microsome membrane 2 PTGS1, PTGS2
Single-pass type I membrane protein 1 TLR2
Secreted 5 ALB, CCK, INS, MUC7, ZG16B
extracellular region 7 ALB, ANXA5, CCK, INS, TAC1, TNF, ZG16B
Mitochondrion matrix 1 SARDH
mitochondrial matrix 3 ABAT, ALDH5A1, SARDH
anchoring junction 1 ALB
photoreceptor outer segment 1 PTGS1
external side of plasma membrane 2 ANXA5, TNF
nucleolus 1 ITPR3
apical part of cell 1 ITPR3
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 1 ABCB1
Membrane raft 2 TLR2, TNF
focal adhesion 1 ANXA5
sarcoplasmic reticulum 1 ITPR3
collagen-containing extracellular matrix 1 ANXA5
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 2 ITPR3, PTGS2
receptor complex 2 ITPR3, TLR2
Zymogen granule membrane 1 ANXA5
neuron projection 2 PTGS1, PTGS2
ciliary basal body 1 ALB
Cytoplasmic vesicle, phagosome membrane 1 TLR2
cell projection 1 TLR2
phagocytic cup 1 TNF
phagocytic vesicle membrane 1 TLR2
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
Endomembrane system 1 PTGS1
endosome lumen 1 INS
cell body 1 TLR2
secretory granule lumen 1 INS
secretory granule membrane 2 ITPR3, TLR2
Golgi lumen 2 INS, MUC7
endoplasmic reticulum lumen 3 ALB, INS, PTGS2
platelet alpha granule lumen 1 ALB
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
vesicle membrane 1 ANXA5
platelet dense tubular network membrane 1 ITPR3
external side of apical plasma membrane 1 ABCB1
Cytoplasmic vesicle, secretory vesicle membrane 1 ITPR3
Apicolateral cell membrane 1 ZG16B
Toll-like receptor 1-Toll-like receptor 2 protein complex 1 TLR2
Toll-like receptor 2-Toll-like receptor 6 protein complex 1 TLR2
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
transport vesicle membrane 1 ITPR3
endothelial microparticle 1 ANXA5
cytoplasmic side of endoplasmic reticulum membrane 1 ITPR3
ciliary transition fiber 1 ALB
4-aminobutyrate transaminase complex 1 ABAT
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Yang Xu, Fang Wang, Hongye Guo, Shihan Wang, Shuling Ni, Yan Zhou, Zhihan Wang, Huiwei Bao, Yongsheng Wang. Antitussive and Anti-inflammatory Dual-active Agents Developed from Natural Product Lead Compound 1-Methylhydantoin. Molecules (Basel, Switzerland). 2019 Jun; 24(13):. doi: 10.3390/molecules24132355. [PMID: 31247960]
  • Bo Yang, Dong Liu, C Zhu Li, F You Liu, Y Ming Peng, Y Sheng Jiang. 1-Methylhydantoin cytotoxicity on renal proximal tubular cells in vitro. Renal failure. 2007; 29(8):1025-9. doi: 10.1080/08860220701641272. [PMID: 18067051]
  • P Fossati, M Ponti, G Passoni, G Tarenghi, G V Melzi d'Eril, L Prencipe. A step forward in enzymatic measurement of creatinine. Clinical chemistry. 1994 Jan; 40(1):130-7. doi: . [PMID: 8287520]
  • M W Sundberg, R W Becker, T W Esders, J Figueras, C T Goodhue. An enzymic creatinine assay and a direct ammonia assay in coated thin films. Clinical chemistry. 1983 Apr; 29(4):645-9. doi: . [PMID: 6831692]