(6R)-Folinic acid (BioDeep_00000000726)

Main id: BioDeep_00000017460

 

human metabolite PANOMIX_OTCML-2023 blood metabolite


代谢物信息卡片


2-[(4-{[(2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid

化学式: C20H23N7O7 (473.1659)
中文名称: 亚叶酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
InChI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)

描述信息

The active metabolite of folic acid. Leucovorin is used principally as its calcium salt as an antidote to folic acid antagonists which block the conversion of folic acid to folinic acid. [HMDB]
D020011 - Protective Agents > D000931 - Antidotes
C2140 - Adjuvant > C2078 - Folic Acid Derivative
Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity[1].
Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity[1].

同义名列表

53 个代谢物同义名

2-[(4-{[(2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid; 2-[(4-{[(2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid; 2-[[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid; L-N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-Glutamic acid; 5-Formlyl-5,6,7,8-tetrahydrofolate,calcium salt; Leucovorin, calcium (1:1) salt, pentahydrate; Leucovorin, calcium (1:1) salt, (DL)-isomer; L(-)-5-Formyl-5,6,7,8-tetrahydrofolic acid; L(-)-5-Formyl-5,6,7,8-tetrahydrofolate; 5-Formyltetrahydropteroylglutamic acid; N5-Formyl-5,6,7,8-tetrahydrofolic acid; 5-Formyl-5,6,7,8-tetrahydrofolic acid; 5-Formyltetrahydropteroylglutamate; N5-Formyl-5,6,7,8-tetrahydrofolate; 5 Formyltetrahydropteroylglutamate; 5-FORMYL-5,6,7,8-TETRAHYDROFOLATE; 10-Formyl-7,8-dihydrofolic acid; (6R,S)-5-Formyltetrahydrofolate; Leucovorin, calcium (1:1) salt; N5-Formyltetrahydrofolic acid; 5-Formyltetrahydrofolic acid; Leucovorin, monosodium salt; N(5)-Formyltetrahydrofolate; 10-Formyl-7,8-dihydrofolate; Monosodium salt leucovorin; n5-formyltetrahydrofolate; 5-formyltetrahydrofolate; 5 Formyltetrahydrofolate; Leucovorin, (DL)-isomer; Leucovorin, (R)-isomer; Leucovorin, (D)-isomer; Leucovorin, calcium; Factor, citrovorum; Calcium leucovorin; Folinate, calcium; (6R)-Folinic acid; Citrovorum factor; Calcium folinate; Folinic acid-SF; Folinic acid SF; Levoleucovorin; Acid, folinic; Folinic acid; l-Leucovorin; Wellcovorin; Leukovorin; leucovorin; Welcovorin; Rescuvolin; Leukovorum; Folinate; Leucal; Folinic acid



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

18 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(1)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(16)

PharmGKB(0)

4 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ALB, DHFR, DPYD, EGFR, ERBB2, IKZF3, MTHFS, TNK1, TP53, VEGFA
Peripheral membrane protein 1 TNK1
Endosome membrane 2 EGFR, ERBB2
Endoplasmic reticulum membrane 3 CD4, EGFR, UGT1A1
Nucleus 8 ALB, DLST, EGFR, ERBB2, GGH, IKZF3, TP53, VEGFA
cytosol 10 ALB, DHFR, DLST, DPYD, ERBB2, IKZF3, MTHFR, MTHFS, TP53, TYMP
centrosome 2 ALB, TP53
nucleoplasm 4 DLST, ERBB2, IKZF3, TP53
Cell membrane 4 CD4, CD8A, EGFR, ERBB2
ruffle membrane 2 EGFR, ERBB2
Early endosome membrane 1 EGFR
cell junction 1 EGFR
cell surface 2 EGFR, VEGFA
glutamatergic synapse 1 EGFR
Golgi apparatus 2 ALB, VEGFA
Golgi membrane 1 EGFR
neuromuscular junction 1 ERBB2
presynaptic membrane 1 ERBB2
Lysosome 1 GGH
endosome 1 EGFR
plasma membrane 7 CD4, CD8A, EGFR, ERBB2, IFNLR1, TNK1, UGT1A1
Membrane 8 DLST, EGFR, ERBB2, IFNLR1, TNK1, TP53, UGT1A1, VEGFA
apical plasma membrane 2 EGFR, ERBB2
basolateral plasma membrane 2 EGFR, ERBB2
extracellular exosome 2 ALB, GGH
endoplasmic reticulum 4 ALB, TP53, UGT1A1, VEGFA
extracellular space 6 ALB, CSF3, EGFR, GGH, IFNA1, VEGFA
lysosomal lumen 1 CSF3
perinuclear region of cytoplasm 3 EGFR, ERBB2, UGT1A1
adherens junction 1 VEGFA
mitochondrion 4 DHFR, DLST, MTHFS, TP53
protein-containing complex 3 ALB, EGFR, TP53
Single-pass type I membrane protein 5 CD4, CD8A, EGFR, ERBB2, IFNLR1
Secreted 4 ALB, CSF3, IFNA1, VEGFA
extracellular region 6 ALB, CD8A, CSF3, ERBB2, GGH, VEGFA
Single-pass membrane protein 1 UGT1A1
[Isoform 2]: Secreted 1 CD8A
Mitochondrion matrix 2 DLST, TP53
mitochondrial matrix 3 DLST, MTHFS, TP53
anchoring junction 1 ALB
transcription regulator complex 1 TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
nuclear membrane 1 EGFR
external side of plasma membrane 2 CD4, CD8A
Secreted, extracellular space, extracellular matrix 1 VEGFA
cytoplasmic vesicle 1 ERBB2
nucleolus 1 TP53
Early endosome 2 CD4, ERBB2
Cell projection, ruffle membrane 1 ERBB2
Cytoplasm, perinuclear region 2 ERBB2, UGT1A1
Membrane raft 2 CD4, EGFR
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 1 EGFR
extracellular matrix 1 VEGFA
intracellular vesicle 1 EGFR
Nucleus, PML body 1 TP53
PML body 1 TP53
secretory granule 1 VEGFA
receptor complex 3 CD8A, EGFR, ERBB2
ciliary basal body 1 ALB
chromatin 1 TP53
[Isoform 3]: Nucleus 1 IKZF3
centriole 1 ALB
Secreted, extracellular space 1 GGH
spindle pole 1 ALB
blood microparticle 1 ALB
site of double-strand break 1 TP53
Melanosome 1 GGH
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 ERBB2
basal plasma membrane 2 EGFR, ERBB2
synaptic membrane 1 EGFR
plasma membrane raft 1 CD8A
endoplasmic reticulum lumen 2 ALB, CD4
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
platelet alpha granule lumen 2 ALB, VEGFA
specific granule lumen 1 GGH
tertiary granule lumen 1 GGH
azurophil granule lumen 1 GGH
semaphorin receptor complex 1 ERBB2
oxoglutarate dehydrogenase complex 1 DLST
clathrin-coated endocytic vesicle membrane 2 CD4, EGFR
Vacuole 1 GGH
[Isoform 1]: Nucleus 2 IKZF3, TP53
[Isoform 1]: Cell membrane 2 CD8A, ERBB2
oxidoreductase complex 1 DLST
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
endocytic vesicle lumen 1 CSF3
T cell receptor complex 2 CD4, CD8A
ERBB3:ERBB2 complex 1 ERBB2
endoplasmic reticulum chaperone complex 1 UGT1A1
oxoadipate dehydrogenase complex 1 DLST
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
cytochrome complex 1 UGT1A1
[Isoform 12]: Cytoplasm 1 IKZF3
ciliary transition fiber 1 ALB
[Isoform 11]: Nucleus 1 IKZF3
interleukin-28 receptor complex 1 IFNLR1
[Isoform 14]: Nucleus 1 IKZF3


文献列表

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