Vincristine (BioDeep_00000000390)

 

Secondary id: BioDeep_00000398852

human metabolite PANOMIX_OTCML-2023 blood metabolite Chemicals and Drugs natural product


代谢物信息卡片


methyl (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-(methoxycarbonyl)-1,11-diazatetracyclo[13.3.1.0^{4,12}.0^{5,10}]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraene-10-carboxylate

化学式: C46H56N4O10 (824.3996236)
中文名称: 长春新碱
谱图信息: 最多检出来源 Viridiplantae(plant) 0.13%

分子结构信息

SMILES: CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O
InChI: InChI=1S/C46H56N4O10/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3

描述信息

Vincristine appears as a white crystalline solid. Melting point 218 °C. Used as an antineoplastic.
Vincristine is a vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer. It has a role as a tubulin modulator, a microtubule-destabilising agent, a plant metabolite, an antineoplastic agent and a drug. It is a methyl ester, an acetate ester, a tertiary alcohol, a member of formamides, an organic heteropentacyclic compound, an organic heterotetracyclic compound, a tertiary amino compound and a vinca alkaloid. It is a conjugate base of a vincristine(2+). It derives from a hydride of a vincaleukoblastine.
Vincristine is a natural product found in Ophioparma ventosa, Cunila, and other organisms with data available.
Vincristine is a natural alkaloid isolated from the plant Vinca rosea Linn. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. (NCI04)
Vincristine is only found in individuals that have used or taken this drug. It is an antitumor alkaloid isolated from Vinca Rosea. (Merck, 11th ed.) The antitumor activity of Vincristine is thought to be due primarily to inhibition of mitosis at metaphase through its interaction with tubulin. Like other vinca alkaloids, Vincristine may also interfere with: 1) amino acid, cyclic AMP, and glutathione metabolism, 2) calmodulin-dependent Ca2+-transport ATPase activity, 3) cellular respiration, and 4) nucleic acid and lipid biosynthesis. Vincristine is indicated for the treatment of acute leukaemia, malignant lymphoma, Hodgkins disease, acute erythraemia, and acute panmyelosis. Vincristine sulfate is often chosen as part of polychemotherapy because of lack of significant bone marrow suppression (at recommended doses) and of unique clinical toxicity (neuropathy).
An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)
See also: Vincristine Sulfate (active moiety of).
Vincristine is only found in individuals that have used or taken this drug. It is an antitumor alkaloid isolated from Vinca Rosea. (Merck, 11th ed.)The antitumor activity of Vincristine is thought to be due primarily to inhibition of mitosis at metaphase through its interaction with tubulin. Like other vinca alkaloids, Vincristine may also interfere with: 1) amino acid, cyclic AMP, and glutathione metabolism, 2) calmodulin-dependent Ca2+-transport ATPase activity, 3) cellular respiration, and 4) nucleic acid and lipid biosynthesis.
A vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer.
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01C - Plant alkaloids and other natural products > L01CA - Vinca alkaloids and analogues
C274 - Antineoplastic Agent > C1931 - Antineoplastic Plant Product > C932 - Vinca Alkaloid Compound
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C273 - Antimitotic Agent
D050258 - Mitosis Modulators > D050256 - Antimitotic Agents > D050257 - Tubulin Modulators
D000970 - Antineoplastic Agents > D050256 - Antimitotic Agents
D000970 - Antineoplastic Agents > D014748 - Vinca Alkaloids
C1907 - Drug, Natural Product

同义名列表

61 个代谢物同义名

methyl (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-(methoxycarbonyl)-1,11-diazatetracyclo[13.3.1.0^{4,12}.0^{5,10}]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraene-10-carboxylate; methyl (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-(methoxycarbonyl)-1,11-diazatetracyclo[13.3.1.0⁴,¹².0⁵,¹⁰]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.0¹,⁹.0²,⁷.0¹⁶,¹⁹]nonadeca-2,4,6,13-tetraene-10-carboxylate; methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate; Vincaleukoblastine, 22-oxo- 22-Oxovincaleukoblastine; Vincasar (1:1 sulfate salt); OGWKCGZFUXNPDA-XQKSVPLYSA-N; Vincaleukoblastine, 22-oxo-; Vincristine (Leurocristine); Vincrex (1:1 sulfate salt); Oncovin (1:1 sulfate salt); 22-oxo-vincaleukoblastine; Vincristinum (INN-Latin); Vincristinum [INN-Latin]; 22-Oxovincaleukoblastine; 22-Oxovincaleukoblastin; oncovin (brand name); Sulfate, Vincristine; Vincristine Sulfate; Vincristina [DCIT]; Vincristin Bristol; Z-D-Val-lys(Z)-OH; Vincristine (INN); Vincristin medac; (+)-Vincristine; rel-Vincristine; Indole alkaloid; UNII-5J49Q6B70F; Tox21_112067_1; Tecnocris (TN); PFS, Vincasar; Leurocristine; Vincasar PFS; Tox21_112067; Vincristinum; NCI60_026703; Kyocristine; leucristine; cellcristin; Onkocristin; CAS-57-22-7; Vincristina; Vincristine; Vincrystine; vincristin; Vinkristin; Vincrstine; Farmistin; Tecnocris; Vincrisul; Vincasar; Oncovine; Oncovin; L01CA02; Citomid; Oncotcs; Vintec; LCR; VIN; VCR; Vincristine (free base); Vincristine



数据库引用编号

28 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(1)

代谢反应

4 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(2)

COVID-19 Disease Map(0)

PathBank(1)

PharmGKB(0)

23 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ian Stoppa, Chiara Dianzani, Nausicaa Clemente, Annalisa Bozza, Valentina Bordano, Sara Garelli, Luigi Cangemi, Umberto Dianzani, Luigi Battaglia. Alendronate-Grafted Nanoemulsions for Bone-Targeted Vincristine Delivery: Preliminary Studies on Cell and Animal Models. Biomolecules. 2024 Feb; 14(2):. doi: 10.3390/biom14020238. [PMID: 38397475]
  • Jin-Yu Ning, Bo Ma, Jing-Yi Huang, Liang Han, Yan-Hua Shao, Feng-Yun Wang. Integrated network pharmacology and metabolomics reveal the action mechanisms of vincristine combined with celastrol against colon cancer. Journal of pharmaceutical and biomedical analysis. 2024 Feb; 239(?):115883. doi: 10.1016/j.jpba.2023.115883. [PMID: 38044218]
  • Mohammad Rasoul Samandari-Bahraseman, Ahmad Ismaili, Saeed Esmaeili-Mahani, Esmaeil Ebrahimie, Evelin Loit. Bunium Persicum Seeds Extract in Combination with Vincristine Mediates Apoptosis in MCF-7 Cells through Regulation of Involved Genes and Proteins Expression. Anti-cancer agents in medicinal chemistry. 2023 Nov; ?(?):. doi: 10.2174/0118715206277444231124051035. [PMID: 38038013]
  • Rahul Shukla, Ajit Singh, Kamalinder K Singh. Vincristine-based nanoformulations: a preclinical and clinical studies overview. Drug delivery and translational research. 2023 Aug; ?(?):. doi: 10.1007/s13346-023-01389-6. [PMID: 37552393]
  • James M Kelvin, Madison L Chimenti, Dan Y Zhang, Evelyn K Williams, Samuel G Moore, Gabrielle M Humber, Travon A Baxter, Lacey A Birnbaum, Min Qui, Henry Zecca, Aashis Thapa, Juhi Jain, Nathan T Jui, Xiaodong Wang, Haian Fu, Yuhong Du, Melissa L Kemp, Wilbur A Lam, Douglas K Graham, Deborah DeRyckere, Erik C Dreaden. Development of constitutively synergistic nanoformulations to enhance chemosensitivity in T-cell leukemia. Journal of controlled release : official journal of the Controlled Release Society. 2023 Aug; ?(?):. doi: 10.1016/j.jconrel.2023.07.045. [PMID: 37543290]
  • Katalin Nagy, Éva Darkó, Gabriella Szalai, Tibor Janda, Zsuzsa Jókai, Márta Ladányi, Mohamed Ramadan Rady, Mihály Dernovics. UPLC-ESI-QTOF-MS assisted targeted metabolomics to study the enrichment of vinca alkaloids and related metabolites in Catharanthus roseus plants grown under controlled LED environment. Journal of pharmaceutical and biomedical analysis. 2023 Jul; 235(?):115611. doi: 10.1016/j.jpba.2023.115611. [PMID: 37542828]
  • Hossam S El-Beltagi, Salwa M El-Sayed, Ahmed N Abdelhamid, Karim M Hassan, Walaa A Elshalakany, Mona Ibrahim Nossier, Nadiyah M Alabdallah, Nadi Awad Al-Harbi, Salem Mesfir Al-Qahtani, Doaa Bahaa Eldin Darwish, Zahid Khorshid Abbas, Hemmat A Ibrahim. Potentiating Biosynthesis of Alkaloids and Polyphenolic Substances in Catharanthus roseus Plant Using ĸ-Carrageenan. Molecules (Basel, Switzerland). 2023 Apr; 28(8):. doi: 10.3390/molecules28083642. [PMID: 37110876]
  • Suneel Kumar, Nitin Swamy, Hardeep Singh Tuli, Seema Rani, Abhijeet Garg, Deepa Mishra, Hadi Sajid Abdulabbas, Sardul Singh Sandhu. Myricetin: a potential plant-derived anticancer bioactive compound-an updated overview. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Apr; ?(?):. doi: 10.1007/s00210-023-02479-5. [PMID: 37083713]
  • Manish L Raorane, Christina Manz, Sarah Hildebrandt, Marion Mielke, Marc Thieme, Judith Keller, Mirko Bunzel, Peter Nick. Cell type matters: competence for alkaloid metabolism differs in two seed-derived cell strains of Catharanthus roseus. Protoplasma. 2023 Mar; 260(2):349-369. doi: 10.1007/s00709-022-01781-y. [PMID: 35697946]
  • Yuanjian Yang, Liuyu Ding, Ying Zhou, Zizheng Guo, Rongmin Yu, Jianhua Zhu. Establishment of recombinant Catharanthus roseus stem cells stably overexpressing ORCA4 for terpenoid indole alkaloids biosynthesis. Plant physiology and biochemistry : PPB. 2023 Feb; 196(?):783-792. doi: 10.1016/j.plaphy.2023.02.039. [PMID: 36848864]
  • Fei Wang, Luo Lu, HuiJuan Chen, Yanhua Yue, Yanting Sun, Feng Yan, Bai He, Rongrong Lin, Weiying Gu. Altered serum lipid levels are associated with prognosis of diffuse large B cell lymphoma and influenced by utility of rituximab. Annals of hematology. 2023 Feb; 102(2):393-402. doi: 10.1007/s00277-023-05092-x. [PMID: 36670246]
  • Purin Candra Purnama, Leonardo Castellanos Hernandez, Robert Verpoorte. Do Fungicides Affect Alkaloid Production in Catharanthus roseus (L.) G. Don. Seedlings?. Molecules (Basel, Switzerland). 2023 Feb; 28(3):. doi: 10.3390/molecules28031405. [PMID: 36771067]
  • Tomasz Kostrzewa, Izabela Nowak, Agnieszka Feliczak-Guzik, Joanna Drzeżdżon, Dagmara Jacewicz, Magdalena Górska-Ponikowska, Alicja Kuban-Jankowska. Encapsulated Oxovanadium(IV) and Dioxovanadium(V) Complexes into Solid Lipid Nanoparticles Increase Cytotoxicity Against MDA-MB-231 Cell Line. International journal of nanomedicine. 2023; 18(?):2507-2523. doi: 10.2147/ijn.s403689. [PMID: 37197025]
  • Mengwei Xu, Rui Peng, Qing Min, Siwen Hui, Xin Chen, Guang Yang, Shuanglin Qin. Bisindole natural products: A vital source for the development of new anticancer drugs. European journal of medicinal chemistry. 2022 Dec; 243(?):114748. doi: 10.1016/j.ejmech.2022.114748. [PMID: 36170798]
  • Fei Fei, Mingfeng Zhang, Somayeh S Tarighat, Eun Ji Joo, Lu Yang, Nora Heisterkamp. Galectin-1 and Galectin-3 in B-Cell Precursor Acute Lymphoblastic Leukemia. International journal of molecular sciences. 2022 Nov; 23(22):. doi: 10.3390/ijms232214359. [PMID: 36430839]
  • Jawad Khan, Gowhar Ali, Asma Khurshid, Aamer Saeed, Sajjad Ahmad, Najeeb Ullah, Ashrafullah Khan, Robert D Sewell, Muhammad Zakria. Mechanistic efficacy assessment of selected novel methanimine derivatives against vincristine induced Neuropathy: In-vivo, Ex-vivo and In-silico correlates. International immunopharmacology. 2022 Nov; 112(?):109246. doi: 10.1016/j.intimp.2022.109246. [PMID: 36116153]
  • Fanfan Li, Stephen Bordeleau, Kyung Hee Kim, Jonathan Turcotte, Benjamin Davis, Lan Liu, Stéphane Bayen, Vincenzo De Luca, Mehran Dastmalchi. A lesion-mimic mutant of Catharanthus roseus accumulates the opioid agonist, akuammicine. Phytochemistry. 2022 Nov; 203(?):113422. doi: 10.1016/j.phytochem.2022.113422. [PMID: 36055422]
  • Adedoyin O Adefisan, Solomon E Owumi, Kehinde O Soetan, Oluwatosin A Adaramoye. Chloroform extract of Calliandra portoricensis inhibits tumourigenic effect of N-methyl-N-nitrosourea and benzo(a)pyrene in breast experimental cancer. Drug and chemical toxicology. 2022 Nov; 45(6):2424-2438. doi: 10.1080/01480545.2021.1957556. [PMID: 34325589]
  • M Ahmadzadeh, A H Keshtkar, K Moslemkhany, M Ahmadzadeh. Effect of the plant probiotic bacteria on terpenoid indole alkaloid biosynthesis pathway gene expression profiling, vinblastine and vincristine content in the root of Catharanthus roseus. Molecular biology reports. 2022 Nov; 49(11):10357-10365. doi: 10.1007/s11033-022-07841-z. [PMID: 36097118]
  • Narges Soltani, Farhad Nazarian Firouzabadi, Alireza Shafeinia, Masoud Shirali, Ayeh Sadat Sadr. De Novo transcriptome assembly and differential expression analysis of catharanthus roseus in response to salicylic acid. Scientific reports. 2022 10; 12(1):17803. doi: 10.1038/s41598-022-20314-4. [PMID: 36280677]
  • A Mujib, Samar Fatima, Moien Qadir Malik. Cryo-derived plants through embryogenesis showed same levels of vinblastine and vincristine (anticancer) in Catharanthus roseus and had normal genome size. Scientific reports. 2022 10; 12(1):16635. doi: 10.1038/s41598-022-20993-z. [PMID: 36198853]
  • Vivek Jain, Ashutosh Pareek, Yashumati Ratan Bhardwaj, Saurabh Kumar Sinha, Madan Mohan Gupta, Nirmal Singh. Punicalagin and ellagic acid containing Punica granatum L. fruit rind extract prevents vincristine-induced neuropathic pain in rats: an in silico and in vivo evidence of GABAergic action and cytokine inhibition. Nutritional neuroscience. 2022 Oct; 25(10):2149-2166. doi: 10.1080/1028415x.2021.1954293. [PMID: 34369317]
  • A Mujib, Samar Fatima, Moien Qadir Malik. Gamma ray-induced tissue responses and improved secondary metabolites accumulation in Catharanthus roseus. Applied microbiology and biotechnology. 2022 Sep; 106(18):6109-6123. doi: 10.1007/s00253-022-12122-7. [PMID: 35962802]
  • Irene Canales Ruiz, Maurizio Martelli, Laurie H Sehn, Umberto Vitolo, Tina G Nielsen, Gila Sellam, Alessia Bottos, Dirk Klingbiel, Lale Kostakoglu. Baseline Total Metabolic Tumor Volume is Prognostic for Refractoriness to Immunochemotherapy in DLBCL: Results From GOYA. Clinical lymphoma, myeloma & leukemia. 2022 Aug; 22(8):e804-e814. doi: 10.1016/j.clml.2022.04.010. [PMID: 35595618]
  • Naomi Shimizu, Daiji Ngayama, Yasuhiro Watanabe, Takashi Yamaguchi, Shoko Nakamura, Masahiro Ohira, Atsuhito Saiki, Hiroki Onda, Shuhei Yamaoka, Kazuki Abe, Chiaki Nakaseko, Ichiro Tatsuno. Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) therapy increases carotid intima-media thickness and plaque score with von Willebrand factor activity elevation in patients with malignant lymphoma. Journal of chemotherapy (Florence, Italy). 2022 Jul; 34(4):258-263. doi: 10.1080/1120009x.2021.1988202. [PMID: 34661507]
  • Shaghufta Perveen, Naila Safdar, Azra Yasmin, Yamin Bibi. DAT and PRX1 gene expression modulates vincristine production in Catharanthus roseus L. propagates using Cu, Fe and Zn nano structures. Plant science : an international journal of experimental plant biology. 2022 Jul; 320(?):111264. doi: 10.1016/j.plantsci.2022.111264. [PMID: 35643614]
  • Murali M Chintagumpala, Elizabeth J Perlman, Brett Tornwall, Yueh-Yun Chi, Yeonil Kim, Fredric A Hoffer, John A Kalapurakal, Anne B Warwick, Robert C Shamberger, Geetika Khanna, Thomas E Hamilton, Kenneth W Gow, Arnold C Paulino, Eric J Gratias, Elizabeth A Mullen, James I Geller, Conrad V Fernandez, Michael L Ritchey, Paul E Grundy, Jeffrey S Dome, Peter F Ehrlich. Outcomes based on histopathologic response to preoperative chemotherapy in children with bilateral Wilms tumor: A prospective study (COG AREN0534). Cancer. 2022 07; 128(13):2493-2503. doi: 10.1002/cncr.34219. [PMID: 35383900]
  • Hasan Nassereldine, Razan Mohty, Hussein Awada, Iman Abou Dalle, Jean El-Cheikh, Ali Bazarbachi. Mantle cell lymphoma negative for t(11,14) involving the kidneys: a case report. Journal of medical case reports. 2022 Jun; 16(1):254. doi: 10.1186/s13256-022-03470-z. [PMID: 35768844]
  • Yuta Shinohara, Mohamed Elbadawy, Megumi Yamanaka, Haru Yamamoto, Amira Abugomaa, Tatsuya Usui, Kazuaki Sasaki. Effect of the liquid form of traditional Chinese medicine, Hozen-S, on gastric motility in dogs. The Journal of veterinary medical science. 2022 Jun; 84(6):841-846. doi: 10.1292/jvms.21-0644. [PMID: 35473800]
  • L T van der Heijden, A Gebretensae, B Thijssen, L van Andel, A L Nijstad, Y Wang, H Rosing, A D R Huitema, J H Beijnen. A highly sensitive bioanalytical method for the quantification of vinblastine, vincristine, vinorelbine and 4-O-deacetylvinorelbine in human plasma using LC-MS/MS. Journal of pharmaceutical and biomedical analysis. 2022 Jun; 215(?):114772. doi: 10.1016/j.jpba.2022.114772. [PMID: 35462284]
  • Hong-Li Zhang, Adina Uticul, Xiao-Wei Xu, Yu-Wei Shi. [Correlation between Serum miR-34a Level and Thrombocytopenia after Chemotherapy in Patients with Diffuse Large B-Cell Lymphoma]. Zhongguo shi yan xue ye xue za zhi. 2022 Jun; 30(3):784-789. doi: 10.19746/j.cnki.issn.1009-2137.2022.03.020. [PMID: 35680806]
  • Marius Mbiantcha, Raymond Guy Feuya Tchouya, William Nana Yousseu, Donatien Albert Atsamo, Hibrahim Foundikou, Jacques Lebibi, Franklin Gamo Zemo. Scyphocephalione A isolated from the stem bark of Scyphocephalium ochocoa (Myristicaceae) attenuate acute and chronic pain through the antiinflammatory activity. Inflammopharmacology. 2022 Jun; 30(3):991-1003. doi: 10.1007/s10787-022-00966-4. [PMID: 35347522]
  • William Mifsud, Rhoikos Furtwängler, Christian Vokuhl, Ellen D'Hooghe, Kathy Pritchard-Jones, Norbert Graf, Gordan M Vujanić. Treatment of patients with stage I focal anaplastic and diffuse anaplastic Wilms tumour: A report from the SIOP-WT-2001 GPOH and UK-CCLG studies. European journal of cancer (Oxford, England : 1990). 2022 05; 166(?):1-7. doi: 10.1016/j.ejca.2022.01.036. [PMID: 35255331]
  • Mohammed Sedeeq, Ahmed Maklad, Taush Dutta, Zikai Feng, Richard Wilson, Nuri Gueven, Iman Azimi. T-Type Calcium Channel Inhibitors Induce Apoptosis in Medulloblastoma Cells Associated with Altered Metabolic Activity. Molecular neurobiology. 2022 May; 59(5):2932-2945. doi: 10.1007/s12035-022-02771-0. [PMID: 35243582]
  • Mohamed Osman Azzazi, Hany Mohamed Hegab, Amro Mohamed Sedky El-Ghammaz, Heba Mohamed Saber, Youssef Adel Afifi. Impact of serum soluble CD155 level at diagnosis on interim response to CHOP with or without rituximab in diffuse large B cell lymphoma. Clinical and experimental medicine. 2022 May; 22(2):173-181. doi: 10.1007/s10238-021-00741-9. [PMID: 34216302]
  • Kanchan Birat, Tariq Omar Siddiqi, Showkat Rasool Mir, Junaid Aslan, Rakhi Bansal, Washim Khan, Rikeshwer Prasad Dewangan, Bibhu Prasad Panda. Enhancement of vincristine under in vitro culture of Catharanthus roseus supplemented with Alternaria sesami endophytic fungal extract as a biotic elicitor. International microbiology : the official journal of the Spanish Society for Microbiology. 2022 May; 25(2):275-284. doi: 10.1007/s10123-021-00213-w. [PMID: 34622356]
  • Kei Saito, Satoshi Ichikawa, Shunsuke Hatta, Yuna Katsuoka, Hideo Harigae, Tohru Izumi. Vincristine therapy for severe and refractory immune thrombocytopenia following COVID-19 vaccination. Annals of hematology. 2022 04; 101(4):885-887. doi: 10.1007/s00277-021-04666-x. [PMID: 34599382]
  • Vyoma Mistry, Siddhi Darji, Pragya Tiwari, Abhishek Sharma. Engineering Catharanthus roseus monoterpenoid indole alkaloid pathway in yeast. Applied microbiology and biotechnology. 2022 Apr; 106(7):2337-2347. doi: 10.1007/s00253-022-11883-5. [PMID: 35333954]
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