Maslinic acid (BioDeep_00000000171)

 

Secondary id: BioDeep_00000264977

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019 natural product


代谢物信息卡片


(4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,11-Dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydro-2H-picene-4a-carboxylic acid

化学式: C30H48O4 (472.3552)
中文名称: 2α-羟基齐墩果酸, 山楂酸, 马斯里酸, 山楂酸，马斯里酸;
谱图信息: 最多检出来源 Homo sapiens(plant) 15.23%

分子结构信息

SMILES: CC1(C)CCC2(C(=O)O)CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(C)C5CCC43C)C2C1
InChI: InChI=1S/C30H48O4/c1-25(2)12-14-30(24(33)34)15-13-28(6)18(19(30)16-25)8-9-22-27(5)17-20(31)23(32)26(3,4)21(27)10-11-29(22,28)7/h8,19-23,31-32H,9-17H2,1-7H3,(H,33,34)

描述信息

Maslinic acid is a compound derived from dry olive-pomace oil (an olive skin wax) which is a byproduct of olive oil extraction. It is a member of the group of triterpenes known as oleananes.; Maslinic acid is a pentacyclic triterpene, found in the non-glyceride fraction of olive pomace oil (Olive pomace oil, also known as "orujo" olive oil, is a blend of refined-pomace oil and virgin olive oil, fit for human consumption). Pentacyclic triterpenes are natural compounds which are widely distributed in plants. These natural products have been demonstrated to possess anti-inflammatory properties. Triterpenoids have been reported to possess antioxidant properties, since they prevent lipid peroxidation and suppress superoxide anion generation. The triterpenes have a history of medicinal use in many Asian countries. Maslinic acid exhibits both pro- and anti-inflammatory properties depending on chemical structure and dose and may be useful in modulating the immune response; further studies are required to confirm the immunomodulatory behaviour of this triterpenoid, and characterise the mechanisms underlying the biphasic nature of some aspects of the inflammatory response. (PMID: 17292619)
Maslinic acid is a pentacyclic triterpene, found in the non-glyceride fraction of olive pomace oil (Olive pomace oil, also known as "orujo" olive oil, is a blend of refined-pomace oil and virgin olive oil, fit for human consumption). Pentacyclic triterpenes are natural compounds which are widely distributed in plants. These natural products have been demonstrated to possess anti-inflammatory properties. Triterpenoids have been reported to possess antioxidant properties, since they prevent lipid peroxidation and suppress superoxide anion generation. The triterpenes have a history of medicinal use in many Asian countries. Maslinic acid exhibits both pro- and anti-inflammatory properties depending on chemical structure and dose and may be useful in modulating the immune response; further studies are required to confirm the immunomodulatory behaviour of this triterpenoid, and characterise the mechanisms underlying the biphasic nature of some aspects of the inflammatory response. (PMID: 17292619).
Maslinic acid is a pentacyclic triterpenoid that is olean-12-ene substituted by hydroxy groups at positions 2 and 3 and a carboxy group at position 28 (the 2alpha,3beta stereoisomer). It is isolated from Olea europaea and Salvia canariensis and exhibits anti-inflammatory, antioxidant and antineoplastic activity. It has a role as an antioxidant, an antineoplastic agent, an anti-inflammatory agent and a plant metabolite. It is a pentacyclic triterpenoid and a dihydroxy monocarboxylic acid. It derives from a hydride of an oleanane.
Maslinic acid is a natural product found in Chaenomeles speciosa, Salvia tomentosa, and other organisms with data available.
See also: Centaurium erythraea whole (part of).
A pentacyclic triterpenoid that is olean-12-ene substituted by hydroxy groups at positions 2 and 3 and a carboxy group at position 28 (the 2alpha,3beta stereoisomer). It is isolated from Olea europaea and Salvia canariensis and exhibits anti-inflammatory, antioxidant and antineoplastic activity.
Maslinic acid can inhibit the DNA-binding activity of NF-κB p65 and abolish the phosphorylation of IκB-α, which is required for p65 activation.
Maslinic acid can inhibit the DNA-binding activity of NF-κB p65 and abolish the phosphorylation of IκB-α, which is required for p65 activation.

同义名列表

44 个代谢物同义名

(4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,11-Dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydro-2H-picene-4a-carboxylic acid; (4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,11-dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid; (4aS,6aR,6aS,6bR,8aR,10R,11R,12aR,14bS)-10,11-dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid; Olean-12-en-28-oic acid, 2,3-dihydroxy-, (2.alpha.,3.beta.)-; olean-12-en-28-oic acid, 2,3-dihydroxy-, (2alpha, 3beta)-; Olean-12-en-28-oic acid, 2,3-dihydroxy-, (2alpha,3beta)-; (2.alpha.,3.beta.)-2,3-dihydroxy-Olean-12-en-28-oic acid; (2alpha, 3beta)-2,3-dihydroxy-olean-12-en-28-oic acid; (2beta, 3alpha)-2,3-dihydroxy-olean-12-en-28-oic acid; (2alpha,3beta)- 2,3-dihydroxy-Olean-12-en-28-oic acid; (2beta, 3alpha)-2,3-dihydroxyolean-12-en-28-oic acid; (2alpha, 3beta)-2,3-dihydroxyolean-12-en-28-oic acid; (2.alpha.,3.beta.)-2,3-dihydroxy-Olean-12-en-28-oate; (2alpha,3beta)-2,3-dihydroxyolean-12-en-28-oic acid; (2alpha,3beta)- 2,3-dihydroxy-Olean-12-en-28-oate; 2alpha,3beta-dihydroxy-olean-12-en-28-oic acid; 2alpha,3beta-Dihydroxyolean-12-en-28-oic acid; 2alpha,3beta-dihydroxy-12-oleanen-28-oic acid; 2alpha,3beta-dihydroxyurs-12-en-29-oic acid; Crategolic acid;2-Hydroxyoleanolic acid; Maslinic acid, analytical standard; 2.ALPHA.-HYDROXYOLEANOLIC ACID; Maslinic acid, >=98\\% (HPLC); 2alpha-hydroxyoleanolic acid; 2alpha-Hydroxyoleanoic Acid; (R)-4-CHLOROMANDELICACID; 2a-Hydroxyoleanolic acid; 2-hydroxyoleanolic acid; 2a-Hydroxyoleanoic Acid; MASLINIC ACID [INCI]; crataegolic acid; bredemolic acid; crategolic acid; Masilinic acid; Maslinic-acid; Maslinic Acid; Maslinicacid; maslic acid; Crategolate; Masilinate; Maslinate; Maslinic; Crataegolic acid; 2α-Hydroxyoleanolic acid



数据库引用编号

25 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

431 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 ANXA5, BCL2, CASP3, CAT, MAPK14, MAPK8, MTOR, PIK3CA, PTGS2, SIRT1, VEGFA
Peripheral membrane protein 4 ANXA5, GORASP1, MTOR, PTGS2
Endoplasmic reticulum membrane 4 BCL2, HMOX1, MTOR, PTGS2
Nucleus 9 BCL2, CASP3, GABPA, HMOX1, MAPK14, MAPK8, MTOR, SIRT1, VEGFA
cytosol 10 ANXA5, BCL2, CASP3, CAT, HMOX1, MAPK14, MAPK8, MTOR, PIK3CA, SIRT1
dendrite 1 MTOR
phagocytic vesicle 1 MTOR
nucleoplasm 7 CASP3, GABPA, HMOX1, MAPK14, MAPK8, MTOR, SIRT1
Cell membrane 1 TNF
Cytoplasmic side 3 GORASP1, HMOX1, MTOR
lamellipodium 1 PIK3CA
Golgi apparatus membrane 2 GORASP1, MTOR
Synapse 1 MAPK8
cell surface 2 TNF, VEGFA
glutamatergic synapse 2 CASP3, MAPK14
Golgi apparatus 2 GORASP1, VEGFA
Golgi membrane 3 GORASP1, INS, MTOR
lysosomal membrane 2 GAA, MTOR
neuronal cell body 2 CASP3, TNF
sarcolemma 1 ANXA5
Lysosome 2 GAA, MTOR
plasma membrane 3 GAA, PIK3CA, TNF
Membrane 7 ANXA5, BCL2, CAT, GAA, HMOX1, MTOR, VEGFA
axon 1 MAPK8
caveola 1 PTGS2
extracellular exosome 3 ANXA5, CAT, GAA
Lysosome membrane 2 GAA, MTOR
endoplasmic reticulum 4 BCL2, HMOX1, PTGS2, VEGFA
extracellular space 6 CCL2, HMOX1, IL6, INS, TNF, VEGFA
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 2 HMOX1, PIK3CA
adherens junction 1 VEGFA
intercalated disc 1 PIK3CA
mitochondrion 4 BCL2, CAT, MAPK14, SIRT1
protein-containing complex 3 BCL2, CAT, PTGS2
intracellular membrane-bounded organelle 2 CAT, GAA
Microsome membrane 2 MTOR, PTGS2
postsynaptic density 1 CASP3
chromatin silencing complex 1 SIRT1
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Secreted 5 CCL2, GAA, IL6, INS, VEGFA
extracellular region 9 ANXA5, CAT, CCL2, GAA, IL6, INS, MAPK14, TNF, VEGFA
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 3 BCL2, HMOX1, MTOR
mitochondrial matrix 1 CAT
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 ANXA5, TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
nucleolus 1 SIRT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
heterochromatin 1 SIRT1
Membrane raft 1 TNF
pore complex 1 BCL2
focal adhesion 2 ANXA5, CAT
cis-Golgi network 1 GORASP1
extracellular matrix 1 VEGFA
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 2 MTOR, SIRT1
PML body 2 MTOR, SIRT1
collagen-containing extracellular matrix 1 ANXA5
secretory granule 1 VEGFA
nuclear speck 1 MAPK14
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 2 PTGS2, SIRT1
nuclear outer membrane 1 PTGS2
Zymogen granule membrane 1 ANXA5
neuron projection 1 PTGS2
chromatin 2 GABPA, SIRT1
phagocytic cup 1 TNF
spindle pole 1 MAPK14
fibrillar center 1 SIRT1
nuclear envelope 2 MTOR, SIRT1
Endomembrane system 1 MTOR
endosome lumen 1 INS
tertiary granule membrane 1 GAA
euchromatin 1 SIRT1
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 2 CAT, MAPK14
secretory granule lumen 3 CAT, INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 IL6, INS, PTGS2
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
transport vesicle 1 INS
azurophil granule membrane 1 GAA
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 GORASP1, INS
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
Single-pass type IV membrane protein 1 HMOX1
vesicle membrane 1 ANXA5
ficolin-1-rich granule membrane 1 GAA
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
eNoSc complex 1 SIRT1
rDNA heterochromatin 1 SIRT1
Cytoplasmic vesicle, phagosome 1 MTOR
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
endothelial microparticle 1 ANXA5
autolysosome lumen 1 GAA
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
[SirtT1 75 kDa fragment]: Cytoplasm 1 SIRT1


文献列表

  • Kun Yang, Sheng-Bing Wang, Dong Pei, Lu-Mei Pu, Xin-Yi Huang. Effective separation of maslinic acid and oleanolic acid from olive pomace using high-speed shear off-line coupled with high-speed countercurrent chromatography and their antibacterial activity test. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2024 Apr; 1236(?):124069. doi: 10.1016/j.jchromb.2024.124069. [PMID: 38442634]
  • Marta Ramos-Barbero, Eva E Rufino-Palomares, Sergio Serrano-Carmona, Manuel Hernández-Yera, Leticia García-Salguero, José Antonio Lupiáñez, Amalia Pérez-Jiménez. Effect of Nutraceutical Factors on Hepatic Intermediary Metabolism in Wistar Rats with Induced Tendinopathy. International journal of molecular sciences. 2024 Jan; 25(1):. doi: 10.3390/ijms25010629. [PMID: 38203800]
  • Aixa Aguilera-Garrido, Pablo Graván, Saúl A Navarro-Marchal, Marta Medina-O'Donnell, Andrés Parra, María José Gálvez-Ruiz, Juan Antonio Marchal, Francisco Galisteo-González. Maslinic acid solid lipid nanoparticles as hydrophobic anticancer drug carriers: Formulation, in vitro activity and in vivo biodistribution. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Jul; 163(?):114828. doi: 10.1016/j.biopha.2023.114828. [PMID: 37163783]
  • Elisabeta-Irina Geana, Corina Teodora Ciucure, Irina Mirela Apetrei, Maria Lisa Clodoveo, Constantin Apetrei. Discrimination of Olive Oil and Extra-Virgin Olive Oil from Other Vegetable Oils by Targeted and Untargeted HRMS Profiling of Phenolic and Triterpenic Compounds Combined with Chemometrics. International journal of molecular sciences. 2023 Mar; 24(6):. doi: 10.3390/ijms24065292. [PMID: 36982366]
  • Fiammetta Alagna, James Reed, Ornella Calderini, Ramesha Thimmappa, Nicolò G M Cultrera, Alice Cattivelli, Davide Tagliazucchi, Soraya Mousavi, Roberto Mariotti, Anne Osbourn, Luciana Baldoni. OeBAS and CYP716C67 catalyze the biosynthesis of health-beneficial triterpenoids in olive (Olea europaea L.) fruits. The New phytologist. 2023 Mar; ?(?):. doi: 10.1111/nph.18863. [PMID: 36880371]
  • Yan He, Yi Wang, Kun Yang, Jia Jiao, Hong Zhan, Youjun Yang, De Lv, Weihong Li, Weijun Ding. Maslinic Acid: A New Compound for the Treatment of Multiple Organ Diseases. Molecules (Basel, Switzerland). 2022 Dec; 27(24):. doi: 10.3390/molecules27248732. [PMID: 36557864]
  • Lin Wang, Yi-Fu Fan, Bing-Rui Li, Wen-Hui Sun, Li-Na Wang. Maslinic Acid Suppresses High Glucose-induced Inflammation by Epigenetically Inhibiting TXNIP Expression. Current medical science. 2022 Dec; 42(6):1213-1219. doi: 10.1007/s11596-022-2657-6. [PMID: 36350490]
  • Aixa Aguilera-Garrido, Elena Arranz, María José Gálvez-Ruiz, Juan Antonio Marchal, Francisco Galisteo-González, Linda Giblin. Solid lipid nanoparticles to improve bioaccessibility and permeability of orally administered maslinic acid. Drug delivery. 2022 Dec; 29(1):1971-1982. doi: 10.1080/10717544.2022.2086937. [PMID: 35762633]
  • Tianqi Li, Huan Wang, Siyu Dong, Meng Liang, Jun Ma, XiaoWen Jiang, Wenhui Yu. Protective effects of maslinic acid on high fat diet-induced liver injury in mice. Life sciences. 2022 Jul; 301(?):120634. doi: 10.1016/j.lfs.2022.120634. [PMID: 35568228]
  • Lin Li, Lei Lin, Shaoqing Lei, Si Shi, Chun Chen, Zhongyuan Xia. Maslinic Acid Inhibits Myocardial Ischemia-Reperfusion Injury-Induced Apoptosis and Necroptosis via Promoting Autophagic Flux. DNA and cell biology. 2022 May; 41(5):487-497. doi: 10.1089/dna.2021.0918. [PMID: 35475713]
  • Karabo R Matee, Akinjide M Akinnuga, Angezwa Siboto, Phikelelani Ngubane, Andile Khathi. Bredemolic acid restores glucose utilization and attenuates oxidative stress in palmitic acid-induced insulin-resistant C2C12 cells. Endocrine regulations. 2022 Apr; 56(2):126-133. doi: 10.2478/enr-2022-0014. [PMID: 35489052]
  • Akinjide Moses Akinnuga, Angezwa Siboto, Bongiwe Khumalo, Ntethelelo Hopewell Sibiya, Phikelelani Ngubane, Andile Khathi. Evaluation of the effects of bredemolic acid on selected markers of glucose homeostasis in diet-induced prediabetic rats. Archives of physiology and biochemistry. 2022 Apr; 128(2):306-312. doi: 10.1080/13813455.2019.1680697. [PMID: 31686537]
  • Huijuan Gao, Hong Wu. Maslinic acid activates renal AMPK/SIRT1 signaling pathway and protects against diabetic nephropathy in mice. BMC endocrine disorders. 2022 Jan; 22(1):25. doi: 10.1186/s12902-022-00935-6. [PMID: 35042497]
  • Jiuwei Chen, Lin Wang. Maslinic Acid Inhibits Cervical Intraepithelial Neoplasia by Suppressing Interleukin- 6 and Enhancing Apoptosis in a Mouse Model. Anti-cancer agents in medicinal chemistry. 2022; 22(3):579-585. doi: 10.2174/1871520621666210903143922. [PMID: 34477530]
  • Ghassab M Al-Mazaideh, Mohammed Hf Shalayel, Saada Nour, Farhan Khashim Al-Swailmi, Saleem Aladaileh. In silico anti-fungal efficacy and the mechanism of binding of some Syzygium aromaticum ingredient compounds to aspartate semialdehyde dehydrogenase, 6C8W and 6C85, enzymes from Blastomyces dermatitidis. Pakistan journal of pharmaceutical sciences. 2021 Nov; 34(6):2219-2226. doi: . [PMID: 35034884]
  • Hani A Alhadrami, Ahmed M Sayed, Ahmed M Sharif, Esam I Azhar, Mostafa E Rateb. Olive-Derived Triterpenes Suppress SARS COV-2 Main Protease: A Promising Scaffold for Future Therapeutics. Molecules (Basel, Switzerland). 2021 May; 26(9):. doi: 10.3390/molecules26092654. [PMID: 34062737]
  • Khong Trong Quan, Byung Gu Min, In Hyun Hwang, Yeon Jung Choi, Sang Kyum Kim, MinKyun Na. Oleanane triterpenoids from Rubia philippinensis and their inhibitory effect on 20-HETE synthesis. Natural product research. 2021 Apr; 35(8):1267-1273. doi: 10.1080/14786419.2019.1645656. [PMID: 31343260]
  • Lei Yu, Xiaofang Xie, Xiaoyu Cao, Junren Chen, Guanru Chen, Yan Chen, Gangmin Li, Junyuan Qin, Fu Peng, Cheng Peng. The Anticancer Potential of Maslinic Acid and Its Derivatives: A Review. Drug design, development and therapy. 2021; 15(?):3863-3879. doi: 10.2147/dddt.s326328. [PMID: 34526766]
  • Liu Liu, Haobin Li, Kaiwen Hu, Qinglong Xu, Xiaoan Wen, Keguang Cheng, Caiping Chen, Haoliang Yuan, Liang Dai, Hongbin Sun. Synthesis and anti-inflammatory activity of saponin derivatives of δ-oleanolic acid. European journal of medicinal chemistry. 2021 Jan; 209(?):112932. doi: 10.1016/j.ejmech.2020.112932. [PMID: 33131725]
  • Kung-Wen Lu, Mei-Due Yang, Shu-Fen Peng, Jaw-Chyun Chen, Po-Yuan Chen, Hung-Yi Chen, Tai-Jung Lu, Fu-Shin Chueh, Jin-Cherng Lien, Kuang-Chi Lai, Kuo-Ching Liu, Yin-Ying Tai. Maslinic Acid Induces DNA Damage and Impairs DNA Repair in Human Cervical Cancer HeLa Cells. Anticancer research. 2020 Dec; 40(12):6869-6877. doi: 10.21873/anticanres.14709. [PMID: 33288579]
  • Feng Zhang, Jian Huang, Rong-Jing He, Lu Wang, Peng-Chao Huo, Xiao-Qing Guan, Sheng-Quan Fang, Yan-Wei Xiang, Shou-Ning Jia, Guang-Bo Ge. Herb-drug interaction between Styrax and warfarin: Molecular basis and mechanism. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Oct; 77(?):153287. doi: 10.1016/j.phymed.2020.153287. [PMID: 32739573]
  • Rafael de la Torre, Marceli Carbó, Mitona Pujadas, Sarah Biel, María-Dolores Mesa, María-Isabel Covas, Manuela Expósito, Juan-Antonio Espejo, Estefanía Sanchez-Rodriguez, Patricia Díaz-Pellicer, Francisco Jimenez-Valladares, Carmen Rosa, Oscar Pozo, Montserrat Fitó. Pharmacokinetics of maslinic and oleanolic acids from olive oil - Effects on endothelial function in healthy adults. A randomized, controlled, dose-response study. Food chemistry. 2020 Aug; 322(?):126676. doi: 10.1016/j.foodchem.2020.126676. [PMID: 32305871]
  • Su Wen Phang, Bee Kee Ooi, Nafees Ahemad, Wei Hsum Yap. Maslinic acid suppresses macrophage foam cells formation: Regulation of monocyte recruitment and macrophage lipids homeostasis. Vascular pharmacology. 2020 May; 128-129(?):106675. doi: 10.1016/j.vph.2020.106675. [PMID: 32200116]
  • Akinjide Moses Akinnuga, Angezwa Siboto, Bongiwe Khumalo, Ntethelelo Hopewell Sibiya, Phikelelani Ngubane, Andile Khathi. Bredemolic Acid Improves Cardiovascular Function and Attenuates Endothelial Dysfunction in Diet-Induced Prediabetes: Effects on Selected Markers. Cardiovascular therapeutics. 2020; 2020(?):1936406. doi: 10.1155/2020/1936406. [PMID: 32117470]
  • Akinjide Moses Akinnuga, Angezwa Siboto, Bongiwe Khumalo, Ntethelelo Hopewell Sibiya, Phikelelani Ngubane, Andile Khathi. Ameliorative Effects of Bredemolic Acid on Markers Associated with Renal Dysfunction in a Diet-Induced Prediabetic Rat Model. Oxidative medicine and cellular longevity. 2020; 2020(?):2978340. doi: 10.1155/2020/2978340. [PMID: 32655765]
  • Akinjide Moses Akinnuga, Angezwa Siboto, Bongiwe Khumalo, Ntethelelo Hopewell Sibiya, Phikelelani Ngubane, Andile Khathi. Bredemolic Acid Ameliorates Selected Liver Function Biomarkers in a Diet-Induced Prediabetic Rat Model. Canadian journal of gastroenterology & hepatology. 2020; 2020(?):2475301. doi: 10.1155/2020/2475301. [PMID: 32149046]
  • Blessing Nkazimulo Mkhwanazi, Fanie Retief van Heerden, Greanious Alfred Mavondo, Musa Vuyisile Mabandla, Cephas Tagumirwa Musabayane. Triterpene derivative improves the renal function of streptozotocin-induced diabetic rats: a follow-up study on maslinic acid. Renal failure. 2019 Nov; 41(1):547-554. doi: 10.1080/0886022x.2019.1623818. [PMID: 31234683]
  • Chian-Jiun Liou, Yi-Wen Dai, Chia-Ling Wang, Li-Wen Fang, Wen-Chung Huang. Maslinic acid protects against obesity-induced nonalcoholic fatty liver disease in mice through regulation of the Sirt1/AMPK signaling pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019 11; 33(11):11791-11803. doi: 10.1096/fj.201900413rrr. [PMID: 31361524]
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