Paeoniflorin (BioDeep_00000000163)

Main id: BioDeep_00000409317

Secondary id: BioDeep_00000398518

PANOMIX_OTCML-2023 Antitumor activity natural product


代谢物信息卡片


((2S,2aR,2a1S,3aR,4R,5aR)-4-Hydroxy-2-methyl-2a-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexahydro-2H-1,5-dioxa-2,4-methanocyclobuta[cd]pentalen-2a1-yl)methyl benzoate

化学式: C23H28O11 (480.1632)
中文名称: 芍药苷, 芍药甙
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC12CC3(C4CC1(C4(C(O2)O3)COC(=O)C5=CC=CC=C5)OC6C(C(C(C(O6)CO)O)O)O)O
InChI: InChI=1S/C23H28O11/c1-20-9-22(29)13-7-23(20,32-18-16(27)15(26)14(25)12(8-24)31-18)21(13,19(33-20)34-22)10-30-17(28)11-5-3-2-4-6-11/h2-6,12-16,18-19,24-27,29H,7-10H2,1H3

描述信息

Paeoniflorin is a terpene glycoside.
Peoniflorin is under investigation in clinical trial NCT02878863 (Paeoniflorin Combination of Hepatoprotective Drugs Versus Hepatoprotective Drugs Only for Auto-immune Hepatitis).
Paeoniflorin is a natural product found in Paeonia, Paeonia tenuifolia, and other organisms with data available.
See also: Paeonia lactiflora root (part of); Paeonia veitchii root (part of); Paeonia X suffruticosa root bark (part of).
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
Paeoniflorin is a heat shock protein-inducing compound and commonly exists in the plants of Paeoniaceae family, with various biological activities, including anticancer activity, anti-inflammatory activity, enhancing cognition and attenuating learning impairment, anti-oxidative stress, antiplatelet aggregation, expansion of blood vessels, and reducing blood viscosity[1][2][3].
Paeoniflorin is a heat shock protein-inducing compound and commonly exists in the plants of Paeoniaceae family, with various biological activities, including anticancer activity, anti-inflammatory activity, enhancing cognition and attenuating learning impairment, anti-oxidative stress, antiplatelet aggregation, expansion of blood vessels, and reducing blood viscosity[1][2][3].

同义名列表

26 个代谢物同义名

((2S,2aR,2a1S,3aR,4R,5aR)-4-Hydroxy-2-methyl-2a-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexahydro-2H-1,5-dioxa-2,4-methanocyclobuta[cd]pentalen-2a1-yl)methyl benzoate; ((2S,2aR,2a1S,3aR,4R,5aR)-4-Hydroxy-2-methyl-2a-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexahydro-2H-1,5-dioxa-2,4-methanocyclobuta[cd]pentalen-2a1-yl)methylbenzoate; .BETA.-D-GLUCOPYRANOSIDE, 5B-((BENZOYLOXY)METHYL)TETRAHYDRO-5-HYDROXY-2-METHYL-2,5-METHANO-1H-3,4-DIOXACYCLOBUTA(CD)PENTALEN-1A(2H)-YL, (1AR-(1A.ALPHA.,2.BETA.,3A.ALPHA.,5.ALPHA.,5A.ALPHA.,5B.ALPHA.))-; beta-D-Glucopyranoside, 5b-((benzoyloxy)methyl)tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta(cd)pentalen-1a(2H)-yl, (1aR-(1a-alpha,2-beta,3a-alpha,5-alpha,5a-alpha,5b-alpha))-; beta-d-Glucopyranoside, 5b-((benzoyloxy)methyl)tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta(cd)pentalen-1a(2H)-yl, (1aR-(1aalpha,2beta,3aalpha,5alpha,5aalpha,5balpha))-; [(1R,2S,3R,5R,6R,8S)-6-hydroxy-8-methyl-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9,10-dioxatetracyclo[4.3.1.02,5.03,8]decan-2-yl]methyl benzoate; .BETA.-D-GLUCOPYRANOSIDE, (1AR,2S,3AR,5R,5AR,5BS)-5B-((BENZOYLOXY)METHYL)TETRAHYDRO-5-HYDROXY-2-METHYL-2,5-METHANO-1H-3,4-DIOXACYCLOBUTA(CD)PENTALEN-1A(2H)-YL; .beta.-D-Glucopyranoside, (1aR,2S,3aR,5R,5aR,5bS)-5b-[(benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl; beta-D-Glucopyranoside, (1aS,2R,3aR,5R,5aR,5bS)-5b-((benzoyloxy)methyl)tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta(cd)pentalen-1a(2H)-yl; beta-D-GLUCOPYRANOSIDE, (1AR,2S,3AR,5R,5AR,5BS)-5B-((BENZOYLOXY)METHYL)TETRAHYDRO-5-HYDROXY-2-METHYL-2,5-METHANO-1H-3,4-DIOXACYCLOBUTA(CD)PENTALEN-1A(2H)-YL; b-D-Glucopyranoside,(1aR,2S,3aR,5R,5aR,5bS)-5b-[(benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl; 5b-((Benzoyloxy)methyl)tetrahydro-5-hydroxy-2-methyl-2,5-methano-lH-3,4-dioxacyclobuta(cd)pentalen-1a(2H)-yl-beta-D-glucopyranoside; [hydroxy-methyl-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-[?]yl]methyl benzoate; Paeoniflorin, analytical standard; Paeoniflorin, >=98\\% (HPLC); PAEONIFLORIN [USP-RS]; peoniflorin sulfonate; PAEONIFLORIN (USP-RS); PEONIFLORIN [INCI]; UNII-21AIQ4EV64; Paeonia moutan; Paeoniflorin; Peoniflorin; 21AIQ4EV64; 1ST157242; Paeoniflorin



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

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BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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PharmGKB(0)

74 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 AKT1, ANG, BCL2, CASP3, IL13, JAK2, MAPK1, MAPK8, MYD88, PIK3CA, PTGS2, STAT3, TLR4, VEGFA
Peripheral membrane protein 2 JAK2, PTGS2
Endosome membrane 2 MYD88, TLR4
Endoplasmic reticulum membrane 3 BCL2, CD4, PTGS2
Nucleus 10 AKT1, ANG, BCL2, CASP3, JAK2, MAPK1, MAPK8, MYD88, STAT3, VEGFA
cytosol 10 AKT1, ANG, BCL2, CASP3, JAK2, MAPK1, MAPK8, MYD88, PIK3CA, STAT3
dendrite 1 ADORA1
centrosome 1 MAPK1
nucleoplasm 6 AKT1, CASP3, JAK2, MAPK1, MAPK8, STAT3
RNA polymerase II transcription regulator complex 1 STAT3
Cell membrane 4 ADORA1, AKT1, CD4, TLR4
lamellipodium 2 AKT1, PIK3CA
Multi-pass membrane protein 1 ADORA1
Synapse 3 ADORA1, MAPK1, MAPK8
cell cortex 1 AKT1
cell surface 3 MYD88, TLR4, VEGFA
glutamatergic synapse 3 AKT1, CASP3, JAK2
Golgi apparatus 2 MAPK1, VEGFA
Golgi membrane 1 INS
growth cone 1 ANG
neuronal cell body 3 ADORA1, ANG, CASP3
postsynapse 2 AKT1, JAK2
presynaptic membrane 1 ADORA1
plasma membrane 10 ADORA1, AKT1, CD4, IGHE, JAK2, MAPK1, MYD88, PIK3CA, STAT3, TLR4
presynaptic active zone 1 ADORA1
terminal bouton 1 ADORA1
Membrane 5 AKT1, BCL2, JAK2, TLR4, VEGFA
axon 1 MAPK8
basolateral plasma membrane 1 ADORA1
caveola 3 JAK2, MAPK1, PTGS2
endoplasmic reticulum 3 BCL2, PTGS2, VEGFA
extracellular space 7 ANG, IGHE, IL13, IL2, IL4, INS, VEGFA
perinuclear region of cytoplasm 2 PIK3CA, TLR4
adherens junction 1 VEGFA
intercalated disc 1 PIK3CA
mitochondrion 2 BCL2, MAPK1
protein-containing complex 4 AKT1, BCL2, MYD88, PTGS2
Microsome membrane 1 PTGS2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 3 CD4, IGHE, TLR4
Secreted 6 ANG, IL13, IL2, IL4, INS, VEGFA
extracellular region 8 ANG, IGHE, IL13, IL2, IL4, INS, MAPK1, VEGFA
cytoplasmic side of plasma membrane 1 JAK2
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
transcription regulator complex 1 STAT3
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 MAPK1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 3 CD4, IL13, TLR4
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 1 ANG
dendritic spine 1 ADORA1
microtubule cytoskeleton 1 AKT1
nucleolus 1 ANG
Early endosome 3 CD4, MAPK1, TLR4
cell-cell junction 1 AKT1
vesicle 1 AKT1
postsynaptic membrane 1 ADORA1
Membrane raft 2 CD4, JAK2
pore complex 1 BCL2
Cell junction, focal adhesion 1 MAPK1
Cytoplasm, cytoskeleton, spindle 1 MAPK1
focal adhesion 2 JAK2, MAPK1
spindle 2 AKT1, MAPK1
axolemma 1 ADORA1
extracellular matrix 1 VEGFA
basement membrane 1 ANG
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
secretory granule 1 VEGFA
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, ruffle 1 TLR4
Late endosome 1 MAPK1
ruffle 1 TLR4
receptor complex 1 TLR4
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 1 STAT3
IgE immunoglobulin complex 1 IGHE
phagocytic cup 1 TLR4
mitotic spindle 1 MAPK1
Chromosome 1 ANG
cytoskeleton 2 JAK2, MAPK1
Nucleus, nucleolus 1 ANG
[Isoform 2]: Cell membrane 1 IGHE
Endomembrane system 1 JAK2
endosome lumen 2 INS, JAK2
Membrane, caveola 1 MAPK1
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
euchromatin 1 JAK2
myelin sheath 1 BCL2
pseudopodium 1 MAPK1
lipopolysaccharide receptor complex 1 TLR4
ficolin-1-rich granule lumen 1 MAPK1
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 CD4, INS, MAPK1, PTGS2
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
endocytic vesicle 1 ANG
transport vesicle 1 INS
azurophil granule lumen 1 MAPK1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
calyx of Held 1 ADORA1
clathrin-coated endocytic vesicle membrane 1 CD4
extrinsic component of cytoplasmic side of plasma membrane 2 JAK2, MYD88
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
extrinsic component of plasma membrane 2 JAK2, MYD88
granulocyte macrophage colony-stimulating factor receptor complex 1 JAK2
interleukin-12 receptor complex 1 JAK2
interleukin-23 receptor complex 1 JAK2
[Isoform 3]: Cell membrane 1 IGHE
T cell receptor complex 1 CD4
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
angiogenin-PRI complex 1 ANG
asymmetric synapse 1 ADORA1
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA


文献列表

  • Cuicui Xu, Xinke Wang, Jinlong Han, Zhengwei Gu, Qingmei Guo. LMD and LC-MS-based chemical constituents and pharmacological effects assessment for two different processing methods of the root of Paeonia lactiflora Pall. Journal of pharmaceutical and biomedical analysis. 2024 Aug; 245(?):116184. doi: 10.1016/j.jpba.2024.116184. [PMID: 38692214]
  • Tian Li, Na Mao, Zihao Xie, Jianing Wang, Fuyu Jin, Yaqian Li, Shupeng Liu, Wenchen Cai, Xuemin Gao, Zhongqiu Wei, Fang Yang, Hong Xu, Heliang Liu, Haibo Zhang, Dingjie Xu. Paeoniflorin mitigates MMP-12 inflammation in silicosis via Yang-Yin-Qing-Fei Decoction in murine models. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jul; 129(?):155616. doi: 10.1016/j.phymed.2024.155616. [PMID: 38669965]
  • Jialing Sun, Mengqing Ma, Xin Zhong, Jing Li, Jinyu Yi, Renjie Zhang, Xingning Liu, Lanfen Peng, Xinfeng Sun, Wenxing Feng, Rui Hu, Qi Huang, Minling Lv, Kongli Fan, Xiaozhou Zhou. Investigating the molecular mechanism of Qizhu anticancer prescription in inhibiting hepatocellular carcinoma based on high-resolution mass spectrometry and network pharmacology. Journal of ethnopharmacology. 2024 Jun; 328(?):117985. doi: 10.1016/j.jep.2024.117985. [PMID: 38417600]
  • Qiu-Yue Wang, Shu-Yu Liu, Dong-Hua Yu, Ping-Ping Chen, Yu Wang, Fang Lu, Shu-Min Liu. Evaluation of drug interactions of Saposhnikoviae Radix and its major components with astragaloside IV and paeoniflorin using in vitro and in vivo experiments. Journal of chromatography. A. 2024 May; 1723(?):464716. doi: 10.1016/j.chroma.2024.464716. [PMID: 38640881]
  • Tiantai Wu, Huan Zhang, Yang Jin, Ming Zhang, Qing Zhao, Herong Li, Shouli Wang, Yuan Lu, Shuaishuai Chen, Huakang Du, Ting Liu, Weiyu Guo, Wen Liu. The active components and potential mechanisms of Wuji Wan in the treatment of ethanol-induced gastric ulcer: An integrated metabolomics, network pharmacology and experimental validation. Journal of ethnopharmacology. 2024 May; 326(?):117901. doi: 10.1016/j.jep.2024.117901. [PMID: 38341112]
  • Shi-Yi Xu, Hui-Yan Cao, Rui-Hong Yang, Rong-Xue Xu, Xing-Yu Zhu, Wei Ma, Xiu-Bo Liu, Xue-Ying Yan, Peng Fu. Genus Paeonia monoterpene glycosides: A systematic review on their pharmacological activities and molecular mechanisms. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 May; 127(?):155483. doi: 10.1016/j.phymed.2024.155483. [PMID: 38432036]
  • Zixia Zhu, Cong Li, Xiaofan Gu, Xiaoting Wang, Gang Zhang, Meng Fan, Yun Zhao, Xuan Liu, Xiongwen Zhang. Paeoniflorin alleviated muscle atrophy in cancer cachexia through inhibiting TLR4/NF-κB signaling and activating AKT/mTOR signaling. Toxicology and applied pharmacology. 2024 Mar; 484(?):116846. doi: 10.1016/j.taap.2024.116846. [PMID: 38331105]
  • Hongxiao Xie, Zhiqiang Xie, Fei Luan, Jiuseng Zeng, Xiumeng Zhang, Li Chen, Nan Zeng, Rong Liu. Potential therapeutic effects of Chinese herbal medicine in postpartum depression: Mechanisms and future directions. Journal of ethnopharmacology. 2024 Jan; 324(?):117785. doi: 10.1016/j.jep.2024.117785. [PMID: 38262525]
  • Haowei Wu, Peipei Zhang, Jiedong Zhou, Songqing Hu, Jinjin Hao, Zuoquan Zhong, Haiju Yu, Juntao Yang, Hangyuan Guo, Jufang Chi. Paeoniflorin confers ferroptosis resistance by regulating the gut microbiota and its metabolites in diabetic cardiomyopathy. American journal of physiology. Cell physiology. 2024 Jan; ?(?):. doi: 10.1152/ajpcell.00565.2023. [PMID: 38223927]
  • Dan Liang, Lu Liu, Yulin Qi, Feng Nan, Ju Huang, Shiyun Tang, Jianyuan Tang, Nianzhi Chen. Jin-Gui-Shen-Qi Wan alleviates fibrosis in mouse diabetic nephropathy via MHC class II. Journal of ethnopharmacology. 2024 Jan; 324(?):117745. doi: 10.1016/j.jep.2024.117745. [PMID: 38228231]
  • Yaoyao Xiao, Lele Zhou, Wenkang Tao, Xuan Yang, Junying Li, Rulin Wang, Yanan Zhao, Can Peng, Caiyun Zhang. Preparation of paeoniflorin-glycyrrhizic acid complex transethosome gel and its preventive and therapeutic effects on melasma. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2024 Jan; 192(?):106664. doi: 10.1016/j.ejps.2023.106664. [PMID: 38061662]
  • Yong Jiang, Liu Xu, Nina Wei, Rui Chen, Yutong Wang, Li Wu, Weidong Li, Zheng Yan, Linwei Chen, Zhipeng Chen. Comparative pharmacokinetics of 11 major bioactive components between two dosage forms of Qixue Shuangbu Prescription in rats by ultra-high-performance liquid chromatography-tandem mass spectrometry. Journal of separation science. 2024 Jan; 47(1):e2300677. doi: 10.1002/jssc.202300677. [PMID: 37994256]
  • Qingchang Wu, Miao Chen, Yao Li, Xiangyun Zhao, Cailian Fan, Yi Dai. Paeoniflorin Alleviates Cisplatin-Induced Diminished Ovarian Reserve by Restoring the Function of Ovarian Granulosa Cells via Activating FSHR/cAMP/PKA/CREB Signaling Pathway. Molecules (Basel, Switzerland). 2023 Dec; 28(24):. doi: 10.3390/molecules28248123. [PMID: 38138611]
  • Shasha Liu, Ying Li, Caojie Wu. Paeoniflorin suppresses the apoptosis and inflammation of human coronary artery endothelial cells induced by oxidized low-density lipoprotein by regulating the Wnt/β-catenin pathway. Pharmaceutical biology. 2023 Dec; 61(1):1454-1461. doi: 10.1080/13880209.2023.2220360. [PMID: 37674320]
  • Ruo Man Wu, Chun Yan Wang, Jie Wang, Xiao Le Xu. Promoting reverse cholesterol transport contributes to the amelioration of atherosclerosis by paeoniflorin. European journal of pharmacology. 2023 Nov; 961(?):176137. doi: 10.1016/j.ejphar.2023.176137. [PMID: 37939989]
  • Li-Ling Si, Lu Niu, Xiao-Yan Wang, Hui Zhang, Ming-Liang Zhang, Shuang Xu, Xian-Qing Ren, Jin-Fa Tang, Wei-Xia Li. [Comparison of distribution of eight components from Liangxue Tuizi Mixture between normal and Henoch-Schonlein purpura rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Nov; 48(21):5915-5931. doi: 10.19540/j.cnki.cjcmm.20230618.202. [PMID: 38114188]
  • Di Xing, Yihua Ma, Miaomiao Lu, Wenlin Liu, Hongli Zhou. Paeoniflorin alleviates hypoxia/reoxygenation injury in HK-2 cells by inhibiting apoptosis and repressing oxidative damage via Keap1/Nrf2/HO-1 pathway. BMC nephrology. 2023 10; 24(1):314. doi: 10.1186/s12882-023-03366-0. [PMID: 37884904]
  • Lin-Feng Tang, Hao Chang, Dan-Dan Wang, Zhu-Qing Liu, Lan Han, Dai-Yin Peng. [Active components and potential mechanism of Taohong Siwu Decoction in regulating ischemic stroke based on target cell trapping combined with network pharmacology, molecular docking, and experimental validation]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Sep; 48(17):4761-4773. doi: 10.19540/j.cnki.cjcmm.20230423.403. [PMID: 37802815]
  • Meng Gao, Dongjian Zhang, Cuihua Jiang, Qiaomei Jin, Jian Zhang. Paeoniflorin inhibits hepatocellular carcinoma growth by reducing PD-L1 expression. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Aug; 166(?):115317. doi: 10.1016/j.biopha.2023.115317. [PMID: 37597322]
  • Shijie Bi, Yanan Liu, Tianyi Lv, Yue Ren, Kaiyang Liu, Chaoqun Liu, Yanling Zhang. Preliminary exploration of method for screening efficacy markers compatibility in TCM prescriptions based on Q-markers: Anti-inflammatory activity of Dachaihu decoction as an example. Journal of ethnopharmacology. 2023 Aug; 312(?):116539. doi: 10.1016/j.jep.2023.116539. [PMID: 37088240]
  • Zhao Su, Beier Hu, Jing Li, Zhichun Zeng, Hu Chen, Yuhang Guo, Yun Mao, Wen Cao. Paeoniflorin inhibits colorectal cancer cell stemness through the miR-3194-5p/catenin beta-interacting protein 1 axis. The Kaohsiung journal of medical sciences. 2023 Aug; ?(?):. doi: 10.1002/kjm2.12736. [PMID: 37530655]
  • Liping Zhai, Hongyan Pei, Heping Shen, Yi Yang, Chenyang Han, Qiaobing Guan. Paeoniflorin suppresses neuronal ferroptosis to improve the cognitive behaviors in Alzheimer's disease mice. Phytotherapy research : PTR. 2023 Jul; ?(?):. doi: 10.1002/ptr.7946. [PMID: 37448137]
  • Yuzhuo Dong, Kazufumi Toume, Shu Zhu, Yanhong Shi, Takayuki Tamura, Kayo Yoshimatsu, Katsuko Komatsu. Metabolomics analysis of peony root using NMR spectroscopy and impact of the preprocessing method for NMR data in multivariate analysis. Journal of natural medicines. 2023 Jul; ?(?):. doi: 10.1007/s11418-023-01721-x. [PMID: 37432536]
  • Yudan Mei, Xiaoyu Tong, Yumei Hu, Wenjun Liu, Jiajia Wang, Kaihong Lv, Xu Li, Liang Cao, Zhenzhong Wang, Wei Xiao, Xia Gao. Comparative pharmacokinetics of six bioactive components of Shen-Wu-Yi-Shen tablets in normal and chronic renal failure rats based on UPLC-TSQ-MS/MS. Journal of ethnopharmacology. 2023 Jun; 317(?):116818. doi: 10.1016/j.jep.2023.116818. [PMID: 37348793]
  • Yang Liu, Chun-Yu He, Xue-Mei Yang, Wei-Cong Chen, Ming-Jia Zhang, Xiao-Dan Zhong, Wei-Guang Chen, Bing-Lian Zhong, Song-Qi He, Hai-Tao Sun. Paeoniflorin Coordinates Macrophage Polarization and Mitigates Liver Inflammation and Fibrogenesis by Targeting the NF-[Formula: see text]B/HIF-1α Pathway in CCl4-Induced Liver Fibrosis. The American journal of Chinese medicine. 2023 Jun; ?(?):1-19. doi: 10.1142/s0192415x2350057x. [PMID: 37317554]
  • Xiaoxia Liang, Ting Su, Pingzhou Wu, Yanting Dai, Yanmin Chen, QiQi Wang, Cheng Cao, Fenglian Chen, Qing Wang, Shuling Wang. Identification of paeoniflorin from Paeonia lactiflora pall. As an inhibitor of tryptophan 2,3-dioxygenase and assessment of its pharmacological effects on depressive mice. Journal of ethnopharmacology. 2023 Jun; ?(?):116714. doi: 10.1016/j.jep.2023.116714. [PMID: 37315645]
  • Kangchen Li, Xinguang Liu, Runsu Hou, Hulei Zhao, Peng Zhao, Yange Tian, Jiansheng Li. Uncovering mechanisms of Baojin Chenfei formula treatment for silicosis by inhibiting inflammation and fibrosis based on serum pharmacochemistry and network analysis. Ecotoxicology and environmental safety. 2023 May; 260(?):115082. doi: 10.1016/j.ecoenv.2023.115082. [PMID: 37257350]
  • Fengyan Zhao, Caiwang Peng, Hengli Li, Haodong Chen, Yantao Yang, Qidi Ai, Naihong Chen, Fang Liu. Paeoniae Radix Rubra extract attenuates cerebral ischemia injury by inhibiting ferroptosis and activating autophagy through the PI3K/Akt signalling pathway. Journal of ethnopharmacology. 2023 May; ?(?):116567. doi: 10.1016/j.jep.2023.116567. [PMID: 37172921]
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