Escin (BioDeep_00000000051)

 

Secondary id: BioDeep_00000227124, BioDeep_00000403113

natural product PANOMIX_OTCML-2023


代谢物信息卡片


(2S,3S,4S,5R,6R)-6-[[(3S,4S,4aR,6aR,6bS,8R,8aR,9R,10R,12aS,14aR,14bR)-9-acetyloxy-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-[(E)-2-methylbut-2-enoyl]oxy-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-4-hydroxy-3,5-bis[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]oxane-2-carboxylic acid

化学式: C55H86O24 (1130.5508756)
中文名称: 七叶皂苷 Ib, 七叶皂苷IA, 七叶皂苷 A, 七叶皂甙, 七叶皂素, 七叶皂苷, 七叶皂苷A, 七叶皂苷 IA, 七叶皂苷 IB
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC=C(C)C(=O)OC1C(C2(C(CC1(C)C)C3=CCC4C5(CCC(C(C5CCC4(C3(CC2O)C)C)(C)CO)OC6C(C(C(C(O6)C(=O)O)OC7C(C(C(C(O7)CO)O)O)O)O)OC8C(C(C(C(O8)CO)O)O)O)C)CO)OC(=O)C
InChI: InChI=1S/C55H86O24/c1-10-23(2)46(71)79-43-44(72-24(3)60)55(22-59)26(17-50(43,4)5)25-11-12-30-51(6)15-14-32(52(7,21-58)29(51)13-16-53(30,8)54(25,9)18-31(55)61)75-49-41(77-48-38(67)36(65)34(63)28(20-57)74-48)39(68)40(42(78-49)45(69)70)76-47-37(66)35(64)33(62)27(19-56)73-47/h10-11,26-44,47-49,56-59,61-68H,12-22H2,1-9H3,(H,69,70)/b23-10+

描述信息

Aescin is a triterpenoid saponin.
escin Ib is a natural product found in Aesculus chinensis, Aesculus hippocastanum, and other organisms with data available.
See also: Horse Chestnut (part of).
D002317 - Cardiovascular Agents
escin Ia is a natural product found in Aesculus chinensis and Aesculus hippocastanum with data available.
See also: Horse Chestnut (part of).
Escin, a natural compound of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, can be used as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent[1].
Escin, a natural compound of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, can be used as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent[1].
Escin IA is a triterpene saponin isolated from Aesculus hippocastanum, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved inhibition of epithelial-mesenchymal transition process by down-regulating LOXL2 expression[1][2].
Escin IA is a triterpene saponin isolated from Aesculus hippocastanum, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved inhibition of epithelial-mesenchymal transition process by down-regulating LOXL2 expression[1][2].
Escin IB is a saponin isolated from skin and the endosperm of seeds of horse chestnut (Aesculus hippocastanum). Escin IB shows inhibitory effect on pancreatic lipase activity[1][2].
Escin IB is a saponin isolated from skin and the endosperm of seeds of horse chestnut (Aesculus hippocastanum). Escin IB shows inhibitory effect on pancreatic lipase activity[1][2].
Escin IB is a saponin isolated from skin and the endosperm of seeds of horse chestnut (Aesculus hippocastanum). Escin IB shows inhibitory effect on pancreatic lipase activity[1][2].

同义名列表

58 个代谢物同义名

β-d-Glucopyranosiduronic acid, [3β,16α,21β(Z),22α]-22-(acetyloxy)-16,24,28-trihydroxy-21-[(2-methyl-1-oxo-2-butenyl)oxy]olean-12-en-3-yl O-β-d-glucopyranosyl-(1→2)-O-[β-d-glucopyranosyl-(1→4)]-; .BETA.-D-GLUCOPYRANOSIDURONIC ACID, (3.BETA.,4.BETA.,16.ALPHA.,21.BETA.,22.ALPHA.)-22-(ACETYLOXY)-16,23,28-TRIHYDROXY-21-(((2Z)-2-METHYL-1-OXO-2-BUTEN-1-YL)OXY)OLEAN-12-EN-3-YL O-.BETA.-D-GLUCOPYRANOSYL-(1->2)-O-(.BETA.-D-GLUCOPYRANOSYL-(1->4))-; 2-Butenoic acid, 2-methyl-, (3.beta.,4.beta.,16.alpha.,21.beta.,22.alpha.)-22-(acetyloxy)-3-[[O-.beta.-D-glucopyranosyl-(1->2)-O-[.beta.-D-glucopyranosyl-(1->4)]-.beta.-D-glucopyranuronosyl]oxy]-16,23,28-trihydroxyolean-12-en-21-yl ester, (2Z)-; beta-D-GLUCOPYRANOSIDURONIC ACID, (3beta,4beta,16alpha,21beta,22alpha)-22-(ACETYLOXY)-16,23,28-TRIHYDROXY-21-(((2Z)-2-METHYL-1-OXO-2-BUTEN-1-YL)OXY)OLEAN-12-EN-3-YL O-beta-D-GLUCOPYRANOSYL-(1->2)-O-(beta-D-GLUCOPYRANOSYL-(1->4))-; beta-D-Glucopyranosiduronic acid, (3beta,16alpha,21beta(Z),22alpha)-22-(acetyloxy)-16,24,28-trihydroxy-21-((2-methyl-1-oxo-2-butenyl)oxy)olean-12-en-3-yl O-beta-D-glucopyranosyl-(1.2)-O-(beta-D-glucopyranosyl-(1.4))-; ESCIN IB (CONSTITUENT OF HORSE CHESTNUT) [DSC]; ESCIN IB (CONSTITUENT OF HORSE CHESTNUT); ESCIN .BETA.-ESCIN [MI]; .BETA.-ESCIN [MI]; ESCIN beta-ESCIN; UNII-QYK0D6H79O; AESCIN IB(SH); Aescine (DCF); .BETA.-AESCIN; Reparil (TN); .beta.-Escin; beta-Aescin; alpha-Escin; beta Aescin; QYK0D6H79O; beta-ESCIN; escine Ib; Aescin IB; Flogencyl; escin-IIb; Aescin B; EscinI B; Escin IA; escin Ib; escin-Ib; Aescine; EscinIB; Aescin; Escin; 6-[[9-acetyloxy-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-[(E)-2-methylbut-2-enoyl]oxy-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-4-hydroxy-3,5-bis[[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]oxane-2-carboxylic acid; (2S,3S,4S,5R,6R)-6-[[(3S,4S,4aR,6aR,6bS,8R,8aR,9R,10R,12aS,14aR,14bR)-9-acetyloxy-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-[(E)-2-methylbut-2-enoyl]oxy-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-4-hydroxy-3,5-bis[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]oxane-2-carboxylic acid; .BETA.-D-GLUCOPYRANOSIDURONIC ACID, (3.BETA.,4.BETA.,16.ALPHA.,21.BETA.,22.ALPHA.)-22-(ACETYLOXY)-16,23,28-TRIHYDROXY-21-(((2E)-2-METHYL-1-OXO-2-BUTEN-1-YL)OXY)OLEAN-12-EN-3-YL O-.BETA.-D-GLUCOPYRANOSYL-(1->2)-O-(.BETA.-D-GLUCOPYRANOSYL-(1->4))-; 2-Butenoic acid, 2-methyl-, (3.beta.,4.beta.,16.alpha.,21.beta.,22.alpha.)-22-(acetyloxy)-3-[[O-.beta.-D-glucopyranosyl-(1->2)-O-[.beta.-D-glucopyranosyl-(1->4)]-.beta.-D-glucopyranuronosyl]oxy]-16,23,28-trihydroxyolean-12-en-21-yl ester, (2E)-; beta-D-Glucopyranosiduronic acid, (3beta,4beta,16alpha,21beta,22alpha)-22-(acetyloxy)-16,23,28-trihydroxy-21-(((2E)-2-methyl-1-oxo-2-buten-1-yl)oxy)olean-12-en-3-yl o-beta-D-glucopyranosyl-(1->2)-O-(beta-D-glucopyranosyl-(1->4))-; Escin ia (constituent of horse chestnut) [DSC]; Escin ia (constituent of horse chestnut); ESCIN .ALPHA.-ESCIN [MI]; Escin alpha-escin [MI]; ESCIN .ALPHA.-ESCIN; Escin IA;Aescin IA; Escin alpha-escin; UNII-LB5DJT9FIW; .ALPHA.-AESCIN; alpha-Aescusan; alpha-Reparil; .alpha.-Escin; alpha-Aescin; LB5DJT9FIW; AESCIN IA; Escine Ia; Aescin A; escin-Ia; (2S,3S,4S,5R,6R)-6-[[(3S,4S,4aR,6aR,6bS,8R,8aR,9R,10R,12aS,14aR,14bR)-9-acetyloxy-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-[(Z)-2-methylbut-2-enoyl]oxy-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-4-hydroxy-3,5-bis[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]oxane-2-carboxylic acid



数据库引用编号

45 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Chandrashekhar Jori, Md Meraj Ansari, Anas Ahmad, Nemat Ali, Syed Shadab Raza, Rehan Khan. Biomaterial-based combinatorial approach of aescin-comprised zein-coated gelatin nanoparticles alleviates synovial inflammation in experimental inflammatory arthritis. Nanoscale. 2024 Apr; 16(16):7965-7975. doi: 10.1039/d3nr06476j. [PMID: 38567436]
  • Freddy Armando Peñaranda Figueredo, Josefina Vicente, Andrea Alejandra Barquero, Carlos Alberto Bueno. Aesculus hippocastanum extract and the main bioactive constituent β-escin as antivirals agents against coronaviruses, including SARS-CoV-2. Scientific reports. 2024 03; 14(1):6418. doi: 10.1038/s41598-024-56759-y. [PMID: 38494515]
  • Yunyu Wang, Xiuwei Han, Xinhuan Wan, Fengjv Niu, Changzheng Zhou. β-Escin: An Updated Review of Its Analysis, Pharmacology, Pharmacokinetics, and Toxicity. The American journal of Chinese medicine. 2023 Oct; ?(?):1-26. doi: 10.1142/s0192415x23500908. [PMID: 37865870]
  • Wei Sun, Qinggang Yin, Huihua Wan, Ranran Gao, Chao Xiong, Chong Xie, Xiangxiao Meng, Yaolei Mi, Xiaotong Wang, Caixia Wang, Weiqiang Chen, Ziyan Xie, Zheyong Xue, Hui Yao, Peng Sun, Xuehua Xie, Zhigang Hu, David R Nelson, Zhichao Xu, Xinxiao Sun, Shilin Chen. Characterization of the horse chestnut genome reveals the evolution of aescin and aesculin biosynthesis. Nature communications. 2023 Oct; 14(1):6470. doi: 10.1038/s41467-023-42253-y. [PMID: 37833361]
  • Yuman Wang, Tianjiao Chu, Xianmei Pan, Yifei Bian, Jing Li. Escin ameliorates inflammation via inhibiting mechanical stretch and chemically induced Piezo1 activation in vascular endothelial cells. European journal of pharmacology. 2023 Aug; 956(?):175951. doi: 10.1016/j.ejphar.2023.175951. [PMID: 37541373]
  • Chenyuan Li, Ziqi He, Feng Yao, Shichong Liao, Kai Sun, Shengrong Sun, Zhiyu Li, Zhong Wang. Role of Escin in breast cancer therapy: potential mechanism for inducing ferroptosis and synergistic antitumor activity with cisplatin. Apoptosis : an international journal on programmed cell death. 2023 May; ?(?):. doi: 10.1007/s10495-023-01849-x. [PMID: 37149513]
  • Hao Yu, Siru Yan, Meiyu Jin, Yunfei Wei, Lilei Zhao, Jiaqi Cheng, Lu Ding, Haihua Feng. Aescin can alleviate NAFLD through Keap1-Nrf2 by activating antioxidant and autophagy. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 May; 113(?):154746. doi: 10.1016/j.phymed.2023.154746. [PMID: 36905866]
  • Philippe Savarino, Emmanuel Colson, Julien André, Pascal Gerbaux. Horse Chestnut Saponins-Escins, Isoescins, Transescins, and Desacylescins. Molecules (Basel, Switzerland). 2023 Feb; 28(5):. doi: 10.3390/molecules28052087. [PMID: 36903330]
  • Sunnatullo Fazliev, Khurshid Tursunov, Jamoliddin Razzokov, Avez Sharipov. Escin's Multifaceted Therapeutic Profile in Treatment and Post-Treatment of Various Cancers: A Comprehensive Review. Biomolecules. 2023 Feb; 13(2):. doi: 10.3390/biom13020315. [PMID: 36830684]
  • Min Li, Shengguang Wang, Ce Zhang, Chenglin Chi, Rongxia Liu, Tian Wang, Fenghua Fu. Escin alleviates stress-induced intestinal dysfunction to protect brain injury by regulating the gut-brain axis in ischemic stroke rats. International immunopharmacology. 2023 Feb; 115(?):109659. doi: 10.1016/j.intimp.2022.109659. [PMID: 36608442]
  • Min Li, Fang Wang, Ce Zhang, Min-An Li, Tian Wang, Yu-Chen Li, Feng-Hua Fu. Integrated systematic pharmacology analysis and experimental validation to reveal the mechanism of action of Semen aesculi on inflammatory bowel diseases. Journal of ethnopharmacology. 2022 Nov; 298(?):115627. doi: 10.1016/j.jep.2022.115627. [PMID: 35985613]
  • I M Tucker, A Burley, R E Petkova, S L Hosking, J R P Webster, P X Li, K Ma, J Doutch, J Penfoldoo, R K Thomas. Self-assembly in escin-nonionic surfactant mixtures: From micelles to vesicles. Journal of colloid and interface science. 2022 Nov; 626(?):305-313. doi: 10.1016/j.jcis.2022.06.122. [PMID: 35792461]
  • Q-H Zhang, X-Y Cui, D Wang, Y Jin, Y-X Guan. Anti-obesity effect of escin: a study on high-fat diet-induced obese mice. European review for medical and pharmacological sciences. 2022 11; 26(21):7797-7812. doi: 10.26355/eurrev_202211_30129. [PMID: 36394728]
  • Mustafa Cengiz, Hatice Mehtap Kutlu, Betül Peker Cengiz, Adnan Ayhancı. Escin attenuates oxidative damage, apoptosis and lipid peroxidation in a model of cyclophosphamide-induced liver damage. Drug and chemical toxicology. 2022 May; 45(3):1180-1187. doi: 10.1080/01480545.2020.1810262. [PMID: 32838567]
  • Peng Qiao, Baokun Zhang, Xueni Liu, Jie Xu, Xuehan Li. Effects of Escin on Oxidative Stress and Apoptosis of H9c2 Cells Induced by H2O2. Disease markers. 2022; 2022(?):7765353. doi: 10.1155/2022/7765353. [PMID: 35126791]
  • Yuqing Sun, Xin Zhang, Xiaofan Shen, Shuo Wang, Qi Wang, Xiuwei Yang. Computational and experimental characterization of isomers of escin-induced renal cytotoxicity by inhibiting heat shock proteins. European journal of pharmacology. 2021 Oct; 908(?):174372. doi: 10.1016/j.ejphar.2021.174372. [PMID: 34324856]
  • Shu Hu, Gianni Belcaro, Maria R Cesarone, Beatrice Feragalli, Roberto Cotellese, Mark Dugall, Claudia Scipione, Valeria Scipione, Claudia Maione, Giada Maramaldi, Stefano Togni, Antonella Riva. A sport cream (Harpago-Boswellia-ginger-escin) for localized neck/shoulder pain. Minerva medica. 2021 Apr; 112(2):255-260. doi: 10.23736/s0026-4806.20.06819-6. [PMID: 32880419]
  • Ramsia Geisler, Martin Cramer Pedersen, Natalie Preisig, Yvonne Hannappel, Sylvain Prévost, Rajeev Dattani, Lise Arleth, Thomas Hellweg. Aescin - a natural soap for the formation of lipid nanodiscs with tunable size. Soft matter. 2021 Feb; 17(7):1888-1900. doi: 10.1039/d0sm02043e. [PMID: 33410858]
  • Sachin V Suryavanshi, Yogesh A Kulkarni. Attenuation of Cardiac Autonomic Neuropathy by Escin in Diabetic Rats. Pharmacology. 2021; 106(3-4):211-217. doi: 10.1159/000509730. [PMID: 32877906]
  • Qian Zhang, Chen Zhao, Lei Zhang, Kai Sun, Linlin Yu, Xianming Wang, Lei Ren, Nan Zhang, Chengyu Chen, Ju Liu, Haimei Wang, Hu Tian. Escin Sodium Improves the Prognosis of Acute Pancreatitis via Promoting Cell Apoptosis by Suppression of the ERK/STAT3 Signaling Pathway. Oxidative medicine and cellular longevity. 2021; 2021(?):9921839. doi: 10.1155/2021/9921839. [PMID: 34422214]
  • Namrta Choudhry, Xin Zhao, Dan Xu, Mark Zanin, Weisan Chen, Zifeng Yang, Jianxin Chen. Chinese Therapeutic Strategy for Fighting COVID-19 and Potential Small-Molecule Inhibitors against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Journal of medicinal chemistry. 2020 11; 63(22):13205-13227. doi: 10.1021/acs.jmedchem.0c00626. [PMID: 32845145]
  • Sachin V Suryavanshi, Yogesh A Kulkarni. Escin alleviates peripheral neuropathy in streptozotocin induced diabetes in rats. Life sciences. 2020 Aug; 254(?):117777. doi: 10.1016/j.lfs.2020.117777. [PMID: 32407839]
  • Sahar Idris, Anuradha Mishra, Mohd Khushtar. Phytochemical, ethanomedicinal and pharmacological applications of escin from Aesculus hippocastanum L. towards future medicine. Journal of basic and clinical physiology and pharmacology. 2020 Jul; 31(5):. doi: 10.1515/jbcpp-2019-0115. [PMID: 32649293]
  • Luca Gallelli, Leiming Zhang, Tian Wang, Fenghua Fu. Severe Acute Lung Injury Related to COVID-19 Infection: A Review and the Possible Role for Escin. Journal of clinical pharmacology. 2020 07; 60(7):815-825. doi: 10.1002/jcph.1644. [PMID: 32441805]
  • Sara Mahmmoud El-Dakhly, Abeer Abdallah Ali Salama, Soha Osama Mahmoud Hassanin, Noha Nazeeh Yassen, Alaaeldin Ahmed Hamza, Amr Amin. Aescin and diosmin each alone or in low dose- combination ameliorate liver damage induced by carbon tetrachloride in rats. BMC research notes. 2020 May; 13(1):259. doi: 10.1186/s13104-020-05094-2. [PMID: 32460808]
  • Ramsia Geisler, Carina Dargel, Thomas Hellweg. The Biosurfactant β-Aescin: A Review on the Physico-Chemical Properties and Its Interaction with Lipid Model Membranes and Langmuir Monolayers. Molecules (Basel, Switzerland). 2019 Dec; 25(1):. doi: 10.3390/molecules25010117. [PMID: 31892278]
  • Ramsia Geisler, Martin Cramer Pedersen, Yvonne Hannappel, Ralf Schweins, Sylvain Prévost, Rajeev Dattani, Lise Arleth, Thomas Hellweg. Aescin-Induced Conversion of Gel-Phase Lipid Membranes into Bicelle-like Lipid Nanoparticles. Langmuir : the ACS journal of surfaces and colloids. 2019 12; 35(49):16244-16255. doi: 10.1021/acs.langmuir.9b02077. [PMID: 31618036]
  • Ramsia Sreij, Carina Dargel, Yvonne Hannappel, Jacques Jestin, Sylvain Prévost, Rajeev Dattani, Oliver Wrede, Thomas Hellweg. Temperature dependent self-organization of DMPC membranes promoted by intermediate amounts of the saponin aescin. Biochimica et biophysica acta. Biomembranes. 2019 05; 1861(5):897-906. doi: 10.1016/j.bbamem.2019.01.015. [PMID: 30735626]
  • Ramsia Sreij, Carina Dargel, Ralf Schweins, Sylvain Prévost, Rajeev Dattani, Thomas Hellweg. Aescin-Cholesterol Complexes in DMPC Model Membranes: A DSC and Temperature-Dependent Scattering Study. Scientific reports. 2019 04; 9(1):5542. doi: 10.1038/s41598-019-41865-z. [PMID: 30944386]
  • Flavia M Michelini, Laura E Alché, Carlos A Bueno. Virucidal, antiviral and immunomodulatory activities of β-escin and Aesculus hippocastanum extract. The Journal of pharmacy and pharmacology. 2018 Nov; 70(11):1561-1571. doi: 10.1111/jphp.13002. [PMID: 30168142]
  • Carolin de Groot, Mathias Müsken, Christel C Müller-Goymann. Novel Colloidal Microstructures of β-Escin and the Liposomal Components Cholesterol and DPPC. Planta medica. 2018 Nov; 84(16):1219-1227. doi: 10.1055/a-0624-2706. [PMID: 29797304]
  • Ramsia Sreij, Sylvain Prévost, Carina Dargel, Rajeev Dattani, Yvonne Hertle, Oliver Wrede, Thomas Hellweg. Interaction of the Saponin Aescin with Ibuprofen in DMPC Model Membranes. Molecular pharmaceutics. 2018 10; 15(10):4446-4461. doi: 10.1021/acs.molpharmaceut.8b00421. [PMID: 30102549]
  • J Penfold, R K Thomas, I Tucker, J T Petkov, S D Stoyanov, N Denkov, K Golemanov, S Tcholakova, J R P Webster. Saponin Adsorption at the Air-Water Interface-Neutron Reflectivity and Surface Tension Study. Langmuir : the ACS journal of surfaces and colloids. 2018 08; 34(32):9540-9547. doi: 10.1021/acs.langmuir.8b02158. [PMID: 30028143]
  • Baojian Wang, Xu Mao, Jianwei Zhu. [β-aescin alleviates acute lung injury induced by lipopolysaccharide by inhibiting lipid peroxidation and inflammation in mice]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 2018 Jul; 34(7):600-604. doi: ". [PMID: 30381123]
  • Ramsia Sreij, Carina Dargel, Philippe Geisler, Yvonne Hertle, Aurel Radulescu, Stefano Pasini, Javier Perez, Lara H Moleiro, Thomas Hellweg. DMPC vesicle structure and dynamics in the presence of low amounts of the saponin aescin. Physical chemistry chemical physics : PCCP. 2018 Apr; 20(14):9070-9083. doi: 10.1039/c7cp08027a. [PMID: 29505043]
  • Shu-Qi Zhao, Shi-Qiang Xu, Jing Cheng, Xiao-Lu Cao, Ying Zhang, Wei-Ping Zhou, Yan-Juan Huang, Jun Wang, Xia-Min Hu. Anti-inflammatory effect of external use of escin on cutaneous inflammation: possible involvement of glucocorticoids receptor. Chinese journal of natural medicines. 2018 Feb; 16(2):105-112. doi: 10.1016/s1875-5364(18)30036-0. [PMID: 29455725]
  • HyeongSeob Kwak, Hongyan An, Md Badrul Alam, Won-Sik Choi, Sang Yong Lee, Sang-Han Lee. Inhibition of Migration and Invasion in Melanoma Cells by β-Escin via the ERK/NF-κB Signaling Pathway. Biological & pharmaceutical bulletin. 2018; 41(10):1606-1610. doi: 10.1248/bpb.b18-00251. [PMID: 30270331]
  • Harsimran Singh, Shabir Sidhu, Kanwaljit Chopra, M U Khan. The novel role of β-aescin in attenuating CCl4-induced hepatotoxicity in rats. Pharmaceutical biology. 2017 Dec; 55(1):749-757. doi: 10.1080/13880209.2016.1275023. [PMID: 28064552]
  • Zhao-Rui Liu, Li-Zhi Sun, Tang-Hong Jia, Dao-Fu Jia. β-Aescin shows potent antiproliferative activity in osteosarcoma cells by inducing autophagy, ROS generation and mitochondrial membrane potential loss. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. 2017 Nov; 22(6):1582-1586. doi: . [PMID: 29332356]
  • Ramsia Sreij, Carina Dargel, Lara H Moleiro, Francisco Monroy, Thomas Hellweg. Aescin Incorporation and Nanodomain Formation in DMPC Model Membranes. Langmuir : the ACS journal of surfaces and colloids. 2017 10; 33(43):12351-12361. doi: 10.1021/acs.langmuir.7b02933. [PMID: 28985678]
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