4-Hydroxyestradiol (BioDeep_00000009764)

Main id: BioDeep_00000637477

 

human metabolite Endogenous


代谢物信息卡片


(1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2,4,6-triene-5,6,14-triol

化学式: C18H24O3 (288.1725)
中文名称: 4-羟基雌二醇
谱图信息: 最多检出来源 Mus musculus(blood) 27.16%

分子结构信息

SMILES: C1=CC2[C@@]3([H])CC[C@]4(C)[C@@H](O)CC[C@@]4([H])[C@]3([H])CCC=2C(O)=C1O
InChI: InChI=1S/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11-,12-,14+,16+,18+/m1/s1

描述信息

4-Hydroxyestradiol is an oncogenic catechol estrogen produced by metabolism of Estrogen.
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
A human metabolite taken as a putative food compound of mammalian origin [HMDB]

同义名列表

26 个代谢物同义名

(1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2,4,6-triene-5,6,14-triol; (17beta)-Estra-1,3,5(10)-triene-3,4,17-triol; 3,4,17beta-Trihydroxy-1,3,5[10]-estratriene; (17Β)-estra-1,3,5(10)-triene-3,4,17-triol; 3,4,17b-Trihydroxy-1,3,5[10]-estratriene; 3,4,17Β-trihydroxy-1,3,5[10]-estratriene; estra-1,3,5(10)-triene-2,4,17beta-triol; Estra-1,3,5(10)-triene-3,4,17beta-triol; Estra-1,3,5(10)-triene-3,4,17β-triol; 4-Hydroxyestradiol-17 alpha; 4-Hydroxy-17beta-estradiol; 4-Hydroxyestradiol-17 beta; 4-Hydroxyestradiol-17beta; 4-Hydroxy-17β-estradiol; 4-Hydroxyestradiol-17β; 4-Hydroxyestradiol-17b; 3,4,17beta-Estriol; 4-hydroxyestradiol; 4-hydroxystradiol; 3,4,17Β-estriol; 3,4,17b-Estriol; 4-OH-Estradiol; ST 18:3;O3; 4OHE2; 4-Hydroxy-17beta-estradiol; 4-Hydroxy-17?estradiol



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(5)

BioCyc(0)

PlantCyc(0)

代谢反应

47 个相关的代谢反应过程信息。

Reactome(45)

BioCyc(0)

WikiPathways(2)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 AHR, BRCA1, CAT, CYP1A1, CYP3A4, ESR1, HPGDS, LPO, NFE2L2, NQO1, TYR, VEGFA
Peripheral membrane protein 3 CYP1A1, CYP1B1, ESR1
Endoplasmic reticulum membrane 6 CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMOX1
Nucleus 8 AHR, BRCA1, ESR1, ESR2, HMOX1, NFE2L2, NQO1, VEGFA
cytosol 8 AHR, CAT, COMT, ESR1, HMOX1, HPGDS, NFE2L2, NQO1
dendrite 2 COMT, NQO1
nuclear body 1 BRCA1
centrosome 1 NFE2L2
nucleoplasm 7 AHR, BRCA1, ESR1, ESR2, HMOX1, HPGDS, NFE2L2
RNA polymerase II transcription regulator complex 1 NFE2L2
Cell membrane 2 COMT, ESR1
Cytoplasmic side 2 ESR1, HMOX1
Multi-pass membrane protein 2 CYP19A1, SLC45A2
Synapse 2 COMT, NQO1
cell surface 1 VEGFA
Golgi apparatus 3 ESR1, NFE2L2, VEGFA
lysosomal membrane 1 EGF
mitochondrial inner membrane 1 CYP1A1
neuronal cell body 1 NQO1
Cytoplasm, cytosol 2 NFE2L2, NQO1
Lysosome 1 TYR
plasma membrane 5 BRCA1, COMT, EGF, ESR1, NFE2L2
Membrane 12 BRCA1, CAT, COMT, CYP19A1, CYP1B1, CYP3A4, EGF, ESR1, HMOX1, NQO1, SLC45A2, VEGFA
axon 1 COMT
basolateral plasma membrane 1 LPO
extracellular exosome 4 CAT, COMT, EGF, LPO
endoplasmic reticulum 3 CYP19A1, HMOX1, VEGFA
extracellular space 4 EGF, HMOX1, LPO, VEGFA
perinuclear region of cytoplasm 2 HMOX1, TYR
adherens junction 1 VEGFA
mitochondrion 4 CAT, CYP1A1, CYP1B1, ESR2
protein-containing complex 4 AHR, BRCA1, CAT, ESR1
intracellular membrane-bounded organelle 9 CAT, COMT, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR2, HPGDS, TYR
Microsome membrane 5 CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4
Single-pass type I membrane protein 1 TYR
Secreted 2 LPO, VEGFA
extracellular region 4 CAT, EGF, LPO, VEGFA
mitochondrial outer membrane 1 HMOX1
mitochondrial matrix 1 CAT
Extracellular side 1 COMT
transcription regulator complex 2 AHR, ESR1
Secreted, extracellular space, extracellular matrix 1 VEGFA
Melanosome membrane 2 SLC45A2, TYR
Golgi-associated vesicle 1 TYR
Single-pass type II membrane protein 1 COMT
Mitochondrion inner membrane 1 CYP1A1
focal adhesion 1 CAT
extracellular matrix 1 VEGFA
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
secretory granule 1 VEGFA
chromatin 4 AHR, ESR1, ESR2, NFE2L2
mediator complex 1 NFE2L2
Chromosome 1 BRCA1
[Isoform 5]: Cytoplasm 1 BRCA1
lateral element 1 BRCA1
aryl hydrocarbon receptor complex 1 AHR
Melanosome 1 TYR
euchromatin 1 ESR1
ubiquitin ligase complex 1 BRCA1
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
male germ cell nucleus 1 BRCA1
platelet alpha granule lumen 2 EGF, VEGFA
XY body 1 BRCA1
Single-pass type IV membrane protein 1 HMOX1
clathrin-coated endocytic vesicle membrane 1 EGF
ribonucleoprotein complex 1 BRCA1
[Isoform 1]: Nucleus 1 ESR1
protein-DNA complex 1 NFE2L2
intracellular non-membrane-bounded organelle 1 BRCA1
DNA repair complex 1 BRCA1
BRCA1-C complex 1 BRCA1
catalase complex 1 CAT
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Isoform Soluble]: Cytoplasm 1 COMT
[Isoform Membrane-bound]: Cell membrane 1 COMT
nuclear aryl hydrocarbon receptor complex 1 AHR
cytosolic aryl hydrocarbon receptor complex 1 AHR
BRCA1-A complex 1 BRCA1
BRCA1-B complex 1 BRCA1
BRCA1-BARD1 complex 1 BRCA1
gamma-tubulin ring complex 1 BRCA1
nuclear ubiquitin ligase complex 1 BRCA1


文献列表

  • Saranya Sedtananun, Kornkanok Promthep. The potential of Mangifera indica Linn. and Musa acuminata extracts to attenuate 4-hydroxyestradiol (4-OHE2 )-induced DNA oxidative damage in MCF-10A cells by upregulating detoxifying and antioxidant enzymes. Journal of food biochemistry. 2021 06; 45(6):e13754. doi: 10.1111/jfbc.13754. [PMID: 33969512]
  • Wahid Ali Khan, Arshi Malik, Mohd Wajid Ali Khan. Estrogenization of insulin by catecholestrogen produced high affinity autoantibodies and altered the normal function of insulin in type 1 diabetes. Life sciences. 2020 Sep; 256(?):117910. doi: 10.1016/j.lfs.2020.117910. [PMID: 32504753]
  • Xu Mao, Jian Wang, Qian Wang, Lan Yang, Yilin Li, Hao Lin, Ying Peng, Jiang Zheng. Nitidine Chloride-Induced CYP1 Enzyme Inhibition and Alteration of Estradiol Metabolism. Drug metabolism and disposition: the biological fate of chemicals. 2019 08; 47(8):919-927. doi: 10.1124/dmd.119.086892. [PMID: 31147316]
  • Nur Ozten, Katherine Vega, Joachim Liehr, Xi Huang, Lori Horton, Ercole L Cavalieri, Eleanor G Rogan, Maarten C Bosland. Role of Estrogen in Androgen-Induced Prostate Carcinogenesis in NBL Rats. Hormones & cancer. 2019 06; 10(2-3):77-88. doi: 10.1007/s12672-019-00360-7. [PMID: 30877616]
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