1-(2-Hydroxy-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2(3H)-one (BioDeep_00000009612)

 

Secondary id: BioDeep_00001876725

human metabolite blood metabolite Volatile Flavor Compounds


代谢物信息卡片


1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2,3-dihydro-1H-1,3-benzodiazol-2-one

化学式: C15H8F6N2O2 (362.04899399999994)
中文名称: NS-1619
谱图信息: 最多检出来源 Homo sapiens(blood) 88.89%

分子结构信息

SMILES: C1=CC2=C(C=C1C(F)(F)F)NC(=O)N2C3=C(C=CC(=C3)C(F)(F)F)O
InChI: InChI=1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25)

描述信息

同义名列表

10 个代谢物同义名

1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2,3-dihydro-1H-1,3-benzodiazol-2-one; 1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one; 5-Trifluoromethyl-2,3-dihydro-1-(5-trifluoromethyl-2-hydroxyphenyl)-1H-2-oxo-benzimidazole; 1-(2-Hydroxy-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2(3H)-one; 1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-3H-1,3-benzodiazol-2-one; 1-(2-Hydroxy-5-trifluoromethylphenyl)-5-trifluoromethyl-2(3H)-benzimidazolone; NS-1619; NS 1619; NS1619; NS 1619



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mikhail V Dubinin, Vlada S Starinets, Yuliya A Chelyadnikova, Natalia V Belosludtseva, Irina B Mikheeva, Daria K Penkina, Anastasia D Igoshkina, Eugeny Yu Talanov, Igor I Kireev, Dmitry B Zorov, Konstantin N Belosludtsev. Effect of Large-Conductance Calcium-Dependent K+ Channel Activator NS1619 on Function of Mitochondria in the Heart of Dystrophin-Deficient Mice. Biochemistry. Biokhimiia. 2023 Feb; 88(2):189-201. doi: 10.1134/s0006297923020037. [PMID: 37072326]
  • Feng-Ling Ning, Jie Tao, Dan-Dan Li, Lu-Lu Tian, Meng-Ling Wang, Svetlana Reilly, Cheng Liu, Hui Cai, Hong Xin, Xue-Mei Zhang. Activating BK channels ameliorates vascular smooth muscle calcification through Akt signaling. Acta pharmacologica Sinica. 2022 Mar; 43(3):624-633. doi: 10.1038/s41401-021-00704-6. [PMID: 34163023]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Min Lin, Danielle Sambo, Habibeh Khoshbouei. Methamphetamine Regulation of Firing Activity of Dopamine Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2016 10; 36(40):10376-10391. doi: 10.1523/jneurosci.1392-16.2016. [PMID: 27707972]
  • M Kocmalova, M Oravec, M Adamkov, V Sadlonova, I Kazimierova, I Medvedova, M Joskova, S Franova, M Sutovska. Potassium ion channels and allergic asthma. Advances in experimental medicine and biology. 2015; 838(?):35-45. doi: 10.1007/5584_2014_76. [PMID: 25315623]
  • Bartłomiej Augustynek, Alexei P Kudin, Piotr Bednarczyk, Adam Szewczyk, Wolfram S Kunz. Hemin inhibits the large conductance potassium channel in brain mitochondria: a putative novel mechanism of neurodegeneration. Experimental neurology. 2014 Jul; 257(?):70-5. doi: 10.1016/j.expneurol.2014.04.022. [PMID: 24792919]
  • Dorota Dymkowska, Beata Drabarek, Justyna Jakubczyk, Sylwia Wojciechowska, Krzysztof Zabłocki. Potassium channel openers prevent palmitate-induced insulin resistance in C2C12 myotubes. Archives of biochemistry and biophysics. 2014 Jan; 541(?):47-52. doi: 10.1016/j.abb.2013.11.003. [PMID: 24262853]
  • R W Kirby, A Martelli, V Calderone, N G McKay, K Lawson. Large conductance Ca(2+)-activated K(+) channel (BKCa) activating properties of a series of novel N-arylbenzamides: Channel subunit dependent effects. Bioorganic & medicinal chemistry. 2013 Jul; 21(14):4186-91. doi: 10.1016/j.bmc.2013.05.003. [PMID: 23707646]
  • Piotr Bednarczyk, Agnieszka Koziel, Wieslawa Jarmuszkiewicz, Adam Szewczyk. Large-conductance Ca²⁺-activated potassium channel in mitochondria of endothelial EA.hy926 cells. American journal of physiology. Heart and circulatory physiology. 2013 Jun; 304(11):H1415-27. doi: 10.1152/ajpheart.00976.2012. [PMID: 23542921]
  • Hui Chang, Yu-Guang Ma, Yun-Ying Wang, Zhen Song, Quan Li, Ning Yang, Hua-Zhou Zhao, Han-Zhong Feng, Yao-Ming Chang, Jin Ma, Zhi-Bin Yu, Man-Jiang Xie. High glucose alters apoptosis and proliferation in HEK293 cells by inhibition of cloned BK Ca channel. Journal of cellular physiology. 2011 Jun; 226(6):1660-75. doi: 10.1002/jcp.22497. [PMID: 21413024]
  • Ludwika Chmielewska, Dominika Malińska. Cytoprotective action of the potassium channel opener NS1619 under conditions of disrupted calcium homeostasis. Pharmacological reports : PR. 2011; 63(1):176-83. doi: 10.1016/s1734-1140(11)70413-3. [PMID: 21441626]
  • Shaohua Chang, Cristiano Mendes Gomes, Joseph A Hypolite, James Marx, Jaber Alanzi, Stephen A Zderic, Bruce Malkowicz, Alan J Wein, Samuel Chacko. Detrusor overactivity is associated with downregulation of large-conductance calcium- and voltage-activated potassium channel protein. American journal of physiology. Renal physiology. 2010 Jun; 298(6):F1416-23. doi: 10.1152/ajprenal.00595.2009. [PMID: 20392804]
  • Mohammed Aldakkak, David F Stowe, Qunli Cheng, Wai-Meng Kwok, Amadou K S Camara. Mitochondrial matrix K+ flux independent of large-conductance Ca2+-activated K+ channel opening. American journal of physiology. Cell physiology. 2010 Mar; 298(3):C530-41. doi: 10.1152/ajpcell.00468.2009. [PMID: 20053924]
  • Jolanta Skalska, Marta Piwońska, Elzbieta Wyroba, Liliana Surmacz, Rafal Wieczorek, Izabela Koszela-Piotrowska, Joanna Zielińska, Piotr Bednarczyk, Krzysztof Dołowy, Grzegorz M Wilczynski, Adam Szewczyk, Wolfram S Kunz. A novel potassium channel in skeletal muscle mitochondria. Biochimica et biophysica acta. 2008 Jul; 1777(7-8):651-9. doi: 10.1016/j.bbabio.2008.05.007. [PMID: 18515063]
  • Tamás Gáspár, Prasad Katakam, James A Snipes, Béla Kis, Ferenc Domoki, Ferenc Bari, David W Busija. Delayed neuronal preconditioning by NS1619 is independent of calcium activated potassium channels. Journal of neurochemistry. 2008 May; 105(4):1115-28. doi: 10.1111/j.1471-4159.2007.05210.x. [PMID: 18182041]
  • Neil G McKay, Robert W Kirby, Kim Lawson. Rubidium efflux as a tool for the pharmacological characterisation of compounds with BK channel opening properties. Methods in molecular biology (Clifton, N.J.). 2008; 491(?):267-77. doi: 10.1007/978-1-59745-526-8_21. [PMID: 18998100]
  • Jeffrey L Romine, Scott W Martin, Nicholas A Meanwell, Valentin K Gribkoff, Christopher G Boissard, Steven I Dworetzky, Joanne Natale, Sandra Moon, Astrid Ortiz, Swamy Yeleswaram, Lorraine Pajor, Qi Gao, John E Starrett. 3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl ]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: opener of large-conductance Ca(2+)-activated potassium (maxi-K) channels, identification, solubility, and SAR. Journal of medicinal chemistry. 2007 Feb; 50(3):528-42. doi: 10.1021/jm061006n. [PMID: 17266205]
  • Keita Mayanagi, Tamás Gáspár, Prasad V G Katakam, Béla Kis, David W Busija. The mitochondrial K(ATP) channel opener BMS-191095 reduces neuronal damage after transient focal cerebral ischemia in rats. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2007 Feb; 27(2):348-55. doi: 10.1038/sj.jcbfm.9600345. [PMID: 16736040]
  • Shigemi Yoshihara, Hiroshi Morimoto, Makoto Ohori, Yumi Yamada, Toshio Abe, Osamu Arisaka. The cannabinoid receptor agonist WIN 55212-2 inhibits neurogenic inflammations in airway tissues. Journal of pharmacological sciences. 2005 May; 98(1):77-82. doi: 10.1254/jphs.fp0050171. [PMID: 15888960]
  • Ashutosh S Parihar, Duncan R Groebe, Victoria E Scott, Jianlin Feng, Xu-Feng Zhang, Usha Warrior, Murali Gopalakrishnan, Char-Chang Shieh. Functional analysis of large conductance Ca2(+)-activated K(+) channels: ion flux studies by atomic absorption spectrometry. Assay and drug development technologies. 2003 Oct; 1(5):647-54. doi: 10.1089/154065803770381002. [PMID: 15090237]
  • Susanne Brakemeier, Ines Eichler, Andrea Knorr, Til Fassheber, Ralf Köhler, Joachim Hoyer. Modulation of Ca2+-activated K+ channel in renal artery endothelium in situ by nitric oxide and reactive oxygen species. Kidney international. 2003 Jul; 64(1):199-207. doi: 10.1046/j.1523-1755.2003.00051.x. [PMID: 12787410]
  • Grazyna Debska, Anna Kicinska, Jerzy Dobrucki, Beata Dworakowska, Ewa Nurowska, Jolanta Skalska, Krzysztof Dolowy, Adam Szewczyk. Large-conductance K+ channel openers NS1619 and NS004 as inhibitors of mitochondrial function in glioma cells. Biochemical pharmacology. 2003 Jun; 65(11):1827-34. doi: 10.1016/s0006-2952(03)00180-1. [PMID: 12781334]
  • Yoshio Tanaka, Takahiro Horinouchi, Hikaru Tanaka, Koki Shigenobu, Katsuo Koike. [BK channels play an important role as a negative feedback mechanism in the regulation of spontaneous rhythmic contraction of urinary bladder smooth muscles]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 2002 Nov; 120(1):106P-108P. doi: 10.1254/fpj.120.13. [PMID: 12491797]
  • Kathryn M Gauthier, Christina Deeter, U Murali Krishna, Y Krishna Reddy, Muralidhar Bondlela, J R Falck, William B Campbell. 14,15-Epoxyeicosa-5(Z)-enoic acid: a selective epoxyeicosatrienoic acid antagonist that inhibits endothelium-dependent hyperpolarization and relaxation in coronary arteries. Circulation research. 2002 May; 90(9):1028-36. doi: 10.1161/01.res.0000018162.87285.f8. [PMID: 12016270]
  • W Long, L Zhang, L D Longo. Cerebral artery K(ATP)- and K(Ca)-channel activity and contractility: changes with development. American journal of physiology. Regulatory, integrative and comparative physiology. 2000 Dec; 279(6):R2004-14. doi: 10.1152/ajpregu.2000.279.6.r2004. [PMID: 11080063]
  • P Song, M Milanese, E Crimi, S Bruzzone, E Zocchi, K Rehder, V Brusasco. G(s) protein dysfunction in allergen-challenged human isolated passively sensitized bronchi. American journal of physiology. Lung cellular and molecular physiology. 2000 Aug; 279(2):L209-15. doi: 10.1152/ajplung.2000.279.2.l209. [PMID: 10926543]
  • D Fulton, J C McGiff, M S Wolin, P Kaminski, J Quilley. Evidence against a cytochrome P450-derived reactive oxygen species as the mediator of the nitric oxide-independent vasodilator effect of bradykinin in the perfused heart of the rat. The Journal of pharmacology and experimental therapeutics. 1997 Feb; 280(2):702-9. doi: NULL. [PMID: 9023282]
  • V K Gribkoff, J T Lum-Ragan, C G Boissard, D J Post-Munson, N A Meanwell, J E Starrett, E S Kozlowski, J L Romine, J T Trojnacki, M C Mckay, J Zhong, S I Dworetzky. Effects of channel modulators on cloned large-conductance calcium-activated potassium channels. Molecular pharmacology. 1996 Jul; 50(1):206-17. doi: . [PMID: 8700114]