NS-1619 (BioDeep_00001876725)

Main id: BioDeep_00000009612

 


代谢物信息卡片


1-(2-Hydroxy-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2(3H)-one

化学式: C15H8F6N2O2 (362.049)
中文名称: NS-1619
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC2=C(C=C1C(F)(F)F)NC(=O)N2C3=C(C=CC(=C3)C(F)(F)F)O
InChI: InChI=1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25)



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 AIMP2, AKT1, CASP3, DMD, FOXO1, NOS3, PIK3CA, PIK3R6, PRKX, RHOA
Peripheral membrane protein 3 CAV1, DMD, PIK3R6
Endoplasmic reticulum membrane 3 CAV1, HMOX1, RHOA
Nucleus 9 AIMP2, AKT1, CASP3, DMD, FOXO1, HMOX1, NOS3, PRKX, RHOA
cytosol 12 AIMP2, AKT1, AVP, CASP3, DMD, FOXO1, HMOX1, NOS3, PIK3CA, PIK3R6, PRKCQ, RHOA
dendrite 1 AVP
nucleoplasm 6 AKT1, CASP3, FOXO1, HMOX1, NOS3, PRKX
Cell membrane 6 AKT1, CAV1, KCNMA1, PIK3R6, RHOA, TNF
Lipid-anchor 1 RHOA
Cytoplasmic side 3 DMD, HMOX1, RHOA
Cleavage furrow 1 RHOA
lamellipodium 3 AKT1, PIK3CA, RHOA
ruffle membrane 1 RHOA
Early endosome membrane 1 CAV1
Multi-pass membrane protein 2 KCNA3, KCNMA1
Golgi apparatus membrane 1 CAV1
Synapse 2 DMD, TAC1
cell cortex 3 AKT1, CAV1, RHOA
cell junction 1 RHOA
cell surface 2 DMD, TNF
glutamatergic synapse 4 AKT1, CASP3, KCNA3, RHOA
Golgi apparatus 2 CAV1, NOS3
Golgi membrane 2 CAV1, NOS3
neuronal cell body 3 CASP3, TAC1, TNF
postsynapse 2 AKT1, RHOA
presynaptic membrane 1 KCNA3
sarcolemma 1 DMD
Cytoplasm, cytosol 1 AIMP2
endosome 2 CAV1, RHOA
plasma membrane 12 AKT1, CAV1, DMD, KCNA3, KCNMA1, KNG1, NOS3, PIK3CA, PIK3R6, PRKCQ, RHOA, TNF
Membrane 8 AIMP2, AKT1, CAV1, DMD, HMOX1, KCNA3, KCNMA1, PIK3R6
apical plasma membrane 2 CAV1, KCNMA1
axon 3 CCK, KCNA3, TAC1
basolateral plasma membrane 1 CAV1
caveola 3 CAV1, KCNMA1, NOS3
extracellular exosome 2 KNG1, RHOA
endoplasmic reticulum 2 CAV1, HMOX1
extracellular space 6 AVP, CCK, HMOX1, KNG1, TAC1, TNF
perinuclear region of cytoplasm 5 CAV1, HMOX1, KCNA3, NOS3, PIK3CA
intercalated disc 1 PIK3CA
mitochondrion 1 FOXO1
protein-containing complex 3 AKT1, CAV1, DMD
filopodium 1 DMD
postsynaptic density 1 CASP3
Secreted 2 AVP, CCK
extracellular region 5 AVP, CCK, KNG1, TAC1, TNF
cytoplasmic side of plasma membrane 1 RHOA
mitochondrial outer membrane 1 HMOX1
centriolar satellite 1 PRKCQ
external side of plasma membrane 1 TNF
dendritic spine 1 RHOA
Z disc 1 DMD
cytoplasmic vesicle 1 CAV1
microtubule cytoskeleton 1 AKT1
midbody 1 RHOA
Cytoplasm, P-body 1 NOS3
P-body 1 NOS3
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 2 AKT1, RHOA
postsynaptic membrane 3 DMD, KCNA3, KCNMA1
Cell membrane, sarcolemma 1 DMD
Cell projection, lamellipodium 1 RHOA
Membrane raft 4 CAV1, DMD, KCNA3, TNF
Cytoplasm, cytoskeleton 1 DMD
focal adhesion 2 CAV1, RHOA
spindle 1 AKT1
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 KNG1
secretory granule 1 AVP
Nucleus outer membrane 1 DMD
nuclear outer membrane 1 DMD
Postsynaptic cell membrane 1 DMD
ciliary basal body 1 AKT1
cilium 1 CAV1
chromatin 1 FOXO1
phagocytic cup 1 TNF
cell periphery 1 RHOA
cytoskeleton 3 DMD, NOS3, RHOA
Secreted, extracellular space 1 KNG1
Golgi apparatus, trans-Golgi network 1 CAV1
Cytoplasm, cell cortex 1 RHOA
blood microparticle 1 KNG1
[Isoform 2]: Cell membrane 1 KCNA3
Lipid droplet 1 CAV1
Membrane, caveola 1 CAV1
Cell projection, dendrite 1 RHOA
Cytoplasm, Stress granule 1 NOS3
cytoplasmic stress granule 1 NOS3
filopodium membrane 1 DMD
voltage-gated potassium channel complex 2 KCNA3, KCNMA1
secretory granule membrane 1 RHOA
endoplasmic reticulum lumen 1 KNG1
platelet alpha granule lumen 1 KNG1
phosphatidylinositol 3-kinase complex 2 PIK3CA, PIK3R6
phosphatidylinositol 3-kinase complex, class IA 2 PIK3CA, PIK3R6
endocytic vesicle membrane 2 CAV1, NOS3
immunological synapse 1 PRKCQ
neuronal dense core vesicle 1 AVP
aggresome 1 PRKCQ
Single-pass type IV membrane protein 2 DMD, HMOX1
calyx of Held 1 KCNA3
clathrin-coated endocytic vesicle membrane 1 AVP
costamere 1 DMD
ficolin-1-rich granule membrane 1 RHOA
death-inducing signaling complex 1 CASP3
apical junction complex 1 RHOA
[Isoform 1]: Cell membrane 1 KCNA3
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
dystrophin-associated glycoprotein complex 1 DMD
acrosomal membrane 1 CAV1
cell-substrate junction 1 DMD
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
neuron projection terminus 1 DMD
syntrophin complex 1 DMD
[Isoform 3]: Cytoplasm, perinuclear region 1 KCNA3
phosphatidylinositol 3-kinase complex, class IB 2 PIK3CA, PIK3R6
caveolar macromolecular signaling complex 1 CAV1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
organelle 1 DMD
plasma membrane bounded cell projection 1 DMD


文献列表

  • Mikhail V Dubinin, Vlada S Starinets, Yuliya A Chelyadnikova, Natalia V Belosludtseva, Irina B Mikheeva, Daria K Penkina, Anastasia D Igoshkina, Eugeny Yu Talanov, Igor I Kireev, Dmitry B Zorov, Konstantin N Belosludtsev. Effect of Large-Conductance Calcium-Dependent K+ Channel Activator NS1619 on Function of Mitochondria in the Heart of Dystrophin-Deficient Mice. Biochemistry. Biokhimiia. 2023 Feb; 88(2):189-201. doi: 10.1134/s0006297923020037. [PMID: 37072326]
  • Feng-Ling Ning, Jie Tao, Dan-Dan Li, Lu-Lu Tian, Meng-Ling Wang, Svetlana Reilly, Cheng Liu, Hui Cai, Hong Xin, Xue-Mei Zhang. Activating BK channels ameliorates vascular smooth muscle calcification through Akt signaling. Acta pharmacologica Sinica. 2022 Mar; 43(3):624-633. doi: 10.1038/s41401-021-00704-6. [PMID: 34163023]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Min Lin, Danielle Sambo, Habibeh Khoshbouei. Methamphetamine Regulation of Firing Activity of Dopamine Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2016 10; 36(40):10376-10391. doi: 10.1523/jneurosci.1392-16.2016. [PMID: 27707972]
  • M Kocmalova, M Oravec, M Adamkov, V Sadlonova, I Kazimierova, I Medvedova, M Joskova, S Franova, M Sutovska. Potassium ion channels and allergic asthma. Advances in experimental medicine and biology. 2015; 838(?):35-45. doi: 10.1007/5584_2014_76. [PMID: 25315623]
  • Bartłomiej Augustynek, Alexei P Kudin, Piotr Bednarczyk, Adam Szewczyk, Wolfram S Kunz. Hemin inhibits the large conductance potassium channel in brain mitochondria: a putative novel mechanism of neurodegeneration. Experimental neurology. 2014 Jul; 257(?):70-5. doi: 10.1016/j.expneurol.2014.04.022. [PMID: 24792919]
  • Dorota Dymkowska, Beata Drabarek, Justyna Jakubczyk, Sylwia Wojciechowska, Krzysztof Zabłocki. Potassium channel openers prevent palmitate-induced insulin resistance in C2C12 myotubes. Archives of biochemistry and biophysics. 2014 Jan; 541(?):47-52. doi: 10.1016/j.abb.2013.11.003. [PMID: 24262853]
  • R W Kirby, A Martelli, V Calderone, N G McKay, K Lawson. Large conductance Ca(2+)-activated K(+) channel (BKCa) activating properties of a series of novel N-arylbenzamides: Channel subunit dependent effects. Bioorganic & medicinal chemistry. 2013 Jul; 21(14):4186-91. doi: 10.1016/j.bmc.2013.05.003. [PMID: 23707646]
  • Piotr Bednarczyk, Agnieszka Koziel, Wieslawa Jarmuszkiewicz, Adam Szewczyk. Large-conductance Ca²⁺-activated potassium channel in mitochondria of endothelial EA.hy926 cells. American journal of physiology. Heart and circulatory physiology. 2013 Jun; 304(11):H1415-27. doi: 10.1152/ajpheart.00976.2012. [PMID: 23542921]
  • Hui Chang, Yu-Guang Ma, Yun-Ying Wang, Zhen Song, Quan Li, Ning Yang, Hua-Zhou Zhao, Han-Zhong Feng, Yao-Ming Chang, Jin Ma, Zhi-Bin Yu, Man-Jiang Xie. High glucose alters apoptosis and proliferation in HEK293 cells by inhibition of cloned BK Ca channel. Journal of cellular physiology. 2011 Jun; 226(6):1660-75. doi: 10.1002/jcp.22497. [PMID: 21413024]
  • Ludwika Chmielewska, Dominika Malińska. Cytoprotective action of the potassium channel opener NS1619 under conditions of disrupted calcium homeostasis. Pharmacological reports : PR. 2011; 63(1):176-83. doi: 10.1016/s1734-1140(11)70413-3. [PMID: 21441626]
  • Shaohua Chang, Cristiano Mendes Gomes, Joseph A Hypolite, James Marx, Jaber Alanzi, Stephen A Zderic, Bruce Malkowicz, Alan J Wein, Samuel Chacko. Detrusor overactivity is associated with downregulation of large-conductance calcium- and voltage-activated potassium channel protein. American journal of physiology. Renal physiology. 2010 Jun; 298(6):F1416-23. doi: 10.1152/ajprenal.00595.2009. [PMID: 20392804]
  • Mohammed Aldakkak, David F Stowe, Qunli Cheng, Wai-Meng Kwok, Amadou K S Camara. Mitochondrial matrix K+ flux independent of large-conductance Ca2+-activated K+ channel opening. American journal of physiology. Cell physiology. 2010 Mar; 298(3):C530-41. doi: 10.1152/ajpcell.00468.2009. [PMID: 20053924]
  • Jolanta Skalska, Marta Piwońska, Elzbieta Wyroba, Liliana Surmacz, Rafal Wieczorek, Izabela Koszela-Piotrowska, Joanna Zielińska, Piotr Bednarczyk, Krzysztof Dołowy, Grzegorz M Wilczynski, Adam Szewczyk, Wolfram S Kunz. A novel potassium channel in skeletal muscle mitochondria. Biochimica et biophysica acta. 2008 Jul; 1777(7-8):651-9. doi: 10.1016/j.bbabio.2008.05.007. [PMID: 18515063]
  • Tamás Gáspár, Prasad Katakam, James A Snipes, Béla Kis, Ferenc Domoki, Ferenc Bari, David W Busija. Delayed neuronal preconditioning by NS1619 is independent of calcium activated potassium channels. Journal of neurochemistry. 2008 May; 105(4):1115-28. doi: 10.1111/j.1471-4159.2007.05210.x. [PMID: 18182041]
  • Neil G McKay, Robert W Kirby, Kim Lawson. Rubidium efflux as a tool for the pharmacological characterisation of compounds with BK channel opening properties. Methods in molecular biology (Clifton, N.J.). 2008; 491(?):267-77. doi: 10.1007/978-1-59745-526-8_21. [PMID: 18998100]
  • Jeffrey L Romine, Scott W Martin, Nicholas A Meanwell, Valentin K Gribkoff, Christopher G Boissard, Steven I Dworetzky, Joanne Natale, Sandra Moon, Astrid Ortiz, Swamy Yeleswaram, Lorraine Pajor, Qi Gao, John E Starrett. 3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl ]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: opener of large-conductance Ca(2+)-activated potassium (maxi-K) channels, identification, solubility, and SAR. Journal of medicinal chemistry. 2007 Feb; 50(3):528-42. doi: 10.1021/jm061006n. [PMID: 17266205]
  • Keita Mayanagi, Tamás Gáspár, Prasad V G Katakam, Béla Kis, David W Busija. The mitochondrial K(ATP) channel opener BMS-191095 reduces neuronal damage after transient focal cerebral ischemia in rats. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2007 Feb; 27(2):348-55. doi: 10.1038/sj.jcbfm.9600345. [PMID: 16736040]
  • Shigemi Yoshihara, Hiroshi Morimoto, Makoto Ohori, Yumi Yamada, Toshio Abe, Osamu Arisaka. The cannabinoid receptor agonist WIN 55212-2 inhibits neurogenic inflammations in airway tissues. Journal of pharmacological sciences. 2005 May; 98(1):77-82. doi: 10.1254/jphs.fp0050171. [PMID: 15888960]
  • Ashutosh S Parihar, Duncan R Groebe, Victoria E Scott, Jianlin Feng, Xu-Feng Zhang, Usha Warrior, Murali Gopalakrishnan, Char-Chang Shieh. Functional analysis of large conductance Ca2(+)-activated K(+) channels: ion flux studies by atomic absorption spectrometry. Assay and drug development technologies. 2003 Oct; 1(5):647-54. doi: 10.1089/154065803770381002. [PMID: 15090237]
  • Susanne Brakemeier, Ines Eichler, Andrea Knorr, Til Fassheber, Ralf Köhler, Joachim Hoyer. Modulation of Ca2+-activated K+ channel in renal artery endothelium in situ by nitric oxide and reactive oxygen species. Kidney international. 2003 Jul; 64(1):199-207. doi: 10.1046/j.1523-1755.2003.00051.x. [PMID: 12787410]
  • Grazyna Debska, Anna Kicinska, Jerzy Dobrucki, Beata Dworakowska, Ewa Nurowska, Jolanta Skalska, Krzysztof Dolowy, Adam Szewczyk. Large-conductance K+ channel openers NS1619 and NS004 as inhibitors of mitochondrial function in glioma cells. Biochemical pharmacology. 2003 Jun; 65(11):1827-34. doi: 10.1016/s0006-2952(03)00180-1. [PMID: 12781334]
  • Yoshio Tanaka, Takahiro Horinouchi, Hikaru Tanaka, Koki Shigenobu, Katsuo Koike. [BK channels play an important role as a negative feedback mechanism in the regulation of spontaneous rhythmic contraction of urinary bladder smooth muscles]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 2002 Nov; 120(1):106P-108P. doi: 10.1254/fpj.120.13. [PMID: 12491797]
  • Kathryn M Gauthier, Christina Deeter, U Murali Krishna, Y Krishna Reddy, Muralidhar Bondlela, J R Falck, William B Campbell. 14,15-Epoxyeicosa-5(Z)-enoic acid: a selective epoxyeicosatrienoic acid antagonist that inhibits endothelium-dependent hyperpolarization and relaxation in coronary arteries. Circulation research. 2002 May; 90(9):1028-36. doi: 10.1161/01.res.0000018162.87285.f8. [PMID: 12016270]
  • W Long, L Zhang, L D Longo. Cerebral artery K(ATP)- and K(Ca)-channel activity and contractility: changes with development. American journal of physiology. Regulatory, integrative and comparative physiology. 2000 Dec; 279(6):R2004-14. doi: 10.1152/ajpregu.2000.279.6.r2004. [PMID: 11080063]
  • P Song, M Milanese, E Crimi, S Bruzzone, E Zocchi, K Rehder, V Brusasco. G(s) protein dysfunction in allergen-challenged human isolated passively sensitized bronchi. American journal of physiology. Lung cellular and molecular physiology. 2000 Aug; 279(2):L209-15. doi: 10.1152/ajplung.2000.279.2.l209. [PMID: 10926543]
  • D Fulton, J C McGiff, M S Wolin, P Kaminski, J Quilley. Evidence against a cytochrome P450-derived reactive oxygen species as the mediator of the nitric oxide-independent vasodilator effect of bradykinin in the perfused heart of the rat. The Journal of pharmacology and experimental therapeutics. 1997 Feb; 280(2):702-9. doi: NULL. [PMID: 9023282]
  • V K Gribkoff, J T Lum-Ragan, C G Boissard, D J Post-Munson, N A Meanwell, J E Starrett, E S Kozlowski, J L Romine, J T Trojnacki, M C Mckay, J Zhong, S I Dworetzky. Effects of channel modulators on cloned large-conductance calcium-activated potassium channels. Molecular pharmacology. 1996 Jul; 50(1):206-17. doi: . [PMID: 8700114]