Methyl 4-(2-benzylbenzoyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate (BioDeep_00000009559)
Secondary id: BioDeep_00001876786
human metabolite blood metabolite
代谢物信息卡片
化学式: C22H21NO3 (347.1521)
中文名称: 2,5-二甲基-4-[2-(苯基甲基)苯甲酰]-1H-吡咯-3-羧酸甲酯
谱图信息:
最多检出来源 Homo sapiens(blood) 100%
分子结构信息
SMILES: CC1=C(C(=C(N1)C)C(=O)OC)C(=O)C2=CC=CC=C2CC3=CC=CC=C3
InChI: InChI=1S/C22H21NO3/c1-14-19(20(15(2)23-14)22(25)26-3)21(24)18-12-8-7-11-17(18)13-16-9-5-4-6-10-16/h4-12,23H,13H2,1-3H3
描述信息
D002317 - Cardiovascular Agents > D014662 - Vasoconstrictor Agents > D002120 - Calcium Channel Agonists
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
同义名列表
11 个代谢物同义名
Methyl-2,5-dimethyl-4-(2-(phenylmethyl)benzoyl)-1H-pyrrole-3-carboxylic acid; 4-(2-Benzyl-benzoyl)-2,5-dimethyl-1H-pyrrole-3-carboxylic acid methyl ester; Methyl 2,5-dimethyl-4-(2-(phenylmethyl)benzoyl)-1H-pyrrole-3-carboxylate; Methyl-2,5-dimethyl-4-(2-(phenylmethyl)benzoyl)-1H-pyrrole-3-carboxylate; 4-(2-Benzyl-benzoyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate methyl ester; Methyl 4-(2-benzylbenzoyl)-2,5-dimethyl-1H-pyrrole-3-carboxylic acid; Methyl 4-(2-benzylbenzoyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate; FPL 64176; FPL-64176; FPL64176; FPL64176
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:249982
- KEGG: C13759
- PubChem: 3423
- HMDB: HMDB0252478
- Metlin: METLIN69688
- ChEMBL: CHEMBL93655
- chemspider: 3305
- CAS: 120934-96-5
- PMhub: MS000023352
- PubChem: 586345
- NIKKAJI: J445.198H
- KNApSAcK: 249982
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Nissar A Darmani, Weixia Zhong, Seetha Chebolu, Mariam Vaezi, Tursun Alkam. Broad-spectrum antiemetic potential of the L-type calcium channel antagonist nifedipine and evidence for its additive antiemetic interaction with the 5-HT(3) receptor antagonist palonosetron in the least shrew (Cryptotis parva).
European journal of pharmacology.
2014 Jan; 722(?):2-12. doi:
10.1016/j.ejphar.2013.08.052. [PMID: 24513517] - Zhong Zhang, Hai Lin, Chunhua Cao, Sandeep Khurana, Thomas L Pallone. Voltage-gated divalent currents in descending vasa recta pericytes.
American journal of physiology. Renal physiology.
2010 Oct; 299(4):F862-71. doi:
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The Journal of pharmacology and experimental therapeutics.
2009 Jul; 330(1):283-93. doi:
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The Journal of clinical investigation.
2006 Dec; 116(12):3139-49. doi:
10.1172/jci28184. [PMID: 17099777] - Valérie De Crescenzo, Kevin E Fogarty, Ronghua Zhuge, Richard A Tuft, Lawrence M Lifshitz, Jeffrey Carmichael, Karl D Bellvé, Stephen P Baker, S Zissimopoulos, F Anthony Lai, José R Lemos, John V Walsh. Dihydropyridine receptors and type 1 ryanodine receptors constitute the molecular machinery for voltage-induced Ca2+ release in nerve terminals.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2006 Jul; 26(29):7565-74. doi:
10.1523/jneurosci.1512-06.2006. [PMID: 16855084] - Stefan I McDonough, Yasuo Mori, Bruce P Bean. FPL 64176 modification of Ca(V)1.2 L-type calcium channels: dissociation of effects on ionic current and gating current.
Biophysical journal.
2005 Jan; 88(1):211-23. doi:
10.1529/biophysj.104.051714. [PMID: 15501945] - J Andrew Wasserstrom, Leslie A Wasserstrom, Andrew J Lokuta, James E Kelly, Sireen T Reddy, Andrew J Frank. Activation of cardiac ryanodine receptors by the calcium channel agonist FPL-64176.
American journal of physiology. Heart and circulatory physiology.
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American journal of physiology. Cell physiology.
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10.1152/ajpcell.2001.280.5.c1306. [PMID: 11287344] - W Macías, R Carlson, A Rajadhyaksha, A Barczak, C Konradi. Potassium chloride depolarization mediates CREB phosphorylation in striatal neurons in an NMDA receptor-dependent manner.
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