Ampalex (BioDeep_00000009504)

   


代谢物信息卡片


1-Piperidinyl-6-quinoxalinyl-methanone

化学式: C14H15N3O (241.1215)
中文名称: 安帕来斯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CCN(CC1)C(=O)C2=CC3=NC=CN=C3C=C2
InChI: InChI=1S/C14H15N3O/c18-14(17-8-2-1-3-9-17)11-4-5-12-13(10-11)16-7-6-15-12/h4-7,10H,1-3,8-9H2

描述信息

CX516 (BDP 12) is an ampakine and acts as an AMPA receptor positive allosteric modulator for the research of Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI)[1].

同义名列表

6 个代谢物同义名

1-Piperidinyl-6-quinoxalinyl-methanone; Ampalex; CX-516; BDP 12; CX516; Ampalex



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ACE, BCL2, BDNF, CA1, CA3, NTRK2, PVALB, RIC8B, STXBP1
Peripheral membrane protein 1 STXBP1
Endosome membrane 1 NTRK2
Endoplasmic reticulum membrane 3 BCL2, GRIA1, GRIN2A
Nucleus 2 ARID3B, BCL2
cytosol 7 BCL2, CA1, CA3, GRIA1, NTRK2, RIC8B, STXBP1
dendrite 5 BDNF, GRIA1, GRIA2, GRIA4, NTRK2
phagocytic vesicle 1 STXBP1
centrosome 1 RIC8B
nucleoplasm 2 ARID3B, STXBP1
Cell membrane 10 ACE, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRIK1, GRIN2A, NTRK2, SCN2A
Cell projection, axon 1 NTRK2
Early endosome membrane 2 GRIA1, NTRK2
Multi-pass membrane protein 9 CACNA1I, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRIK1, GRIN2A, SCN2A
Synapse 3 GRIA1, GRIN2A, PVALB
cell cortex 1 RIC8B
cell surface 2 GRIA1, GRIN2A
dendritic shaft 1 GRIA1
glutamatergic synapse 6 GRIA1, GRID1, GRIN2A, ICAM5, SCN2A, STXBP1
neuromuscular junction 1 GRIA1
neuronal cell body 3 GRIA1, GRIA2, GRIA4
postsynapse 3 GRIA2, ICAM5, STXBP1
presynaptic membrane 3 GRIK1, GRIN2A, SCN2A
synaptic vesicle 2 BDNF, GRIN2A
Cytoplasm, cytosol 1 STXBP1
Lysosome 1 ACE
Presynapse 1 GRIA1
endosome 1 ACE
plasma membrane 14 ACE, CACNA1I, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRIK1, GRIN2A, ICAM5, NTRK2, RIC8B, SCN2A, STXBP1
synaptic vesicle membrane 1 GRIA1
terminal bouton 1 NTRK2
Membrane 12 ACE, BCL2, BDNF, CACNA1I, GRIA1, GRIA2, GRIA4, GRIN2A, ICAM5, NTRK2, SCN2A, STXBP1
axon 5 BDNF, NTRK2, PVALB, SCN2A, STXBP1
extracellular exosome 4 ACE, CA1, GRID1, STXBP1
endoplasmic reticulum 2 BCL2, GRIN2A
extracellular space 2 ACE, BDNF
perinuclear region of cytoplasm 3 BDNF, NTRK2, STXBP1
intercalated disc 1 SCN2A
mitochondrion 2 BCL2, STXBP1
protein-containing complex 2 BCL2, STXBP1
intracellular membrane-bounded organelle 1 GRIK1
postsynaptic density 4 GRIA1, GRIA2, GRIN2A, NTRK2
Single-pass type I membrane protein 3 ACE, ICAM5, NTRK2
Secreted 2 ACE, BDNF
extracellular region 2 ACE, BDNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
excitatory synapse 2 GRIA1, GRIA2
neuronal cell body membrane 1 GRIA1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 3 ACE, GRIA1, GRIA2
Extracellular vesicle 1 GRIA4
dendritic spine 6 GRIA1, GRIA2, GRIA3, GRIA4, GRIN2A, NTRK2
T-tubule 1 SCN2A
neuron spine 1 GRIA1
Early endosome 1 NTRK2
cell-cell junction 1 GRIA1
recycling endosome 1 GRIA1
postsynaptic membrane 7 GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRIK1, GRIN2A
presynaptic active zone membrane 1 GRIA1
Cytoplasm, perinuclear region 1 NTRK2
pore complex 1 BCL2
GABA-ergic synapse 1 GRID1
Cell projection, dendritic spine 2 GRIA1, GRIN2A
secretory granule 1 STXBP1
Postsynaptic cell membrane 7 GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRIK1, GRIN2A
kainate selective glutamate receptor complex 1 GRIK1
receptor complex 1 NTRK2
neuron projection 1 GRIN2A
brush border membrane 1 ACE
Cytoplasm, cell cortex 1 RIC8B
sperm midpiece 1 ACE
postsynaptic density, intracellular component 1 GRIA1
Recycling endosome membrane 1 GRIA1
Cytoplasmic vesicle membrane 1 GRIN2A
AMPA glutamate receptor complex 4 GRIA1, GRIA2, GRIA3, GRIA4
Cell projection, dendrite 3 GRIA1, GRIA4, NTRK2
myelin sheath 1 BCL2
basal plasma membrane 1 ACE
synaptic membrane 2 GRIA1, GRIN2A
platelet alpha granule 1 STXBP1
endoplasmic reticulum lumen 1 BDNF
axon terminus 1 NTRK2
voltage-gated calcium channel complex 1 CACNA1I
endocytic vesicle membrane 4 GRIA1, GRIA2, GRIA3, GRIA4
node of Ranvier 1 SCN2A
paranode region of axon 1 SCN2A
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GRIA1
postsynaptic density membrane 7 GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRIK1, GRIN2A
postsynaptic endocytic zone 1 GRIA2
ER to Golgi transport vesicle membrane 1 GRIA1
parallel fiber to Purkinje cell synapse 2 GRIA3, STXBP1
presynaptic active zone cytoplasmic component 1 STXBP1
NMDA selective glutamate receptor complex 1 GRIN2A
voltage-gated sodium channel complex 1 SCN2A
dendritic spine membrane 1 GRIA1
presynaptic cytosol 1 STXBP1
extrinsic component of presynaptic membrane 1 STXBP1
asymmetric synapse 1 GRIA2
BAD-BCL-2 complex 1 BCL2
proximal dendrite 1 GRIA1
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
axonal spine 1 GRIA1
perisynaptic space 1 GRIA1


文献列表

  • A C Arai, Y-F Xia, E Suzuki. Modulation of AMPA receptor kinetics differentially influences synaptic plasticity in the hippocampus. Neuroscience. 2004; 123(4):1011-24. doi: 10.1016/j.neuroscience.2003.10.033. [PMID: 14751292]
  • Tracey K Murray, Katherine Whalley, Christine S Robinson, Mark A Ward, Caroline A Hicks, David Lodge, Jim L Vandergriff, Polly Baumbarger, Edward Siuda, Mary Gates, Ann M Ogden, Phil Skolnick, Dennis M Zimmerman, Eric S Nisenbaum, David Bleakman, Michael J O'Neill. LY503430, a novel alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor potentiator with functional, neuroprotective and neurotrophic effects in rodent models of Parkinson's disease. The Journal of pharmacology and experimental therapeutics. 2003 Aug; 306(2):752-62. doi: 10.1124/jpet.103.049445. [PMID: 12730350]
  • Ben A Bahr, Jennifer Bendiske, Queenie B Brown, Subramani Munirathinam, Ebru Caba, Markus Rudin, Stephan Urwyler, André Sauter, Gary Rogers. Survival signaling and selective neuroprotection through glutamatergic transmission. Experimental neurology. 2002 Mar; 174(1):37-47. doi: 10.1006/exnr.2001.7852. [PMID: 11869032]