Sulfametopyrazine (BioDeep_00000009363)
Secondary id: BioDeep_00000858471
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
4-amino-N-(3-methoxypyrazin-2-yl)benzene-1-sulfonamide
化学式: C11H12N4O3S (280.063)
中文名称: 磺胺林
谱图信息:
最多检出来源 Homo sapiens(urine) 51.32%
分子结构信息
SMILES: COC1=NC=CN=C1NS(=O)(=O)C1=CC=C(N)C=C1
InChI: InChI=1S/C11H12N4O3S/c1-18-11-10(13-6-7-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,15)
描述信息
Sulfametopyrazine is only found in individuals that have used or taken this drug. It is a long-acting plasma-bound sulfonamide used for respiratory and urinary tract infections and also for malaria. [PubChem]Sulfametopyrazine is a competitive inhibitor of the bacterial enzyme dihydropteroate synthetase. Para-aminobenzoic acid (PABA), a substrate of the enzyme is prevented from binding. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01E - Sulfonamides and trimethoprim > J01ED - Long-acting sulfonamides
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C254 - Anti-Infective Agent > C29739 - Sulfonamide Anti-Infective Agent
D000890 - Anti-Infective Agents > D013424 - Sulfanilamides
Same as: D01216
同义名列表
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:32162
- KEGG: C12616
- PubChem: 9047
- HMDB: HMDB0014802
- Metlin: METLIN69463
- DrugBank: DB00664
- ChEMBL: CHEMBL1525826
- Wikipedia: Sulfalene
- MeSH: Sulfalene
- chemspider: 8695
- CAS: 5175-55-3
- CAS: 152-47-6
- PMhub: MS000023135
- PubChem: 583006
- NIKKAJI: J3.271I
- KNApSAcK: 32162
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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Journal of the Medical Association of Thailand = Chotmaihet thangphaet.
2010 Dec; 93 Suppl 7(?):S131-5. doi:
". [PMID: 21298838] - Hidenori Takahashi, Katsunaka Mikami, Ryou Nishino, Takashi Matsuoka, Moto Kimura, Yasuhiro Koga. Comparative analysis of the properties of bifidobacterial isolates from fecal samples of mother-infant pairs.
Journal of pediatric gastroenterology and nutrition.
2010 Nov; 51(5):653-60. doi:
10.1097/mpg.0b013e3181f0e032. [PMID: 20890213] - Hannah R Vasanthi, R P Parameswari. Indian spices for healthy heart - an overview.
Current cardiology reviews.
2010 Nov; 6(4):274-9. doi:
10.2174/157340310793566172. [PMID: 22043203] - J M Laparra, A López-Rubio, J M Lagaron, Y Sanz. Dietary glycosaminoglycans interfere in bacterial adhesion and gliadin-induced pro-inflammatory response in intestinal epithelial (Caco-2) cells.
International journal of biological macromolecules.
2010 Nov; 47(4):458-64. doi:
10.1016/j.ijbiomac.2010.06.015. [PMID: 20637226] - Megha Pathak, Hitesh Vyas, Mahesh Kumar Vyas. A clinical trial of Pippali (Piper longum Linn.) with special reference to Abheshaja.
Ayu.
2010 Oct; 31(4):442-6. doi:
10.4103/0974-8520.82038. [PMID: 22048536] - Umadevi Subramanian, Sharmila Poongavanam, A J Vanisree. Studies on the neuroprotective role of Piper longum in C6 glioma induced rats.
Investigational new drugs.
2010 Oct; 28(5):615-23. doi:
10.1007/s10637-009-9301-1. [PMID: 19730792] - Gi-Sang Bae, Min-Sun Kim, Won-Seok Jung, Sang-Wan Seo, Seung-Won Yun, Sung Gyu Kim, Rae-Kil Park, Eun-Cheol Kim, Ho-Joon Song, Sung-Joo Park. Inhibition of lipopolysaccharide-induced inflammatory responses by piperine.
European journal of pharmacology.
2010 Sep; 642(1-3):154-62. doi:
10.1016/j.ejphar.2010.05.026. [PMID: 20621590] - Sarita Kumar, Radhika Warikoo, Naim Wahab. Larvicidal potential of ethanolic extracts of dried fruits of three species of peppercorns against different instars of an indian strain of dengue fever mosquito, Aedes aegypti L. (Diptera: Culicidae).
Parasitology research.
2010 Sep; 107(4):901-7. doi:
10.1007/s00436-010-1948-1. [PMID: 20549234] - Cecilia Santini, Loredana Baffoni, Francesca Gaggia, Marta Granata, Rossana Gasbarri, Diana Di Gioia, Bruno Biavati. Characterization of probiotic strains: an application as feed additives in poultry against Campylobacter jejuni.
International journal of food microbiology.
2010 Jul; 141 Suppl 1(?):S98-108. doi:
10.1016/j.ijfoodmicro.2010.03.039. [PMID: 20452074] - Assam J P Assam, J P Dzoyem, C A Pieme, V B Penlap. In vitro antibacterial activity and acute toxicity studies of aqueous-methanol extract of Sida rhombifolia Linn. (Malvaceae).
BMC complementary and alternative medicine.
2010 Jul; 10(?):40. doi:
10.1186/1472-6882-10-40. [PMID: 20663208] - Giacomo Biasucci, Monica Rubini, Sara Riboni, Lorenzo Morelli, Elena Bessi, Cristiana Retetangos. Mode of delivery affects the bacterial community in the newborn gut.
Early human development.
2010 Jul; 86 Suppl 1(?):13-5. doi:
10.1016/j.earlhumdev.2010.01.004. [PMID: 20133091] - David A Sela, David A Mills. Nursing our microbiota: molecular linkages between bifidobacteria and milk oligosaccharides.
Trends in microbiology.
2010 Jul; 18(7):298-307. doi:
10.1016/j.tim.2010.03.008. [PMID: 20409714] - Adel A Amran, Zaiton Zakaria, Faizah Othman, Srijit Das, Santhana Raj, Nor-Anita M M Nordin. Aqueous extract of Piper sarmentosum decreases atherosclerotic lesions in high cholesterolemic experimental rabbits.
Lipids in health and disease.
2010 Apr; 9(?):44. doi:
10.1186/1476-511x-9-44. [PMID: 20433693] - Marco Candela, Clarissa Consolandi, Marco Severgnini, Elena Biagi, Bianca Castiglioni, Beatrice Vitali, Gianluca De Bellis, Patrizia Brigidi. High taxonomic level fingerprint of the human intestinal microbiota by ligase detection reaction--universal array approach.
BMC microbiology.
2010 Apr; 10(?):116. doi:
10.1186/1471-2180-10-116. [PMID: 20398430] - Gulcin Alp, Belma Aslim. Relationship between the resistance to bile salts and low pH with exopolysaccharide (EPS) production of Bifidobacterium spp. isolated from infants feces and breast milk.
Anaerobe.
2010 Apr; 16(2):101-5. doi:
10.1016/j.anaerobe.2009.06.006. [PMID: 19576995] - R T Long, W S Zeng, L Y Chen, J Guo, Y Z Lin, Q S Huang, S Q Luo. Bifidobacterium as an oral delivery carrier of oxyntomodulin for obesity therapy: inhibitory effects on food intake and body weight in overweight mice.
International journal of obesity (2005).
2010 Apr; 34(4):712-9. doi:
10.1038/ijo.2009.277. [PMID: 20065960] - Hyang Mi An, Eun Hye Baek, Seok Jang, Do Kyung Lee, Mi Jin Kim, Jung Rae Kim, Kang Oh Lee, Jong Gi Park, Nam Joo Ha. Efficacy of Lactic Acid Bacteria (LAB) supplement in management of constipation among nursing home residents.
Nutrition journal.
2010 Feb; 9(?):5. doi:
10.1186/1475-2891-9-5. [PMID: 20137076] - Kazutoshi Yoshimura, Takane Matsui, Kikuji Itoh. Prevention of Escherichia coli O157:H7 infection in gnotobiotic mice associated with Bifidobacterium strains.
Antonie van Leeuwenhoek.
2010 Feb; 97(2):107-17. doi:
10.1007/s10482-009-9391-y. [PMID: 19911297] - Beatrice Vitali, Maurice Ndagijimana, Federica Cruciani, Paola Carnevali, Marco Candela, Maria Elisabetta Guerzoni, Patrizia Brigidi. Impact of a synbiotic food on the gut microbial ecology and metabolic profiles.
BMC microbiology.
2010 Jan; 10(?):4. doi:
10.1186/1471-2180-10-4. [PMID: 20055983] - Osamu Ohno, Taeko Watabe, Kazuhiko Nakamura, Masaru Kawagoshi, Nobuo Uotsu, Tomohiro Chiba, Masayoshi Yamada, Kohji Yamaguchi, Kaoru Yamada, Kenji Miyamoto, Daisuke Uemura. Inhibitory effects of bakuchiol, bavachin, and isobavachalcone isolated from Piper longum on melanin production in B16 mouse melanoma cells.
Bioscience, biotechnology, and biochemistry.
2010; 74(7):1504-6. doi:
10.1271/bbb.100221. [PMID: 20622433] - P Nilani, B Duraisamy, P Dhamodaran, S Ravichandran, K Elango. Effect of selected antiasthmatic plant constituents against micro organism causing upper respiratory tract infection.
Ancient science of life.
2010 Jan; 29(3):30-2. doi:
. [PMID: 22557357] - Lotta Krogius-Kurikka, Anna Lyra, Erja Malinen, Johannes Aarnikunnas, Jarno Tuimala, Lars Paulin, Harri Mäkivuokko, Kajsa Kajander, Airi Palva. Microbial community analysis reveals high level phylogenetic alterations in the overall gastrointestinal microbiota of diarrhoea-predominant irritable bowel syndrome sufferers.
BMC gastroenterology.
2009 Dec; 9(?):95. doi:
10.1186/1471-230x-9-95. [PMID: 20015409] - Thakur Uttam Singh, Dinesh Kumar, Surendra Kumar Tandan, Santosh Kumar Mishra. Inhibitory effect of essential oils of Allium sativum and Piper longum on spontaneous muscular activity of liver fluke, Fasciola gigantica.
Experimental parasitology.
2009 Dec; 123(4):302-8. doi:
10.1016/j.exppara.2009.08.002. [PMID: 19679128] - Wenfeng Liu, Zhiyong Jiang, Jijun Chen, Xuemei Zhang, Yunbao Ma. [Chemical constituents from Piper longum].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2009 Nov; 34(22):2891-4. doi:
". [PMID: 20209953] - Daniela C U Cavallini, Dulcinéia S P Abdalla, Regina C Vendramini, Raquel Bedani, Laura Q Bomdespacho, Nadiége D Pauly-Silveira, Graciela F de Valdez, Elizeu A Rossi. Effects of isoflavone-supplemented soy yogurt on lipid parameters and atherosclerosis development in hypercholesterolemic rabbits: a randomized double-blind study.
Lipids in health and disease.
2009 Oct; 8(?):40. doi:
10.1186/1476-511x-8-40. [PMID: 19814806] - Mahamadou S Sissoko, Abdoulaye Dabo, Hamidou Traoré, Mouctar Diallo, Boubacar Traoré, Drissa Konaté, Boubacar Niaré, Moussa Diakité, Bourama Kamaté, Abdrahamane Traoré, Aboudramane Bathily, Amadou Tapily, Ousmane B Touré, Sarah Cauwenbergh, Herwig F Jansen, Ogobara K Doumbo. Efficacy of artesunate + sulfamethoxypyrazine/pyrimethamine versus praziquantel in the treatment of Schistosoma haematobium in children.
PloS one.
2009 Oct; 4(10):e6732. doi:
10.1371/journal.pone.0006732. [PMID: 19802383] - Arlette Santacruz, Ascensión Marcos, Julia Wärnberg, Amelia Martí, Miguel Martin-Matillas, Cristina Campoy, Luis A Moreno, Oscar Veiga, Carlos Redondo-Figuero, Jesús M Garagorri, Cristina Azcona, Manuel Delgado, Miguel García-Fuentes, Maria C Collado, Yolanda Sanz. Interplay between weight loss and gut microbiota composition in overweight adolescents.
Obesity (Silver Spring, Md.).
2009 Oct; 17(10):1906-15. doi:
10.1038/oby.2009.112. [PMID: 19390523] - Marianna Roselli, Alberto Finamore, Silvia Nuccitelli, Paola Carnevali, Patrizia Brigidi, Beatrice Vitali, Fabio Nobili, Rita Rami, Ivana Garaguso, Elena Mengheri. Prevention of TNBS-induced colitis by different Lactobacillus and Bifidobacterium strains is associated with an expansion of gammadeltaT and regulatory T cells of intestinal intraepithelial lymphocytes.
Inflammatory bowel diseases.
2009 Oct; 15(10):1526-36. doi:
10.1002/ibd.20961. [PMID: 19504616] - Helena Pastell, Peter Westermann, Anne S Meyer, Päivi Tuomainen, Maija Tenkanen. In vitro fermentation of arabinoxylan-derived carbohydrates by bifidobacteria and mixed fecal microbiota.
Journal of agricultural and food chemistry.
2009 Sep; 57(18):8598-606. doi:
10.1021/jf901397b. [PMID: 19694435] - Gwendoline Kint, Kathleen Aj Sonck, Geert Schoofs, David De Coster, Jos Vanderleyden, Sigrid Cj De Keersmaecker. 2D proteome analysis initiates new insights on the Salmonella Typhimurium LuxS protein.
BMC microbiology.
2009 Sep; 9(?):198. doi:
10.1186/1471-2180-9-198. [PMID: 19754952] - Emmanuel Denou, Enea Rezzonico, Jean-Michel Panoff, Fabrizio Arigoni, Harald Brüssow. A Mesocosm of Lactobacillus johnsonii, Bifidobacterium longum, and Escherichia coli in the mouse gut.
DNA and cell biology.
2009 Aug; 28(8):413-22. doi:
10.1089/dna.2009.0873. [PMID: 19534605] - Emiko Iwata, Hisako Hotta, Masahiro Goto. The screening method of a bifidogenic dietary fiber extracted from inedible parts of vegetables.
Journal of nutritional science and vitaminology.
2009 Aug; 55(4):385-8. doi:
10.3177/jnsv.55.385. [PMID: 19763042] - Jitendra K Pandey, D K Singh. Molluscicidal activity of Piper cubeba Linn., Piper longum Linn. and Tribulus terrestris Linn. and their combinations against snail Indoplanorbis exustus Desh.
Indian journal of experimental biology.
2009 Aug; 47(8):643-8. doi:
". [PMID: 19775070] - Pallavi Rai, Ashutosh Pathak, Sadhana J Rajput. Stability-indicating reversed-phase liquid chromatographic methods for the determination of aconitine and piperine in a polyherbal formulation.
Journal of AOAC International.
2009 Jul; 92(4):1044-54. doi:
. [PMID: 19714970] - Firas A Al-Bayati. Isolation and identification of antimicrobial compound from Mentha longifolia L. leaves grown wild in Iraq.
Annals of clinical microbiology and antimicrobials.
2009 Jun; 8(?):20. doi:
10.1186/1476-0711-8-20. [PMID: 19523224] - Do Kyung Lee, Seok Jang, Eun Hye Baek, Mi Jin Kim, Kyung Soon Lee, Hea Soon Shin, Myung Jun Chung, Jin Eung Kim, Kang Oh Lee, Nam Joo Ha. Lactic acid bacteria affect serum cholesterol levels, harmful fecal enzyme activity, and fecal water content.
Lipids in health and disease.
2009 Jun; 8(?):21. doi:
10.1186/1476-511x-8-21. [PMID: 19515264] - Yanbin Lu, Alain Berthod, Ruilin Hu, Wenyan Ma, Yuanjiang Pan. Screening of complex natural extracts by countercurrent chromatography using a parallel protocol.
Analytical chemistry.
2009 May; 81(10):4048-59. doi:
10.1021/ac9002547. [PMID: 19331393] - Wenfeng Liu, Zhiyong Jiang, Jijun Chen, Xuemei Zhang, Yunbao Ma. [Chemical constituents from air-dried Piper longum].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2009 May; 34(9):1101-3. doi:
". [PMID: 19685743] - P Nilani, N Kasthuribai, B Duraisamy, P Dhamodaran, S Ravichandran, K Ilango, B Suresh. Invitro antioxidant activity of selected antiasthmatic herbal constituents.
Ancient science of life.
2009 Apr; 28(4):3-6. doi:
. [PMID: 22557323] - E V Ivanova, N B Perunova, A V Valyshev, I V Valysheva, O V Bukharin. [Species characteristic and factors of persistence of gut bifidoflora during healthy state and dysbiosis].
Zhurnal mikrobiologii, epidemiologii i immunobiologii.
2009 Mar; ?(2):89-93. doi:
NULL. [PMID: 19462518] - Mariyamma Thomas, K S Sujatha, Sisilamma George. Protective effect of Piper longum Linn. on monosodium glutamate induced oxidative stress in rats.
Indian journal of experimental biology.
2009 Mar; 47(3):186-92. doi:
NULL. [PMID: 19405384] - Noriko Yamada, Chie Nishihara, Hiroyuki Yoshimura, Yasunaga Yamaguchi, Ryoji Takagaki, Masazumi Miyakoshi, Kenji Mizutani. [Effects of Piper longum L. on chills in Japanese young women: time-dependent changes in skin surface temperature and its recovery rate following the exposure to mild cold stress].
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology.
2009 Feb; 29(1):7-15. doi:
". [PMID: 19326811] - Carlett Ramirez-Farias, Kathleen Slezak, Zoë Fuller, Alan Duncan, Grietje Holtrop, Petra Louis. Effect of inulin on the human gut microbiota: stimulation of Bifidobacterium adolescentis and Faecalibacterium prausnitzii.
The British journal of nutrition.
2009 Feb; 101(4):541-50. doi:
10.1017/s0007114508019880. [PMID: 18590586]
