Tazarotene (BioDeep_00000009354)

 

Secondary id: BioDeep_00000398924

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


ethyl 6-[2-(4,4-dimethyl-3,4-dihydro-2H-1-benzothiopyran-6-yl)ethynyl]pyridine-3-carboxylate

化学式: C21H21NO2S (351.1293)
中文名称: 他扎罗汀
谱图信息: 最多检出来源 Escherichia coli(natural_products) 33.33%

分子结构信息

SMILES: CCOC(=O)C1=CN=C(C=C1)C#CC1=CC2=C(SCCC2(C)C)C=C1
InChI: InChI=1S/C21H21NO2S/c1-4-24-20(23)16-7-9-17(22-14-16)8-5-15-6-10-19-18(13-15)21(2,3)11-12-25-19/h6-7,9-10,13-14H,4,11-12H2,1-3H3

描述信息

Tazarotene is only found in individuals that have used or taken this drug. It is a prescription topical retinoid sold as a cream or gel. This medication is approved for treatment of psoriasis, acne, and sun damaged skin (photodamage). [Wikipedia]Although the exact mechanism of tazarotene action is not known, studies have shown that the active form of the drug (tazarotenic acid) binds to all three members of the retinoic acid receptor (RAR) family: RARa, RARb, and RARg, but shows relative selectivity for RARb, and RARg and may modify gene expression. It also has affinity for RXR receptors.
C274 - Antineoplastic Agent > C2122 - Cell Differentiating Agent > C1934 - Differentiation Inducer
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C804 - Retinoic Acid Agent
D - Dermatologicals > D05 - Antipsoriatics > D05A - Antipsoriatics for topical use
C308 - Immunotherapeutic Agent > C129820 - Antineoplastic Immunomodulating Agent
D003879 - Dermatologic Agents > D007641 - Keratolytic Agents
D009676 - Noxae > D013723 - Teratogens
Same as: D01132

同义名列表

9 个代谢物同义名

ethyl 6-[2-(4,4-dimethyl-3,4-dihydro-2H-1-benzothiopyran-6-yl)ethynyl]pyridine-3-carboxylate; Tazarotenum; Tazarotene; Tazaroteno; Tazorac; Fabior; Avage; Zorac; Tazarotene



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 ANG, ANXA5, BCL2, BGLAP, GRK5, PLAAT4, RARA, RARB, RARG, RBP1, VEGFA
Peripheral membrane protein 1 ANXA5
Endoplasmic reticulum membrane 1 BCL2
Nucleus 7 ANG, BCL2, RARA, RARB, RARG, RBP1, VEGFA
cytosol 7 ANG, ANXA5, BCL2, GRK5, PLAAT4, RARA, RBP1
dendrite 2 BGLAP, RARA
nucleoplasm 4 RARA, RARB, RARG, RBP1
RNA polymerase II transcription regulator complex 1 RARA
Cell membrane 3 CMKLR1, PTCH1, TNF
Multi-pass membrane protein 2 CMKLR1, PTCH1
cell surface 2 TNF, VEGFA
glutamatergic synapse 1 RBP1
Golgi apparatus 1 VEGFA
growth cone 1 ANG
neuronal cell body 2 ANG, TNF
sarcolemma 1 ANXA5
plasma membrane 8 CMKLR1, GRK5, IFNLR1, PTCH1, RARA, RBP1, TNF, TNFRSF11B
Membrane 10 ANXA5, BCL2, CMKLR1, IFNLR1, PGF, PLAAT4, PTCH1, RARG, RARRES1, VEGFA
caveola 1 PTCH1
extracellular exosome 2 ANXA5, RARRES1
endoplasmic reticulum 2 BCL2, VEGFA
extracellular space 8 ANG, BGLAP, PGF, RARRES1, RARRES2, TNF, TNFRSF11B, VEGFA
perinuclear region of cytoplasm 2 PTCH1, RARA
adherens junction 1 VEGFA
mitochondrion 2 BCL2, RBP1
protein-containing complex 2 BCL2, RARA
intracellular membrane-bounded organelle 1 PTCH1
Single-pass type I membrane protein 1 IFNLR1
Secreted 8 ANG, BGLAP, IL23A, PGF, RARRES1, RARRES2, TNFRSF11B, VEGFA
extracellular region 9 ANG, ANXA5, BGLAP, IL23A, PGF, RARRES2, TNF, TNFRSF11B, VEGFA
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 2 BCL2, PLAAT4
mitochondrial outer membrane 1 BCL2
transcription regulator complex 2 RARA, RARG
ciliary membrane 1 PTCH1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, GRK5
external side of plasma membrane 2 ANXA5, TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 2 ANG, RARA
perikaryon 1 BGLAP
nucleolus 2 ANG, RARA
midbody 1 PTCH1
apical part of cell 1 PTCH1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 BGLAP
postsynaptic membrane 1 PTCH1
Membrane raft 1 TNF
pore complex 1 BCL2
focal adhesion 1 ANXA5
extracellular matrix 3 RARRES2, TNFRSF11B, VEGFA
basement membrane 1 ANG
collagen-containing extracellular matrix 2 ANXA5, RARRES2
secretory granule 1 VEGFA
nuclear speck 1 GRK5
receptor complex 1 TNFRSF11B
Zymogen granule membrane 1 ANXA5
chromatin 3 RARA, RARB, RARG
axonal growth cone 1 PTCH1
phagocytic cup 1 TNF
Chromosome 1 ANG
Nucleus, nucleolus 1 ANG
Lipid droplet 1 RBP1
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
cell body 1 RBP1
dendritic growth cone 1 PTCH1
myelin sheath 1 BCL2
Golgi lumen 1 BGLAP
endoplasmic reticulum lumen 2 BGLAP, IL23A
transcription repressor complex 1 RBP1
platelet alpha granule lumen 1 VEGFA
endocytic vesicle membrane 1 PTCH1
endocytic vesicle 1 ANG
Single-pass type III membrane protein 1 RARRES1
calyx of Held 1 RBP1
vesicle membrane 1 ANXA5
Sin3-type complex 1 RBP1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
platelet dense granule lumen 1 RARRES2
angiogenin-PRI complex 1 ANG
endothelial microparticle 1 ANXA5
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
interleukin-23 complex 1 IL23A
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Sunita Thakur, Md Meraj Anjum, Shweta Jaiswal, Anand Kumar, Payal Deepak, Sneha Anand, Sanjay Singh, Paruvathanahalli Siddalingam Rajinikanth. Novel Synergistic Approach: Tazarotene-Calcipotriol-Loaded-PVA/PVP-Nanofibers Incorporated in Hydrogel Film for Management and Treatment of Psoriasis. Molecular pharmaceutics. 2023 Feb; 20(2):997-1014. doi: 10.1021/acs.molpharmaceut.2c00713. [PMID: 36630478]
  • Lei Li, Xing-Fei Zhang, Guo-Ping Yang, Jie Huang, Xiao-Yan Yang, Ling Ye, Can Guo, Shuang Yang, Xiao-Min Wang. Safety, Tolerability, and Pharmacokinetics of Tazarotene Clindamycin Cream: A Single-Dose, 3-Period Crossover Study. Clinical pharmacology in drug development. 2021 06; 10(6):598-606. doi: 10.1002/cpdd.890. [PMID: 33241616]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Chunxia He, Hongzhong Jin, Xiguang Liu, Fengming Hu, Litao Zhang, Shifa Zhang, Yanling He, Xiumin Yang, Hao Chen, Xiaohua Wang, Chao Ji, Chengzhi Lv, Guoying Miao, Xiaojing Li, Qingchun Diao, Linfeng Li, Xuefei Li, Yuzhen Li, Rupeng Wang, Lijuan Zhang, Xiaoyong Zhou, Xiujuan Xia, Min Yan, Jiquan Song, Ruzhi Zhang, Long Geng, Min Zheng, Qianjin Lu, Tao Lu, Yuling Shi, Haixia Jing, Xiaojie Zhang, Jianqiang Shi, Jue Xia, Yu Gao, Yun Wang. Tazarotene/Betamethasone Dipropionate Cream in Patients with Plaque Psoriasis: Results of a Prospective, Multicenter, Observational Study. Dermatology (Basel, Switzerland). 2021; 237(4):603-610. doi: 10.1159/000511891. [PMID: 33352561]
  • Yu-Ting Lu, Rong Guan, Jia-Run Zheng, Tai-Jun Hang, Min Song. Determination of clobetasol propionate, tazarotene and tazarotenic acid in Bama mini-pig skin by UPLC-MS/MS: Application to pharmacokinetic and drug-drug interaction studies. Journal of pharmaceutical and biomedical analysis. 2020 Jul; 186(?):113322. doi: 10.1016/j.jpba.2020.113322. [PMID: 32380355]
  • Arisha Mahmood, Vamshi Krishna Rapalli, Tejashree Waghule, Srividya Gorantla, Sunil Kumar Dubey, Ranendra Narayan Saha, Gautam Singhvi. UV spectrophotometric method for simultaneous estimation of betamethasone valerate and tazarotene with absorption factor method: Application for in-vitro and ex-vivo characterization of lipidic nanocarriers for topical delivery. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2020 Jul; 235(?):118310. doi: 10.1016/j.saa.2020.118310. [PMID: 32251894]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Luana Niculescu, Cristel Ruini, Jerome Srour, Suzanna Salzer, Ines Schönbuchner, Tanja von Braunmühl, Thomas Ruzicka, Ulrich Hohenleutner, Kathrin A Giehl, Judith Fischer, Andreas Wollenberg. Tazarotene 0.015\% Cream as a Potential Topical Agent for Management of Ichthyosis in Dorfman-Chanarin Syndrome. Acta dermato-venereologica. 2019 Mar; 99(3):345-346. doi: 10.2340/00015555-3087. [PMID: 30460372]
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