Tazarotene (BioDeep_00000398924)
Main id: BioDeep_00000009354
natural product
代谢物信息卡片
Tazarotene (Avage)
化学式: C21H21NO2S (351.1293)
中文名称: 他扎罗汀
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC(C2=C(S1)C=CC(=C2)C#CC3=NC=C(C=C3)C(=O)OCC)(C)C
InChI: InChI=1S/C21H21NO2S/c1-4-24-20(23)16-7-9-17(22-14-16)8-5-15-6-10-19-18(13-15)21(2,3)11-12-25-19/h6-7,9-10,13-14H,4,11-12H2,1-3H3
描述信息
C274 - Antineoplastic Agent > C2122 - Cell Differentiating Agent > C1934 - Differentiation Inducer
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C804 - Retinoic Acid Agent
D - Dermatologicals > D05 - Antipsoriatics > D05A - Antipsoriatics for topical use
C308 - Immunotherapeutic Agent > C129820 - Antineoplastic Immunomodulating Agent
D003879 - Dermatologic Agents > D007641 - Keratolytic Agents
D009676 - Noxae > D013723 - Teratogens
Same as: D01132
同义名列表
3 个代谢物同义名
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:32184
- KEGG: C12531
- KEGGdrug: D01132
- PubChem: 5381
- DrugBank: DB00799
- ChEMBL: CHEMBL1657
- CAS: 118292-40-3
- MoNA: CCMSLIB00000078188
- PubChem: 582921
- NIKKAJI: J679.813F
- KNApSAcK: 32184
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Sunita Thakur, Md Meraj Anjum, Shweta Jaiswal, Anand Kumar, Payal Deepak, Sneha Anand, Sanjay Singh, Paruvathanahalli Siddalingam Rajinikanth. Novel Synergistic Approach: Tazarotene-Calcipotriol-Loaded-PVA/PVP-Nanofibers Incorporated in Hydrogel Film for Management and Treatment of Psoriasis.
Molecular pharmaceutics.
2023 Feb; 20(2):997-1014. doi:
10.1021/acs.molpharmaceut.2c00713. [PMID: 36630478] - Lei Li, Xing-Fei Zhang, Guo-Ping Yang, Jie Huang, Xiao-Yan Yang, Ling Ye, Can Guo, Shuang Yang, Xiao-Min Wang. Safety, Tolerability, and Pharmacokinetics of Tazarotene Clindamycin Cream: A Single-Dose, 3-Period Crossover Study.
Clinical pharmacology in drug development.
2021 06; 10(6):598-606. doi:
10.1002/cpdd.890. [PMID: 33241616] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Chunxia He, Hongzhong Jin, Xiguang Liu, Fengming Hu, Litao Zhang, Shifa Zhang, Yanling He, Xiumin Yang, Hao Chen, Xiaohua Wang, Chao Ji, Chengzhi Lv, Guoying Miao, Xiaojing Li, Qingchun Diao, Linfeng Li, Xuefei Li, Yuzhen Li, Rupeng Wang, Lijuan Zhang, Xiaoyong Zhou, Xiujuan Xia, Min Yan, Jiquan Song, Ruzhi Zhang, Long Geng, Min Zheng, Qianjin Lu, Tao Lu, Yuling Shi, Haixia Jing, Xiaojie Zhang, Jianqiang Shi, Jue Xia, Yu Gao, Yun Wang. Tazarotene/Betamethasone Dipropionate Cream in Patients with Plaque Psoriasis: Results of a Prospective, Multicenter, Observational Study.
Dermatology (Basel, Switzerland).
2021; 237(4):603-610. doi:
10.1159/000511891. [PMID: 33352561] - Yu-Ting Lu, Rong Guan, Jia-Run Zheng, Tai-Jun Hang, Min Song. Determination of clobetasol propionate, tazarotene and tazarotenic acid in Bama mini-pig skin by UPLC-MS/MS: Application to pharmacokinetic and drug-drug interaction studies.
Journal of pharmaceutical and biomedical analysis.
2020 Jul; 186(?):113322. doi:
10.1016/j.jpba.2020.113322. [PMID: 32380355] - Arisha Mahmood, Vamshi Krishna Rapalli, Tejashree Waghule, Srividya Gorantla, Sunil Kumar Dubey, Ranendra Narayan Saha, Gautam Singhvi. UV spectrophotometric method for simultaneous estimation of betamethasone valerate and tazarotene with absorption factor method: Application for in-vitro and ex-vivo characterization of lipidic nanocarriers for topical delivery.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2020 Jul; 235(?):118310. doi:
10.1016/j.saa.2020.118310. [PMID: 32251894] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
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Acta dermato-venereologica.
2019 Mar; 99(3):345-346. doi:
10.2340/00015555-3087. [PMID: 30460372] - Beata Nowak, Agnieszka Matuszewska, Jarosław Filipiak, Anna Nikodem, Anna Merwid-Ląd, Małgorzata Pieśniewska, Lidia Fereniec-Gołębiewska, Joanna Kwiatkowska, Adam Szeląg. The influence of bexarotene, a selective agonist of the retinoid receptor X (RXR), and tazarotene, a selective agonist of the retinoid acid receptor (RAR), on bone metabolism in rats.
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10.17219/acem/41860. [PMID: 27627552] - Ying Tong, Hong Pan, Chenglong Sun, Xiaofei Xin, Li Ding, Pengcheng Ma. Simultaneous determination of tazarotene and its active metabolite tazarotenic acid in minipig plasma by LC-MS/MS and its application in pharmacokinetic study after topical administration of tazarotene gel.
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Dermatology online journal.
2013 Jun; 19(6):18575. doi:
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Clinical drug investigation.
2013 Apr; 33(4):283-9. doi:
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PloS one.
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Allergy, asthma & immunology research.
2011 Apr; 3(2):96-102. doi:
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Investigative ophthalmology & visual science.
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International journal of nanomedicine.
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BMC cardiovascular disorders.
2006 Jun; 6(?):29. doi:
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Journal of pharmaceutical sciences.
2005 Oct; 94(10):2246-55. doi:
10.1002/jps.20427. [PMID: 16136553] - G Deplanque, S Madhusudan, P H Jones, S Wellmann, K Christodoulos, D C Talbot, T S Ganesan, A Blann, A L Harris. Phase II trial of the antiangiogenic agent IM862 in metastatic renal cell carcinoma.
British journal of cancer.
2004 Nov; 91(9):1645-50. doi:
10.1038/sj.bjc.6602126. [PMID: 15354209] - Zhiling Yu, Dale Yu, Patricia S Walker, Diane D-S Tang-Liu. Tazarotene does not affect the pharmacokinetics and efficacy of a norethindrone/ethinylestradiol oral contraceptive.
Clinical pharmacokinetics.
2004; 43(10):673-84. doi:
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British journal of cancer.
2003 Sep; 89(5):808-15. doi:
10.1038/sj.bjc.6601169. [PMID: 12942109] - Zhiling Yu, John Sefton, Deborah Lew-Kaya, Patricia Walker, Dale Yu, Diane D-S Tang-Liu. Pharmacokinetics of tazarotene cream 0.1\% after a single dose and after repeat topical applications at clinical or exaggerated application rates in patients with acne vulgaris or photodamaged skin.
Clinical pharmacokinetics.
2003; 42(10):921-9. doi:
10.2165/00003088-200342100-00004. [PMID: 12885265] - Tania J Phillips, Alice B Gottlieb, James J Leyden, Nicholas J Lowe, Deborah A Lew-Kaya, John Sefton, Patricia S Walker, John R Gibson. Efficacy of 0.1\% tazarotene cream for the treatment of photodamage: a 12-month multicenter, randomized trial.
Archives of dermatology.
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2000 Aug; 43(2 Pt 3):S31-5. doi:
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1999 Oct; 37(4):273-87. doi:
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