Ginsenoside Rb1 (BioDeep_00000000009)

 

Secondary id: BioDeep_00000365343, BioDeep_00001867456

human metabolite PANOMIX_OTCML-2023 Endogenous Chemicals and Drugs


代谢物信息卡片


2-{[2-(5-{[4,5-dihydroxy-6-(hydroxymethyl)-3-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-16-hydroxy-2,6,6,10,11-pentamethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-14-yl)-6-methylhept-5-en-2-yl]oxy}-6-({[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)oxane-3,4,5-triol

化学式: C54H92O23 (1108.6029)
中文名称: 人参皂苷 Rb1, 人参皂苷
谱图信息: 最多检出来源 Viridiplantae(plant) 47.79%

Reviewed

Last reviewed on 2024-06-29.

Cite this Page

Ginsenoside Rb1. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/ginsenoside_rb1 (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000000009). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1C[C@H](O[C@H]2[C@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)[C@@H](O)[C@H](O)[C@@H](CO)O2)C(C)(C)[C@]2([H])CC[C@@]3(C)[C@]4(C)CC[C@@]([C@](O[C@H]5[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)O5)(C)CC/C=C(\C)/C)([H])[C@@]4([H])[C@H](O)C[C@]3([H])[C@@]12C
InChI: InChI=1S/C54H92O23/c1-23(2)10-9-14-54(8,77-48-44(69)40(65)37(62)29(74-48)22-70-46-42(67)38(63)34(59)26(19-55)71-46)24-11-16-53(7)33(24)25(58)18-31-51(5)15-13-32(50(3,4)30(51)12-17-52(31,53)6)75-49-45(41(66)36(61)28(21-57)73-49)76-47-43(68)39(64)35(60)27(20-56)72-47/h10,24-49,55-69H,9,11-22H2,1-8H3

描述信息

Ginsenoside Rb1 is a ginsenoside found in Panax ginseng and Panax japonicus var. major that is ginsenoside Rd in which the beta-D-glucopyranoside group at position 20 is replaced by a beta-D-glucopyranosyl-beta-D-glucopyranoside group. It has a role as a neuroprotective agent, an anti-obesity agent, an anti-inflammatory drug, an apoptosis inhibitor, a radical scavenger and a plant metabolite. It is a ginsenoside, a glycoside and a tetracyclic triterpenoid. It is functionally related to a ginsenoside Rd.
Ginsenosides are a class of steroid glycosides, and triterpene saponins, found exclusively in the plant genus Panax (ginseng). Ginsenosides have been the target of research, as they are viewed as the active compounds behind the claims of ginsengs efficacy. Because ginsenosides appear to affect multiple pathways, their effects are complex and difficult to isolate. Rb1 appears to be most abundant in Panax quinquefolius (American Ginseng). Rb1 seems to affect the reproductive system in animal testicles. Recent research shows that Rb1 affects rat embryo development and has teratogenic effects, causing birth defects. Another study shows that Rb1 may increase testosterone production in male rats indirectly through the stimulation of the luteinizing hormone.
Ginsenoside rb1 is a natural product found in Panax vietnamensis, Gynostemma pentaphyllum, and other organisms with data available.
See also: Asian Ginseng (part of); American Ginseng (part of); Panax notoginseng root (part of).
Ginsenoside Rb1 is found in tea. Ginsenoside Rb1 is a constituent of Panax ginseng (ginseng)
Constituent of Panax ginseng (ginseng). Ginsenoside Rb1 is found in tea.

Ginsenoside Rb1. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=41753-43-9 (retrieved 2024-06-29) (CAS RN: 41753-43-9). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na+, K+-ATPase activity with an IC50 of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65 .
Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na+, K+-ATPase activity with an IC50 of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65 .

同义名列表

44 个代谢物同义名

2-{[2-(5-{[4,5-dihydroxy-6-(hydroxymethyl)-3-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-16-hydroxy-2,6,6,10,11-pentamethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-14-yl)-6-methylhept-5-en-2-yl]oxy}-6-({[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)oxane-3,4,5-triol; .BETA.-D-GLUCOPYRANOSIDE, (3.BETA.,12.BETA.)-20-((6-O-.BETA.-D-GLUCOPYRANOSYL-.BETA.-D-GLUCOPYRANOSYL)OXY)-12-HYDROXYDAMMAR-24-EN-3-YL 2-O-.BETA.-D-GLUCOPYRANOSYL-; beta-D-Glucopyranoside, (3-beta,12-beta)-20-((6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy)-12-hydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-; beta-D-GLUCOPYRANOSIDE, (3beta,12beta)-20-((6-O-beta-D-GLUCOPYRANOSYL-beta-D-GLUCOPYRANOSYL)OXY)-12-HYDROXYDAMMAR-24-EN-3-YL 2-O-beta-D-GLUCOPYRANOSYL-; (3beta,12beta)-20-{[6-O-(beta-D-glucopyranosyl)-beta-D-glucopyranosyl]oxy}-12-hydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside; (3beta,12beta)-20-((6-O-(beta-D-glucopyranosyl)-beta-D-glucopyranosyl)oxy)-12-hydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside; (3beta,12beta)-20-[(6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside; (3beta,12beta)-20-((6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy)-12-hydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside; 2-O-beta-Glucopyranosyl-(3beta,12beta)-20-[(6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl beta-D-glucopyranoside; 2-O-beta-Glucopyranosyl-(3beta,12beta)-20-((6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy)-12-hydroxydammar-24-en-3-yl-beta-D-glucopyranoside; 20-[(6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]-12beta-hydroxydammar-24-en-3beta-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside; 3beta-[beta-D-glucopyranosyl-(1->2)-beta-D glucopyranosyloxy]-20-[beta-D-glucopyranosyl-(1->2)-beta-D glucopyranosyloxy]dammar-24-en-12beta-ol; 3beta-(beta-D-glucopyranosyl-(1->2)-beta-D glucopyranosyloxy)-20-(beta-D-glucopyranosyl-(1->2)-beta-D glucopyranosyloxy)dammar-24-en-12beta-ol; GINSENOSIDE RB1 (CONSTITUENT OF AMERICAN GINSENG, ASIAN GINSENG, AND TIENCHI GINSENG) [DSC]; GINSENOSIDE RB1 (CONSTITUENT OF AMERICAN GINSENG, ASIAN GINSENG, AND TIENCHI GINSENG); Ginsenoside Rb1, European Pharmacopoeia (EP) Reference Standard; Ginsenoside Rb1, primary pharmaceutical reference standard; 13 - Ginseng supplement chemical analysis; 3-GlcGlc-20-GlcGlc-ginsenoside; GZYPWOGIYAIIPV-JBDTYSNRSA-N; GINSENOSIDE RB1 [WHO-DD]; GINSENOSIDE RB1 [USP-RS]; GINSENOSIDE RB1 (USP-RS); Ginsenoside Rb1 - 94\\%; (20S)-ginsenoside Rb1; 20(S)-ginsenoside Rb1; pseudoginsenoside D; notoginsenoside Rb1; Gypenoside cento; sanchinoside Rb1; sanchinoside E1; Ginsenoside Rb1; ginsenoside-Rb1; panax saponin E; GinsenosideRb1; panaxoside Rb1; gypenoside III; Panaxsaponin E; arasaponin E1; gynosaponin C; Ginsenoside; GS-Rb1; GRb 1; GSRb1



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(3)

PlantCyc(1)

代谢反应

5 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(3)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(2)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

60 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 18 AKT1, ANG, ANXA5, BCL2, BDNF, CA1, CASP3, CASP9, MAPK14, MAPK8, MTOR, NFE2L2, PIK3CA, PRKAA2, PTGS2, RB1, SIRT1, VEGFA
Peripheral membrane protein 3 ANXA5, MTOR, PTGS2
Endoplasmic reticulum membrane 3 BCL2, MTOR, PTGS2
Nucleus 14 AKT1, ANG, BCL2, CASP3, CASP9, MAPK14, MAPK8, MTOR, NFE2L2, PRKAA2, RB1, RBL2, SIRT1, VEGFA
cytosol 16 AKT1, ANG, ANXA5, BCL2, CA1, CASP3, CASP9, MAPK14, MAPK8, MTOR, NFE2L2, PIK3CA, PRKAA2, RB1, RBL2, SIRT1
dendrite 3 BDNF, MTOR, PRKAA2
phagocytic vesicle 1 MTOR
centrosome 1 NFE2L2
nucleoplasm 10 AKT1, CASP3, MAPK14, MAPK8, MTOR, NFE2L2, PRKAA2, RB1, RBL2, SIRT1
RNA polymerase II transcription regulator complex 1 NFE2L2
Cell membrane 1 AKT1
Cytoplasmic side 1 MTOR
lamellipodium 2 AKT1, PIK3CA
Golgi apparatus membrane 1 MTOR
Synapse 1 MAPK8
cell cortex 1 AKT1
cell surface 1 VEGFA
glutamatergic synapse 3 AKT1, CASP3, MAPK14
Golgi apparatus 3 NFE2L2, PRKAA2, VEGFA
Golgi membrane 2 INS, MTOR
growth cone 1 ANG
lysosomal membrane 1 MTOR
neuronal cell body 3 ANG, CASP3, PRKAA2
postsynapse 1 AKT1
sarcolemma 1 ANXA5
synaptic vesicle 1 BDNF
Cytoplasm, cytosol 1 NFE2L2
Lysosome 1 MTOR
plasma membrane 3 AKT1, NFE2L2, PIK3CA
Membrane 7 AKT1, ANXA5, BCL2, BDNF, MTOR, PRKAA2, VEGFA
axon 3 BDNF, MAPK8, PRKAA2
caveola 1 PTGS2
extracellular exosome 3 ANXA5, CA1, RBL2
Lysosome membrane 1 MTOR
endoplasmic reticulum 3 BCL2, PTGS2, VEGFA
extracellular space 4 ANG, BDNF, INS, VEGFA
perinuclear region of cytoplasm 2 BDNF, PIK3CA
adherens junction 1 VEGFA
intercalated disc 1 PIK3CA
mitochondrion 4 BCL2, CASP9, MAPK14, SIRT1
protein-containing complex 4 AKT1, BCL2, CASP9, PTGS2
Microsome membrane 2 MTOR, PTGS2
postsynaptic density 1 CASP3
chromatin silencing complex 1 SIRT1
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Secreted 4 ANG, BDNF, INS, VEGFA
extracellular region 6 ANG, ANXA5, BDNF, INS, MAPK14, VEGFA
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, MTOR
transcription regulator complex 1 RBL2
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 ANXA5
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 1 ANG
microtubule cytoskeleton 1 AKT1
nucleolus 3 ANG, RBL2, SIRT1
cell-cell junction 1 AKT1
vesicle 1 AKT1
heterochromatin 1 SIRT1
pore complex 1 BCL2
focal adhesion 1 ANXA5
spindle 2 AKT1, RB1
extracellular matrix 1 VEGFA
basement membrane 1 ANG
Nucleus, PML body 2 MTOR, SIRT1
PML body 3 MTOR, RB1, SIRT1
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 ANXA5
secretory granule 1 VEGFA
nuclear speck 2 MAPK14, PRKAA2
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 2 PTGS2, SIRT1
nuclear outer membrane 1 PTGS2
Zymogen granule membrane 1 ANXA5
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 4 NFE2L2, RB1, RBL2, SIRT1
mediator complex 1 NFE2L2
Chromosome 2 ANG, RBL2
Nucleus, nucleolus 1 ANG
spindle pole 1 MAPK14
fibrillar center 1 SIRT1
nuclear envelope 2 MTOR, SIRT1
Endomembrane system 1 MTOR
endosome lumen 1 INS
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 2 ANG, PRKAA2
euchromatin 1 SIRT1
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 2 INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 BDNF, INS, PTGS2
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
endocytic vesicle 1 ANG
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
SWI/SNF complex 1 RB1
apoptosome 1 CASP9
vesicle membrane 1 ANXA5
protein-DNA complex 1 NFE2L2
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
eNoSc complex 1 SIRT1
rDNA heterochromatin 1 SIRT1
nucleotide-activated protein kinase complex 1 PRKAA2
Cytoplasmic vesicle, phagosome 1 MTOR
angiogenin-PRI complex 1 ANG
chromatin lock complex 1 RB1
Rb-E2F complex 1 RB1
endothelial microparticle 1 ANXA5
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
caspase complex 1 CASP9
[SirtT1 75 kDa fragment]: Cytoplasm 1 SIRT1


文献列表

  • Louyin Ji, Hui Han, Xiaoli Shan, Pei Zhao, Huihua Chen, Chen Zhang, Ming Xu, Rong Lu, Wei Guo. Ginsenoside Rb1 ameliorates lipotoxicity-induced myocardial injury in diabetes mellitus by regulating Mfn2. European journal of pharmacology. 2024 Jul; 974(?):176609. doi: 10.1016/j.ejphar.2024.176609. [PMID: 38677536]
  • Yafei Zhai, Jinmeng Bai, Ying Peng, Jinhua Cao, Guangming Fang, Yiming Dong, Ze Wang, Yanyu Lu, Mengyu Wang, Mengduan Liu, Yangyang Liu, Xiaowei Li, Jianzeng Dong, Xiaoyan Zhao. Ginsenoside Rb1 attenuates doxorubicin induced cardiotoxicity by suppressing autophagy and ferroptosis. Biochemical and biophysical research communications. 2024 May; 710(?):149910. doi: 10.1016/j.bbrc.2024.149910. [PMID: 38593619]
  • Cuihan Zhang, Huan Hou, Changhong Shen, Qian Ran, Fang Cheng, Ziqing Yao, Ruoqi Zhang, Cheng Peng. Protective effect of ginsenoside Rb1 against aconitine cardiotoxicity studied by myocardial injury, action potential, and calcium signaling. Toxicon : official journal of the International Society on Toxinology. 2024 May; 242(?):107693. doi: 10.1016/j.toxicon.2024.107693. [PMID: 38519012]
  • Lianjie Hou, Zhiming Zou, Yu Wang, Hui Pi, Zeyue Yuan, Qin He, Yongfang Kuang, Guojun Zhao. Exploring the anti-atherosclerosis mechanism of ginsenoside Rb1 by integrating network pharmacology and experimental verification. Aging. 2024 Mar; 16(8):6745-6756. doi: 10.18632/aging.205680. [PMID: 38546402]
  • Kang-Xi Zhang, Yue Zhu, Shu-Xia Song, Qing-Yun Bu, Xiao-Yan You, Hong Zou, Guo-Ping Zhao. Ginsenoside Rb1, Compound K and 20(S)-Protopanaxadiol Attenuate High-Fat Diet-Induced Hyperlipidemia in Rats via Modulation of Gut Microbiota and Bile Acid Metabolism. Molecules (Basel, Switzerland). 2024 Mar; 29(5):. doi: 10.3390/molecules29051108. [PMID: 38474620]
  • Kailu Zhou, Yangyang Zhang, Yikai Zhou, Minghao Xu, Shanshan Yu. Production of Gypenoside XVII from Ginsenoside Rb1 by Enzymatic Transformation and Their Anti-Inflammatory Activity In Vitro and In Vivo. Molecules (Basel, Switzerland). 2023 Oct; 28(19):. doi: 10.3390/molecules28197001. [PMID: 37836844]
  • Liu Bingbing, L I Jieru, S I Jianchao, Chen Qi, Yang Shengchang, J I Ensheng. Ginsenoside Rb1 alleviates chronic intermittent hypoxia-induced diabetic cardiomyopathy in db/db mice by regulating the adenosine monophosphate-activated protein kinase/Nrf2/heme oxygenase-1 signaling pathway. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2023 10; 43(5):906-914. doi: 10.19852/j.cnki.jtcm.20221206.004. [PMID: 37679978]
  • Jingyuan Zeng, Xican Li, Rongxin Cai, Ban Chen, Chunhou Li, Qingzhong Hu, Yue Sun. Proposing anti-counterfeiting pharmacopoeia quality markers for Shenlingbaizhu granule based on UHPLC-Q-orbitrap-MS identification. Phytochemical analysis : PCA. 2023 Sep; ?(?):. doi: 10.1002/pca.3284. [PMID: 37735858]
  • Yannan Li, Junnan Li, Lixuan Yang, Feifei Ren, Kaiqiang Dong, Zhonghui Zhao, Wenzhe Duan, Wei Wei, Rongjuan Guo. Ginsenoside Rb1 protects hippocampal neurons in depressed rats based on mitophagy-regulated astrocytic pyroptosis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Sep; 121(?):155083. doi: 10.1016/j.phymed.2023.155083. [PMID: 37722244]
  • Likang Lu, Hui Ao, Jingxin Fu, Manzhen Li, Yaoyao Guo, Yifei Guo, Meihua Han, Rongxing Shi, Xiangtao Wang. Ginsenoside Rb1 stabilized and paclitaxel / protopanaxadiol co-loaded nanoparticles for synergistic treatment of breast tumor. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Jul; 163(?):114870. doi: 10.1016/j.biopha.2023.114870. [PMID: 37187019]
  • Min Zhang, Wei Lin, Xiaoyue Tao, Wei Zhou, Zhiming Liu, Zhe Zhang, Shuqing Jin, Haojie Zhang, Cheng Teng, Jianghu Zhu, Xiaoling Guo, Zhenlang Lin. Ginsenoside Rb1 inhibits ferroptosis to ameliorate hypoxic-ischemic brain damage in neonatal rats. International immunopharmacology. 2023 Jun; 121(?):110503. doi: 10.1016/j.intimp.2023.110503. [PMID: 37364327]
  • Chuting Li, Xuting Zhang, Jie Li, Liyin Liang, Jingran Zeng, Min Wen, Linjie Pan, Dongxin Lv, Min Liu, Yuanyuan Cheng, Heqing Huang. Ginsenoside Rb1 promotes the activation of PPARα pathway via inhibiting FADD to ameliorate heart failure. European journal of pharmacology. 2023 Mar; 947(?):175676. doi: 10.1016/j.ejphar.2023.175676. [PMID: 37001580]
  • Junchen Liu, Yuehang Wu, Wenrui Ma, Hongyan Zhang, Xianyao Meng, Huirong Zhang, Miaomiao Guo, Xiao Ling, Li Li. Anti-Inflammatory Activity of Panax notoginseng Flower Saponins Quantified Using LC/MS/MS. Molecules (Basel, Switzerland). 2023 Mar; 28(5):. doi: 10.3390/molecules28052416. [PMID: 36903661]
  • Rongrong Zhou, Dan He, Haichao Zhang, Jing Xie, Shuihan Zhang, Xuefei Tian, Hongliang Zeng, Yuhui Qin, Luqi Huang. Ginsenoside Rb1 protects against diabetes-associated metabolic disorders in Kkay mice by reshaping gut microbiota and fecal metabolic profiles. Journal of ethnopharmacology. 2023 Mar; 303(?):115997. doi: 10.1016/j.jep.2022.115997. [PMID: 36509256]
  • Linwei Chen, Nina Wei, Yong Jiang, Chengye Yuan, Luwei Xu, Jindong Li, Min Kong, Yan Chen, Qin Wang. Comparative pharmacokinetics of seven bioactive components after oral administration of crude and processed Qixue Shuangbu Prescription in chronic heart failure rats by microdialysis combined with UPLC-MS/MS. Journal of ethnopharmacology. 2023 Mar; 303(?):116035. doi: 10.1016/j.jep.2022.116035. [PMID: 36513265]
  • Amany Mohamed Shalaby, Sulaiman Mohammed Alnasser, Dina Ahmed Khairy, Mohamed Ali Alabiad, Mohammed Alorini, Fatima A Jaber, Shereen Elsayed Tawfeek. The neuroprotective effect of ginsenoside Rb1 on the cerebral cortex changes induced by aluminium chloride in a mouse model of Alzheimer's disease: A histological, immunohistochemical, and biochemical study. Journal of chemical neuroanatomy. 2023 Feb; 129(?):102248. doi: 10.1016/j.jchemneu.2023.102248. [PMID: 36764334]
  • Ling Wang, Qing Qing Zhang, Yu Yu Xu, Rui Zhang, Qing Zhao, Yu-Qing Zhang, Xue-Hong Huang, Bin Jiang, Min Ni. Ginsenoside Rb1 Suppresses AOM/DSS-Induced Colon Carcinogenesis. Anti-cancer agents in medicinal chemistry. 2023 Jan; ?(?):. doi: 10.2174/1871520623666230119092735. [PMID: 36655530]
  • Zhuoqun Meng, Jianing Lu, Guangcai Ge, Guang Wang, Ran Zhang, Yuhan Li, Shuang Guan, Jing Lu. Ginsenoside Rb1 induces autophagic lipid degradation via miR-128 targeting TFEB. Food & function. 2023 Jan; 14(1):240-249. doi: 10.1039/d2fo02719d. [PMID: 36484324]
  • Chuanqi Wan, Rufeng Lu, Chen Zhu, Haibo Wu, Guannan Shen, Yang Yang, Xiaowei Wu, Bangjiang Fang, Yuzhou He. Ginsenoside Rb1 enhanced immunity and altered the gut microflora in mice immunized by H1N1 influenza vaccine. PeerJ. 2023; 11(?):e16226. doi: 10.7717/peerj.16226. [PMID: 37868069]
  • Lili Niu, Xiangyu Qin, Litao Wang, Na Guo, Hongyan Cao, Hanghang Li, Chunjian Zhao, Huimei Wang, Yujie Fu. Upgrading the accumulation of ginsenoside Rd in Panax notoginseng by a novel glycosidase-producing endophytic fungus G11-7. Folia microbiologica. 2022 Dec; ?(?):. doi: 10.1007/s12223-022-01020-0. [PMID: 36571675]
  • Hong-Shi Li, Jiang-Ying Kuang, Gui-Jun Liu, Wei-Jie Wu, Xian-Lun Yin, Hao-Dong Li, Lei Wang, Tao Qin, Wen-Cheng Zhang, Yuan-Yuan Sun. Myostain is involved in ginsenoside Rb1-mediated anti-obesity. Pharmaceutical biology. 2022 Dec; 60(1):1106-1115. doi: 10.1080/13880209.2022.2074056. [PMID: 35639355]
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