Ginsenoside_Rb1 (BioDeep_00001867456)

Main id: BioDeep_00000365343

 

PANOMIX_OTCML-2023 Chemicals and Drugs


代谢物信息卡片


.BETA.-D-GLUCOPYRANOSIDE, (3.BETA.,12.BETA.)-20-((6-O-.BETA.-D-GLUCOPYRANOSYL-.BETA.-D-GLUCOPYRANOSYL)OXY)-12-HYDROXYDAMMAR-24-EN-3-YL 2-O-.BETA.-D-GLUCOPYRANOSYL-

化学式: C54H92O23 (1108.6029082)
中文名称: 人参皂苷 Rb1, 人参皂苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C[C@H](O[C@H]2[C@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)[C@@H](O)[C@H](O)[C@@H](CO)O2)C(C)(C)[C@]2([H])CC[C@@]3(C)[C@]4(C)CC[C@@]([C@](O[C@H]5[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)O5)(C)CC/C=C(\C)/C)([H])[C@@]4([H])[C@H](O)C[C@]3([H])[C@@]12C
InChI: InChI=1S/C54H92O23/c1-23(2)10-9-14-54(8,77-48-44(69)40(65)37(62)29(74-48)22-70-46-42(67)38(63)34(59)26(19-55)71-46)24-11-16-53(7)33(24)25(58)18-31-51(5)15-13-32(50(3,4)30(51)12-17-52(31,53)6)75-49-45(41(66)36(61)28(21-57)73-49)76-47-43(68)39(64)35(60)27(20-56)72-47/h10,24-49,55-69H,9,11-22H2,1-8H3/t24-,25+,26+,27+,28+,29+,30-,31+,32-,33-,34+,35+,36+,37+,38-,39-,40-,41-,42+,43+,44+,45+,46+,47-,48-,49-,51-,52+,53+,54-/m0/s1

描述信息

Ginsenoside Rb1 is a ginsenoside found in Panax ginseng and Panax japonicus var. major that is ginsenoside Rd in which the beta-D-glucopyranoside group at position 20 is replaced by a beta-D-glucopyranosyl-beta-D-glucopyranoside group. It has a role as a neuroprotective agent, an anti-obesity agent, an anti-inflammatory drug, an apoptosis inhibitor, a radical scavenger and a plant metabolite. It is a ginsenoside, a glycoside and a tetracyclic triterpenoid. It is functionally related to a ginsenoside Rd.
Ginsenosides are a class of steroid glycosides, and triterpene saponins, found exclusively in the plant genus Panax (ginseng). Ginsenosides have been the target of research, as they are viewed as the active compounds behind the claims of ginsengs efficacy. Because ginsenosides appear to affect multiple pathways, their effects are complex and difficult to isolate. Rb1 appears to be most abundant in Panax quinquefolius (American Ginseng). Rb1 seems to affect the reproductive system in animal testicles. Recent research shows that Rb1 affects rat embryo development and has teratogenic effects, causing birth defects. Another study shows that Rb1 may increase testosterone production in male rats indirectly through the stimulation of the luteinizing hormone.
Ginsenoside rb1 is a natural product found in Panax vietnamensis, Gynostemma pentaphyllum, and other organisms with data available.
See also: Asian Ginseng (part of); American Ginseng (part of); Panax notoginseng root (part of).
A ginsenoside found in Panax ginseng and Panax japonicus var. major that is ginsenoside Rd in which the beta-D-glucopyranoside group at position 20 is replaced by a beta-D-glucopyranosyl-beta-D-glucopyranoside group.
Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na+, K+-ATPase activity with an IC50 of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65 .
Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na+, K+-ATPase activity with an IC50 of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65 .

同义名列表

43 个代谢物同义名

.BETA.-D-GLUCOPYRANOSIDE, (3.BETA.,12.BETA.)-20-((6-O-.BETA.-D-GLUCOPYRANOSYL-.BETA.-D-GLUCOPYRANOSYL)OXY)-12-HYDROXYDAMMAR-24-EN-3-YL 2-O-.BETA.-D-GLUCOPYRANOSYL-; beta-D-Glucopyranoside, (3-beta,12-beta)-20-((6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy)-12-hydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-; beta-D-GLUCOPYRANOSIDE, (3beta,12beta)-20-((6-O-beta-D-GLUCOPYRANOSYL-beta-D-GLUCOPYRANOSYL)OXY)-12-HYDROXYDAMMAR-24-EN-3-YL 2-O-beta-D-GLUCOPYRANOSYL-; (3beta,12beta)-20-{[6-O-(beta-D-glucopyranosyl)-beta-D-glucopyranosyl]oxy}-12-hydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside; (3beta,12beta)-20-((6-O-(beta-D-glucopyranosyl)-beta-D-glucopyranosyl)oxy)-12-hydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside; (3beta,12beta)-20-[(6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside; (3beta,12beta)-20-((6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy)-12-hydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside; 2-O-beta-Glucopyranosyl-(3beta,12beta)-20-[(6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl beta-D-glucopyranoside; 2-O-beta-Glucopyranosyl-(3beta,12beta)-20-((6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy)-12-hydroxydammar-24-en-3-yl-beta-D-glucopyranoside; 20-[(6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]-12beta-hydroxydammar-24-en-3beta-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside; 3beta-[beta-D-glucopyranosyl-(1->2)-beta-D glucopyranosyloxy]-20-[beta-D-glucopyranosyl-(1->2)-beta-D glucopyranosyloxy]dammar-24-en-12beta-ol; 3beta-(beta-D-glucopyranosyl-(1->2)-beta-D glucopyranosyloxy)-20-(beta-D-glucopyranosyl-(1->2)-beta-D glucopyranosyloxy)dammar-24-en-12beta-ol; GINSENOSIDE RB1 (CONSTITUENT OF AMERICAN GINSENG, ASIAN GINSENG, AND TIENCHI GINSENG) [DSC]; GINSENOSIDE RB1 (CONSTITUENT OF AMERICAN GINSENG, ASIAN GINSENG, AND TIENCHI GINSENG); Ginsenoside Rb1, European Pharmacopoeia (EP) Reference Standard; Ginsenoside Rb1, primary pharmaceutical reference standard; 13 - Ginseng supplement chemical analysis; 3-GlcGlc-20-GlcGlc-ginsenoside; GZYPWOGIYAIIPV-JBDTYSNRSA-N; GINSENOSIDE RB1 [WHO-DD]; GINSENOSIDE RB1 [USP-RS]; GINSENOSIDE RB1 (USP-RS); Ginsenoside Rb1 - 94\\%; (20S)-ginsenoside Rb1; 20(S)-ginsenoside Rb1; pseudoginsenoside D; notoginsenoside Rb1; Gypenoside cento; sanchinoside Rb1; sanchinoside E1; Ginsenoside Rb1; ginsenoside-Rb1; panax saponin E; GinsenosideRb1; panaxoside Rb1; gypenoside III; Panaxsaponin E; arasaponin E1; gynosaponin C; Ginsenoside; GS-Rb1; GRb 1; GSRb1



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(3)

PlantCyc(1)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Louyin Ji, Hui Han, Xiaoli Shan, Pei Zhao, Huihua Chen, Chen Zhang, Ming Xu, Rong Lu, Wei Guo. Ginsenoside Rb1 ameliorates lipotoxicity-induced myocardial injury in diabetes mellitus by regulating Mfn2. European journal of pharmacology. 2024 Jul; 974(?):176609. doi: 10.1016/j.ejphar.2024.176609. [PMID: 38677536]
  • Yafei Zhai, Jinmeng Bai, Ying Peng, Jinhua Cao, Guangming Fang, Yiming Dong, Ze Wang, Yanyu Lu, Mengyu Wang, Mengduan Liu, Yangyang Liu, Xiaowei Li, Jianzeng Dong, Xiaoyan Zhao. Ginsenoside Rb1 attenuates doxorubicin induced cardiotoxicity by suppressing autophagy and ferroptosis. Biochemical and biophysical research communications. 2024 May; 710(?):149910. doi: 10.1016/j.bbrc.2024.149910. [PMID: 38593619]
  • Cuihan Zhang, Huan Hou, Changhong Shen, Qian Ran, Fang Cheng, Ziqing Yao, Ruoqi Zhang, Cheng Peng. Protective effect of ginsenoside Rb1 against aconitine cardiotoxicity studied by myocardial injury, action potential, and calcium signaling. Toxicon : official journal of the International Society on Toxinology. 2024 May; 242(?):107693. doi: 10.1016/j.toxicon.2024.107693. [PMID: 38519012]
  • Lianjie Hou, Zhiming Zou, Yu Wang, Hui Pi, Zeyue Yuan, Qin He, Yongfang Kuang, Guojun Zhao. Exploring the anti-atherosclerosis mechanism of ginsenoside Rb1 by integrating network pharmacology and experimental verification. Aging. 2024 Mar; 16(8):6745-6756. doi: 10.18632/aging.205680. [PMID: 38546402]
  • Kang-Xi Zhang, Yue Zhu, Shu-Xia Song, Qing-Yun Bu, Xiao-Yan You, Hong Zou, Guo-Ping Zhao. Ginsenoside Rb1, Compound K and 20(S)-Protopanaxadiol Attenuate High-Fat Diet-Induced Hyperlipidemia in Rats via Modulation of Gut Microbiota and Bile Acid Metabolism. Molecules (Basel, Switzerland). 2024 Mar; 29(5):. doi: 10.3390/molecules29051108. [PMID: 38474620]
  • Kailu Zhou, Yangyang Zhang, Yikai Zhou, Minghao Xu, Shanshan Yu. Production of Gypenoside XVII from Ginsenoside Rb1 by Enzymatic Transformation and Their Anti-Inflammatory Activity In Vitro and In Vivo. Molecules (Basel, Switzerland). 2023 Oct; 28(19):. doi: 10.3390/molecules28197001. [PMID: 37836844]
  • Liu Bingbing, L I Jieru, S I Jianchao, Chen Qi, Yang Shengchang, J I Ensheng. Ginsenoside Rb1 alleviates chronic intermittent hypoxia-induced diabetic cardiomyopathy in db/db mice by regulating the adenosine monophosphate-activated protein kinase/Nrf2/heme oxygenase-1 signaling pathway. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2023 10; 43(5):906-914. doi: 10.19852/j.cnki.jtcm.20221206.004. [PMID: 37679978]
  • Jingyuan Zeng, Xican Li, Rongxin Cai, Ban Chen, Chunhou Li, Qingzhong Hu, Yue Sun. Proposing anti-counterfeiting pharmacopoeia quality markers for Shenlingbaizhu granule based on UHPLC-Q-orbitrap-MS identification. Phytochemical analysis : PCA. 2023 Sep; ?(?):. doi: 10.1002/pca.3284. [PMID: 37735858]
  • Yannan Li, Junnan Li, Lixuan Yang, Feifei Ren, Kaiqiang Dong, Zhonghui Zhao, Wenzhe Duan, Wei Wei, Rongjuan Guo. Ginsenoside Rb1 protects hippocampal neurons in depressed rats based on mitophagy-regulated astrocytic pyroptosis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Sep; 121(?):155083. doi: 10.1016/j.phymed.2023.155083. [PMID: 37722244]
  • Likang Lu, Hui Ao, Jingxin Fu, Manzhen Li, Yaoyao Guo, Yifei Guo, Meihua Han, Rongxing Shi, Xiangtao Wang. Ginsenoside Rb1 stabilized and paclitaxel / protopanaxadiol co-loaded nanoparticles for synergistic treatment of breast tumor. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Jul; 163(?):114870. doi: 10.1016/j.biopha.2023.114870. [PMID: 37187019]
  • Min Zhang, Wei Lin, Xiaoyue Tao, Wei Zhou, Zhiming Liu, Zhe Zhang, Shuqing Jin, Haojie Zhang, Cheng Teng, Jianghu Zhu, Xiaoling Guo, Zhenlang Lin. Ginsenoside Rb1 inhibits ferroptosis to ameliorate hypoxic-ischemic brain damage in neonatal rats. International immunopharmacology. 2023 Jun; 121(?):110503. doi: 10.1016/j.intimp.2023.110503. [PMID: 37364327]
  • Chuting Li, Xuting Zhang, Jie Li, Liyin Liang, Jingran Zeng, Min Wen, Linjie Pan, Dongxin Lv, Min Liu, Yuanyuan Cheng, Heqing Huang. Ginsenoside Rb1 promotes the activation of PPARα pathway via inhibiting FADD to ameliorate heart failure. European journal of pharmacology. 2023 Mar; 947(?):175676. doi: 10.1016/j.ejphar.2023.175676. [PMID: 37001580]
  • Junchen Liu, Yuehang Wu, Wenrui Ma, Hongyan Zhang, Xianyao Meng, Huirong Zhang, Miaomiao Guo, Xiao Ling, Li Li. Anti-Inflammatory Activity of Panax notoginseng Flower Saponins Quantified Using LC/MS/MS. Molecules (Basel, Switzerland). 2023 Mar; 28(5):. doi: 10.3390/molecules28052416. [PMID: 36903661]
  • Rongrong Zhou, Dan He, Haichao Zhang, Jing Xie, Shuihan Zhang, Xuefei Tian, Hongliang Zeng, Yuhui Qin, Luqi Huang. Ginsenoside Rb1 protects against diabetes-associated metabolic disorders in Kkay mice by reshaping gut microbiota and fecal metabolic profiles. Journal of ethnopharmacology. 2023 Mar; 303(?):115997. doi: 10.1016/j.jep.2022.115997. [PMID: 36509256]
  • Linwei Chen, Nina Wei, Yong Jiang, Chengye Yuan, Luwei Xu, Jindong Li, Min Kong, Yan Chen, Qin Wang. Comparative pharmacokinetics of seven bioactive components after oral administration of crude and processed Qixue Shuangbu Prescription in chronic heart failure rats by microdialysis combined with UPLC-MS/MS. Journal of ethnopharmacology. 2023 Mar; 303(?):116035. doi: 10.1016/j.jep.2022.116035. [PMID: 36513265]
  • Amany Mohamed Shalaby, Sulaiman Mohammed Alnasser, Dina Ahmed Khairy, Mohamed Ali Alabiad, Mohammed Alorini, Fatima A Jaber, Shereen Elsayed Tawfeek. The neuroprotective effect of ginsenoside Rb1 on the cerebral cortex changes induced by aluminium chloride in a mouse model of Alzheimer's disease: A histological, immunohistochemical, and biochemical study. Journal of chemical neuroanatomy. 2023 Feb; 129(?):102248. doi: 10.1016/j.jchemneu.2023.102248. [PMID: 36764334]
  • Ling Wang, Qing Qing Zhang, Yu Yu Xu, Rui Zhang, Qing Zhao, Yu-Qing Zhang, Xue-Hong Huang, Bin Jiang, Min Ni. Ginsenoside Rb1 Suppresses AOM/DSS-Induced Colon Carcinogenesis. Anti-cancer agents in medicinal chemistry. 2023 Jan; ?(?):. doi: 10.2174/1871520623666230119092735. [PMID: 36655530]
  • Zhuoqun Meng, Jianing Lu, Guangcai Ge, Guang Wang, Ran Zhang, Yuhan Li, Shuang Guan, Jing Lu. Ginsenoside Rb1 induces autophagic lipid degradation via miR-128 targeting TFEB. Food & function. 2023 Jan; 14(1):240-249. doi: 10.1039/d2fo02719d. [PMID: 36484324]
  • Chuanqi Wan, Rufeng Lu, Chen Zhu, Haibo Wu, Guannan Shen, Yang Yang, Xiaowei Wu, Bangjiang Fang, Yuzhou He. Ginsenoside Rb1 enhanced immunity and altered the gut microflora in mice immunized by H1N1 influenza vaccine. PeerJ. 2023; 11(?):e16226. doi: 10.7717/peerj.16226. [PMID: 37868069]
  • Lili Niu, Xiangyu Qin, Litao Wang, Na Guo, Hongyan Cao, Hanghang Li, Chunjian Zhao, Huimei Wang, Yujie Fu. Upgrading the accumulation of ginsenoside Rd in Panax notoginseng by a novel glycosidase-producing endophytic fungus G11-7. Folia microbiologica. 2022 Dec; ?(?):. doi: 10.1007/s12223-022-01020-0. [PMID: 36571675]
  • Hong-Shi Li, Jiang-Ying Kuang, Gui-Jun Liu, Wei-Jie Wu, Xian-Lun Yin, Hao-Dong Li, Lei Wang, Tao Qin, Wen-Cheng Zhang, Yuan-Yuan Sun. Myostain is involved in ginsenoside Rb1-mediated anti-obesity. Pharmaceutical biology. 2022 Dec; 60(1):1106-1115. doi: 10.1080/13880209.2022.2074056. [PMID: 35639355]
  • Danni Feng, Zhongxiang Fang, Pangzhen Zhang. The melanin inhibitory effect of plants and phytochemicals: A systematic review. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Dec; 107(?):154449. doi: 10.1016/j.phymed.2022.154449. [PMID: 36126406]
  • Wen-Tao Sun, Cindy L H Yang, Terry C T Or, Dan Luo, James C B Li. Ginsenoside Rb1 from Panax notoginseng Suppressed TNF-α-Induced Matrix Metalloproteinase-9 via the Suppression of Double-Strand RNA-Dependent Protein Kinase (PKR)/NF-κB Pathway. Molecules (Basel, Switzerland). 2022 Nov; 27(22):. doi: 10.3390/molecules27228050. [PMID: 36432152]
  • Yue Jiang, Sizhang Liu, Li Li, Kaiyou Zang, Yanfang Wang, Mingzhu Zhao, Kangyu Wang, Lei Zhu, Ping Chen, Jun Lei, Yi Wang, Meiping Zhang. Transcriptome and Phenotype Integrated Analysis Identifies Genes Controlling Ginsenoside Rb1 Biosynthesis and Reveals Their Interactions in the Process in Panax ginseng. International journal of molecular sciences. 2022 Nov; 23(22):. doi: 10.3390/ijms232214016. [PMID: 36430494]
  • Zi-Chao Wang, Kai-Ming Niu, Yu-Jie Wu, Kai-Rui Du, Lian-Wen Qi, Ye-Bo Zhou, Hai-Jian Sun. A dual Keap1 and p47phox inhibitor Ginsenoside Rb1 ameliorates high glucose/ox-LDL-induced endothelial cell injury and atherosclerosis. Cell death & disease. 2022 09; 13(9):824. doi: 10.1038/s41419-022-05274-x. [PMID: 36163178]
  • Xue-Chun Ni, Hong-Fei Wang, Yuan-Yuan Cai, Dai Yang, Raphael N Alolga, Baolin Liu, Jia Li, Feng-Qing Huang. Ginsenoside Rb1 inhibits astrocyte activation and promotes transfer of astrocytic mitochondria to neurons against ischemic stroke. Redox biology. 2022 08; 54(?):102363. doi: 10.1016/j.redox.2022.102363. [PMID: 35696763]
  • Mengdie Yin, Juanfang Lin, Mingyue Yang, Chao Li, Pengyu Wu, Junjie Zou, Yajing Jiang, Jingwei Shao. Platelet membrane-cloaked selenium/ginsenoside Rb1 nanosystem as biomimetic reactor for atherosclerosis therapy. Colloids and surfaces. B, Biointerfaces. 2022 Jun; 214(?):112464. doi: 10.1016/j.colsurfb.2022.112464. [PMID: 35334311]
  • Jia-Yi He, Quan Hong, Bi-Xia Chen, Shao-Yuan Cui, Ran Liu, Guang-Yan Cai, Jiao Guo, Xiang-Mei Chen. Ginsenoside Rb1 alleviates diabetic kidney podocyte injury by inhibiting aldose reductase activity. Acta pharmacologica Sinica. 2022 Feb; 43(2):342-353. doi: 10.1038/s41401-021-00788-0. [PMID: 34811512]
  • Wenyi Liang, Yue Liu, Kun Zhou, Ping Jian, Qiunan Zhang, Zihao Chang, Lingfang Wu, Hongsheng Chang, Lanzhen Zhang. Ginsenoside Rb1 prevents lipopolysaccharide-induced depressive-like behavior by inhibiting inflammation and neural dysfunction and F2 elicits a novel antidepressant-like effect: A metabolite-based network pharmacology study. Journal of ethnopharmacology. 2022 Jan; 282(?):114655. doi: 10.1016/j.jep.2021.114655. [PMID: 34537284]
  • Jingjing Liu, Guoqing Fan, Ningning Tao, Feifei Feng, Chao Meng, Tieying Sun. Ginsenoside Rb1 Alleviates Bleomycin-Induced Pulmonary Inflammation and Fibrosis by Suppressing Central Nucleotide-Binding Oligomerization-, Leucine-Rich Repeat-, and Pyrin Domains-Containing Protein Three Inflammasome Activation and the NF-κB Pathway. Drug design, development and therapy. 2022; 16(?):1793-1809. doi: 10.2147/dddt.s361748. [PMID: 35719213]
  • Zhixing Cai, Yue Chen. Synergetic protective effect of berberine and ginsenoside Rb1 against tumor necrosis factor alpha-induced inflammation in adipocytes. Bioengineered. 2021 12; 12(2):11784-11796. doi: 10.1080/21655979.2021.1996508. [PMID: 34699329]
  • Jianing Lu, Jing Lu, Xiujuan Bu, Yazhuo Li, Guangcai Ge, Shuang Guan. Ginsenoside Rb1 alleviates liver injury induced by 3-chloro-1,2-propanediol by stimulating autophagic flux. Journal of food science. 2021 Dec; 86(12):5503-5515. doi: 10.1111/1750-3841.15968. [PMID: 34812491]
  • Shiye Ke, Lin Wu, Min Wang, Dinghui Liu, Guangyao Shi, Jieming Zhu, Xiaoxian Qian. Ginsenoside Rb1 attenuates age-associated vascular impairment by modulating the Gas6 pathway. Pharmaceutical biology. 2021 Dec; 59(1):1369-1377. doi: 10.1080/13880209.2021.1986076. [PMID: 34629012]
  • Aftab Shaukat, Irfan Shaukat, Shahid Ali Rajput, Rizwan Shukat, Sana Hanif, Imran Shaukat, Xinxin Zhang, Chao Chen, Xuyang Sun, Tingzhu Ye, Kaifeng Niu, Zhiqiu Yao, Shadab Shaukat, Muhammad Safdar, Mohamed Abdelrahman, Umair Riaz, Junwei Zhao, Xiaoying Gu, Liguo Yang. Ginsenoside Rb1 Mitigates Escherichia coli Lipopolysaccharide-Induced Endometritis through TLR4-Mediated NF-κB Pathway. Molecules (Basel, Switzerland). 2021 Nov; 26(23):. doi: 10.3390/molecules26237089. [PMID: 34885671]
  • Shuai Zhou, Shan Lu, Sen Guo, Luosha Zhao, Zhanying Han, Zhenzhen Li. Protective Effect of Ginsenoside Rb1 Nanoparticles Against Contrast-Induced Nephropathy by Inhibiting High Mobility Group Box 1 Gene/Toll-Like Receptor 4/NF-κB Signaling Pathway. Journal of biomedical nanotechnology. 2021 Oct; 17(10):2085-2098. doi: 10.1166/jbn.2021.3163. [PMID: 34706808]
  • Lijuan Zhang, Minmin Tang, Xiaofang Xie, Qiuying Zhao, Nan Hu, Hui He, Gangcai Liu, Shiqi Huang, Cheng Peng, Ying Xiao, Zili You. Ginsenoside Rb1 induces a pro-neurogenic microglial phenotype via PPARγ activation in male mice exposed to chronic mild stress. Journal of neuroinflammation. 2021 Aug; 18(1):171. doi: 10.1186/s12974-021-02185-0. [PMID: 34372875]
  • Aftab Shaukat, Irfan Shaukat, Shahid Ali Rajput, Rizwan Shukat, Sana Hanif, Kangfeng Jiang, Tao Zhang, Muhammad Akhtar, Imran Shaukat, Xiaofei Ma, Junfeng Liu, Shadab Shaukat, Talha Umar, Masood Akhtar, Liguo Yang, Ganzhen Deng. Ginsenoside Rb1 protects from Staphylococcus aureus-induced oxidative damage and apoptosis through endoplasmic reticulum-stress and death receptor-mediated pathways. Ecotoxicology and environmental safety. 2021 Aug; 219(?):112353. doi: 10.1016/j.ecoenv.2021.112353. [PMID: 34034046]
  • Tzu-Yi Chiang, Hong-Jaan Wang, Yen-Cih Wang, Elise Chia-Hui Tan, I-Jung Lee, Chul-Ho Yun, Yune-Fang Ueng. Effects of Shengmai San on key enzymes involved in hepatic and intestinal drug metabolism in rats. Journal of ethnopharmacology. 2021 May; 271(?):113914. doi: 10.1016/j.jep.2021.113914. [PMID: 33571617]
  • Ning Jiang, Kezhu Wang, Yiwen Zhang, Hong Huang, Jing-Wei Lv, Qiong Wang, Hai-Xia Wang, Tian-Ji Xia, Xin-Min Liu. Protective effect of ginsenoside Rb1 against chronic restraint stress (CRS)-induced memory impairments in rats. Behavioural brain research. 2021 05; 405(?):113146. doi: 10.1016/j.bbr.2021.113146. [PMID: 33545198]
  • Shi-Ye Ke, Shu-Jie Yu, Ding-Hui Liu, Guang-Yao Shi, Min Wang, Bin Zhou, Lin Wu, Zhi-Ming Song, Jie-Ming Zhu, Chao-Dong Wu, Xiao-Xian Qian. Ginsenoside Rb1 Protects Human Umbilical Vein Endothelial Cells against High Glucose-Induced Mitochondria-Related Apoptosis through Activating SIRT3 Signalling Pathway. Chinese journal of integrative medicine. 2021 May; 27(5):336-344. doi: 10.1007/s11655-020-3478-8. [PMID: 33420900]
  • Jee Youn Lee, Hae Young Choi, Chan Sol Park, Dong Hyun Kim, Tae Young Yune. Total saponin extract, ginsenoside Rb1, and compound K alleviate peripheral and central neuropathic pain through estrogen receptors on rats. Phytotherapy research : PTR. 2021 Apr; 35(4):2119-2132. doi: 10.1002/ptr.6960. [PMID: 33205558]
  • Jia Lianqun, Ju Xing, Ma Yixin, Chen Si, Lv Xiaoming, Song Nan, Sui Guoyuan, Cao Yuan, Yu Ning, Wu Yao, Zhao Na, Zhan Kaixuan, Yang Guanlin. Comprehensive multiomics analysis of the effect of ginsenoside Rb1 on hyperlipidemia. Aging. 2021 03; 13(7):9732-9747. doi: 10.18632/aging.202728. [PMID: 33744860]
  • Min Wang, Ruiying Wang, Hong Sun, Guibo Sun, Xiaobo Sun. Ginsenoside Rb1 ameliorates cardiotoxicity triggered by aconitine via inhibiting calcium overload and pyroptosis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Mar; 83(?):153468. doi: 10.1016/j.phymed.2021.153468. [PMID: 33513559]
  • Ke Changhong, Yuan Peng, Zhengqiang Yuan, Jiye Cai. Ginsenoside Rb1 protected PC12 cells from Aβ25-35-induced cytotoxicity via PPARγ activation and cholesterol reduction. European journal of pharmacology. 2021 Feb; 893(?):173835. doi: 10.1016/j.ejphar.2020.173835. [PMID: 33359145]
  • Naixin Kang, Hongwei Gao, Luan He, Yanli Liu, Handong Fan, Qiongming Xu, Shilin Yang. Ginsenoside Rb1 is an immune-stimulatory agent with antiviral activity against enterovirus 71. Journal of ethnopharmacology. 2021 Feb; 266(?):113401. doi: 10.1016/j.jep.2020.113401. [PMID: 32980486]
  • Qingxin Fan, Pengjiao Xi, Derun Tian, Lianqun Jia, Yuan Cao, Kaixuan Zhan, Tianwei Sun, Yinlong Zhang, Qiming Wang. Ginsenoside Rb1 Facilitates Browning by Repressing Wnt/β-Catenin Signaling in 3T3-L1 Adipocytes. Medical science monitor : international medical journal of experimental and clinical research. 2021 Jan; 27(?):e928619. doi: 10.12659/msm.928619. [PMID: 33503016]
  • Ying Guo, Jianping Xie, Lanchun Zhang, Lingli Yang, Jiaqing Ma, Yufan Bai, Wenjie Ma, Ling Wang, Haofei Yu, Yueqin Zeng, Haiyun Luo, Rongping Zhang. Ginsenoside Rb1 exerts antidepressant-like effects via suppression inflammation and activation of AKT pathway. Neuroscience letters. 2021 01; 744(?):135561. doi: 10.1016/j.neulet.2020.135561. [PMID: 33359924]
  • Guo-Wei Qin, Pan Lu, Li Peng, Wei Jiang. Ginsenoside Rb1 Inhibits Cardiomyocyte Autophagy via PI3K/Akt/mTOR Signaling Pathway and Reduces Myocardial Ischemia/Reperfusion Injury. The American journal of Chinese medicine. 2021; 49(8):1913-1927. doi: 10.1142/s0192415x21500907. [PMID: 34775933]
  • Jing-Hua Zhang, Hui-Zeng Yang, Hao Su, Jun Song, Yu Bai, Lan Deng, Chun-Peng Feng, Hong-Xia Guo, Yi Wang, Xin Gao, Yan Gu, Zhong Zhen, Yao Lu. Berberine and Ginsenoside Rb1 Ameliorate Depression-Like Behavior in Diabetic Rats. The American journal of Chinese medicine. 2021; 49(5):1195-1213. doi: 10.1142/s0192415x21500579. [PMID: 34049474]
  • Xianghua Liu, Jinwei Chen, Ning Sun, Ningning Li, Zhenqiang Zhang, Tao Zheng, Zhenzhen Li. Ginsenoside Rb1 ameliorates autophagy via the AMPK/mTOR pathway in renal tubular epithelial cells in vitro and in vivo. International journal of biological macromolecules. 2020 Nov; 163(?):996-1009. doi: 10.1016/j.ijbiomac.2020.07.060. [PMID: 32659400]
  • Wioletta Ratajczak-Wrona, Natalia Wawrusiewicz-Kurylonek, Marzena Garley, Adam Jacek Kretowski, Ewa Jablonska. A Proliferation-Inducing Ligand Regulation in Polymorphonuclear Neutrophils by Panax ginseng. Archivum immunologiae et therapiae experimentalis. 2020 Oct; 68(6):32. doi: 10.1007/s00005-020-00597-z. [PMID: 33125603]
  • Shuang-Hui Qi, Feng Xiao, Bing Wei, Can Qin. [Value of ginsenoside Rb1 in alleviating coronary artery lesion in a mouse model of Kawasaki disease]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. 2020 Sep; 22(9):1034-1040. doi: . [PMID: 32933639]
  • Tianqian Jin, Zuhui Liu, Yang Chu, Xiaohui Ma, Shuming Li, Xiangyang Wang, Genbei Wang, Shuiping Zhou, He Sun, Jin Yang. UFLC-MS/MS Determination and Population Pharmacokinetic Study of Tanshinol, Ginsenoside Rb1 and Rg1 in Rat Plasma After Oral Administration of Compound Danshen Dripping Pills. European journal of drug metabolism and pharmacokinetics. 2020 Aug; 45(4):523-533. doi: 10.1007/s13318-020-00618-4. [PMID: 32304023]
  • Shujie Yu, Hui Xia, Yanlei Guo, Xiaoxian Qian, Xiaojuan Zou, Huabing Yang, Mingzhu Yin, Hongtao Liu. Ginsenoside Rb1 retards aging process by regulating cell cycle, apoptotic pathway and metabolism of aging mice. Journal of ethnopharmacology. 2020 Jun; 255(?):112746. doi: 10.1016/j.jep.2020.112746. [PMID: 32165173]
  • Fei Li, Zhaoxia Wu, Xin Sui. Biotransformation of ginsenoside Rb1 with wild Cordyceps sinensis and Ascomycota sp. and its antihyperlipidemic effects on the diet-induced cholesterol of zebrafish. Journal of food biochemistry. 2020 06; 44(6):e13192. doi: 10.1111/jfbc.13192. [PMID: 32207149]
  • Hongwei Gao, Naixin Kang, Chao Hu, Ziyu Zhang, Qiongming Xu, Yanli Liu, Shilin Yang. Ginsenoside Rb1 exerts anti-inflammatory effects in vitro and in vivo by modulating toll-like receptor 4 dimerization and NF-kB/MAPKs signaling pathways. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Apr; 69(?):153197. doi: 10.1016/j.phymed.2020.153197. [PMID: 32146298]
  • S Zhang, J Luo, J Xie, Z Wang, W Xiao, L Zhao. Cooperated biotransformation of ginsenoside extracts into ginsenoside 20(S)-Rg3 by three thermostable glycosidases. Journal of applied microbiology. 2020 Mar; 128(3):721-734. doi: 10.1111/jam.14513. [PMID: 31715079]
  • Guangyao Shi, Dinghui Liu, Bin Zhou, Yong Liu, Baoshun Hao, Shujie Yu, Lin Wu, Min Wang, Zhiming Song, Chaodong Wu, Jieming Zhu, Xiaoxian Qian. Ginsenoside Rb1 Alleviates Oxidative Low-Density Lipoprotein-Induced Vascular Endothelium Senescence via the SIRT1/Beclin-1/Autophagy Axis. Journal of cardiovascular pharmacology. 2020 02; 75(2):155-167. doi: 10.1097/fjc.0000000000000775. [PMID: 31658172]
  • Ji-Hyeon Jeon, Sowon Lee, Wonpyo Lee, Sojeong Jin, Mihwa Kwon, Chul Hwi Shin, Min-Koo Choi, Im-Sook Song. Herb-Drug Interaction of Red Ginseng Extract and Ginsenoside Rc with Valsartan in Rats. Molecules (Basel, Switzerland). 2020 Jan; 25(3):. doi: 10.3390/molecules25030622. [PMID: 32023909]
  • Shuai Lu, Yubo Zhang, Huajun Li, Jing Zhang, Yingqian Ci, Mei Han. Ginsenoside Rb1 can ameliorate the key inflammatory cytokines TNF-α and IL-6 in a cancer cachexia mouse model. BMC complementary medicine and therapies. 2020 Jan; 20(1):11. doi: 10.1186/s12906-019-2797-9. [PMID: 32020864]
  • Shi-Ye Ke, Ding-Hui Liu, Lin Wu, Xian-Guan Yu, Min Wang, Guang-Yao Shi, Ren-Hui Wen, Bin Zhou, Bao-Shun Hao, Yong Liu, Jie-Ming Zhu, Xiao-Xian Qian. Ginsenoside Rb1 Ameliorates Age-Related Myocardial Dysfunction by Regulating the NF-[Formula: see text]B Signaling Pathway. The American journal of Chinese medicine. 2020; 48(6):1369-1383. doi: 10.1142/s0192415x20500676. [PMID: 32933311]
  • Bing Song, Yao Sun, Yafen Chu, Jing Wang, Hongwei Zheng, Lili Liu, Wang Cai, Haoqiang Zhang. Ginsenoside Rb1 Alleviated High-Fat-Diet-Induced Hepatocytic Apoptosis via Peroxisome Proliferator-Activated Receptor γ. BioMed research international. 2020; 2020(?):2315230. doi: 10.1155/2020/2315230. [PMID: 32733933]
  • Fengwei Nan, Guibo Sun, Weijie Xie, Tianyuan Ye, Xiao Sun, Ping Zhou, Xi Dong, Jiafu Sun, Xiaobo Sun, Mengren Zhang. Ginsenoside Rb1 mitigates oxidative stress and apoptosis induced by methylglyoxal in SH-SY5Y cells via the PI3K/Akt pathway. Molecular and cellular probes. 2019 12; 48(?):101469. doi: 10.1016/j.mcp.2019.101469. [PMID: 31629029]
  • Seon-Joo Park, Miey Park, Anshul Sharma, Kihyun Kim, Hae-Jeung Lee. Black Ginseng and Ginsenoside Rb1 Promote Browning by Inducing UCP1 Expression in 3T3-L1 and Primary White Adipocytes. Nutrients. 2019 Nov; 11(11):. doi: 10.3390/nu11112747. [PMID: 31726767]
  • Chunlan Fan, Qing Ma, Meng Xu, Yuan Qiao, Yi Zhang, Pin Li, Yucong Bi, Minke Tang. Ginsenoside Rb1 Attenuates High Glucose-Induced Oxidative Injury via the NAD-PARP-SIRT Axis in Rat Retinal Capillary Endothelial Cells. International journal of molecular sciences. 2019 Oct; 20(19):. doi: 10.3390/ijms20194936. [PMID: 31590397]
  • Guoliang Yang, Jun Zhuo, Yuedong Lin, Meng Zhang, Lixin Liu, Xueying Chen, Ronghua Gao. Ginsenoside Rb1 Prevents Dysfunction of Endothelial Cells by Suppressing Inflammatory Response and Apoptosis in the High-Fat Diet Plus Balloon Catheter-Injured Rabbit Model via the G Protein-Coupled Estrogen Receptor-Mediated Phosphatidylinositol 3-Kinases (PI3K)/Akt Pathway. Medical science monitor : international medical journal of experimental and clinical research. 2019 Oct; 25(?):7407-7417. doi: 10.12659/msm.912986. [PMID: 31609302]
  • Peng Zhou, Xinyu Zhang, Mengqi Guo, Rong Guo, Lei Wang, Zihao Zhang, Zongwei Lin, Mei Dong, Hongyan Dai, Xiaoping Ji, Huixia Lu. Ginsenoside Rb1 ameliorates CKD-associated vascular calcification by inhibiting the Wnt/β-catenin pathway. Journal of cellular and molecular medicine. 2019 10; 23(10):7088-7098. doi: 10.1111/jcmm.14611. [PMID: 31423730]
  • Shuai Ji, Xian Shao, Zhen-Yu Su, Lei Ji, Yu-Jie Wang, Yun-Su Ma, Lu Zhao, Yan Du, Meng-Zhe Guo, Dao-Quan Tang. Segmented scan modes and polarity-based LC-MS for pharmacokinetic interaction study between Fufang Danshen Dripping Pill and Clopidogrel Bisulfate Tablet. Journal of pharmaceutical and biomedical analysis. 2019 Sep; 174(?):367-375. doi: 10.1016/j.jpba.2019.05.055. [PMID: 31202879]
  • Jin-Tao Ye, Feng-Tao Li, Sheng-Li Huang, Jian-Li Xue, Yirixiati Aihaiti, Hao Wu, Ruo-Xi Liu, Bin Cheng. Effects of ginsenoside Rb1 on spinal cord ischemia-reperfusion injury in rats. Journal of orthopaedic surgery and research. 2019 Aug; 14(1):259. doi: 10.1186/s13018-019-1299-2. [PMID: 31412899]
  • Xiaona Shao, Chen Chen, Chunsheng Miao, Xiaoyan Yu, Xiangjun Li, Jianan Geng, Dongyan Fan, Xueyuan Lin, Zhen Chen, Yan Shi. Expression analysis of microRNAs and their target genes during experimental diabetic renal lesions in rats administered with ginsenoside Rb1 and trigonelline. Die Pharmazie. 2019 08; 74(8):492-498. doi: 10.1691/ph.2019.8903. [PMID: 31526443]
  • Yan Liu, Xiaodan Zong, Jie Huang, Yanfei Guan, Yuanquan Li, Ting Du, Keyin Liu, Xinpan Kang, Chunyan Dou, Xiangdong Sun, Renhua Wu, Lei Wen, Yunlong Zhang. Ginsenoside Rb1 regulates prefrontal cortical GABAergic transmission in MPTP-treated mice. Aging. 2019 07; 11(14):5008-5034. doi: 10.18632/aging.102095. [PMID: 31314744]
  • Haihua Zhang, Yongmei Su, Jiantao Wang, Ying Gao, Fuhe Yang, Guangyu Li, Qiumei Shi. Ginsenoside Rb1 promotes the growth of mink hair follicle via PI3K/AKT/GSK-3β signaling pathway. Life sciences. 2019 Jul; 229(?):210-218. doi: 10.1016/j.lfs.2019.05.033. [PMID: 31102746]
  • Sheng-Nan Dai, Ai-Jie Hou, Shu-Mei Zhao, Xiao-Ming Chen, Hua-Ting Huang, Bo-Han Chen, Hong-Liang Kong. Ginsenoside Rb1 Ameliorates Autophagy of Hypoxia Cardiomyocytes from Neonatal Rats via AMP-Activated Protein Kinase Pathway. Chinese journal of integrative medicine. 2019 Jul; 25(7):521-528. doi: 10.1007/s11655-018-3018-y. [PMID: 30088211]
  • Yuki Toyokawa, Tomohisa Takagi, Kazuhiko Uchiyama, Katsura Mizushima, Ken Inoue, Chihiro Ushiroda, Saori Kashiwagi, Takahiro Nakano, Yuma Hotta, Makoto Tanaka, Osamu Dohi, Tetsuya Okayama, Naohisa Yoshida, Kazuhiro Katada, Kazuhiro Kamada, Takeshi Ishikawa, Osamu Handa, Hideyuki Konishi, Yuji Naito, Yoshito Itoh. Ginsenoside Rb1 promotes intestinal epithelial wound healing through extracellular signal-regulated kinase and Rho signaling. Journal of gastroenterology and hepatology. 2019 Jul; 34(7):1193-1200. doi: 10.1111/jgh.14532. [PMID: 30394577]
  • Thai Hoang, Kavitha Ramadass, Thach Thi Loc, Tran Thi Mai, Le Duc Giang, Vu Viet Thang, Tran Minh Tuan, Nguyen Thuy Chinh. Novel Drug Delivery System Based on Ginsenoside Rb1 Loaded to Chitosan/Alginate Nanocomposite Films. Journal of nanoscience and nanotechnology. 2019 06; 19(6):3293-3300. doi: 10.1166/jnn.2019.16116. [PMID: 30744756]
  • Wei Li, Yi Wu, Mali Wan, Yang Chu, Xiangyang Wang, Shuming Li, Zuhui Liu, Xue Chen, Navaneethakrishnan Polachi, Shuiping Zhou, He Sun. Simultaneous determination of three saponins in human plasma after oral administration of compound danshen dripping pills by LC-MS/MS and its application in a pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2019 May; 169(?):254-259. doi: 10.1016/j.jpba.2019.03.008. [PMID: 30878903]
  • Sufang Chen, Xiang Li, Yanling Wang, Panwei Mu, Chaojin Chen, Pinjie Huang, Dezhao Liu. Ginsenoside Rb1 attenuates intestinal ischemia/reperfusion‑induced inflammation and oxidative stress via activation of the PI3K/Akt/Nrf2 signaling pathway. Molecular medicine reports. 2019 May; 19(5):3633-3641. doi: 10.3892/mmr.2019.10018. [PMID: 30864725]
  • Shaogang Qu, Xingjun Meng, Yan Liu, Xiuping Zhang, Yunlong Zhang. Ginsenoside Rb1 prevents MPTP-induced changes in hippocampal memory via regulation of the α-synuclein/PSD-95 pathway. Aging. 2019 04; 11(7):1934-1964. doi: 10.18632/aging.101884. [PMID: 30958793]
  • Zhekang Cheng, Meng Zhang, Chengli Ling, Ying Zhu, Hongwei Ren, Chao Hong, Jing Qin, Tongxiang Liu, Jianxin Wang. Neuroprotective Effects of Ginsenosides against Cerebral Ischemia. Molecules (Basel, Switzerland). 2019 Mar; 24(6):. doi: 10.3390/molecules24061102. [PMID: 30897756]
  • Ping Zhou, Weijie Xie, Shuaibing He, Yifan Sun, Xiangbao Meng, Guibo Sun, Xiaobo Sun. Ginsenoside Rb1 as an Anti-Diabetic Agent and Its Underlying Mechanism Analysis. Cells. 2019 02; 8(3):. doi: 10.3390/cells8030204. [PMID: 30823412]
  • Ping Zhou, Weijie Xie, Yifan Sun, Ziru Dai, Guang Li, Guibo Sun, Xiaobo Sun. Ginsenoside Rb1 and mitochondria: A short review of the literature. Molecular and cellular probes. 2019 02; 43(?):1-5. doi: 10.1016/j.mcp.2018.12.001. [PMID: 30529056]
  • Jing Zhou, Jie Wu, Cheng-Ying Wu, Fang Long, Hong Shen, Wei Zhang, Song-Lin Li. Herb-drug interaction: A case study of effects and involved mechanisms of cisplatin on the pharmacokinetics of ginsenoside Rb1 in tumor-bearing mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Feb; 110(?):95-104. doi: 10.1016/j.biopha.2018.11.021. [PMID: 30466007]
  • Jin-Chul Kim, Joo-Yeong Jeon, Woong-Suk Yang, Cheorl-Ho Kim, Dae-Woon Eom. Combined Amelioration of Ginsenoside (Rg1, Rb1, and Rg3)-enriched Korean Red Ginseng and Probiotic Lactobacillus on Non-alcoholic Fatty Liver Disease. Current pharmaceutical biotechnology. 2019; 20(3):222-231. doi: 10.2174/1389201020666190311143554. [PMID: 30854954]
  • Xianhui Kang, Wandong Hong, Kangjie Xie, Hongli Tang, Jingjing Tang, Shan Luo, Wujun Geng, Danyun Jia. Ginsenoside Rb1 pretreatment reverses hippocampal changes in BDNF/TrkB mRNA and protein in rats subjected to acute immobilization stress. Drug design, development and therapy. 2019; 13(?):2127-2134. doi: 10.2147/dddt.s201135. [PMID: 31308626]
  • Shen Ren, Jing Leng, Xing-Yue Xu, Shuang Jiang, Ying-Ping Wang, Xiao-Tong Yan, Zhi Liu, Chen Chen, Zi Wang, Wei Li. Ginsenoside Rb1, A Major Saponin from Panax ginseng, Exerts Protective Effects Against Acetaminophen-Induced Hepatotoxicity in Mice. The American journal of Chinese medicine. 2019; 47(8):1815-1831. doi: 10.1142/s0192415x19500927. [PMID: 31786947]
  • Renjie Yan, Rui Chen, Jiahui Wang, Jian Shi, Wagner Ferreira Dos Santos, Zhiru Xu, Li Liu. Jingshu Keli and its Components Notoginsenoside R1 and Ginsenoside Rb1 Alleviate the Symptoms of Cervical Myelopathy through Kir3.1 Mediated Mechanisms. CNS & neurological disorders drug targets. 2019; 18(8):631-642. doi: 10.2174/0929866526666190911150514. [PMID: 31530268]
  • Fubao Jia, Lei Mou, Hanming Ge. Protective effects of ginsenoside Rb1 on H2O2-induced oxidative injury in human endothelial cell line (EA.hy926) via miR-210. International journal of immunopathology and pharmacology. 2019 Jan; 33(?):2058738419866021. doi: 10.1177/2058738419866021. [PMID: 31359794]
  • Guo-Li Wang, Ying-Ping Wang, Jing-Yu Zheng, Lian-Xue Zhang. Monoaminergic and aminoacidergic receptors are involved in the antidepressant-like effect of ginsenoside Rb1 in mouse hippocampus (CA3) and prefrontal cortex. Brain research. 2018 11; 1699(?):44-53. doi: 10.1016/j.brainres.2018.05.035. [PMID: 29802841]
  • Ping Zhou, Weijie Xie, Yun Luo, Shan Lu, Ziru Dai, Ruiying Wang, Xuelian Zhang, Guang Li, Guibo Sun, Xiaobo Sun. Inhibitory Effects of Ginsenoside Rb1 on Early Atherosclerosis in ApoE-/- Mice via Inhibition of Apoptosis and Enhancing Autophagy. Molecules (Basel, Switzerland). 2018 Nov; 23(11):. doi: 10.3390/molecules23112912. [PMID: 30413028]
  • Kyong-Oh Shin, Sung Jay Choe, Yoshikazu Uchida, Inyong Kim, Yoonhwa Jeong, Kyungho Park. Ginsenoside Rb1 Enhances Keratinocyte Migration by a Sphingosine-1-Phosphate-Dependent Mechanism. Journal of medicinal food. 2018 Nov; 21(11):1129-1136. doi: 10.1089/jmf.2018.4246. [PMID: 30148701]
  • Jun Lu, Lu Yao, Jin-Xin Li, Shu-Jie Liu, Yan-Ying Hu, Shi-Hui Wang, Wen-Xia Liang, Lu-Qi Huang, Yu-Jie Dai, Juan Wang, Wen-Yuan Gao. Characterization of UDP-Glycosyltransferase Involved in Biosynthesis of Ginsenosides Rg1 and Rb1 and Identification of Critical Conserved Amino Acid Residues for Its Function. Journal of agricultural and food chemistry. 2018 Sep; 66(36):9446-9455. doi: 10.1021/acs.jafc.8b02544. [PMID: 30095259]
  • Jing Li, Ruigang Li, Na Li, Fei Zheng, Yulin Dai, Yan Ge, Hao Yue, Shanshan Yu. Mechanism of antidiabetic and synergistic effects of ginseng polysaccharide and ginsenoside Rb1 on diabetic rat model. Journal of pharmaceutical and biomedical analysis. 2018 Sep; 158(?):451-460. doi: 10.1016/j.jpba.2018.06.024. [PMID: 30032757]
  • Fugeng Zhang, Yu Zhang, Xiaofeng Li, Shaoqiang Zhang, Mingdan Zhu, Wuxun Du, Xuefeng Xiao. Research on Q-markers of Qiliqiangxin capsule for chronic heart failure treatment based on pharmacokinetics and pharmacodynamics association. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 May; 44(?):220-230. doi: 10.1016/j.phymed.2018.03.003. [PMID: 29699844]
  • Hong Shen, Xue-Jiao Gao, Ting Li, Wang-Hui Jing, Bei-Lei Han, Yu-Meng Jia, Nan Hu, Zhi-Xiang Yan, Song-Lin Li, Ru Yan. Ginseng polysaccharides enhanced ginsenoside Rb1 and microbial metabolites exposure through enhancing intestinal absorption and affecting gut microbial metabolism. Journal of ethnopharmacology. 2018 Apr; 216(?):47-56. doi: 10.1016/j.jep.2018.01.021. [PMID: 29366768]
  • Xiao-Nan Chen, Dan-Qi Li, Meng-di Zhao, Gang-Yan Yu, Shou-Ying Du, Yang Lu, Jie Bai, Peng-Yue Li, Ya-Li Wu, Zhi-Hao Tian, Yan-Ying Zeng. Pharmacokinetics of Panax notoginseng Saponins in Adhesive and Normal Preparation of Fufang Danshen. European journal of drug metabolism and pharmacokinetics. 2018 Apr; 43(2):215-225. doi: 10.1007/s13318-017-0433-y. [PMID: 28916980]
  • Yun-Long Zhang, Yan Liu, Xin-Pan Kang, Chun-Yan Dou, Ren-Gong Zhuo, Shu-Qiong Huang, Li Peng, Lei Wen. Ginsenoside Rb1 confers neuroprotection via promotion of glutamate transporters in a mouse model of Parkinson's disease. Neuropharmacology. 2018 03; 131(?):223-237. doi: 10.1016/j.neuropharm.2017.12.012. [PMID: 29241654]
  • Shan Jiang, De-Fang Fang, Ying Chen. Involvement of N-Methyl-D-Aspartic Acid Receptor and DL-α-Amino-3-Hydroxy-5- Methyl-4-Isoxazole Propionic Acid Receptor in Ginsenosides Rb1 and Rb3 against Oxygen-Glucose Deprivation-Induced Injury in Hippocampal Slices from Rat. Pharmacology. 2018; 101(3-4):133-139. doi: 10.1159/000481710. [PMID: 29207398]
  • Fang Li, Xiao-Xue Fan, Chun Chu, Yu Zhang, Jun-Ping Kou, Bo-Yang Yu. A Strategy for Optimizing the Combination of Active Components Based on Chinese Medicinal Formula Sheng-Mai-San for Myocardial Ischemia. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2018; 45(4):1455-1471. doi: 10.1159/000487572. [PMID: 29466787]
  • Xiujun Wu, Yang You, Gonglin Qu, Ran Ma, Mingxue Zhang. Simultaneous determination of ginsenoside Rb1, ginsenoside Rg1, paeoniflorin, albiflorin and oxypaeoniflorin in rat plasma by liquid chromatography-tandem mass spectrometry: Application to a pharmacokinetic study of wen-Yang-Huo-Xue soft capsule. Biomedical chromatography : BMC. 2017 Dec; 31(12):. doi: 10.1002/bmc.4019. [PMID: 28557007]