Practolol (BioDeep_00000008809)

human metabolite blood metabolite Chemicals and Drugs

代谢物信息卡片

N-[4-[(2S)-2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide

化学式: C14H22N2O3 (266.163)
中文名称: 普拉洛尔
谱图信息: 最多检出来源 Rattus norvegicus(blood) 50.99%

分子结构信息

SMILES: CC(=O)Nc1ccc(OCC(O)CNC(C)C)cc1
InChI: InChI=1S/C14H22N2O3/c1-10(2)15-8-13(18)9-19-14-6-4-12(5-7-14)16-11(3)17/h4-7,10,13,15,18H,8-9H2,1-3H3,(H,16,17)

描述信息

Practolol is only found in individuals that have used or taken this drug. It is a beta-adrenergic antagonist that has been used in the emergency treatment of cardiac arrhythmias. [PubChem]Like other beta-adrenergic antagonists, practolol competes with adrenergic neurotransmitters such as catecholamines for binding at sympathetic receptor sites. Like propranolol and timolol, practolol binds at beta(1)-adrenergic receptors in the heart and vascular smooth muscle, inhibiting the effects of the catecholamines epinephrine and norepinephrine and decreasing heart rate, cardiac output, and systolic and diastolic blood pressure.
C - Cardiovascular system > C07 - Beta blocking agents > C07A - Beta blocking agents > C07AB - Beta blocking agents, selective
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
Same as: D05587
Practolol is a potent and selective β1-adrenergic receptor antagonist. Practolol can be used for the research of cardiac arrhythmias[1][2][3].

同义名列表

13 个代谢物同义名

N-[4-[(2S)-2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide; N-(4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)acetamide; N-(4-{2-hydroxy-3-[(propan-2-yl)amino]propoxy}phenyl)acetamide; 1-(4-Acetamidophenoxy)-3-isopropylamino-2-propanol; 4-(2-Hydroxy-3-(isopropylamino)propoxy)acetanilide; Practolol, eralzdin; Eralzdin practolol; (+-)-Practolol; Practololum; Tocris-0831; practolol; Dalzic; Practolol

数据库引用编号

17 个数据库交叉引用编号

ChEBI: CHEBI:258351
KEGG: C11696
PubChem: 443371
PubChem: 4883
HMDB: HMDB0015411
Metlin: METLIN44683
DrugBank: DB01297
ChEMBL: CHEMBL6995
Wikipedia: Practolol
MeSH: Practolol
chemspider: 4715
CAS: 6673-35-4
PMhub: MS000022510
PubChem: 13861
NIKKAJI: J8.428J
medchemexpress: HY-119802
KNApSAcK: 258351

分类词条

Acetanilides

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 - Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位		关联基因列表
Cytoplasm	7	ADRA1A, ALB, ATN1, AXIN2, DBH, POMC, PRL
Endosome membrane	1	ADRB2
Nucleus	6	ADRA1A, ADRB2, ALB, ATN1, AXIN2, PRL
cytosol	4	ADRA1A, ALB, AXIN2, SST
centrosome	2	ALB, AXIN2
nucleoplasm	4	ADRA1A, ATN1, ATP2B1, PRL
RNA polymerase II transcription regulator complex	1	PRL
Cell membrane	5	ADRA1A, ADRB1, ADRB2, ADRB3, ATP2B1
Multi-pass membrane protein	5	ADRA1A, ADRB1, ADRB2, ADRB3, ATP2B1
Synapse	2	ATP2B1, DBH
cell junction	1	ATN1
glutamatergic synapse	1	ATP2B1
Golgi apparatus	2	ADRB2, ALB
Golgi membrane	1	INS
neuronal cell body	1	SST
presynaptic membrane	1	ATP2B1
Lysosome	1	ADRB2
endosome	1	ADRB2
plasma membrane	11	ADRA1A, ADRB1, ADRB2, ADRB3, ATP2B1, AXIN2, EDNRA, F2, GCG, KNG1, REN
synaptic vesicle membrane	1	ATP2B1
Membrane	4	ADRB2, ATP2B1, DBH, REN
apical plasma membrane	1	ADRB2
basolateral plasma membrane	1	ATP2B1
caveola	1	ADRA1A
extracellular exosome	5	ALB, ATP2B1, F2, KNG1, LYZ
endoplasmic reticulum	2	ALB, DBH
extracellular space	12	ALB, DBH, F2, GAST, GCG, INS, KNG1, LYZ, POMC, PRL, REN, SST
perinuclear region of cytoplasm	1	ATN1
Schaffer collateral - CA1 synapse	1	ADRB1
protein-containing complex	1	ALB
intracellular membrane-bounded organelle	3	ADRA1A, ATP2B1, DBH
Secreted	10	ALB, DBH, F2, GAST, GCG, INS, POMC, PRL, REN, SST
extracellular region	12	ALB, DBH, F2, GAST, GCG, INS, KNG1, LYZ, POMC, PRL, REN, SST
anchoring junction	2	ALB, ATN1
centriolar satellite	1	DBH
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane	1	ATP2B1
Nucleus membrane	1	ADRA1A
nuclear membrane	1	ADRA1A
beta-catenin destruction complex	1	AXIN2
Early endosome	2	ADRB1, ADRB2
apical part of cell	1	REN
Single-pass type II membrane protein	1	DBH
GABA-ergic synapse	1	SST
collagen-containing extracellular matrix	2	F2, KNG1
secretory granule	1	POMC
lateral plasma membrane	1	ATP2B1
receptor complex	2	ADRB2, ADRB3
ciliary basal body	1	ALB
chromatin	1	PRL
cell projection	1	ATP2B1
centriole	1	ALB
Secreted, extracellular space	1	KNG1
spindle pole	1	ALB
blood microparticle	3	ALB, F2, KNG1
Basolateral cell membrane	1	ATP2B1
endosome lumen	2	INS, PRL
Membrane, caveola	1	ADRA1A
Presynaptic cell membrane	1	ATP2B1
secretory granule lumen	4	DBH, GCG, INS, POMC
secretory granule membrane	1	DBH
Golgi lumen	2	F2, INS
endoplasmic reticulum lumen	5	ALB, F2, GCG, INS, KNG1
nuclear matrix	1	ATN1
platelet alpha granule lumen	2	ALB, KNG1
specific granule lumen	1	LYZ
tertiary granule lumen	1	LYZ
transport vesicle	1	INS
azurophil granule lumen	1	LYZ
Endoplasmic reticulum-Golgi intermediate compartment membrane	1	INS
immunological synapse	1	ATP2B1
neuronal dense core vesicle	3	ADRB1, ADRB2, SST
clathrin-coated endocytic vesicle membrane	1	ADRB2
Cytoplasmic vesicle, secretory vesicle membrane	1	DBH
Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen	1	DBH
chromaffin granule lumen	1	DBH
[Glucagon-like peptide 1]: Secreted	1	GCG
transport vesicle membrane	1	DBH
[Soluble dopamine beta-hydroxylase]: Cytoplasmic vesicle, secretory vesicle lumen	1	DBH
Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane	1	DBH
chromaffin granule membrane	1	DBH
photoreceptor ribbon synapse	1	ATP2B1
ciliary transition fiber	1	ALB

文献列表

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