practolol (BioDeep_00000858537)

Main id: BioDeep_00000008809

 

Volatile Flavor Compounds


代谢物信息卡片


practolol

化学式: C14H22N2O3 (266.16303419999997)
中文名称: 普拉洛尔
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)NCC(COC1=CC=C(C=C1)NC(=O)C)O
InChI: InChI=1S/C14H22N2O3/c1-10(2)15-8-13(18)9-19-14-6-4-12(5-7-14)16-11(3)17/h4-7,10,13,15,18H,8-9H2,1-3H3,(H,16,17)

描述信息

C - Cardiovascular system > C07 - Beta blocking agents > C07A - Beta blocking agents > C07AB - Beta blocking agents, selective
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
Same as: D05587
Practolol is a potent and selective β1-adrenergic receptor antagonist. Practolol can be used for the research of cardiac arrhythmias[1][2][3].

同义名列表

2 个代谢物同义名

practolol; Practolol



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Yunliang Wei, Changsheng Guo, Jingsheng Zhao, Jun Yang, Weiguo Yi, Hong Liu, Xinwei Lin, Zhengchen Zhang. X indening oral liquid improves cardiac function of rats with chronic cardiac failure via TGF-ß1/Smad3 and p38 MAPK pathway. Anatolian journal of cardiology. 2017 May; 17(5):367-373. doi: 10.14744/anatoljcardiol.2016.7438. [PMID: 28100897]
  • Daniel Plano, Shantu Amin, Arun K Sharma. Importance of sphingosine kinase (SphK) as a target in developing cancer therapeutics and recent developments in the synthesis of novel SphK inhibitors. Journal of medicinal chemistry. 2014 Jul; 57(13):5509-24. doi: 10.1021/jm4011687. [PMID: 24471412]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Sarah Dawson, Simone Stahl, Nikki Paul, Jane Barber, J Gerald Kenna. In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug metabolism and disposition: the biological fate of chemicals. 2012 Jan; 40(1):130-8. doi: 10.1124/dmd.111.040758. [PMID: 21965623]
  • Monika Merkle, Markus Wörnle. Sclerosing peritonitis: a rare but fatal complication of peritoneal inflammation. Mediators of inflammation. 2012; 2012(?):709673. doi: 10.1155/2012/709673. [PMID: 22619486]
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  • Etienne de Montmollin, Jerome Aboab, Arnaud Mansart, Djillali Annane. Bench-to-bedside review: Beta-adrenergic modulation in sepsis. Critical care (London, England). 2009; 13(5):230. doi: 10.1186/cc8026. [PMID: 19863760]
  • Tung Si Ho, Stig Pedersen-Bjergaard, Knut Einar Rasmussen. Experiences with carrier-mediated transport in liquid-phase microextraction. Journal of chromatographic science. 2006 Jul; 44(6):308-16. doi: 10.1093/chromsci/44.6.308. [PMID: 16884585]
  • Tung Si Ho, Jan Leon Egge Reubsaet, Hanne Sofie Anthonsen, Stig Pedersen-Bjergaard, Knut Einar Rasmussen. Liquid-phase microextraction based on carrier mediated transport combined with liquid chromatography-mass spectrometry. New concept for the determination of polar drugs in a single drop of human plasma. Journal of chromatography. A. 2005 Apr; 1072(1):29-36. doi: 10.1016/j.chroma.2004.11.078. [PMID: 15881456]
  • Beom Seok Kim, Hoon Young Choi, Dong-Ryeol Ryu, Tae Hyun Yoo, Hyeong Cheon Park, Shin Wook Kang, Kyu Hun Choi, Sung Kyu Ha, Dae Suk Han, Ho Yung Lee. Clinical characteristics of dialysis related sclerosing encapsulating peritonitis: multi-center experience in Korea. Yonsei medical journal. 2005 Feb; 46(1):104-11. doi: 10.3349/ymj.2005.46.1.104. [PMID: 15744812]
  • G B Scarfe, J C Lindon, J K Nicholson, P Martin, B Wright, S Taylor, E Lenz, I D Wilson. Investigation of the metabolism of 14C/13C-practolol in rat using directly coupled radio-HPLC-NMR-MS. Xenobiotica; the fate of foreign compounds in biological systems. 2000 Jul; 30(7):717-29. doi: 10.1080/00498250050078020. [PMID: 10963062]
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  • K R Schwarz, M Hofmann, W Mäurer, C Kadel, K von Olshausen, B Rauch, W Kübler. [Chronic therapy of congestive cardiomyopathy: effects of prenalterol and digoxin]. Zeitschrift fur Kardiologie. 1985 Jul; 74(7):374-83. doi: . [PMID: 3929486]
  • E J Sainsbury, D Fitzpatrick, H Ikram, M G Nicholls, E A Espiner, J J Ashley. Pharmacokinetics and plasma-concentration-effect relationships of prenalterol in cardiac failure. European journal of clinical pharmacology. 1985; 28(4):397-403. doi: 10.1007/bf00544357. [PMID: 2863151]
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  • R Brandt, E Seppälä, J Nowak, H Vapaatalo. Effect of propranolol, practolol and atenolol on human platelet thromboxane formation and plasma levels of prostaglandins 6-keto-F1 alpha and E2. Prostaglandins, leukotrienes, and medicine. 1984 Nov; 16(2):191-203. doi: 10.1016/0262-1746(84)90071-4. [PMID: 6597450]
  • M C Petch, C Wisbey, O Ormerod, C Scott, R M Goodfellow. Acute haemodynamic effects of oral prenalterol in severe heart failure. British heart journal. 1984 Jul; 52(1):49-52. doi: 10.1136/hrt.52.1.49. [PMID: 6146324]
  • M D Johnson, J W Freese, D E Schmitt. Effects of a beta 1-adrenoceptor agonist, prenalterol, on renal function and renin secretion rate in anesthetized dogs. Journal of cardiovascular pharmacology. 1984 Jul; 6(4):627-33. doi: 10.1097/00005344-198407000-00012. [PMID: 6206317]
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  • P O Lagerström, P Carlebom, A F Clarke, D B Jack. Determination of prenalterol in plasma and urine by liquid chromatography with electrochemical detection. Journal of chromatography. 1984 Apr; 307(1):230-4. doi: 10.1016/s0378-4347(00)84094-3. [PMID: 6144691]
  • A Heath, P Mårin, I Sjöstrand. Inotropic effect of prenalterol in amitriptyline poisoning. Intensive care medicine. 1984; 10(4):209-11. doi: 10.1007/bf00259441. [PMID: 6147367]
  • J Goovaerts, C Verfaillie, D Knockaert, R Fagard, R Fiocchi, A Amery, P Lijnen. Prenalterol in the treatment of orthostatic hypotension in Shy-Drager syndrome. Acta cardiologica. 1984; 39(2):147-55. doi: . [PMID: 6145274]
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  • J H Vincent, F Boomsma, A J Man in 't Veld, M A Schalekamp. Beta-receptor stimulation by adrenaline elevates plasma noradrenaline and enhances the pressor responses to cold exposure and isometric exercise. Journal of hypertension. Supplement : official journal of the International Society of Hypertension. 1983 Dec; 1(2):74-6. doi: . [PMID: 6152740]
  • G Jennings, A Bobik, C Oddie, M Hargreaves, P Korner. Cardioselectivity of prenalterol and isoproterenol. Clinical pharmacology and therapeutics. 1983 Dec; 34(6):749-57. doi: 10.1038/clpt.1983.245. [PMID: 6641090]
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  • L Corea, M Bentivoglio, P Verdecchia, M Provvidenza. Acute effects of beta 1 agonism with prenalterol on catecholamine circulating levels in patients with congestive heart failure. Giornale italiano di cardiologia. 1983 Nov; 13(11):330-4. doi: . [PMID: 6141975]
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