CORFREE M1 (BioDeep_00000860441)

Main id: BioDeep_00000002588

 

PANOMIX_OTCML-2023


代谢物信息卡片


4-02-00-02078 (Beilstein Handbook Reference)

化学式: C10H18O4 (202.1205)
中文名称: 癸二酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(CCCCC(=O)O)CCCC(=O)O
InChI: InChI=1S/C10H18O4/c11-9(12)7-5-3-1-2-4-6-8-10(13)14/h1-8H2,(H,11,12)(H,13,14)

描述信息

Decanedioic acid, a normal urinary acid, is found to be associated with carnitine-acylcarnitine translocase deficiency and medium chain acyl-CoA dehydrogenase deficiency.
Decanedioic acid, a normal urinary acid, is found to be associated with carnitine-acylcarnitine translocase deficiency and medium chain acyl-CoA dehydrogenase deficiency.

同义名列表

45 个代谢物同义名

4-02-00-02078 (Beilstein Handbook Reference); Dodecanedioic acid and sebacic acid; Decanedioic acid, homopolymer; Mixture of undecanedioic acid; 1,8-Octanedicarboxylic acid; Polysebacic polyanhydride; Acide sebacique [French]; Decanedicarboxylic acid; Sebacinsaure [German]; 4-Oxodecanedioic acid; 1,10-Decanedioic acid; 4,7-Dioxosebacic acid; N-Decanedioic acid; 4-Oxosebacic acid; EINECS 203-845-5; Decanedioic acid; NCIOpen2_008624; NCGC00164361-01; 422088_ALDRICH; 283258_ALDRICH; Sebacinsaeure; Sebacic acids; S1752_ALDRICH; LMFA01170006; Sebacic acid; NCI60_001628; BRN 1210591; AIDS-002604; CHEBI:41865; 84809_FLUKA; 84810_FLUKA; 14047-57-5; AIDS002604; CCRIS 2290; 32734-00-2; 26776-29-4; WLN: QV8VQ; CORFREE M1; NSC 19492; AI3-09127; Usaf hc-1; NSC19492; 111-20-6; C08277; Sebacic acid



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

15 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ALB, APOE, BGLAP, PCK1, PEG3, PVALB
Peripheral membrane protein 1 AP1S2
Nucleus 3 ALB, APOE, PEG3
autophagosome 1 PEG3
cytosol 5 ALB, AP1S2, LIPE, PCK1, SLC2A4
dendrite 3 APOE, BGLAP, RCVRN
trans-Golgi network 1 SLC2A4
centrosome 1 ALB
Cell membrane 5 CD80, CD86, LIPE, SLC2A4, TNF
Lipid-anchor 1 RCVRN
Cytoplasmic side 2 AP1S2, RCVRN
Multi-pass membrane protein 2 RHO, SLC2A4
Synapse 1 PVALB
cell surface 5 BMP2, CD40, CD80, CD86, TNF
glutamatergic synapse 1 APOE
Golgi apparatus 4 ALB, AP1S2, APOE, RHO
Golgi membrane 3 AP1S2, INS, RHO
lysosomal membrane 1 AP1S2
neuronal cell body 3 APOE, CD40, TNF
sarcolemma 1 SLC2A4
Cytoplasm, cytosol 2 LIPE, PCK1
Presynapse 1 SLC2A4
plasma membrane 8 APOE, BMP2, CD40, CD80, CD86, RHO, SLC2A4, TNF
Membrane 8 APOE, CD40, CD80, CD86, LIPE, RCVRN, RHO, SLC2A4
axon 1 PVALB
caveola 1 LIPE
extracellular exosome 8 ALB, APOE, BMP3, CD40, CD86, LYZ, PCK1, SLC2A4
endoplasmic reticulum 3 ALB, APOE, PCK1
extracellular space 10 ALB, APOE, BGLAP, BMP2, BMP3, CD40, IL10, INS, LYZ, TNF
perinuclear region of cytoplasm 1 SLC2A4
protein-containing complex 1 ALB
intracellular membrane-bounded organelle 3 AP1S2, BMP2, CD40
Single-pass type I membrane protein 3 CD40, CD80, CD86
Secreted 7 ALB, APOE, BGLAP, BMP2, BMP3, IL10, INS
extracellular region 9 ALB, APOE, BGLAP, BMP2, BMP3, IL10, INS, LYZ, TNF
anchoring junction 1 ALB
centriolar satellite 1 CD86
ciliary membrane 1 RHO
photoreceptor inner segment 2 RCVRN, RHO
photoreceptor outer segment 2 RCVRN, RHO
CD40 receptor complex 1 CD40
external side of plasma membrane 5 CD40, CD80, CD86, SLC2A4, TNF
varicosity 1 CD40
Endosome, multivesicular body 1 APOE
Extracellular vesicle 1 APOE
Secreted, extracellular space, extracellular matrix 1 APOE
chylomicron 1 APOE
high-density lipoprotein particle 1 APOE
low-density lipoprotein particle 1 APOE
multivesicular body 2 APOE, SLC2A4
very-low-density lipoprotein particle 1 APOE
T-tubule 1 SLC2A4
perikaryon 2 BGLAP, RCVRN
Early endosome 2 AP1S2, APOE
Membrane, clathrin-coated pit 1 AP1S2
cell-cell junction 1 RHO
clathrin-coated pit 2 AP1S2, SLC2A4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 BGLAP
Cytoplasm, perinuclear region 1 SLC2A4
Membrane raft 2 SLC2A4, TNF
extracellular matrix 1 APOE
sarcoplasmic reticulum 1 SLC2A4
collagen-containing extracellular matrix 1 APOE
ciliary basal body 1 ALB
phagocytic cup 1 TNF
centriole 1 ALB
Cell projection, cilium, photoreceptor outer segment 2 RCVRN, RHO
Secreted, extracellular space 1 APOE
spindle pole 1 ALB
blood microparticle 2 ALB, APOE
sperm midpiece 1 RHO
Endomembrane system 2 AP1S2, SLC2A4
endosome lumen 1 INS
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
Cytoplasmic vesicle membrane 2 AP1S2, SLC2A4
Melanosome 1 APOE
Golgi-associated vesicle membrane 1 RHO
clathrin-coated vesicle 1 SLC2A4
trans-Golgi network membrane 1 AP1S2
trans-Golgi network transport vesicle 1 SLC2A4
secretory granule lumen 1 INS
Golgi lumen 2 BGLAP, INS
endoplasmic reticulum lumen 4 ALB, APOE, BGLAP, INS
platelet alpha granule lumen 1 ALB
Photoreceptor inner segment membrane 1 RHO
specific granule lumen 1 LYZ
tertiary granule lumen 1 LYZ
transport vesicle 1 INS
azurophil granule lumen 1 LYZ
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
vesicle membrane 1 SLC2A4
clathrin-coated endocytic vesicle membrane 1 APOE
synaptic cleft 1 APOE
AP-type membrane coat adaptor complex 1 AP1S2
membrane coat 1 AP1S2
photoreceptor outer segment membrane 2 RCVRN, RHO
sperm head plasma membrane 1 RHO
AP-1 adaptor complex 1 AP1S2
discoidal high-density lipoprotein particle 1 APOE
photoreceptor disc membrane 1 RHO
endocytic vesicle lumen 1 APOE
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
chylomicron remnant 1 APOE
intermediate-density lipoprotein particle 1 APOE
lipoprotein particle 1 APOE
multivesicular body, internal vesicle 1 APOE
rod photoreceptor outer segment 1 RHO
protein complex involved in cell adhesion 1 CD80
BMP receptor complex 1 BMP2
insulin-responsive compartment 1 SLC2A4
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Zhipeng Dai, Minyan Dang, Wenzhi Zhang, Sumathra Murugan, Seoh Wei Teh, Haiyan Pan. Biomimetic hydroxyapatite/poly xylitol sebacic adibate/vitamin K nanocomposite for enhancing bone regeneration. Artificial cells, nanomedicine, and biotechnology. 2019 Dec; 47(1):1898-1907. doi: 10.1080/21691401.2019.1573183. [PMID: 31066314]
  • Qi-Rui Bi, Jin-Jun Hou, Min Yang, Yao Shen, Peng Qi, Rui-Hong Feng, Zhuo Dai, Bing-Peng Yan, Jian-Wei Wang, Xiao-Jian Shi, Wan-Ying Wu, De-An Guo. A Strategy Combining Higher Energy C-Trap Dissociation with Neutral Loss- and Product Ion-Based MSn Acquisition for Global Profiling and Structure Annotation of Fatty Acids Conjugates. Journal of the American Society for Mass Spectrometry. 2017 03; 28(3):443-451. doi: 10.1007/s13361-016-1558-y. [PMID: 27924497]
  • N A Ushakova, E S Brodskii, A A Kovalenko, A I Bastrakov, A A Kozlova, D S Pavlov. Characteristics of lipid fractions of larvae of the black soldier fly Hermetia illucens. Doklady. Biochemistry and biophysics. 2016 May; 468(1):209-12. doi: 10.1134/s1607672916030145. [PMID: 27417723]
  • M Gołębiowski, M Cerkowniak, A Urbanek, M Dawgul, W Kamysz, M I Boguś, D Sosnowska, P Stepnowski. Antimicrobial activity of untypical lipid compounds in the cuticular and internal lipids of four fly species. Journal of applied microbiology. 2014 Feb; 116(2):269-87. doi: 10.1111/jam.12370. [PMID: 24238211]
  • Brenda R Carrillo-Conde, Amanda E Ramer-Tait, Michael J Wannemuehler, Balaji Narasimhan. Chemistry-dependent adsorption of serum proteins onto polyanhydride microparticles differentially influences dendritic cell uptake and activation. Acta biomaterialia. 2012 Oct; 8(10):3618-28. doi: 10.1016/j.actbio.2012.06.001. [PMID: 22684115]
  • A Nakai. [Floppy female infant with congenital hydrocephalus, hepatic dysfunction and refractory convulsions]. No to hattatsu = Brain and development. 2011 Nov; 43(6):433-4. doi: NULL. [PMID: 22180956]
  • Michael H Chiu, Elmar J Prenner. Differential scanning calorimetry: An invaluable tool for a detailed thermodynamic characterization of macromolecules and their interactions. Journal of pharmacy & bioallied sciences. 2011 Jan; 3(1):39-59. doi: 10.4103/0975-7406.76463. [PMID: 21430954]
  • M Membrez, C J Chou, F Raymond, R Mansourian, M Moser, I Monnard, C Ammon-Zufferey, K Mace, G Mingrone, C Binnert. Six weeks' sebacic acid supplementation improves fasting plasma glucose, HbA1c and glucose tolerance in db/db mice. Diabetes, obesity & metabolism. 2010 Dec; 12(12):1120-6. doi: 10.1111/j.1463-1326.2010.01308.x. [PMID: 20977585]
  • Swati A Guhagarkar, Rajiv V Gaikwad, Abdul Samad, Vinod C Malshe, Padma V Devarajan. Polyethylene sebacate-doxorubicin nanoparticles for hepatic targeting. International journal of pharmaceutics. 2010 Nov; 401(1-2):113-22. doi: 10.1016/j.ijpharm.2010.09.012. [PMID: 20854883]
  • Udayanath Aich, M Adam Meledeo, Srinivasa-Gopalan Sampathkumar, Jie Fu, Mark B Jones, Christopher A Weier, Sung Yun Chung, Benjamin C Tang, Ming Yang, Justin Hanes, Kevin J Yarema. Development of delivery methods for carbohydrate-based drugs: controlled release of biologically-active short chain fatty acid-hexosamine analogs. Glycoconjugate journal. 2010 May; 27(4):445-59. doi: 10.1007/s10719-010-9292-3. [PMID: 20458533]
  • Xiaohua Liu, Glenda J Pettway, Laurie K McCauley, Peter X Ma. Pulsatile release of parathyroid hormone from an implantable delivery system. Biomaterials. 2007 Oct; 28(28):4124-31. doi: 10.1016/j.biomaterials.2007.05.034. [PMID: 17576005]
  • Guilherme L Sassaki, Philip A J Gorin, Rodrigo A Reis, Rodrigo V Serrato, Selene L Elífio, Marcello Iacomini. Carbohydrate, glycolipid, and lipid components from the photobiont (Scytonema sp.) of the lichen, Dictyomema glabratum. Carbohydrate research. 2005 Aug; 340(11):1808-17. doi: 10.1016/j.carres.2005.05.004. [PMID: 15963960]
  • Alexandra Muth, Jochen Jung, Steffi Bilke, Annette Scharrer, Armin Mosandl, Adrian C Sewell, Hans Böhles. Simultaneous enantioselective analysis of chiral urinary metabolites in patients with Zellweger syndrome. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2003 Jul; 792(2):269-77. doi: 10.1016/s1570-0232(03)00285-x. [PMID: 12860034]
  • J R Harris. In vitro fibrillogenesis of the amyloid beta 1-42 peptide: cholesterol potentiation and aspirin inhibition. Micron (Oxford, England : 1993). 2002; 33(7-8):609-26. doi: 10.1016/s0968-4328(02)00029-x. [PMID: 12475558]
  • S Yamaguchi, M Iga, M Kimura, Y Suzuki, N Shimozawa, T Fukao, N Kondo, Y Tazawa, T Orii. Urinary organic acids in peroxisomal disorders: a simple screening method. Journal of chromatography. B, Biomedical sciences and applications. 2001 Jul; 758(1):81-6. doi: 10.1016/s0378-4347(01)00102-5. [PMID: 11482738]
  • E Capristo, G Mingrone, A De Gaetano, G Addolorato, A V Greco, G Gasbarrini. A new HPLC method for the direct analysis of triglycerides of dicarboxylic acids in biological samples. Clinica chimica acta; international journal of clinical chemistry. 1999 Nov; 289(1-2):11-21. doi: 10.1016/s0009-8981(99)00145-x. [PMID: 10556649]
  • A M Favuzzi, G Mingrone, A Bertuzzi, S Salinari, A Gandolfi, A V Greco. Pharmacokinetics of sebacic acid in rats. European review for medical and pharmacological sciences. 1999 May; 3(3):119-25. doi: . [PMID: 10827815]
  • T Hagen, M S Korson, M Sakamoto, J E Evans. A GC/MS/MS screening method for multiple organic acidemias from urine specimens. Clinica chimica acta; international journal of clinical chemistry. 1999 May; 283(1-2):77-88. doi: 10.1016/s0009-8981(99)00037-6. [PMID: 10404733]
  • G Liu, B Hinch, A D Beavis. Mechanisms for the transport of alpha,omega-dicarboxylates through the mitochondrial inner membrane. The Journal of biological chemistry. 1996 Oct; 271(41):25338-44. doi: 10.1074/jbc.271.41.25338. [PMID: 8810298]
  • A J Domb, M Rock, C Perkin, G Yipchuck, B Broxup, J G Villemure. Excretion of a radiolabelled anticancer biodegradable polymeric implant from the rabbit brain. Biomaterials. 1995 Sep; 16(14):1069-72. doi: 10.1016/0142-9612(95)98902-q. [PMID: 8519927]
  • A J Domb, M Rock, J Schwartz, C Perkin, G Yipchuk, B Broxup, J G Villemure. Metabolic disposition and elimination studies of a radiolabelled biodegradable polymeric implant in the rat brain. Biomaterials. 1994 Jul; 15(9):681-8. doi: 10.1016/0142-9612(94)90166-x. [PMID: 7948590]
  • C A Raguso, G Mingrone, A V Greco, P A Tataranni, A De Gaetano, M Castagneto. Dicarboxylic acids and glucose utilization in humans: effect of sebacate. JPEN. Journal of parenteral and enteral nutrition. 1994 Jan; 18(1):9-13. doi: 10.1177/014860719401800109. [PMID: 8164314]
  • J J Pitt, A Poulos. Excretion of 3,6-epoxydicarboxylic acids in peroxisomal disorders. Clinica chimica acta; international journal of clinical chemistry. 1993 Dec; 223(1-2):23-9. doi: 10.1016/0009-8981(93)90059-d. [PMID: 7511488]
  • G Mingrone, A V Greco, M Castagneto, A De Gaetano, P A Tataranni, C Raguso. Kinetics and thermogenesis of medium-chain monocarboxylic and dicarboxylic acids in man: sebacate and medium-chain triglycerides. JPEN. Journal of parenteral and enteral nutrition. 1993 May; 17(3):257-64. doi: 10.1177/0148607193017003257. [PMID: 8505832]
  • A Bertuzzi, E Finotti, G Mingrone, A V Greco. Sebacic acid binding to human plasma albumin. Biochemical pharmacology. 1993 Feb; 45(3):697-702. doi: 10.1016/0006-2952(93)90145-m. [PMID: 8442769]
  • A V Greco, G Mingrone, C Raguso, A Tataranni, E Finotti, R M Tacchino, E Capristo, A De Gaetano, M Castagneto. Metabolic effects and disposition of sebacate, an alternate dicarboxylic fuel substrate. Annals of nutrition & metabolism. 1992; 36(1):1-11. doi: 10.1159/000177693. [PMID: 1590667]
  • G Mingrone, R M Tacchino, M Castagneto, E Finotti, A V Greco. Use of even-numbered carbon atom dicarboxylic salts in parenteral nutrition as fuel substrate. JPEN. Journal of parenteral and enteral nutrition. 1992 Jan; 16(1):32-8. doi: 10.1177/014860719201600132. [PMID: 1738216]
  • M J Bennett, M C Ragni, I Hood, D E Hale. Azelaic and pimelic acids: metabolic intermediates or artefacts?. Journal of inherited metabolic disease. 1992; 15(2):220-3. doi: 10.1007/bf01799635. [PMID: 1527989]
  • P A Tataranni, G Mingrone, A De Gaetano, C Raguso, A V Greco. Tracer study of metabolism and tissue distribution of sebacic acid in rats. Annals of nutrition & metabolism. 1992; 36(5-6):296-303. doi: 10.1159/000177733. [PMID: 1492757]
  • G Mingrone, A V Greco, A Bertuzzi, E Arcieri-Mastromattei, R M Tacchino, F Marino, E Finotti, M Castagneto. Tissue uptake and oxidation of disodium sebacate in man. JPEN. Journal of parenteral and enteral nutrition. 1991 Jul; 15(4):454-9. doi: 10.1177/0148607191015004454. [PMID: 1910110]
  • H Brem, M S Mahaley, N A Vick, K L Black, S C Schold, P C Burger, A H Friedman, I S Ciric, T W Eller, J W Cozzens. Interstitial chemotherapy with drug polymer implants for the treatment of recurrent gliomas. Journal of neurosurgery. 1991 Mar; 74(3):441-6. doi: 10.3171/jns.1991.74.3.0441. [PMID: 1993909]
  • H Böhles, Z Akcetin, W Lehnert. The influence of i.v. MCT and carnitine on the excretion of dicarboxylic acids. Beitrage zu Infusionstherapie und klinische Ernahrung. 1988; 20(?):69-74. doi: NULL. [PMID: 3132147]
  • N Gregersen, P B Mortensen, S Kølvraa. On the biologic origin of C6-C10-dicarboxylic and C6-C10-omega-1-hydroxy monocarboxylic acids in human and rat with acyl-CoA dehydrogenation deficiencies: in vitro studies on the omega- and omega-1-oxidation of medium-chain (C6-C12) fatty acids in human and rat liver. Pediatric research. 1983 Oct; 17(10):828-34. doi: 10.1203/00006450-198310000-00013. [PMID: 6634246]
  • N Gregersen, S Kølvraa, K Rasmussen, P B Mortensen, P Divry, M David, N Hobolth. General (medium-chain) acyl-CoA dehydrogenase deficiency (non-ketotic dicarboxylic aciduria): quantitative urinary excretion pattern of 23 biologically significant organic acids in three cases. Clinica chimica acta; international journal of clinical chemistry. 1983 Aug; 132(2):181-91. doi: 10.1016/0009-8981(83)90246-2. [PMID: 6616873]
  • N Gregersen, S Kølvraa, P B Mortensen, K Rasmussen. C6-C10-dicarboxylic aciduria: biochemical considerations in relation to diagnosis of beta-oxidation defects. Scandinavian journal of clinical and laboratory investigation. Supplementum. 1982; 161(?):15-27. doi: 10.3109/00365518209168396. [PMID: 6959231]
  • P B Mortensen. Urinary excretion of C4--C10-dicarboxylic acids and antiketogenic properties of adipic acid in ketogenic-stimulated rats due to diabetes, long-chain and short-chain monocarboxylic acids. Biochimica et biophysica acta. 1981 May; 664(2):335-48. doi: 10.1016/0005-2760(81)90056-4. [PMID: 7248329]
  • P B Mortensen. C6--C10-dicarboxylic aciduria in starved, fat-fed and diabetic rats receiving decanoic acid or medium-chain triacylglycerol. An in vivo measure of the rate of beta-oxidation of fatty acids. Biochimica et biophysica acta. 1981 May; 664(2):349-55. doi: 10.1016/0005-2760(81)90057-6. [PMID: 7248330]
  • P B Mortensen, N Gregersen, S Kølvraa, E Christensen. The occurrence of C6--C10-dicarboxylic acids in urine from patients and rats treated with dipropylacetate. Biochemical medicine. 1980 Oct; 24(2):153-61. doi: 10.1016/0006-2944(80)90006-x. [PMID: 6779814]
  • N Gregersen, F Rosleff, S Kølvraa, N Hobolth, K Rasmussen, R Lauritzen. Non-ketotic C6-C10-dicarboxylic aciduria: biochemical investigations of two cases. Clinica chimica acta; international journal of clinical chemistry. 1980 Mar; 102(2-3):179-89. doi: 10.1016/0009-8981(80)90031-5. [PMID: 6892795]