Batilol (BioDeep_00000858642)

Main id: BioDeep_00000230841

 

PANOMIX_OTCML-2023


代谢物信息卡片


3-octadecoxypropane-1,2-diol

  化学式: C21H44O3 (344.329)
中文名称: 鲨肝醇, 甘油单酯
  谱图信息: 最多检出来源 () %

分子结构信息

SMILES: CCCCCCCCCCCCCCCCCCOCC(CO)O
InChI: InChI=1S/C4H8O4/c5-1-4(2-6)8-3-7/h3-6H,1-2H2


描述信息

Monoacyl glycerol is a member of the class of compounds known as 2-monoacylglycerols. 2-monoacylglycerols are monoacylglycerols containing a glycerol acylated at the 2-position. Monoacyl glycerol is soluble (in water) and a very weakly acidic compound (based on its pKa). Monoacyl glycerol can be found in fig, which makes monoacyl glycerol a potential biomarker for the consumption of this food product. Monoglycerides (also: acylglycerols or monoacylglycerols) are a class of glycerides which are composed of a molecule of glycerol linked to a fatty acid via an ester bond. As glycerol contains both primary and secondary alcohol groups two different types of monoglycerides may be formed; 1-monoacylglycerols where the fatty acid is attached to a primary alcohol, or a 2-monoacylglycerols where the fatty acid is attached to the secondary alcohol .
C26170 - Protective Agent > C797 - Radioprotective Agent
3-(Octadecyloxy)propane-1,2-diol is an endogenous metabolite.

同义名列表

83 个代谢物同义名

Monoacyl glycerol; Batilol; 3-octadecoxypropane-1,2-diol; Batyl alcohol; UNII-39YR661C4U; WLN: Q1YQ1O18; 1-O-Octadecyl-sn-glycerol; .alpha.-Octadecylether of glycerol; (+/-)-3-(OCTADECYLOXY)-1,2-PROPANEDIOL; 1-(Octadecyloxy)-2,3-dihydroxypropane; 1-O-Octadecyl-rac-glycerol; 1-O-octadecylglycerol; 1, 3-(octadecyloxy)-; 1,2-Propanediol, 3-(octadecyloxy)-; 1,2Propanediol, 3(octadecyloxy); 1(Octadecyloxy)2,3dihydroxypropane; 1OOctadecylglycerol; 3-(Octadecyloxy)-1,2-propanediol; 3-(octadecyloxy)propane-1,2-diol; 3-Octadecyloxy-1,2-propanediol; 3-octadecyloxy-propane-1,2-diol; 3-octadecyloxypropane-1,2-diol; 3(Octadecyloxy)1,2propanediol; 39YR661C4U; 4-01-00-02758 (Beilstein Handbook Reference); 4-Oxadocosane-1,2-diol; AI3-18451; alpha-Octadecylether of glycerol; alphaOctadecylether of glycerol; Bathyl alcohol; Batil alcohol; Batilol [INN]; BATILOL [WHO-DD]; Batilol; Glycerol monooctadecyl ether; Stearyl monoglyceride; Batilolum; Batilolum (INN-Latin); Batilolum [INN-Latin]; BATYL ALCOHOL [INCI]; BATYL ALCOHOL [MI]; batyl alcohol, (DL)-isomer; batyl alcohol, (R)-isomer; batyl alcohol, (S)-isomer; Batyl alcohol, 99%; Batyl alcohol;Batilol; Batylalcohol; Batylol; C14-22 Monoglycerides; C18:0 Glyceryl 1-ethe; C18:0 Glyceryl 1-ether; C18:0 Glyceryl 1ether; DivK1c_001035; dl-Batyl alcohol; DL-Batylalcohol; Glycerine 1-monostearyl ether; Glycerine 1monostearyl ether; Glycerol 1-octadecyl ether; Glycerol 1octadecyl ether; Glycerol alpha-Monostearyl Ether; Glycerol monooctadecyl ether; Glycerol octadecyl ether; glyceryl 1-octadecyl ether; Glyceryl-1-octadecyl ether; Glyceryl1octadecyl ether; IDI1_001035; InChI=1/C21H44O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-24-20-21(23)19-22/h21-23H,2-20H2,1H3; KBio1_001035; KBio2_002138; KBio2_004706; KBio2_007274; KBio3_001516; Monoglycerides; Monooctadecyl ether of glycerol; NCI60_002329; OGBUMNBNEWYMNJ-UHFFFAOYSA-; rac- 1-O-N-Octadecyl glycerol; rac-Glycerol 1-octadecyl ether; Spectrum2_001609; Spectrum3_000738; Spectrum4_001778; Spectrum5_000395; Stearyl monoglyceride; Tox21_111515; Tox21_111515_1



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome()

BioCyc()

PlantCyc()

代谢反应

个相关的代谢反应过程信息。

Reactome()

BioCyc()

WikiPathways()

Plant Reactome()

INOH()

PlantCyc()

COVID-19 Disease Map()

PathBank()

PharmGKB()

6 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ABCB1, APOE, AXIN2, GPX1, PEX7, PLA2G12A
Peripheral membrane protein 1 GNPAT
Endoplasmic reticulum membrane 1 MFSD2A
Mitochondrion membrane 1 ABCG2
Nucleus 2 APOE, AXIN2
cytosol 6 AXIN2, GNPAT, GPX1, LEP, LIPE, PEX7
dendrite 1 APOE
mitochondrial membrane 2 ABCG2, GNPAT
centrosome 1 AXIN2
nucleoplasm 1 ABCG2
Cell membrane 5 ABCB1, ABCG2, LIPE, MFSD2A, TNF
Multi-pass membrane protein 3 ABCB1, ABCG2, MFSD2A
cell surface 4 ABCB1, ADIPOQ, EPO, TNF
glutamatergic synapse 1 APOE
Golgi apparatus 1 APOE
Golgi membrane 1 INS
neuronal cell body 2 APOE, TNF
Cytoplasm, cytosol 2 LIPE, PEX7
plasma membrane 6 ABCB1, ABCG2, APOE, AXIN2, MFSD2A, TNF
Membrane 6 ABCB1, ABCG2, APOE, GNPAT, LIPE, MFSD2A
apical plasma membrane 2 ABCB1, ABCG2
caveola 1 LIPE
extracellular exosome 3 ABCB1, APOE, EPO
endoplasmic reticulum 2 ADIPOQ, APOE
extracellular space 10 ADIPOQ, APOE, CSF3, EPO, IGF1, IL10, INS, LEP, LOX, TNF
lysosomal lumen 1 CSF3
mitochondrion 1 GPX1
Secreted 10 ADIPOQ, APOE, CSF3, EPO, IGF1, IL10, INS, LEP, LOX, PLA2G12A
extracellular region 11 ADIPOQ, APOE, CSF3, EPO, IGF1, IL10, INS, LEP, LOX, PLA2G12A, TNF
mitochondrial matrix 1 GPX1
external side of plasma membrane 1 TNF
Endosome, multivesicular body 1 APOE
Extracellular vesicle 1 APOE
Secreted, extracellular space, extracellular matrix 1 APOE
chylomicron 1 APOE
high-density lipoprotein particle 1 APOE
low-density lipoprotein particle 1 APOE
multivesicular body 1 APOE
very-low-density lipoprotein particle 1 APOE
beta-catenin destruction complex 1 AXIN2
Early endosome 1 APOE
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 2 ABCB1, ABCG2
Matrix side 1 GNPAT
Membrane raft 2 ABCG2, TNF
extracellular matrix 2 APOE, LOX
Peroxisome 2 GNPAT, PEX7
collagen trimer 2 ADIPOQ, LOX
Peroxisome matrix 1 PEX7
peroxisomal matrix 2 GNPAT, PEX7
peroxisomal membrane 2 GNPAT, PEX7
collagen-containing extracellular matrix 3 ADIPOQ, APOE, LOX
phagocytic cup 1 TNF
Secreted, extracellular space 2 APOE, LOX
brush border membrane 1 ABCG2
blood microparticle 1 APOE
Endomembrane system 1 GNPAT
endosome lumen 1 INS
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
Melanosome 1 APOE
cell body 1 EPO
Peroxisome membrane 1 GNPAT
exocytic vesicle 1 IGF1
secretory granule lumen 2 EPO, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 APOE, INS
platelet alpha granule lumen 1 IGF1
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
clathrin-coated endocytic vesicle membrane 1 APOE
synaptic cleft 1 APOE
external side of apical plasma membrane 2 ABCB1, ABCG2
discoidal high-density lipoprotein particle 1 APOE
endocytic vesicle lumen 2 APOE, CSF3
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
chylomicron remnant 1 APOE
intermediate-density lipoprotein particle 1 APOE
lipoprotein particle 1 APOE
multivesicular body, internal vesicle 1 APOE
alphav-beta3 integrin-IGF-1-IGF1R complex 1 IGF1
insulin-like growth factor binding protein complex 1 IGF1
insulin-like growth factor ternary complex 1 IGF1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Fabian Dorninger, Frédéric M Vaz, Hans R Waterham, Jan B van Klinken, Gerhard Zeitler, Sonja Forss-Petter, Johannes Berger, Christoph Wiesinger. Ether lipid transfer across the blood-brain and placental barriers does not improve by inactivation of the most abundant ABC transporters. Brain research bulletin. 2022 10; 189(?):69-79. doi: 10.1016/j.brainresbull.2022.08.006. [PMID: 35981629]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Yow Keat Tham, Kevin Huynh, Natalie A Mellett, Darren C Henstridge, Helen Kiriazis, Jenny Y Y Ooi, Aya Matsumoto, Natalie L Patterson, Junichi Sadoshima, Peter J Meikle, Julie R McMullen. Distinct lipidomic profiles in models of physiological and pathological cardiac remodeling, and potential therapeutic strategies. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2018 Mar; 1863(3):219-234. doi: 10.1016/j.bbalip.2017.12.003. [PMID: 29217479]
  • Aliki A Rasmiena, Christopher K Barlow, Nada Stefanovic, Kevin Huynh, Ricardo Tan, Arpeeta Sharma, Dedreia Tull, Judy B de Haan, Peter J Meikle. Plasmalogen modulation attenuates atherosclerosis in ApoE- and ApoE/GPx1-deficient mice. Atherosclerosis. 2015 Dec; 243(2):598-608. doi: 10.1016/j.atherosclerosis.2015.10.096. [PMID: 26545014]
  • Nancy E Braverman, Ann B Moser. Functions of plasmalogen lipids in health and disease. Biochimica et biophysica acta. 2012 Sep; 1822(9):1442-52. doi: 10.1016/j.bbadis.2012.05.008. [PMID: 22627108]
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  • Diana Martín, María I Morán-Valero, Francisco J Señoráns, Guillermo Reglero, Carlos F Torres. In vitro intestinal bioaccessibility of alkylglycerols versus triacylglycerols as vehicles of butyric acid. Lipids. 2011 Mar; 46(3):277-85. doi: 10.1007/s11745-010-3520-2. [PMID: 21225371]
  • Pedro Brites, Ana Sofia Ferreira, Tiago Ferreira da Silva, Vera F Sousa, Ana R Malheiro, Marinus Duran, Hans R Waterham, Myriam Baes, Ronald J A Wanders. Alkyl-glycerol rescues plasmalogen levels and pathology of ether-phospholipid deficient mice. PloS one. 2011; 6(12):e28539. doi: 10.1371/journal.pone.0028539. [PMID: 22163031]
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