Flucloxacillin (BioDeep_00000858543)
代谢物信息卡片
Flucloxacillin
化学式: C19H17ClFN3O5S (453.0561)
中文名称: 氟氯西林
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C(=NO1)C2=C(C=CC=C2Cl)F)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)O
InChI: InChI=1S/C19H17ClFN3O5S/c1-7-10(12(23-29-7)11-8(20)5-4-6-9(11)21)15(25)22-13-16(26)24-14(18(27)28)19(2,3)30-17(13)24/h4-6,13-14,17H,1-3H3,(H,22,25)(H,27,28)/t13-,14+,17-/m1/s1
描述信息
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01C - Beta-lactam antibacterials, penicillins > J01CF - Beta-lactamase resistant penicillins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D010406 - Penicillins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
同义名列表
2 个代谢物同义名
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:5098
- KEGGdrug: D04196
- PubChem: 21319
- DrugBank: DB00301
- ChEMBL: CHEMBL222645
- MeSH: Floxacillin
- CAS: 5250-39-5
- RefMet: Flucloxacillin
- KEGG: C11748
- PubChem: 13913
- KNApSAcK: 5098
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kristina Öbrink-Hansen, Anh Duc Pham, Mats Bue, Pelle Hanberg, Mathias Bendtsen, Josefine Slater, Lena E Friberg, Anders Thorsted, Maiken Stilling. Population Pharmacokinetics of Flucloxacillin In Bone and Soft Tissue- Standard Dosing is Not Sufficient to Achieve Therapeutic Concentrations.
Pharmaceutical research.
2022 Jul; 39(7):1633-1643. doi:
10.1007/s11095-022-03197-y. [PMID: 35233728] - Mathias A F Bendtsen, Pelle Hanberg, Josefine Slater, Jakob Hansen, Kristina Öbrink-Hansen, Maiken Stilling, Mats Bue. Steady-state concentrations of flucloxacillin in porcine vertebral cancellous bone and intervertebral disc following oral and intravenous administration assessed by microdialysis.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society.
2022 Jun; 31(6):1508-1514. doi:
10.1007/s00586-022-07208-9. [PMID: 35488132] - Emiel Leegwater, Annette C Westgeest, Emile F Schippers, Erik B Wilms, Cees van Nieuwkoop, Loes E Visser. Hypokalaemia in patients treated with intravenous flucloxacillin: Incidence and risk factors.
British journal of clinical pharmacology.
2022 06; 88(6):2938-2945. doi:
10.1111/bcp.15236. [PMID: 35060153] - Saartje Verfaillie, Laurent Godinas, Isabel Spriet, Robin Vos, Geert M Verleden. Interaction between posaconazole and flucloxacillin in a lung transplant patient: decrease in plasma exposure of posaconazole and possible undertreatment of invasive aspergillosis: case report.
BMC pulmonary medicine.
2022 Mar; 22(1):110. doi:
10.1186/s12890-022-01904-4. [PMID: 35346142] - Jonathan Save, Yok-Ai Que, José M Entenza, Camille Kolenda, Frédéric Laurent, Grégory Resch. Bacteriophages Combined With Subtherapeutic Doses of Flucloxacillin Act Synergistically Against Staphylococcus aureus Experimental Infective Endocarditis.
Journal of the American Heart Association.
2022 02; 11(3):e023080. doi:
10.1161/jaha.121.023080. [PMID: 35043655] - Stephan Moser, Sophia Rehm, Nicolas Guertler, Vladimira Hinic, Sarah Dräger, Stefano Bassetti, Katharina M Rentsch, Parham Sendi, Michael Osthoff. Probability of pharmacological target attainment with flucloxacillin in Staphylococcus aureus bloodstream infection: a prospective cohort study of unbound plasma and individual MICs.
The Journal of antimicrobial chemotherapy.
2021 06; 76(7):1845-1854. doi:
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Therapeutic drug monitoring.
2021 04; 43(2):264-270. doi:
10.1097/ftd.0000000000000827. [PMID: 33086362] - Anis Zand Irani, Grace Borchert, Brendan Craven, Holly Gibbons. Flucloxacillin and paracetamol induced pyroglutamic acidosis.
BMJ case reports.
2021 Jan; 14(1):. doi:
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British journal of community nursing.
2020 Aug; 25(8):376-380. doi:
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The Journal of infection.
2020 01; 80(1):42-53. doi:
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Molecular pharmacology.
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The American journal of tropical medicine and hygiene.
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Therapeutic drug monitoring.
2018 12; 40(6):682-692. doi:
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Transfusion.
2016 Jan; 56(1):67-72. doi:
10.1111/trf.13284. [PMID: 26331798] - Ryan Nattrass, Lee Faulkner, Marc Vocanson, Daniel J Antoine, Anja Kipar, Gerry Kenna, Jean-Francois Nicolas, B Kevin Park, Dean J Naisbitt. Activation of Flucloxacillin-Specific CD8+ T-Cells With the Potential to Promote Hepatocyte Cytotoxicity in a Mouse Model.
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