8-Bromoadenosine (BioDeep_00000008569)
代谢物信息卡片
化学式: C10H12BrN5O4 (345.0073)
中文名称: 8-溴腺苷
谱图信息:
最多检出来源 Homo sapiens(plant) 50%
分子结构信息
SMILES: C1=NC(=C2C(=N1)N(C(=N2)Br)C3C(C(C(O3)CO)O)O)N
InChI: InChI=1S/C10H12BrN5O4/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,13,14)/t3-,5-,6-,9-/m1/s1
描述信息
8-Bromoadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277)[1].
同义名列表
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:2312
- KEGG: C11266
- PubChem: 96544
- PubChem: 254688
- Metlin: METLIN68950
- ChEMBL: CHEMBL1775009
- CAS: 2946-39-6
- PMhub: MS000022199
- PubChem: 13443
- PDB-CCD: GBA
- NIKKAJI: J136.591F
- medchemexpress: HY-W013195
- KNApSAcK: 2312
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Fengling Cui, Yinghua Yan, Qiangzhai Zhang, Xiaojun Yao, Guirong Qu, Yan Lu. Characterization of the interaction between 8-bromoadenosine with human serum albumin and its analytical application.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2009 Nov; 74(4):964-71. doi:
10.1016/j.saa.2009.09.001. [PMID: 19775931] - Long Xu, Ting-Lou, Nonghua Lv, Xuan Zhu, Youxiang Chen, Jing Yang. Emodin augments calcium activated chloride channel in colonic smooth muscle cells by Gi/Go protein.
European journal of pharmacology.
2009 Aug; 615(1-3):171-6. doi:
10.1016/j.ejphar.2009.04.045. [PMID: 19409890] - Kenneth R Hallows, Huamin Wang, Robert S Edinger, Michael B Butterworth, Nicholas M Oyster, Hui Li, Jochen Buck, Lonny R Levin, John P Johnson, Núria M Pastor-Soler. Regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells.
The Journal of biological chemistry.
2009 Feb; 284(9):5774-83. doi:
10.1074/jbc.m805501200. [PMID: 19126549] - Frederick B Loiselle, Patricio E Morgan, Bernardo V Alvarez, Joseph R Casey. Regulation of the human NBC3 Na+/HCO3- cotransporter by carbonic anhydrase II and PKA.
American journal of physiology. Cell physiology.
2004 Jun; 286(6):C1423-33. doi:
10.1152/ajpcell.00382.2003. [PMID: 14736710] - Donald F Smee, Robert W Sidwell. Anti-cowpox virus activities of certain adenosine analogs, arabinofuranosyl nucleosides, and 2'-fluoro-arabinofuranosyl nucleosides.
Nucleosides, nucleotides & nucleic acids.
2004; 23(1-2):375-83. doi:
10.1081/ncn-120028334. [PMID: 15043161] - S M Siddiqi, K A Jacobson, J L Esker, M E Olah, X D Ji, N Melman, K N Tiwari, J A Secrist, S W Schneller, G Cristalli. Search for new purine- and ribose-modified adenosine analogues as selective agonists and antagonists at adenosine receptors.
Journal of medicinal chemistry.
1995 Mar; 38(7):1174-88. doi:
10.1021/jm00007a014. [PMID: 7707320]
