calpeptin (BioDeep_00000008565)

   


代谢物信息卡片


N-[4-methyl-1-oxo-1-(1-oxohexan-2-ylamino)pentan-2-yl]carbamic acid (phenylmethyl) ester

化学式: C20H30N2O4 (362.220546)
中文名称: 钙肽素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCC(C=O)NC(=O)C(CC(C)C)N=C(O)OCc1ccccc1
InChI: InChI=1S/C20H30N2O4/c1-4-5-11-17(13-23)21-19(24)18(12-15(2)3)22-20(25)26-14-16-9-7-6-8-10-16/h6-10,13,15,17-18H,4-5,11-12,14H2,1-3H3,(H,21,24)(H,22,25)

描述信息

D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D015853 - Cysteine Proteinase Inhibitors

同义名列表

3 个代谢物同义名

N-Cbz-leu-nleu-al; calpeptin; N-[4-methyl-1-oxo-1-(1-oxohexan-2-ylamino)pentan-2-yl]carbamic acid (phenylmethyl) ester



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ola E Mohamed, Dalaal M Abdallah, Ahmed M Fayez, Reem A Mohamed, Hanan S El-Abhar. Morin post-treatment surpassed calpeptin in ameliorating 3-NP-induced cortical neurotoxicity via modulation of glutamate/calpain axis, Kidins220, and BDNF/TrkB/AKT/CREB trajectory. International immunopharmacology. 2023 Feb; 116(?):109771. doi: 10.1016/j.intimp.2023.109771. [PMID: 36736222]
  • Emily G Hicks, Sylvie E Kandel, Jed N Lampe. Identification of Aloe-derived natural products as prospective lead scaffolds for SARS-CoV-2 main protease (Mpro) inhibitors. Bioorganic & medicinal chemistry letters. 2022 06; 66(?):128732. doi: 10.1016/j.bmcl.2022.128732. [PMID: 35427739]
  • Sonia Mediouni, Huihui Mou, Yuka Otsuka, Joseph Anthony Jablonski, Robert Scott Adcock, Lalit Batra, Dong-Hoon Chung, Christopher Rood, Ian Mitchelle S de Vera, Ronald Rahaim, Sultan Ullah, Xuerong Yu, Yulia A Getmanenko, Nicole M Kennedy, Chao Wang, Tu-Trinh Nguyen, Mitchell Hull, Emily Chen, Thomas D Bannister, Pierre Baillargeon, Louis Scampavia, Michael Farzan, Susana T Valente, Timothy P Spicer. Identification of potent small molecule inhibitors of SARS-CoV-2 entry. SLAS discovery : advancing life sciences R & D. 2022 01; 27(1):8-19. doi: 10.1016/j.slasd.2021.10.012. [PMID: 35058179]
  • Bjoern Meyer, Jeanne Chiaravalli, Stacy Gellenoncourt, Philip Brownridge, Dominic P Bryne, Leonard A Daly, Arturas Grauslys, Marius Walter, Fabrice Agou, Lisa A Chakrabarti, Charles S Craik, Claire E Eyers, Patrick A Eyers, Yann Gambin, Andrew R Jones, Emma Sierecki, Eric Verdin, Marco Vignuzzi, Edward Emmott. Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential. Nature communications. 2021 09; 12(1):5553. doi: 10.1038/s41467-021-25796-w. [PMID: 34548480]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Chunlong Ma, Michael Dominic Sacco, Brett Hurst, Julia Alma Townsend, Yanmei Hu, Tommy Szeto, Xiujun Zhang, Bart Tarbet, Michael Thomas Marty, Yu Chen, Jun Wang. Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease. Cell research. 2020 08; 30(8):678-692. doi: 10.1038/s41422-020-0356-z. [PMID: 32541865]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Sisi Liu, Yanyan Xing, Junbing Wang, Rui Pan, Guangming Li, Haijie Tang, Guiling Chen, Liang Yan, Luyan Guo, Mingliang Jiang, Zheng Gong, Liqing Lin, Jun Dong. The Dual Role of HIV-1 gp120 V3 Loop-Induced Autophagy in the Survival and Apoptosis of the Primary Rat Hippocampal Neurons. Neurochemical research. 2019 Jul; 44(7):1636-1652. doi: 10.1007/s11064-019-02788-3. [PMID: 31006091]
  • Raghavendar Chandran, Mollie Capone, Denise Matzelle, Rachel Polcyn, Elizabeth Kau, Azizul Haque, Naren L Banik. Distinct Cytokine and Chemokine Expression in Plasma and Calpeptin-Treated PBMCs of a Relapsing-Remitting Multiple Sclerosis Patient: A Case Report. Neurochemical research. 2018 Dec; 43(12):2224-2231. doi: 10.1007/s11064-018-2655-z. [PMID: 30291537]
  • Sara Gutiérrez, María Morón, Mercedes Griera, David Sucunza, Laura Calleros, Andrea García-Jérez, Claire Coderch, Francisco J Hermoso, Carolina Burgos, Manuel Rodríguez-Puyol, Beatriz de Pascual-Teresa, María L Diez-Marques, Antonio Jimenez, Miguel Toro-Londoño, Diego Rodríguez-Puyol, Juan J Vaquero. Discovery of potent calpain inhibitors based on the azolo-imidazolidenone scaffold. European journal of medicinal chemistry. 2018 Sep; 157(?):946-959. doi: 10.1016/j.ejmech.2018.08.045. [PMID: 30165342]
  • Zsolt Fejes, Szilárd Póliska, Zsolt Czimmerer, Miklós Káplár, András Penyige, Gabriella Gál Szabó, Ildikó Beke Debreceni, Satya P Kunapuli, János Kappelmayer, Béla Nagy. Hyperglycaemia suppresses microRNA expression in platelets to increase P2RY12 and SELP levels in type 2 diabetes mellitus. Thrombosis and haemostasis. 2017 02; 117(3):529-542. doi: 10.1160/th16-04-0322. [PMID: 27975100]
  • Tengyu Yang, Fang Fang, Yawen Chen, Jing Ma, Zhaowen Xiao, Songfeng Zou, Na Zheng, Dewen Yan, Songyan Liao, Shaoyuan Chen, Hongchen Fang, Chekmen Yu, Jie Liu, Ming Dong. Elevated plasma interleukin-37 playing an important role in acute coronary syndrome through suppression of ROCK activation. Oncotarget. 2017 Feb; 8(6):9686-9695. doi: 10.18632/oncotarget.14195. [PMID: 28039466]
  • S-S Rao, Q Mu, Y Zeng, P-C Cai, F Liu, J Yang, Y Xia, Q Zhang, L-J Song, L-L Zhou, F-Z Li, Y-X Lin, J Fang, P A Greer, H-Z Shi, W-L Ma, Y Su, H Ye. Calpain-activated mTORC2/Akt pathway mediates airway smooth muscle remodelling in asthma. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2017 Feb; 47(2):176-189. doi: 10.1111/cea.12805. [PMID: 27649066]
  • Yang Wu, Laura N Cruz, Tadge Szestak, Gavin Laing, Gemma R Molyneux, Celia R S Garcia, Alister G Craig. An external sensing system in Plasmodium falciparum-infected erythrocytes. Malaria journal. 2016 Feb; 15(?):103. doi: 10.1186/s12936-016-1144-6. [PMID: 26893139]
  • Stefano Fogli, Fabio Stefanelli, Barbara Battolla, Francesco Bianchi, Maria C Breschi, Letizia Mattii. Salbutamol inhibits RhoA activation in normal but not in desensitized bronchial smooth muscle cells. The Journal of pharmacy and pharmacology. 2015 Oct; 67(10):1416-20. doi: 10.1111/jphp.12444. [PMID: 26076973]
  • Heike Hardelauf, Julia Sisnaiske, Amir Ali Taghipour-Anvari, Peter Jacob, Evelyn Drabiniok, Ulrich Marggraf, Jean-Philippe Frimat, Jan G Hengstler, Andreas Neyer, Christoph van Thriel, Jonathan West. High fidelity neuronal networks formed by plasma masking with a bilayer membrane: analysis of neurodegenerative and neuroprotective processes. Lab on a chip. 2011 Aug; 11(16):2763-71. doi: 10.1039/c1lc20257j. [PMID: 21709920]
  • Natsuki Hori, Hisamitsu Hayashi, Yuichi Sugiyama. Calpain-mediated cleavage negatively regulates the expression level of ABCG1. Atherosclerosis. 2011 Apr; 215(2):383-91. doi: 10.1016/j.atherosclerosis.2010.12.033. [PMID: 21295304]
  • J P Lopes de Almeida, T Freitas-Santos, C Saldanha. Evidence that the degree of band 3 phosphorylation modulates human erythrocytes nitric oxide efflux--in vitro model of hyperfibrinogenemia. Clinical hemorheology and microcirculation. 2011; 49(1-4):407-16. doi: 10.3233/ch-2011-1490. [PMID: 22214711]
  • Yadira Bastián, Ana L Roa-Espitia, Adela Mújica, Enrique O Hernández-González. Calpain modulates capacitation and acrosome reaction through cleavage of the spectrin cytoskeleton. Reproduction (Cambridge, England). 2010 Nov; 140(5):673-84. doi: 10.1530/rep-09-0545. [PMID: 20716611]
  • Elise Dargelos, Cédric Brulé, Pascal Stuelsatz, Vincent Mouly, Philippe Veschambre, Patrick Cottin, Sylvie Poussard. Up-regulation of calcium-dependent proteolysis in human myoblasts under acute oxidative stress. Experimental cell research. 2010 Jan; 316(1):115-25. doi: 10.1016/j.yexcr.2009.07.025. [PMID: 19651121]
  • Jason Peter Mansell, David Farrar, Scott Jones, Maryam Nowghani. Cytoskeletal reorganisation, 1alpha,25-dihydroxy vitamin D3 and human MG63 osteoblast maturation. Molecular and cellular endocrinology. 2009 Jun; 305(1-2):38-46. doi: 10.1016/j.mce.2009.02.032. [PMID: 19433260]
  • Michael J Ferragamo, Jessica L Reinardy, Stanley A Thayer. Ca2+-dependent, stimulus-specific modulation of the plasma membrane Ca2+ pump in hippocampal neurons. Journal of neurophysiology. 2009 May; 101(5):2563-71. doi: 10.1152/jn.90774.2008. [PMID: 19244356]
  • Declan P McKernan, Marc B Guerin, Colm J O'Brien, Thomas G Cotter. A key role for calpains in retinal ganglion cell death. Investigative ophthalmology & visual science. 2007 Dec; 48(12):5420-30. doi: 10.1167/iovs.07-0287. [PMID: 18055788]
  • Charles S Brown, William L Dean. Regulation of plasma membrane Ca2+-ATPase in human platelets by calpain. Platelets. 2007 May; 18(3):207-11. doi: 10.1080/09537100600954037. [PMID: 17497432]
  • William J Pottorf, Tanner M Johanns, Stephen M Derrington, Emanuel E Strehler, Agnes Enyedi, Stanley A Thayer. Glutamate-induced protease-mediated loss of plasma membrane Ca2+ pump activity in rat hippocampal neurons. Journal of neurochemistry. 2006 Sep; 98(5):1646-56. doi: 10.1111/j.1471-4159.2006.04063.x. [PMID: 16923173]
  • Alejandro Sandoval, Norma Oviedo, Abir Tadmouri, Traudy Avila, Michel De Waard, Ricardo Felix. Two PEST-like motifs regulate Ca2+/calpain-mediated cleavage of the CaVbeta3 subunit and provide important determinants for neuronal Ca2+ channel activity. The European journal of neuroscience. 2006 May; 23(9):2311-20. doi: 10.1111/j.1460-9568.2006.04749.x. [PMID: 16706839]
  • Kosuke Ando, Yoshihisa Kudo, Masami Takahashi. Negative regulation of neurotransmitter release by calpain: a possible involvement of specific SNAP-25 cleavage. Journal of neurochemistry. 2005 Aug; 94(3):651-8. doi: 10.1111/j.1471-4159.2005.03160.x. [PMID: 15992386]
  • Nicolas Marie, Andrew J Lindsay, Mary W McCaffrey. Rab coupling protein is selectively degraded by calpain in a Ca2+-dependent manner. The Biochemical journal. 2005 Jul; 389(Pt 1):223-31. doi: 10.1042/bj20042116. [PMID: 15769254]
  • Nathan Sandbo, Yimin Qin, Sebastien Taurin, D Kyle Hogarth, Barry Kreutz, Nickolai O Dulin. Regulation of serum response factor-dependent gene expression by proteasome inhibitors. Molecular pharmacology. 2005 Mar; 67(3):789-97. doi: 10.1124/mol.104.006874. [PMID: 15550677]
  • M Bonomini, S Dottori, L Amoroso, A Arduini, V Sirolli. Increased platelet phosphatidylserine exposure and caspase activation in chronic uremia. Journal of thrombosis and haemostasis : JTH. 2004 Aug; 2(8):1275-81. doi: 10.1111/j.1538-7836.2004.00837.x. [PMID: 15304031]
  • Vinita Wadhawan, Zubair A Karim, Saikat Mukhopadhyay, Ramkrishna Gupta, Madhu Dikshit, Debabrata Dash. Platelet storage under in vitro condition is associated with calcium-dependent apoptosis-like lesions and novel reorganization in platelet cytoskeleton. Archives of biochemistry and biophysics. 2004 Feb; 422(2):183-90. doi: 10.1016/j.abb.2003.12.024. [PMID: 14759606]
  • Shobha Gopalakrishnan, Mark A Hallett, Simon J Atkinson, James A Marrs. Differential regulation of junctional complex assembly in renal epithelial cell lines. American journal of physiology. Cell physiology. 2003 Jul; 285(1):C102-11. doi: 10.1152/ajpcell.00583.2002. [PMID: 12777255]
  • Nan Wang, Wengen Chen, Patrick Linsel-Nitschke, Laurent O Martinez, Birgit Agerholm-Larsen, David L Silver, Alan R Tall. A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA-I. The Journal of clinical investigation. 2003 Jan; 111(1):99-107. doi: 10.1172/jci16808. [PMID: 12511593]
  • Andres A Caro, Arthur I Cederbaum. Ca2+-dependent and independent mitochondrial damage in HepG2 cells that overexpress CYP2E1. Archives of biochemistry and biophysics. 2002 Dec; 408(2):162-70. doi: 10.1016/s0003-9861(02)00544-1. [PMID: 12464267]
  • L M Botion, A R Brasier, B Tian, V Udupi, A Green. Inhibition of proteasome activity blocks the ability of TNF alpha to down-regulate G(i) proteins and stimulate lipolysis. Endocrinology. 2001 Dec; 142(12):5069-75. doi: 10.1210/endo.142.12.8518. [PMID: 11713199]
  • M Takaoka, M Itoh, S Hayashi, T Kuro, Y Matsumura. Proteasome participates in the pathogenesis of ischemic acute renal failure in rats. European journal of pharmacology. 1999 Nov; 384(1):43-6. doi: 10.1016/s0014-2999(99)00664-0. [PMID: 10611418]
  • S M Schoenwaelder, K Burridge. Evidence for a calpeptin-sensitive protein-tyrosine phosphatase upstream of the small GTPase Rho. A novel role for the calpain inhibitor calpeptin in the inhibition of protein-tyrosine phosphatases. The Journal of biological chemistry. 1999 May; 274(20):14359-67. doi: 10.1074/jbc.274.20.14359. [PMID: 10318859]
  • S M Schoenwaelder, S Kulkarni, H H Salem, S Imajoh-Ohmi, W Yamao-Harigaya, T C Saido, S P Jackson. Distinct substrate specificities and functional roles for the 78- and 76-kDa forms of mu-calpain in human platelets. The Journal of biological chemistry. 1997 Oct; 272(40):24876-84. doi: 10.1074/jbc.272.40.24876. [PMID: 9312088]
  • T Yamazaki, C Haass, T C Saido, S Omura, Y Ihara. Specific increase in amyloid beta-protein 42 secretion ratio by calpain inhibition. Biochemistry. 1997 Jul; 36(27):8377-83. doi: 10.1021/bi970209y. [PMID: 9204885]
  • H Miyoshi, K Umeshita, M Sakon, S Imajoh-Ohmi, K Fujitani, M Gotoh, E Oiki, J Kambayashi, M Monden. Calpain activation in plasma membrane bleb formation during tert-butyl hydroperoxide-induced rat hepatocyte injury. Gastroenterology. 1996 Jun; 110(6):1897-904. doi: 10.1053/gast.1996.v110.pm8964416. [PMID: 8964416]
  • P Gaffet, N Bettache, A Bienvenüe. Phosphatidylserine exposure on the platelet plasma membrane during A23187-induced activation is independent of cytoskeleton reorganization. European journal of cell biology. 1995 Aug; 67(4):336-45. doi: . [PMID: 8521873]
  • Y Tsuji, J Kambayashi, E Shiba, M Sakon, T Kawasaki, T Mori. Involvement of calpain in myonephropathic metabolic syndrome (MNMS). European journal of vascular surgery. 1994 Jul; 8(4):482-8. doi: 10.1016/s0950-821x(05)80969-7. [PMID: 8088401]
  • Y Yano, E Shiba, J Kambayashi, M Sakon, T Kawasaki, K Fujitani, J Kang, T Mori. The effects of calpeptin (a calpain specific inhibitor) on agonist induced microparticle formation from the platelet plasma membrane. Thrombosis research. 1993 Sep; 71(5):385-96. doi: 10.1016/0049-3848(93)90163-i. [PMID: 8236165]
  • K L March, R L Wilensky, R W Roeske, D R Hathaway. Effects of thiol protease inhibitors on cell cycle and proliferation of vascular smooth muscle cells in culture. Circulation research. 1993 Feb; 72(2):413-23. doi: 10.1161/01.res.72.2.413. [PMID: 8418992]