(S)-(-)-5-Fluorowillardiine (BioDeep_00000855638)

   


代谢物信息卡片


2-Amino-3-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-YL)-propionic acid

化学式: C7H8FN3O4 (217.0499)
中文名称: (S)-(-)-5-氟拉迪碱
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=C(C(=O)NC(=O)N1CC(C(=O)O)N)F
InChI: InChI=1S/C7H8FN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1



数据库引用编号

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相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 ANXA5, CA1, CA3, GFAP
Peripheral membrane protein 1 ANXA5
Endoplasmic reticulum membrane 1 GRIA1
Nucleus 3 REPIN1, SATB1, SATB2
cytosol 6 ANXA5, CA1, CA3, GFAP, GRIA1, REPIN1
dendrite 4 GRIA1, GRIA2, GRIA4, GRIK3
nuclear body 1 SATB1
nucleoplasm 5 GRIK2, GRIK5, REPIN1, SATB1, SATB2
Cell membrane 11 GLRA2, GPRC5A, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRIK1, GRIK2, GRIK3, GRIK5
Early endosome membrane 1 GRIA1
Multi-pass membrane protein 12 CACNA1I, GLRA2, GPRC5A, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRIK1, GRIK2, GRIK3, GRIK5
Synapse 2 GLRA2, GRIA1
cell surface 1 GRIA1
dendritic shaft 1 GRIA1
glutamatergic synapse 4 GRIA1, GRID1, GRIK2, GRIK3
neuromuscular junction 1 GRIA1
neuronal cell body 3 GRIA1, GRIA2, GRIA4
postsynapse 1 GRIA2
presynaptic membrane 4 GRIK1, GRIK2, GRIK3, GRIK5
sarcolemma 1 ANXA5
Cytoplasm, cytosol 1 REPIN1
Presynapse 1 GRIA1
plasma membrane 12 CACNA1I, GLRA2, GPRC5A, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRIK1, GRIK2, GRIK3, GRIK5
synaptic vesicle membrane 1 GRIA1
terminal bouton 2 GRIK2, GRIK3
Membrane 9 ANXA5, CACNA1I, GLRA2, GRIA1, GRIA2, GRIA4, GRIK2, GRIK3, GRIK5
axon 1 GRIK3
extracellular exosome 4 ANXA5, CA1, GPRC5A, GRID1
endoplasmic reticulum 2 GRIK2, GRIK5
extracellular space 1 IL10
intracellular membrane-bounded organelle 3 GLRA2, GPRC5A, GRIK1
postsynaptic density 3 GRIA1, GRIA2, GRIK2
Secreted 1 IL10
extracellular region 2 ANXA5, IL10
astrocyte end-foot 1 GFAP
excitatory synapse 2 GRIA1, GRIA2
hippocampal mossy fiber to CA3 synapse 2 GRIK2, GRIK5
neuronal cell body membrane 1 GRIA1
transcription regulator complex 1 SATB2
nuclear membrane 1 REPIN1
external side of plasma membrane 3 ANXA5, GRIA1, GRIA2
Extracellular vesicle 1 GRIA4
dendritic spine 4 GRIA1, GRIA2, GRIA3, GRIA4
perikaryon 2 GRIK2, GRIK3
nucleolus 1 GPRC5A
neuron spine 1 GRIA1
cell-cell junction 1 GRIA1
recycling endosome 1 GRIA1
vesicle 1 GPRC5A
postsynaptic membrane 8 GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRIK1, GRIK2, GRIK3
presynaptic active zone membrane 1 GRIA1
focal adhesion 1 ANXA5
GABA-ergic synapse 2 GLRA2, GRID1
Cell projection, dendritic spine 1 GRIA1
Nucleus, PML body 1 SATB1
PML body 1 SATB1
collagen-containing extracellular matrix 1 ANXA5
intermediate filament 1 GFAP
Postsynaptic cell membrane 10 GLRA2, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRIK1, GRIK2, GRIK3, GRIK5
dendrite cytoplasm 2 GRIK2, GRIK3
kainate selective glutamate receptor complex 4 GRIK1, GRIK2, GRIK3, GRIK5
mossy fiber rosette 1 GRIK2
receptor complex 1 GPRC5A
Zymogen granule membrane 1 ANXA5
neuron projection 1 GLRA2
chromatin 2 SATB1, SATB2
cell projection 4 GFAP, GLRA2, GRIK2, GRIK5
Chromosome 1 REPIN1
postsynaptic density, intracellular component 1 GRIA1
transmembrane transporter complex 1 GLRA2
Recycling endosome membrane 1 GRIA1
chloride channel complex 1 GLRA2
Cytoplasmic vesicle membrane 1 GPRC5A
AMPA glutamate receptor complex 4 GRIA1, GRIA2, GRIA3, GRIA4
Cell projection, dendrite 2 GRIA1, GRIA4
Presynaptic cell membrane 2 GRIK2, GRIK5
cell body 1 GFAP
intermediate filament cytoskeleton 1 GFAP
synaptic membrane 1 GRIA1
nuclear matrix 2 SATB1, SATB2
voltage-gated calcium channel complex 1 CACNA1I
endocytic vesicle membrane 4 GRIA1, GRIA2, GRIA3, GRIA4
histone deacetylase complex 1 SATB2
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GRIA1
postsynaptic density membrane 9 GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRIK1, GRIK2, GRIK3, GRIK5
postsynaptic endocytic zone 1 GRIA2
ER to Golgi transport vesicle membrane 1 GRIA1
Nucleus matrix 2 SATB1, SATB2
parallel fiber to Purkinje cell synapse 1 GRIA3
vesicle membrane 1 ANXA5
postsynaptic specialization membrane 1 GLRA2
dendritic spine membrane 1 GRIA1
cytoplasmic side of lysosomal membrane 1 GFAP
glycinergic synapse 1 GLRA2
asymmetric synapse 1 GRIA2
endothelial microparticle 1 ANXA5
proximal dendrite 1 GRIA1
axonal spine 1 GRIA1
perisynaptic space 1 GRIA1


文献列表

  • S Olivera, D Rodriguez-Ithurralde, J M Henley. Regional localization and developmental profile of acetylcholinesterase-evoked increases in [(3)H]-5-fluororwillardiine binding to AMPA receptors in rat brain. British journal of pharmacology. 2001 Aug; 133(7):1055-62. doi: 10.1038/sj.bjp.0704167. [PMID: 11487516]
  • M Kessler, G Rogers, A Arai. The norbornenyl moiety of cyclothiazide determines the preference for flip-flop variants of AMPA receptor subunits. Neuroscience letters. 2000 Jun; 287(2):161-5. doi: 10.1016/s0304-3940(00)01180-0. [PMID: 10854736]
  • R K Lee, R J Wurtman, A J Cox, R M Nitsch. Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors. Proceedings of the National Academy of Sciences of the United States of America. 1995 Aug; 92(17):8083-7. doi: 10.1073/pnas.92.17.8083. [PMID: 7644542]