Estramustine (BioDeep_00000008551)
Secondary id: BioDeep_00000858522
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
(1S,10R,11S,14S,15S)-14-hydroxy-15-methyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-2,4,6-trien-5-yl N,N-bis(2-chloroethyl)carbamate
化学式: C23H31Cl2NO3 (439.1681)
中文名称: 雌莫司汀
谱图信息:
最多检出来源 Homo sapiens(blood) 78.48%
分子结构信息
SMILES: C1C(=CC2=C(C=1)[C@@]1([H])CC[C@]3(C)[C@@H](O)CC[C@@]3([H])[C@]1([H])CC2)OC(N(CCCl)CCCl)=O
InChI: InChI=1S/C23H31Cl2NO3/c1-23-9-8-18-17-5-3-16(29-22(28)26(12-10-24)13-11-25)14-15(17)2-4-19(18)20(23)6-7-21(23)27/h3,5,14,18-21,27H,2,4,6-13H2,1H3
描述信息
Estramustine is only found in individuals that have used or taken this drug. It is a nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties. [PubChem]Estramustine is a derivative of estradiol with a nitrogen mustard moiety. This gives it alkylating properties. In vivo, the nitrogen mustard component is active and can alklyate DNA and other cellular components (such as tubulin components) of rapidly dividing cells. This causes DNA strandbreaks or misscoding events. This leads to apoptosis and cell death. Also, due to the drugs estrogen component, it can bind more selectively to active estrogen receptors.
D000970 - Antineoplastic Agents > D018906 - Antineoplastic Agents, Alkylating > D009588 - Nitrogen Mustard Compounds
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C273 - Antimitotic Agent
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents
D009676 - Noxae > D000477 - Alkylating Agents
Same as: D04066
同义名列表
26 个代谢物同义名
(1S,10R,11S,14S,15S)-14-hydroxy-15-methyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-2,4,6-trien-5-yl N,N-bis(2-chloroethyl)carbamate; (17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl) N,N-bis(2-chloroethyl)carbamate; estra-1,3,5(10)-triene-3,17beta-diol, 3-[bis(2-chloroethyl)carbamate]; 17beta-Estradiol 3-(bis(2-chloroethyl)carbamic acid); 17b-Estradiol 3-(bis(2-chloroethyl)carbamic acid); 17Β-estradiol 3-(bis(2-chloroethyl)carbamic acid); Estradiol 3-(N,N-bis(2-chloroethyl)carbamic acid); 17beta-Estradiol 3-(bis(2-chloroethyl)carbamate); 17Β-estradiol 3-(bis(2-chloroethyl)carbamate); Estradiol 3-(N,N-bis(2-chloroethyl)carbamate); 17b-Estradiol 3-(bis(2-chloroethyl)carbamate); Phosphate sodium, estramustine; Estramustine phosphate sodium; Estramustine sodium phosphate; Estramustin sodium phosphate; Phosphate, estramustin; Estramustin phosphate; Estramustinphosphate; Estramustinum; Estramustina; estramustine; Estracyt; Leo-275; Leo 275; Emcyt; Estramustine
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:4868
- KEGG: C11228
- PubChem: 259331
- PubChem: 18140
- HMDB: HMDB0015327
- Metlin: METLIN41831
- DrugBank: DB01196
- ChEMBL: CHEMBL290686
- ChEMBL: CHEMBL1575
- Wikipedia: Estramustine
- LipidMAPS: LMST02010038
- MeSH: Estramustine
- chemspider: 227635
- CAS: 2998-57-4
- PMhub: MS000022179
- PubChem: 13407
- NIKKAJI: J7.659G
- RefMet: Estramustine
- KNApSAcK: 4868
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Clément Dumont, Giulia Baciarello, Pierre-Olivier Bosset, Pernelle Lavaud, Emeline Colomba, Christophe Massard, Yohann Loriot, Laurence Albiges, Pierre Blanchard, Alberto Bossi, Soazig Nenan, Karim Fizazi. Long-term Castration-related Outcomes in Patients With High-risk Localized Prostate Cancer Treated With Androgen Deprivation Therapy With or Without Docetaxel and Estramustine in the UNICANCER GETUG-12 Trial.
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European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2017 Nov; 109(?):316-323. doi:
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