Valspodar (BioDeep_00000008544)

   


代谢物信息卡片


3-Keto-bmt(1)-val(2)-cyclosporin A

化学式: C63H111N11O12 (1213.8413246)
中文名称: 伐司扑达
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C/C=C/C[C@@H](C)C(=O)[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N(C)CC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C
InChI: InChI=1S/C63H111N11O12/c1-26-27-28-41(16)53(76)52-57(80)67-49(38(10)11)61(84)68(19)33-48(75)69(20)44(29-34(2)3)56(79)66-50(39(12)13)62(85)70(21)45(30-35(4)5)55(78)64-42(17)54(77)65-43(18)58(81)71(22)46(31-36(6)7)59(82)72(23)47(32-37(8)9)60(83)73(24)51(40(14)15)63(86)74(52)25/h26-27,34-47,49-52H,28-33H2,1-25H3,(H,64,78)(H,65,77)(H,66,79)(H,67,80)/b27-26+/t41-,42+,43-,44+,45+,46+,47+,49+,50+,51+,52+/m1/s1

描述信息

D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents > D003524 - Cyclosporins
C1744 - Multidrug Resistance Modulator
Same as: D06277

同义名列表

5 个代谢物同义名

3-Keto-bmt(1)-val(2)-cyclosporin A; SDZ PSC 833; Valspodar; DB-061935; SDZ PSC 833



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Wang Yin, Dongxi Xiang, Tao Wang, Yumei Zhang, Cuong V Pham, Shufeng Zhou, Guoqin Jiang, Yingchun Hou, Yimin Zhu, Yinglu Han, Liang Qiao, Phuong H-L Tran, Wei Duan. The inhibition of ABCB1/MDR1 or ABCG2/BCRP enables doxorubicin to eliminate liver cancer stem cells. Scientific reports. 2021 05; 11(1):10791. doi: 10.1038/s41598-021-89931-9. [PMID: 34031441]
  • Christopher Rowbottom, Alicia Pietrasiewicz, Taras Tuczewycz, Richard Grater, Daniel Qiu, Sudarshan Kapadnis, Patrick Trapa. Optimization of dose and route of administration of the P-glycoprotein inhibitor, valspodar (PSC-833) and the P-glycoprotein and breast cancer resistance protein dual-inhibitor, elacridar (GF120918) as dual infusion in rats. Pharmacology research & perspectives. 2021 04; 9(2):e00740. doi: 10.1002/prp2.740. [PMID: 33660938]
  • Yuhong Cao, Yan Cao, Yiwei Shi, Ying Cai, Langdong Chen, Dongyao Wang, Yue Liu, Xiaofei Chen, Zhenyu Zhu, Zhanying Hong, Yifeng Chai. Surface plasmon resonance biosensor combined with lentiviral particle stabilization strategy for rapid and specific screening of P-Glycoprotein ligands. Analytical and bioanalytical chemistry. 2021 Mar; 413(7):2021-2031. doi: 10.1007/s00216-021-03170-5. [PMID: 33528601]
  • Mirco Glitscher, David Heiler Martín, Kathrin Woytinek, Benjamin Schmidt, Denna Tabari, Catharina Scholl, Julia C Stingl, Evelyn Seelow, Mira Choi, Eberhard Hildt. Targeting Cholesterol Metabolism as Efficient Antiviral Strategy Against the Hepatitis E Virus. Cellular and molecular gastroenterology and hepatology. 2021; 12(1):159-180. doi: 10.1016/j.jcmgh.2021.02.002. [PMID: 33601063]
  • Siti R Yusof, Mahathir Mohd Uzid, Eng-Huat Teh, Nur Aziah Hanapi, Mazlin Mohideen, Ahmad Saifuddin Mohamad Arshad, Mohd Nizam Mordi, Irena Loryan, Margareta Hammarlund-Udenaes. Rate and extent of mitragynine and 7-hydroxymitragynine blood-brain barrier transport and their intra-brain distribution: the missing link in pharmacodynamic studies. Addiction biology. 2019 09; 24(5):935-945. doi: 10.1111/adb.12661. [PMID: 30088322]
  • Maciej Zalewski, Julita Kulbacka, Jolanta Saczko, Małgorzata Drag-Zalesinska, Anna Choromanska. Valspodar-modulated chemotherapy in human ovarian cancer cells SK-OV-3 and MDAH-2774. Bosnian journal of basic medical sciences. 2019 Aug; 19(3):234-241. doi: 10.17305/bjbms.2019.4073. [PMID: 30957724]
  • Jie Bai, Shengyu Zhao, Xiaoqing Fan, Yonghui Chen, Xiaowen Zou, Minwan Hu, Baolian Wang, Jing Jin, Xiaojian Wang, Jinping Hu, Dan Zhang, Yan Li. Inhibitory effects of flavonoids on P-glycoprotein in vitro and in vivo: Food/herb-drug interactions and structure-activity relationships. Toxicology and applied pharmacology. 2019 04; 369(?):49-59. doi: 10.1016/j.taap.2019.02.010. [PMID: 30790579]
  • Lada Ivanova, Christiane Kruse Fæste, Anita Solhaug. Role of P-glycoprotein in deoxynivalenol-mediated in vitro toxicity. Toxicology letters. 2018 Mar; 284(?):21-28. doi: 10.1016/j.toxlet.2017.11.021. [PMID: 29174985]
  • Ziyad Binkhathlan. Cremophor EL Alters the Plasma Protein Binding and Pharmacokinetic Profile of Valspodar in Rats. Drug research. 2017 Oct; 67(10):591-595. doi: 10.1055/s-0043-111411. [PMID: 28628923]
  • Ahmed Reda, Anke Raaijmakers, Saskia van Dorst, Charlotte G G M Pauwels, Karel Allegaert, Mohamed A Elmonem, Rosalinde Masereeuw, Lambertus van den Heuvel, Elena Levtchenko, Fanny Oliveira Arcolino. A Human Proximal Tubular Epithelial Cell Model to Explore a Knowledge Gap on Neonatal Drug Disposition. Current pharmaceutical design. 2017; 23(38):5911-5918. doi: 10.2174/1381612823666171009143146. [PMID: 28990525]
  • Yu-Hang Li, Shi-Liang Yu, Xiu-Guo Gan, Shang-Ha Pan, Yue-Qiu Teng, Rui-Hua An. Externalization of phosphatidylserine via multidrug resistance 1 (MDR1)/P-glycoprotein in oxalate-treated renal epithelial cells: implications for calcium oxalate urolithiasis. International urology and nephrology. 2016 Feb; 48(2):175-81. doi: 10.1007/s11255-015-1155-1. [PMID: 26560472]
  • Nicolas Tournier, Wadad Saba, Sébastien Goutal, Philippe Gervais, Héric Valette, Jean-Michel Scherrmann, Michel Bottlaender, Salvatore Cisternino. Influence of P-Glycoprotein Inhibition or Deficiency at the Blood-Brain Barrier on (18)F-2-Fluoro-2-Deoxy-D-glucose ( (18)F-FDG) Brain Kinetics. The AAPS journal. 2015 May; 17(3):652-9. doi: 10.1208/s12248-015-9739-3. [PMID: 25716150]
  • Claudia Stäubert, Hasanuzzaman Bhuiyan, Anna Lindahl, Oliver Jay Broom, Yafeng Zhu, Saiful Islam, Sten Linnarsson, Janne Lehtiö, Anders Nordström. Rewired metabolism in drug-resistant leukemia cells: a metabolic switch hallmarked by reduced dependence on exogenous glutamine. The Journal of biological chemistry. 2015 Mar; 290(13):8348-59. doi: 10.1074/jbc.m114.618769. [PMID: 25697355]
  • Maria Bexten, Stefan Oswald, Markus Grube, Jia Jia, Tanja Graf, Uwe Zimmermann, Kathrin Rodewald, Oliver Zolk, Ulrich Schwantes, Werner Siegmund, Markus Keiser. Expression of drug transporters and drug metabolizing enzymes in the bladder urothelium in man and affinity of the bladder spasmolytic trospium chloride to transporters likely involved in its pharmacokinetics. Molecular pharmaceutics. 2015 Jan; 12(1):171-8. doi: 10.1021/mp500532x. [PMID: 25466967]
  • Xia Wen, Christopher J Gibson, Ill Yang, Brian Buckley, Michael J Goedken, Jason R Richardson, Lauren M Aleksunes. MDR1 transporter protects against paraquat-induced toxicity in human and mouse proximal tubule cells. Toxicological sciences : an official journal of the Society of Toxicology. 2014 Oct; 141(2):475-83. doi: 10.1093/toxsci/kfu141. [PMID: 25015657]
  • Yaqiong Zu, Zhiyong Yang, Songshan Tang, Ying Han, Jun Ma. Effects of P-glycoprotein and its inhibitors on apoptosis in K562 cells. Molecules (Basel, Switzerland). 2014 Aug; 19(9):13061-75. doi: 10.3390/molecules190913061. [PMID: 25157469]
  • Faouzi Dahdouh, Maximilian Raane, Frank Thévenod, Wing-Kee Lee. Nickel-induced cell death and survival pathways in cultured renal proximal tubule cells: roles of reactive oxygen species, ceramide and ABCB1. Archives of toxicology. 2014 Apr; 88(4):881-92. doi: 10.1007/s00204-014-1194-x. [PMID: 24448832]
  • Wing-Kee Lee, Prabir K Chakraborty, Frank Thévenod. Pituitary homeobox 2 (PITX2) protects renal cancer cell lines against doxorubicin toxicity by transcriptional activation of the multidrug transporter ABCB1. International journal of cancer. 2013 Aug; 133(3):556-67. doi: 10.1002/ijc.28060. [PMID: 23354914]
  • Emma Portnoy, Marina Gurina, Shlomo Magdassi, Sara Eyal. Evaluation of the near infrared compound indocyanine green as a probe substrate of p-glycoprotein. Molecular pharmaceutics. 2012 Dec; 9(12):3595-601. doi: 10.1021/mp300472y. [PMID: 23098218]
  • Ishrat Jabeen, Karin Pleban, Uwe Rinner, Peter Chiba, Gerhard F Ecker. Structure-activity relationships, ligand efficiency, and lipophilic efficiency profiles of benzophenone-type inhibitors of the multidrug transporter P-glycoprotein. Journal of medicinal chemistry. 2012 Apr; 55(7):3261-73. doi: 10.1021/jm201705f. [PMID: 22452412]
  • Elmira Bajelan, Azadeh Haeri, Amir Masoud Vali, Seyed Nasser Ostad, Simin Dadashzadeh. Co-delivery of doxorubicin and PSC 833 (Valspodar) by stealth nanoliposomes for efficient overcoming of multidrug resistance. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques. 2012; 15(4):568-82. doi: 10.18433/j3sc7j. [PMID: 23106959]
  • Hirokazu Kurihara, Takashi Sato, Noriko Akimoto, Takayuki Ogura, Akira Ito. Identification and characterization of ABCB1-mediated and non-apoptotic sebum secretion in differentiated hamster sebocytes. Biochimica et biophysica acta. 2011 Dec; 1811(12):1090-6. doi: 10.1016/j.bbalip.2011.08.011. [PMID: 21889999]
  • Wing-Kee Lee, Blazej Torchalski, Naschla Kohistani, Frank Thévenod. ABCB1 protects kidney proximal tubule cells against cadmium-induced apoptosis: roles of cadmium and ceramide transport. Toxicological sciences : an official journal of the Society of Toxicology. 2011 Jun; 121(2):343-56. doi: 10.1093/toxsci/kfr071. [PMID: 21436125]
  • Liang Jin, Jian Li, Roger L Nation, Joseph A Nicolazzo. Impact of p-glycoprotein inhibition and lipopolysaccharide administration on blood-brain barrier transport of colistin in mice. Antimicrobial agents and chemotherapy. 2011 Feb; 55(2):502-7. doi: 10.1128/aac.01273-10. [PMID: 21115788]
  • Nicola F Smith, Sridhar Mani, Erin G Schuetz, Kazuto Yasuda, Tristan M Sissung, Susan E Bates, William D Figg, Alex Sparreboom. Induction of CYP3A4 by vinblastine: Role of the nuclear receptor NR1I2. The Annals of pharmacotherapy. 2010 Nov; 44(11):1709-17. doi: 10.1345/aph.1p354. [PMID: 20959500]
  • Ziyad Binkhathlan, Dalia A Hamdy, Dion R Brocks, Afsaneh Lavasanifar. Development of a polymeric micellar formulation for valspodar and assessment of its pharmacokinetics in rat. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2010 Jun; 75(2):90-5. doi: 10.1016/j.ejpb.2010.03.010. [PMID: 20332028]
  • Stefan Oswald, Karen May, Juliane Rosin, Dieter Lütjohann, Werner Siegmund. Synergistic influence of Abcb1 and Abcc2 on disposition and sterol lowering effects of ezetimibe in rats. Journal of pharmaceutical sciences. 2010 Jan; 99(1):422-9. doi: 10.1002/jps.21821. [PMID: 19504475]
  • Z Binkhathlan, D A Hamdy, D R Brocks, A Lavasanifar. Pharmacokinetics of PSC 833 (valspodar) in its Cremophor EL formulation in rat. Xenobiotica; the fate of foreign compounds in biological systems. 2010 Jan; 40(1):55-61. doi: 10.3109/00498250903331056. [PMID: 19903013]
  • Gert Luurtsema, Robert C Schuit, Rob P Klok, Joost Verbeek, Josée E Leysen, Adriaan A Lammertsma, Albert D Windhorst. Evaluation of [11C]laniquidar as a tracer of P-glycoprotein: radiosynthesis and biodistribution in rats. Nuclear medicine and biology. 2009 Aug; 36(6):643-9. doi: 10.1016/j.nucmedbio.2009.03.004. [PMID: 19647170]
  • Uwe Muenster, Birgit Grieshop, Karsten Ickenroth, Mark Jean Gnoth. Characterization of substrates and inhibitors for the in vitro assessment of Bcrp mediated drug-drug interactions. Pharmaceutical research. 2008 Oct; 25(10):2320-6. doi: 10.1007/s11095-008-9632-1. [PMID: 18523872]
  • Andrew Crowe, Susanna Diep. pH dependent efflux of methamphetamine derivatives and their reversal through human Caco-2 cell monolayers. European journal of pharmacology. 2008 Sep; 592(1-3):7-12. doi: 10.1016/j.ejphar.2008.06.090. [PMID: 18638470]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • Ziyad Binkhathlan, Vishwa Somayaji, Dion R Brocks, Afsaneh Lavasanifar. Development of a liquid chromatography-mass spectrometry (LC/MS) assay method for the quantification of PSC 833 (Valspodar) in rat plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2008 Jun; 869(1-2):31-7. doi: 10.1016/j.jchromb.2008.05.003. [PMID: 18514043]
  • Benayahu Elbaz, Ariella Alperovitch, Michael M Gottesman, Chava Kimchi-Sarfaty, Hannah Rahamimoff. Modulation of Na+-Ca2+ exchanger expression by immunosuppressive drugs is isoform-specific. Molecular pharmacology. 2008 Apr; 73(4):1254-63. doi: 10.1124/mol.107.041582. [PMID: 18182482]
  • Robert W Robey, Suneet Shukla, Elizabeth M Finley, Robert K Oldham, Daryl Barnett, Suresh V Ambudkar, Tito Fojo, Susan E Bates. Inhibition of P-glycoprotein (ABCB1)- and multidrug resistance-associated protein 1 (ABCC1)-mediated transport by the orally administered inhibitor, CBT-1((R)). Biochemical pharmacology. 2008 Mar; 75(6):1302-12. doi: 10.1016/j.bcp.2007.12.001. [PMID: 18234154]
  • Ignacio Ortega, Monica Rodriguez, Elena Suarez, Juan Jose Perez-Ruixo, Rosario Calvo. Modeling methadone pharmacokinetics in rats in presence of P-glycoprotein inhibitor valspodar. Pharmaceutical research. 2007 Jul; 24(7):1299-308. doi: 10.1007/s11095-007-9251-2. [PMID: 17380267]
  • Steffen Baltes, Alexandra M Gastens, Maren Fedrowitz, Heidrun Potschka, Volkhard Kaever, Wolfgang Löscher. Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein. Neuropharmacology. 2007 Feb; 52(2):333-46. doi: 10.1016/j.neuropharm.2006.07.038. [PMID: 17045309]
  • D Anglicheau, N Pallet, M Rabant, P Marquet, B Cassinat, P Méria, P Beaune, C Legendre, E Thervet. Role of P-glycoprotein in cyclosporine cytotoxicity in the cyclosporine-sirolimus interaction. Kidney international. 2006 Sep; 70(6):1019-25. doi: 10.1038/sj.ki.5001649. [PMID: 16837925]
  • Jun-Sheng Wang, Hao-Jie Zhu, John S Markowitz, Jennifer L Donovan, C Lindsay DeVane. Evaluation of antipsychotic drugs as inhibitors of multidrug resistance transporter P-glycoprotein. Psychopharmacology. 2006 Sep; 187(4):415-23. doi: 10.1007/s00213-006-0437-9. [PMID: 16810505]
  • Mehrdad Hamidi. Role of P-glycoprotein in tissue uptake of indinavir in rat. Life sciences. 2006 Aug; 79(10):991-8. doi: 10.1016/j.lfs.2006.05.010. [PMID: 16793066]
  • Grégoire Dirson, Christine Fernandez, Patrick Hindlet, Françoise Roux, Michèle German-Fattal, François Gimenez, Robert Farinotti. Efavirenz does not interact with the ABCB1 transporter at the blood-brain barrier. Pharmaceutical research. 2006 Jul; 23(7):1525-32. doi: 10.1007/s11095-006-0279-5. [PMID: 16779703]
  • Hiroaki Fukuda, Manabu Arai, Tomoki Soh, Nobuhiko Yamauchi, Masa-Aki Hattori. Progesterone regulation of the expression and function of multidrug resistance type I in porcine granulosa cells. Reproductive toxicology (Elmsford, N.Y.). 2006 Jul; 22(1):62-8. doi: 10.1016/j.reprotox.2005.11.003. [PMID: 16337358]
  • Jan Schrickx, Yuri Lektarau, J Fink-Gremmels. Ochratoxin A secretion by ATP-dependent membrane transporters in Caco-2 cells. Archives of toxicology. 2006 May; 80(5):243-9. doi: 10.1007/s00204-005-0041-5. [PMID: 16244858]
  • Bradley Miller, Vimal A Patel, Andrey Sorokin. Cyclooxygenase-2 rescues rat mesangial cells from apoptosis induced by adriamycin via upregulation of multidrug resistance protein 1 (P-glycoprotein). Journal of the American Society of Nephrology : JASN. 2006 Apr; 17(4):977-85. doi: 10.1681/asn.2005101076. [PMID: 16540558]
  • Young-Joo Lee, Jun Maeda, Hiroyuki Kusuhara, Takashi Okauchi, Motoki Inaji, Yuji Nagai, Shigeru Obayashi, Ryuji Nakao, Kazutoshi Suzuki, Yuichi Sugiyama, Tetsuya Suhara. In vivo evaluation of P-glycoprotein function at the blood-brain barrier in nonhuman primates using [11C]verapamil. The Journal of pharmacology and experimental therapeutics. 2006 Feb; 316(2):647-53. doi: 10.1124/jpet.105.088328. [PMID: 16293715]
  • Naoko Yoshida, Akiyoshi Takagi, Hidenori Kitazawa, Junichi Kawakami, Isao Adachi. Inhibition of P-glycoprotein-mediated transport by extracts of and monoterpenoids contained in Zanthoxyli fructus. Toxicology and applied pharmacology. 2005 Dec; 209(2):167-73. doi: 10.1016/j.taap.2005.04.001. [PMID: 15890377]
  • Emma Boström, Ulrika S H Simonsson, Margareta Hammarlund-Udenaes. Oxycodone pharmacokinetics and pharmacodynamics in the rat in the presence of the P-glycoprotein inhibitor PSC833. Journal of pharmaceutical sciences. 2005 May; 94(5):1060-6. doi: 10.1002/jps.20327. [PMID: 15799017]
  • Peter Prehm. Inhibitors of hyaluronan export prevent proteoglycan loss from osteoarthritic cartilage. The Journal of rheumatology. 2005 Apr; 32(4):690-6. doi: NULL. [PMID: 15801027]
  • Misbah Qadir, Kieran L O'Loughlin, Stacy M Fricke, Nicole A Williamson, William R Greco, Hans Minderman, Maria R Baer. Cyclosporin A is a broad-spectrum multidrug resistance modulator. Clinical cancer research : an official journal of the American Association for Cancer Research. 2005 Mar; 11(6):2320-6. doi: 10.1158/1078-0432.ccr-04-1725. [PMID: 15788683]
  • Iouri Bachmakov, Sabine Rekersbrink, Ute Hofmann, Michel Eichelbaum, Martin F Fromm. Characterisation of (R/S)-propafenone and its metabolites as substrates and inhibitors of P-glycoprotein. Naunyn-Schmiedeberg's archives of pharmacology. 2005 Mar; 371(3):195-201. doi: 10.1007/s00210-005-1025-y. [PMID: 15900513]
  • Heleen A Bardelmeijer, Mariët Ouwehand, Jos H Beijnen, Jan H M Schellens, Olaf van Tellingen. Efficacy of novel P-glycoprotein inhibitors to increase the oral uptake of paclitaxel in mice. Investigational new drugs. 2004 Aug; 22(3):219-29. doi: 10.1023/b:drug.0000026248.45084.21. [PMID: 15122069]
  • Susan E Bates, Susan Bakke, Min Kang, Robert W Robey, Suoping Zhai, Paul Thambi, Clara C Chen, Sheela Patil, Tom Smith, Seth M Steinberg, Maria Merino, Barry Goldspiel, Beverly Meadows, Wilfred D Stein, Peter Choyke, Frank Balis, William D Figg, Tito Fojo. A phase I/II study of infusional vinblastine with the P-glycoprotein antagonist valspodar (PSC 833) in renal cell carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2004 Jul; 10(14):4724-33. doi: 10.1158/1078-0432.ccr-0829-03. [PMID: 15269145]
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  • Andrew Crowe, Penny Wong. pH dependent uptake of loperamide across the gastrointestinal tract: an in vitro study. Drug development and industrial pharmacy. 2004 May; 30(5):449-59. doi: 10.1081/ddc-120037471. [PMID: 15244080]
  • Monica Rodriguez, Ignacio Ortega, Itziar Soengas, Elena Suarez, John C Lukas, Rosario Calvo. Effect of P-glycoprotein inhibition on methadone analgesia and brain distribution in the rat. The Journal of pharmacy and pharmacology. 2004 Mar; 56(3):367-74. doi: 10.1211/0022357022782. [PMID: 15025862]
  • Albert J ten Tije, Timothy W Synold, Darcy Spicer, Jaap Verweij, James H Doroshow, Alex Sparreboom. Effect of valspodar on the pharmacokinetics of unbound paclitaxel. Investigational new drugs. 2003 Aug; 21(3):291-8. doi: 10.1023/a:1025412509730. [PMID: 14578679]
  • E Marleen Kemper, A Erik van Zandbergen, Cindy Cleypool, Henk A Mos, Willem Boogerd, Jos H Beijnen, Olaf van Tellingen. Increased penetration of paclitaxel into the brain by inhibition of P-Glycoprotein. Clinical cancer research : an official journal of the American Association for Cancer Research. 2003 Jul; 9(7):2849-55. doi: NULL. [PMID: 12855665]
  • S Deferme, A Kamuhabwa, C Nshimo, P de Witte, P Augustijns. Screening of Tanzanian plant extracts for their potential inhibitory effect on P-glycoprotein mediated efflux. Phytotherapy research : PTR. 2003 May; 17(5):459-64. doi: 10.1002/ptr.1173. [PMID: 12748979]
  • Chetan S Karyekar, Natalie D Eddington, Tushar S Garimella, Paul O Gubbins, Thomas C Dowling. Evaluation of P-glycoprotein-mediated renal drug interactions in an MDR1-MDCK model. Pharmacotherapy. 2003 Apr; 23(4):436-42. doi: 10.1592/phco.23.4.436.32125. [PMID: 12680473]
  • Stephan Fellner, Björn Bauer, David S Miller, Martina Schaffrik, Martina Fankhänel, Thilo Spruss, Günther Bernhardt, Claudia Graeff, Lothar Färber, Harald Gschaidmeier, Armin Buschauer, Gert Fricker. Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo. The Journal of clinical investigation. 2002 Nov; 110(9):1309-18. doi: 10.1172/jci15451. [PMID: 12417570]
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