PMEG (BioDeep_00000008533)

   


代谢物信息卡片


9-((2-Phosphonylmethoxy)ethyl)guanine

化学式: C8H12N5O5P (289.0576)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=NC2=C(N1CCOCP(=O)(O)O)N=C(NC2=O)N
InChI: InChI=1S/C8H12N5O5P/c9-8-11-6-5(7(14)12-8)10-3-13(6)1-2-18-4-19(15,16)17/h3H,1-2,4H2,(H2,15,16,17)(H3,9,11,12,14)

描述信息

同义名列表

3 个代谢物同义名

9-((2-Phosphonylmethoxy)ethyl)guanine; PMEG; PMEG



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ADA, AIMP2, ATM, CASP3, CASP8, CASP9, CCR5, DCK, FAS, MAPK11, MAPK8, POLB
Peripheral membrane protein 1 ADA
Endosome membrane 1 ATP8A2
Nucleus 11 ADK, AIMP2, ATM, CASP3, CASP8, CASP9, DCK, MAPK11, MAPK8, PARP1, POLB
cytosol 13 ADA, ADAL, ADK, AIMP2, ATM, CASP3, CASP8, CASP9, DCK, FAS, MAPK11, MAPK8, PARP1
nuclear body 2 FAS, PARP1
centrosome 1 ATM
nucleoplasm 10 ADK, ATM, ATP8A2, CASP3, CASP8, DCK, MAPK11, MAPK8, PARP1, POLB
Cell membrane 5 ADA, ATP8A2, CCR5, FAS, TNF
lamellipodium 1 CASP8
Multi-pass membrane protein 2 ATP8A2, CCR5
Golgi apparatus membrane 1 ATP8A2
Synapse 1 MAPK8
cell junction 1 ADA
cell surface 4 ADA, CCR5, FAS, TNF
glutamatergic synapse 1 CASP3
Golgi apparatus 2 ATP8A2, FAS
Golgi membrane 1 ATP8A2
neuronal cell body 2 CASP3, TNF
Cytoplasm, cytosol 2 AIMP2, PARP1
Lysosome 1 ADA
endosome 1 CCR5
plasma membrane 7 ADA, ADK, ATP8A2, CCR5, FAS, IFNLR1, TNF
Membrane 7 ADA, AIMP2, ATP8A2, CCR5, FAS, IFNLR1, PARP1
axon 1 MAPK8
extracellular exosome 1 FAS
extracellular space 3 IL10, IL2, TNF
mitochondrion 4 CASP8, CASP9, DCK, PARP1
protein-containing complex 4 CASP8, CASP9, PARP1, POLB
intracellular membrane-bounded organelle 1 ATM
postsynaptic density 1 CASP3
Single-pass type I membrane protein 2 FAS, IFNLR1
Secreted 2 IL10, IL2
extracellular region 3 IL10, IL2, TNF
mitochondrial outer membrane 1 CASP8
Extracellular side 1 ADA
Cytoplasmic vesicle lumen 1 ADA
anchoring junction 1 ADA
transcription regulator complex 1 PARP1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 ATM
external side of plasma membrane 4 ADA, CCR5, FAS, TNF
cytoplasmic vesicle 1 ATM
nucleolus 2 ATM, PARP1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Cell projection, lamellipodium 1 CASP8
Membrane raft 2 FAS, TNF
microtubule 1 POLB
spindle 1 ATM
Peroxisome matrix 1 ATM
peroxisomal matrix 1 ATM
chromatin 1 PARP1
cell projection 1 ATP8A2
phagocytic cup 1 TNF
Chromosome 1 PARP1
cytoskeleton 1 CASP8
Nucleus, nucleolus 1 PARP1
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
site of double-strand break 2 ATM, PARP1
nuclear envelope 1 PARP1
Endomembrane system 1 ATP8A2
Melanosome 1 FAS
cell body 1 CASP8
Photoreceptor inner segment membrane 1 ATP8A2
extrinsic component of synaptic vesicle membrane 1 ATM
apoptosome 1 CASP9
[Isoform 2]: Cytoplasm 1 ADK
[Isoform 1]: Nucleus 1 ADK
protein-DNA complex 1 PARP1
spindle microtubule 1 POLB
basal dendrite 1 MAPK8
CD95 death-inducing signaling complex 2 CASP8, FAS
death-inducing signaling complex 3 CASP3, CASP8, FAS
ripoptosome 1 CASP8
[Isoform 1]: Cell membrane 1 FAS
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
photoreceptor outer segment membrane 1 ATP8A2
phospholipid-translocating ATPase complex 1 ATP8A2
DNA repair complex 1 ATM
site of DNA damage 1 PARP1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
glycogen granule 1 FAS
caspase complex 1 CASP9
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Xudong Jiang, Guangyuan Xiang, Guanting Du, Xiaoqiang Li, Peng Wu, Xiaolong Du. A hemodynamic analysis of fenestrated physician-modified endograft repair for complicated aortic dissections involving the visceral arteries. Computer methods and programs in biomedicine. 2023 Dec; 242(?):107785. doi: 10.1016/j.cmpb.2023.107785. [PMID: 37678097]
  • Chuankui Fu, Yiheng Zhang, Wen Jie Xi, Kejia Xu, Fansheng Meng, Tianle Ma, Weidong Li, Li Wu, Zhipeng Chen. Dahuang Zhechong pill attenuates hepatic sinusoidal capillarization in liver cirrhosis and hepatocellular carcinoma rat model via the MK/integrin signaling pathway. Journal of ethnopharmacology. 2023 Jan; 308(?):116191. doi: 10.1016/j.jep.2023.116191. [PMID: 36731809]
  • Mei Chen, Jiangping Hou, Guilin Tan, Peng Xie, William R Freeman, James R Beadle, Karl Y Hostetler, Lingyun Cheng. A novel lipid prodrug strategy for sustained delivery of hexadecyloxypropyl 9-[2-(phosphonomethoxy)ethyl]guanine (HDP-PMEG) on unwanted ocular proliferation. Drug delivery. 2017 Nov; 24(1):1703-1712. doi: 10.1080/10717544.2017.1399303. [PMID: 29115885]
  • Jana Mandíková, Marie Volková, Petr Pávek, Michal Česnek, Zlatko Janeba, Vladimír Kubíček, František Trejtnar. Interactions with selected drug renal transporters and transporter-mediated cytotoxicity in antiviral agents from the group of acyclic nucleoside phosphonates. Toxicology. 2013 Sep; 311(3):135-46. doi: 10.1016/j.tox.2013.07.004. [PMID: 23856525]
  • T Cihlar, D C Lin, J B Pritchard, M D Fuller, D B Mendel, D H Sweet. The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1. Molecular pharmacology. 1999 Sep; 56(3):570-80. doi: 10.1124/mol.56.3.570. [PMID: 10462545]