Dimethyl sulphone (BioDeep_00000008513)
Secondary id: BioDeep_00000405596, BioDeep_00000866166
human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite
代谢物信息卡片
Methane, 1,1′-sulfonylbis-
化学式: C2H6O2S (94.0088496)
中文名称: 二甲基砜
谱图信息:
最多检出来源 Homo sapiens(blood) 0.21%
Reviewed
Last reviewed on 2024-08-21.
Cite this Page
Dimethyl sulphone. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/dimethyl_sulphone (retrieved
2024-11-03) (BioDeep RN: BioDeep_00000008513). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: CS(=O)(=O)C
InChI: InChI=1S/C2H6O2S/c1-5(2,3)4/h1-2H3
描述信息
Dimethyl sulfone, also known as sulfonylbismethane or lignisul MSM, belongs to the class of organic compounds known as sulfones. Sulfones are compounds containing a sulfonyl group, which has the general structure RS(=O)2R (R,R =alkyl, aryl), attached to two carbon atoms. Dimethyl sulfone (DMSO2) is an organic sulfur compound belonging to a class of chemicals known as sulfones. It derives from dietary sources, from intestinal bacterial metabolism and from human endogenous methanethiol metabolism. DMSO2 reflects its close chemical relationship to dimethyl sulfoxide (DMSO), which differs only in the oxidation state of the sulfur atom. Dimethyl sulfone is possibly neutral. Dimethyl sulfone exists in all living organisms, ranging from bacteria to humans. DMSO2 is the primary metabolite of DMSO in humans, and it shares some of the properties of DMSO. Dimethyl sulfone is sulfurous tasting compound. dimethyl sulfone is found on average in the highest concentration in milk (cow). Dimethyl sulfone has also been detected, but not quantified in asparagus and guava. This could make dimethyl sulfone a potential biomarker for the consumption of these foods. Dimethyl sulfone can be found in Afipia. It occurs naturally in some primitive plants and is present in small amounts in many foods and beverages. Dimethyl sulfone can be found in plasma and CSF of normal humans.
Methylsulfonylmethane (MSM) is an organosulfur compound with the formula (CH3)2SO2. It is also known by several other names including DMSO2, methyl sulfone, and dimethyl sulfone. This colorless solid features the sulfonyl functional group and is considered relatively inert chemically. It occurs naturally in some primitive plants and is present in small amounts in many foods and beverages and it is marketed as a dietary supplement. Dimethyl sulfone is found in guava.
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D000893 - Anti-Inflammatory Agents
Dimethyl sulfone (Methyl Sulfonyl Methane) is a metabolic product of endogenous methanethiol metabolism and intestinal bacterial metabolism. Dimethyl sulfone inhibits choriocapillary endothelial (CCE) cell proliferation, also has many biological effects, including antiinflammatory, antioxidant, and local anesthetic effects that could be neuroprotective[1][2][3].
Dimethyl sulfone (Methyl Sulfonyl Methane) is a metabolic product of endogenous methanethiol metabolism and intestinal bacterial metabolism. Dimethyl sulfone inhibits choriocapillary endothelial (CCE) cell proliferation, also has many biological effects, including antiinflammatory, antioxidant, and local anesthetic effects that could be neuroprotective[1][2][3].
同义名列表
16 个代谢物同义名
Dimethyl sulfone, 13C-labeled; (Methylsulfonyl)methane; methanesulfonylmethane; Methylsulphonylmethane; Methylsulfonylmethane; Methyl sulfonmethane; Sulphonylbismethane; Sulfonylbis-methane; Sulfonylbismethane; Sulphonyldimethane; Dimethyl sulphone; Dimethyl sulfone; Dimethylsulfone; Methyl sulfone; Lignisul MSM; Opti MSM
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:9349
- KEGG: C11142
- PubChem: 6213
- HMDB: HMDB0004983
- Metlin: METLIN7236
- DrugBank: DB14090
- ChEMBL: CHEMBL25028
- Wikipedia: Methylsulfonylmethane
- foodb: FDB006725
- chemspider: 5978
- CAS: 67-71-0
- PMhub: MS000022138
- NIKKAJI: J1.412E
- RefMet: Dimethyl sulfone
- medchemexpress: HY-Y1314
分类词条
相关代谢途径
Reactome(0)
BioCyc(3)
PlantCyc(0)
代谢反应
3 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(3)
- dimethyl sulfide degradation II (oxidation):
H+ + NADPH + O2 + dimethyl sulfide ⟶ H2O + NADP+ + dimethyl sulfoxide - dimethyl sulfone degradation:
H2O + NAD+ + dimethyl sulfoxide ⟶ H+ + NADH + dimethyl sulfone - superpathway of dimethylsulfone degradation:
H+ + NADH + O2 + dimethyl sulfide ⟶ H2O + NAD+ + formaldehyde + methanethiol
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
7 个相关的物种来源信息
- 1080010 - Aloe africana: 10.1021/JF010179C
- 3589 - Basella alba: 10.1016/0889-1575(91)90017-Z
- 3258 - Equisetum arvense: 10.1002/HLCA.19490320724
- 3262 - Equisetum hyemale L.: -
- 9606 - Homo sapiens: -
- 9606 - Homo sapiens: 10.1007/S11306-015-0840-5
- 120290 - Psidium guajava: 10.1080/10412905.1994.9698430
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Elizabeth A Tanner, Melody A Gary, Stephan Michalik, Asheal A Davis, Brian K McFarlin. Optimized Curcumin, Pomegranate Extract, and Methylsulfonylmethane Reduce Acute, Systemic Inflammatory Response to a Half-marathon Race.
Alternative therapies in health and medicine.
2022 Sep; 28(6):72-81. doi:
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Journal of medicinal food.
2022 Jun; 25(6):607-617. doi:
10.1089/jmf.2021.0196. [PMID: 35708633] - Yueming Guo, Pengpeng Li, Zongliang Wang, Peibiao Zhang, Xiaodong Wu. Sustained Delivery of Methylsulfonylmethane from Biodegradable Scaffolds Enhances Efficient Bone Regeneration.
International journal of nanomedicine.
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10.2147/ijn.s377036. [PMID: 36246935] - Da-Yeon Lee, Chan-Yang Lee, Jin-Na Shin, Jeong-Ho Oh, Soon-Mi Shim. Impact of soy lecithin, zinc oxide, and methylsulfonylmethane, as excipient ingredients, on the bioaccessibility and intestinal transport of branched-chain amino acids from animal and plant protein mixtures.
Food & function.
2021 Nov; 12(22):11399-11407. doi:
10.1039/d1fo01712h. [PMID: 34673869] - X Liu, S Robbins, J Eyles, T Fedorova, S Virk, L A Deveza, A J McLachlan, D J Hunter. Efficacy and safety of a supplement combination on hand pain among people with symptomatic hand osteoarthritis an internet-based, randomised clinical trial the RADIANT study.
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Poultry science.
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