benalfocin (BioDeep_00000008420)
Secondary id: BioDeep_00001876758
human metabolite blood metabolite Volatile Flavor Compounds
代谢物信息卡片
化学式: C11H14ClN (195.0814714)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 3.57%
分子结构信息
SMILES: CN1CCC2=C(CC1)C(=CC=C2)Cl
InChI: InChI=1S/C11H14ClN/c1-13-7-5-9-3-2-4-11(12)10(9)6-8-13/h2-4H,5-8H2,1H3
描述信息
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
同义名列表
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:8986
- KEGG: C10970
- PubChem: 123981
- HMDB: HMDB0248942
- Metlin: METLIN68732
- ChEMBL: CHEMBL123349
- chemspider: 110500
- CAS: 73943-10-9
- PMhub: MS000022039
- PubChem: 13153
- NIKKAJI: J23.755H
- KNApSAcK: 8986
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Jesús Sáiz, Angel Pazos, Elena Del Olmo, Vanesa Sáiz, Adela Sánchez. Yohimbine-induced alterations in alpha(2)-adrenoceptors in kidney regions of the spontaneously hypertensive rats: an autoradiographic analysis.
Pharmacological reports : PR.
2008 May; 60(3):391-8. doi:
. [PMID: 18622064]
- B Szabo, C Bock, U Nordheim, N Niederhoffer. Mechanism of the sympathoinhibition produced by the clonidine-like drugs rilmenidine and moxonidine.
Annals of the New York Academy of Sciences.
1999 Jun; 881(?):253-64. doi:
10.1111/j.1749-6632.1999.tb09367.x
. [PMID: 10415923] - C Bock, N Niederhoffer, B Szabo. Analysis of the receptor involved in the central hypotensive effect of rilmenidine and moxonidine.
Naunyn-Schmiedeberg's archives of pharmacology.
1999 Apr; 359(4):262-71. doi:
10.1007/pl00005351
. [PMID: 10344524] - B Szabo, R Urban. Mechanism of sympathoinhibition by imidazolines.
Annals of the New York Academy of Sciences.
1995 Jul; 763(?):552-65. doi:
10.1111/j.1749-6632.1995.tb32449.x
. [PMID: 7677373] - R Urban, B Szabo, K Starke. Is the sympathoinhibitory effect of rilmenidine mediated by alpha-2 adrenoceptors or imidazoline receptors?.
The Journal of pharmacology and experimental therapeutics.
1994 Aug; 270(2):572-8. doi:
. [PMID: 7915315]
- K Xu, L Näveri, K U Frerichs, J M Hallenbeck, G Feuerstein, J N Davis, A L Sirén. Extracellular catecholamine levels in rat hippocampus after a selective alpha-2 adrenoceptor antagonist or a selective dopamine uptake inhibitor: evidence for dopamine release from local dopaminergic nerve terminals.
The Journal of pharmacology and experimental therapeutics.
1993 Oct; 267(1):211-7. doi:
. [PMID: 7901393]
- J P Hieble, A J Nichols, T A Fredrickson, P D DePalma, R R Ruffolo, D P Brooks. Cardiovascular actions of a new selective postjunctional alpha-adrenoceptor antagonist, SK&F 104856, in normotensive and hypertensive dogs.
British journal of pharmacology.
1992 Apr; 105(4):992-6. doi:
10.1111/j.1476-5381.1992.tb09090.x
. [PMID: 1354539] - R F Schafers, H L Elliott, C A Howie, J L Reid. An evaluation of the alpha-adrenoceptor antagonism produced by SK&F 86466 in healthy normotensive males.
British journal of clinical pharmacology.
1990 Dec; 30(6):884-8. doi:
10.1111/j.1365-2125.1990.tb05455.x
. [PMID: 1981137] - J P Hieble, A C Sulpizio, L Gutzait, C T Gombar. Cardiovascular effects of SK&F 104078, a novel alpha-adrenoceptor antagonist, in normotensive and hypertensive rats.
Journal of cardiovascular pharmacology.
1990 May; 15(5):845-52. doi:
10.1097/00005344-199005000-00022
. [PMID: 1692947] - C de Mey, D Enterling, S Hansen-Schmidt, I Meineke. SK&F 86466, a novel alpha-adrenolytic drug: effects on heart rate, blood pressure, and neuroendocrine function in supine resting position and in response to postural and cold stimulation in normal humans.
Journal of cardiovascular pharmacology.
1989 Jan; 13(1):25-31. doi:
. [PMID: 2468932]
- M Taouis, M Berlan, P Montastruc, M Lafontan. Mechanism of the lipid-mobilizing effect of alpha-2 adrenergic antagonists in the dog.
The Journal of pharmacology and experimental therapeutics.
1988 Dec; 247(3):1172-80. doi:
. [PMID: 2905003]
- J Galitzky, M Taouis, M Berlan, D Rivière, M Garrigues, M Lafontan. Alpha 2-antagonist compounds and lipid mobilization: evidence for a lipid mobilizing effect of oral yohimbine in healthy male volunteers.
European journal of clinical investigation.
1988 Dec; 18(6):587-94. doi:
10.1111/j.1365-2362.1988.tb01272.x
. [PMID: 2906290] - K Straub, M Davis, B Hwang. Benzazepine metabolism revisited. Evidence for the formation of novel amine conjugates.
Drug metabolism and disposition: the biological fate of chemicals.
1988 May; 16(3):359-66. doi:
. [PMID: 2900726]
- P Kerth, M Frisk-Holmberg. Clinical evaluation of the cardiovascular effects and the pharmacokinetics of benalfocin and its metabolite in healthy subjects during repeated dosing.
Fundamental & clinical pharmacology.
1988; 2(3):215-22. doi:
10.1111/j.1472-8206.1988.tb00633.x
. [PMID: 2900185] - P Levandoski, K Straub, D Shah, R DeMarinis, C de Mey. High sensitivity assay for the alpha 2 antagonist 6-chloro-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and its desmethyl metabolite in plasma using gas chromatography mass spectrometry with ammonia/CCl4 chemical ionization.
Biomedical & environmental mass spectrometry.
1986 Oct; 13(10):523-30. doi:
10.1002/bms.1200131002
. [PMID: 2878696] - C T Gombar, K Straub, P Levandoski, L Gutzait, J Swagzdis, C Garvie, G Joseph, B D Potts, B A Mico. Pharmacokinetics, metabolism, and disposition of 6-chloro-2,3,4,5-tetrahydro-3-methyl-1H-3-benzazepine (SK&F 86466) in rats and dogs.
Drug metabolism and disposition: the biological fate of chemicals.
1986 Sep; 14(5):540-8. doi:
NULL
. [PMID: 2876859] - J M Roesler, J P McCafferty, R M DeMarinis, W D Matthews, J P Hieble. Characterization of the antihypertensive activity of SK&F 86466, a selective alpha-2 antagonist, in the rat.
The Journal of pharmacology and experimental therapeutics.
1986 Jan; 236(1):1-7. doi:
. [PMID: 2867209]
- K M Straub, P Levandoski. Quantitative analysis of an N-oxide metabolite by fast atom bombardment tandem mass spectrometry.
Biomedical mass spectrometry.
1985 Jul; 12(7):338-43. doi:
10.1002/bms.1200120705
. [PMID: 2933090]