DL-Dithiothreitol (BioDeep_00000837572)

Main id: BioDeep_00000001728

 

BioNovoGene_Lab2019


代谢物信息卡片


(2S,3S)-1,4-Dimercaptobutane-2,3-diol

化学式: C4H10O2S2 (154.0122)
中文名称: DL-二硫苏糖醇(DTT), 二硫代苏糖醇, L-1,4-二硫代苏糖醇, 二硫苏糖醇, 1,4-二硫苏糖醇
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(C(C(CS)O)O)S
InChI: InChI=1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4-/m0/s1

描述信息

COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

7 个代谢物同义名

(2S,3S)-1,4-Dimercaptobutane-2,3-diol; D-1,4-dithiothreitol; DL-Dithiothreitol; 2,3-DIHYDROXY-1,4-dithiobutane; 1,4-Dithiothreitol; Dithiothreitol; 1,4-Dithiothreitol



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(47)

PlantCyc(5)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ALB, CASP3, CAT, ELANE, ERN1, G6PD, GAPDH, MYLK, TXN, XDH
Peripheral membrane protein 1 G6PD
Endosome membrane 1 INSR
Endoplasmic reticulum membrane 2 ERN1, HSP90B1
Nucleus 5 ALB, CASP3, GAPDH, HSP90B1, TXN
cytosol 10 ALB, CASP3, CAT, ELANE, G6PD, GAPDH, HSP90B1, MYLK, TXN, XDH
phagocytic vesicle 1 ELANE
centrosome 1 ALB
nucleoplasm 3 ATP2B1, CASP3, TXN
Cell membrane 4 AGTR2, ATP2B1, INSR, ITGAM
Cleavage furrow 1 MYLK
lamellipodium 1 MYLK
Multi-pass membrane protein 2 AGTR2, ATP2B1
Synapse 2 ATP2B1, MYLK
cell surface 3 CD38, ELANE, ITGAM
glutamatergic synapse 2 ATP2B1, CASP3
Golgi apparatus 2 ALB, SERPINA1
Golgi membrane 1 INS
neuronal cell body 1 CASP3
presynaptic membrane 1 ATP2B1
smooth endoplasmic reticulum 1 HSP90B1
Cytoplasm, cytosol 2 G6PD, GAPDH
Lysosome 1 INSR
plasma membrane 7 AGTR2, ATP2B1, CD38, GAPDH, INSR, ITGAM, MYLK
synaptic vesicle membrane 1 ATP2B1
Membrane 8 ATP2B1, CAT, CD38, G6PD, GAPDH, HSP90B1, INSR, ITGAM
axon 1 INSR
basolateral plasma membrane 2 ATP2B1, CD38
caveola 1 INSR
extracellular exosome 13 ALB, ATP2B1, CAT, CD38, ELANE, G6PD, GAPDH, HSP90B1, INSR, ITGAM, LYZ, SERPINA1, TXN
endoplasmic reticulum 4 ALB, ERN1, HSP90B1, SERPINA1
extracellular space 8 ALB, ELANE, IL6, INS, ITGAM, LYZ, SERPINA1, XDH
perinuclear region of cytoplasm 2 GAPDH, HSP90B1
mitochondrion 2 CAT, ERN1
protein-containing complex 3 ALB, CAT, HSP90B1
intracellular membrane-bounded organelle 5 ATP2B1, CAT, G6PD, GAPDH, SERPINA1
postsynaptic density 1 CASP3
Single-pass type I membrane protein 3 ERN1, INSR, ITGAM
Secreted 4 ALB, IL6, INS, TXN
extracellular region 9 ALB, CAT, ELANE, HSP90B1, IL6, INS, LYZ, SERPINA1, TXN
cytoplasmic side of plasma membrane 1 G6PD
neuronal cell body membrane 1 INSR
mitochondrial matrix 1 CAT
anchoring junction 1 ALB
centriolar satellite 1 G6PD
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
nuclear membrane 2 CD38, GAPDH
external side of plasma membrane 2 INSR, ITGAM
actin cytoskeleton 1 MYLK
microtubule cytoskeleton 1 GAPDH
midbody 1 HSP90B1
COPII-coated ER to Golgi transport vesicle 1 SERPINA1
Single-pass type II membrane protein 1 CD38
vesicle 1 GAPDH
Cell projection, lamellipodium 1 MYLK
Cytoplasm, perinuclear region 1 GAPDH
Membrane raft 1 ITGAM
Cytoplasm, cytoskeleton 1 GAPDH
focal adhesion 2 CAT, HSP90B1
Peroxisome 2 CAT, XDH
sarcoplasmic reticulum 1 XDH
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 3 ELANE, HSP90B1, SERPINA1
secretory granule 1 ELANE
lateral plasma membrane 1 ATP2B1
nuclear inner membrane 1 ERN1
Late endosome 1 INSR
receptor complex 1 INSR
ciliary basal body 1 ALB
cell projection 1 ATP2B1
cytoskeleton 1 GAPDH
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
Basolateral cell membrane 1 ATP2B1
endosome lumen 1 INS
Lipid droplet 1 GAPDH
specific granule membrane 1 ITGAM
tertiary granule membrane 1 ITGAM
Melanosome 1 HSP90B1
Presynaptic cell membrane 1 ATP2B1
sperm plasma membrane 1 HSP90B1
stress fiber 1 MYLK
plasma membrane raft 1 ITGAM
ficolin-1-rich granule lumen 2 CAT, SERPINA1
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 5 ALB, HSP90B1, IL6, INS, SERPINA1
transcription repressor complex 1 ELANE
platelet alpha granule lumen 2 ALB, SERPINA1
specific granule lumen 2 ELANE, LYZ
tertiary granule lumen 1 LYZ
transport vesicle 1 INS
azurophil granule lumen 2 ELANE, LYZ
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 INS, SERPINA1
immunological synapse 1 ATP2B1
Sarcoplasmic reticulum lumen 1 HSP90B1
Cytoplasm, cytoskeleton, stress fiber 1 MYLK
ribonucleoprotein complex 1 GAPDH
death-inducing signaling complex 1 CASP3
dendrite membrane 1 INSR
Cytoplasmic vesicle, phagosome 1 ELANE
GAIT complex 1 GAPDH
AIP1-IRE1 complex 1 ERN1
Ire1 complex 1 ERN1
IRE1-RACK1-PP2A complex 1 ERN1
IRE1-TRAF2-ASK1 complex 1 ERN1
integrin complex 1 ITGAM
endocytic vesicle lumen 1 HSP90B1
catalase complex 1 CAT
integrin alphaM-beta2 complex 1 ITGAM
interleukin-6 receptor complex 1 IL6
insulin receptor complex 1 INSR
endoplasmic reticulum chaperone complex 1 HSP90B1
photoreceptor ribbon synapse 1 ATP2B1
ciliary transition fiber 1 ALB


文献列表

  • Xuemei Zhang, Chao Geng, Yang Fu, Zhen Lv, Zhonglin Wei, Hongda Wang, Shixue Wang. A Facile and Green Approach for the Preparation of Amine-Functionalized Poly(ethylene glycol) by Reducing Poly(ethylene glycol) Azide with Dithiothreitol. Biomacromolecules. 2024 Mar; 25(3):1972-1977. doi: 10.1021/acs.biomac.3c01370. [PMID: 38359265]
  • Renata Bufollo Rodrigues, Mariana Maciel de Oliveira, Francielle Pelegrin Garcia, Tânia Ueda-Nakamura, Sueli de Oliveira Silva, Celso Vataru Nakamura. Dithiothreitol reduces oxidative stress and necrosis caused by ultraviolet A radiation in L929 fibroblasts. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 2024 Feb; ?(?):. doi: 10.1007/s43630-023-00516-z. [PMID: 38305951]
  • Meng Huang, Meng Li, Ying Zhang, Huan Gong, Yuju Zhou, Danping Zhu, Lingxi Li, Ning Ma, Yan Cui. Novel flavan-3-ol-dithiothreitol conjugates derived from the degradation of grape seed proanthocyanidins and their neuroprotective potential. Food chemistry. 2023 Mar; 405(Pt A):134825. doi: 10.1016/j.foodchem.2022.134825. [PMID: 36356360]
  • Song Li, Sheng-Jie Yue, Peng Huang, Tong-Tong Feng, Hong-Yan Zhang, Rui-Lian Yao, Wei Wang, Xue-Hong Zhang, Hong-Bo Hu. Comparative metabolomics and transcriptomics analyses provide insights into the high-yield mechanism of phenazines biosynthesis in Pseudomonas chlororaphis GP72. Journal of applied microbiology. 2022 Nov; 133(5):2790-2801. doi: 10.1111/jam.15727. [PMID: 35870153]
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  • Gokul G, Jogender Singh. Dithiothreitol causes toxicity in C. elegans by modulating the methionine-homocysteine cycle. eLife. 2022 04; 11(?):. doi: 10.7554/elife.76021. [PMID: 35438636]
  • Karollyny Roger Pereira Lima, Francisco Lucas Pacheco Cavalcante, Stelamaris de Oliveira Paula-Marinho, Isabelle Mary Costa Pereira, Lineker de Sousa Lopes, João Victor Serra Nunes, Ítalo Antônio Cotta Coutinho, Enéas Gomes-Filho, Humberto Henrique de Carvalho. Metabolomic profiles exhibit the influence of endoplasmic reticulum stress on sorghum seedling growth over time. Plant physiology and biochemistry : PPB. 2022 Jan; 170(?):192-205. doi: 10.1016/j.plaphy.2021.11.041. [PMID: 34902782]
  • Nunzia Limatola, Jong Tai Chun, Sawsen Cherraben, Jean-Louis Schmitt, Jean-Marie Lehn, Luigia Santella. Effects of Dithiothreitol on Fertilization and Early Development in Sea Urchin. Cells. 2021 12; 10(12):. doi: 10.3390/cells10123573. [PMID: 34944081]
  • Ramses Cruz-Valencia, Aldo A Arvizu-Flores, Jesús A Rosas-Rodríguez, Elisa M Valenzuela-Soto. Effect of the drug cyclophosphamide on the activity of porcine kidney betaine aldehyde dehydrogenase. Molecular and cellular biochemistry. 2021 Mar; 476(3):1467-1475. doi: 10.1007/s11010-020-04010-3. [PMID: 33389495]
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  • Xing Yu, Tanchun Wang, Meichen Zhu, Liting Zhang, Fengzhi Zhang, Enen Jing, Yongzhe Ren, Zhiqiang Wang, Zeyu Xin, Tongbao Lin. Transcriptome and physiological analyses for revealing genes involved in wheat response to endoplasmic reticulum stress. BMC plant biology. 2019 May; 19(1):193. doi: 10.1186/s12870-019-1798-7. [PMID: 31072347]
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  • Tugce Nihal Gevrek, Merve Cosar, Duygu Aydin, Elif Kaga, Mehmet Arslan, Rana Sanyal, Amitav Sanyal. Facile Fabrication of a Modular 'Catch and Release' Hydrogel Interface: Harnessing Thiol-Disulfide Exchange for Reversible Protein Capture and Cell Attachment. ACS applied materials & interfaces. 2018 May; 10(17):14399-14409. doi: 10.1021/acsami.8b00802. [PMID: 29637775]
  • J-P Sigle, B Mihm, R Suna, M Bargetzi. Extending shelf life of dithiothreitol-treated panel RBCs to 28 days. Vox sanguinis. 2018 May; 113(4):397-399. doi: 10.1111/vox.12645. [PMID: 29512161]
  • Laura Martos, Luis Andrés Ramón, Julia Oto, Álvaro Fernández-Pardo, Santiago Bonanad, Ana Rosa Cid, Andras Gruber, John H Griffin, Francisco España, Silvia Navarro, Pilar Medina. α2-Macroglobulin Is a Significant In Vivo Inhibitor of Activated Protein C and Low APC:α2M Levels Are Associated with Venous Thromboembolism. Thrombosis and haemostasis. 2018 04; 118(4):630-638. doi: 10.1055/s-0038-1629902. [PMID: 29448296]
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  • Asmae Zerrouki, Sanae Ouadghiri, Nadia Benseffaj, Rachid Razine, Malika Essakalli. Reason and Resolution of High Negative Control Beads in Solid-Phase Immunoassay. Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation. 2018 Feb; 16(1):38-43. doi: 10.6002/ect.2016.0239. [PMID: 28540842]
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  • Pingping Liang, Juan Canoura, Haixiang Yu, Obtin Alkhamis, Yi Xiao. Dithiothreitol-Regulated Coverage of Oligonucleotide-Modified Gold Nanoparticles To Achieve Optimized Biosensor Performance. ACS applied materials & interfaces. 2018 Jan; 10(4):4233-4242. doi: 10.1021/acsami.7b16914. [PMID: 29313333]
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