1-Hexacosanol (BioDeep_00000007796)

 

Secondary id: BioDeep_00000629712

human metabolite blood metabolite


代谢物信息卡片


1-Hexacosanol, aluminum (1:3) salt

化学式: C26H54O (382.4174)
中文名称: 1-二十六烷醇
谱图信息: 最多检出来源 Mus musculus(plant) 4.27%

分子结构信息

SMILES: CCCCCCCCCCCCCCCCCCCCCCCCCCO
InChI: InChI=1S/C26H54O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27/h27H,2-26H2,1H3

描述信息

同义名列表

9 个代谢物同义名

1-Hexacosanol, aluminum (1:3) salt; Hexacosyl alcohol; Cerylic alcohol; hexacosan-1-ol; N-Hexacosanol; Ceryl alcohol; 1-Hexacosanol; Cerotin; Hexacosan-1-ol



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

90 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 ALB, BDNF, CA3, CEP104, EGLN1, ENO2, KEAP1, NOS1, NOS2, NOS3, PRKAA2, SLC40A1, SREBF2, TGFB1
Peripheral membrane protein 2 ACHE, NOS1
Endoplasmic reticulum membrane 2 HMGCR, SREBF2
Nucleus 11 ACHE, ALB, EGLN1, GABPA, KEAP1, NOS1, NOS2, NOS3, PRKAA2, SREBF2, TGFB1
cytosol 11 ALB, CA3, EGLN1, ENO2, KEAP1, NOS1, NOS2, NOS3, PRKAA2, SLC40A1, SREBF2
dendrite 2 BDNF, PRKAA2
centrosome 2 ALB, CEP104
nucleoplasm 8 GABPA, KEAP1, NOS1, NOS2, NOS3, PRKAA2, SLC40A1, SREBF2
Cell membrane 3 ACHE, ENO2, SLC40A1
Multi-pass membrane protein 3 HMGCR, SLC40A1, SREBF2
Golgi apparatus membrane 1 SREBF2
Synapse 2 ACHE, NOS1
cell surface 2 ACHE, TGFB1
glutamatergic synapse 1 EGLN1
Golgi apparatus 4 ACHE, ALB, NOS3, PRKAA2
Golgi membrane 3 INS, NOS3, SREBF2
neuromuscular junction 1 ACHE
neuronal cell body 2 PRKAA2, TGFB1
sarcolemma 1 NOS1
synaptic vesicle 2 BDNF, SLC40A1
Cytoplasm, cytosol 1 NOS2
plasma membrane 7 ACHE, ENO2, NOS1, NOS2, NOS3, SLC40A1, TGFB1
Membrane 6 ACHE, BDNF, ENO2, HMGCR, PRKAA2, SLC40A1
axon 3 BDNF, PRKAA2, TGFB1
basolateral plasma membrane 1 SLC40A1
caveola 1 NOS3
extracellular exosome 3 ALB, BMP3, ENO2
endoplasmic reticulum 4 ALB, HMGCR, KEAP1, SREBF2
extracellular space 8 ACHE, ALB, ARTN, BDNF, BMP3, ENO2, INS, TGFB1
perinuclear region of cytoplasm 5 ACHE, BDNF, NOS1, NOS2, NOS3
mitochondrion 1 NOS1
protein-containing complex 2 ALB, NOS1
intracellular membrane-bounded organelle 2 EGLN1, SREBF2
postsynaptic density 2 EGLN1, NOS1
Secreted 7 ACHE, ALB, ARTN, BDNF, BMP3, INS, TGFB1
extracellular region 7 ACHE, ALB, ARTN, BDNF, BMP3, INS, TGFB1
Extracellular side 1 ACHE
anchoring junction 1 ALB
Cell projection, cilium 1 CEP104
centriolar satellite 1 KEAP1
photoreceptor inner segment 2 ENO2, NOS1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 CEP104
Secreted, extracellular space, extracellular matrix 1 TGFB1
dendritic spine 1 NOS1
perikaryon 1 ENO2
midbody 1 KEAP1
Cytoplasm, P-body 2 NOS2, NOS3
P-body 2 NOS2, NOS3
Cell membrane, sarcolemma 1 NOS1
Cytoplasm, perinuclear region 2 NOS1, NOS2
Membrane raft 1 NOS1
extracellular matrix 1 TGFB1
Peroxisome 1 NOS2
basement membrane 1 ACHE
sarcoplasmic reticulum 1 NOS1
peroxisomal matrix 1 NOS2
peroxisomal membrane 1 HMGCR
Cell projection, dendritic spine 1 NOS1
collagen-containing extracellular matrix 1 TGFB1
secretory granule 1 TGFB1
lateral plasma membrane 1 SLC40A1
nuclear speck 1 PRKAA2
ciliary basal body 1 ALB
cilium 1 CEP104
chromatin 2 GABPA, SREBF2
cell periphery 1 NOS1
cytoskeleton 2 NOS1, NOS3
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole 1 CEP104
centriole 2 ALB, CEP104
spindle pole 2 ALB, CEP104
actin filament 1 KEAP1
blood microparticle 2 ALB, TGFB1
Basolateral cell membrane 1 SLC40A1
Lipid-anchor, GPI-anchor 1 ACHE
Cul3-RING ubiquitin ligase complex 1 KEAP1
endosome lumen 1 INS
Cytoplasm, Stress granule 1 NOS3
cytoplasmic stress granule 2 NOS3, PRKAA2
side of membrane 1 ACHE
Peroxisome membrane 1 HMGCR
secretory granule lumen 1 INS
Golgi lumen 2 INS, TGFB1
endoplasmic reticulum lumen 3 ALB, BDNF, INS
platelet alpha granule lumen 2 ALB, TGFB1
endocytic vesicle membrane 1 NOS3
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
ER to Golgi transport vesicle membrane 1 SREBF2
synaptic cleft 1 ACHE
SREBP-SCAP-Insig complex 1 SREBF2
nucleotide-activated protein kinase complex 1 PRKAA2
Cytoplasmic vesicle, COPII-coated vesicle membrane 1 SREBF2
[Latency-associated peptide]: Secreted, extracellular space, extracellular matrix 1 TGFB1
[Transforming growth factor beta-1]: Secreted 1 TGFB1
cortical cytoskeleton 1 NOS2
inclusion body 1 KEAP1
phosphopyruvate hydratase complex 1 ENO2
[Isoform H]: Cell membrane 1 ACHE
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
ciliary transition fiber 1 ALB
[Sterol regulatory element-binding protein 2]: Endoplasmic reticulum membrane 1 SREBF2
[Processed sterol regulatory element-binding protein 2]: Nucleus 1 SREBF2


文献列表

  • Ji Hae Lee, Yaoyao Jia, Trung Thanh Thach, Yuri Han, Bobae Kim, Chunyan Wu, Yeonji Kim, Woo Duck Seo, Sung-Joon Lee. Hexacosanol reduces plasma and hepatic cholesterol by activation of AMP-activated protein kinase and suppression of sterol regulatory element-binding protein-2 in HepG2 and C57BL/6J mice. Nutrition research (New York, N.Y.). 2017 Jul; 43(?):89-99. doi: 10.1016/j.nutres.2017.05.013. [PMID: 28676202]
  • Sriramya Gade, Maheshwari Rajamanikyam, Varahalarao Vadlapudi, Krishna Madhav Nukala, Rajendar Aluvala, Chandrasekhar Giddigari, Naga Jyothi Karanam, Nabin C Barua, Richa Pandey, Vijaya Saradhi V Upadhyayula, Prabhakar Sripadi, Ramars Amanchy, Suryanarayana Murty Upadhyayula. Acetylcholinesterase inhibitory activity of stigmasterol & hexacosanol is responsible for larvicidal and repellent properties of Chromolaena odorata. Biochimica et biophysica acta. General subjects. 2017 Mar; 1861(3):541-550. doi: 10.1016/j.bbagen.2016.11.044. [PMID: 27916676]
  • Anderson Marques de Oliveira, Lucia M Conserva, Jamylle N De Souza Ferro, Fabíola de Almeida Brito, Rosângela P Lyra Lemos, Emiliano Barreto. Antinociceptive and anti-inflammatory effects of octacosanol from the leaves of Sabicea grisea var. grisea in mice. International journal of molecular sciences. 2012; 13(2):1598-1611. doi: 10.3390/ijms13021598. [PMID: 22408410]
  • P Daisy, K Saipriya. Biochemical analysis of Cassia fistula aqueous extract and phytochemically synthesized gold nanoparticles as hypoglycemic treatment for diabetes mellitus. International journal of nanomedicine. 2012; 7(?):1189-202. doi: 10.2147/ijn.s26650. [PMID: 22419867]
  • Dong Min Jung, Mi Jin Lee, Suk Hoo Yoon, Mun Yhung Jung. A gas chromatography-tandem quadrupole mass spectrometric analysis of policosanols in commercial vegetable oils. Journal of food science. 2011 Aug; 76(6):C891-9. doi: 10.1111/j.1750-3841.2011.02232.x. [PMID: 22417487]
  • Xiang-Gang Zhang, Wen-Qiang Yan, Yan-Ting Lin, Xiao-Jing Liu, Xiao-Yan Lin, Yong-Hong Zhang. [Studies on the diterpenoids of Wedelia prostrata]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2011 Mar; 34(3):383-6. doi: . [PMID: 21823454]
  • Khozirah Shaari, Seema Zareen, Muhammad Nadeem Akhtar, Nordin Hj Lajis. Chemical constituents of Melicope ptelefolia. Natural product communications. 2011 Mar; 6(3):343-8. doi: . [PMID: 21485271]
  • Anton Hansjakob, Sebastian Bischof, Gerhard Bringmann, Markus Riederer, Ulrich Hildebrandt. Very-long-chain aldehydes promote in vitro prepenetration processes of Blumeria graminis in a dose- and chain length-dependent manner. The New phytologist. 2010 Dec; 188(4):1039-54. doi: 10.1111/j.1469-8137.2010.03419.x. [PMID: 20731784]
  • Faouzi Sakouhi, Christelle Absalon, Guido Flamini, Pier Luigi Cioni, Habib Kallel, Sadok Boukhchina. Lipid components of olive oil from Tunisian Cv. Sayali: characterization and authenticity. Comptes rendus biologies. 2010 Sep; 333(9):642-8. doi: 10.1016/j.crvi.2010.05.001. [PMID: 20816644]
  • Amanda K Broz, Corey D Broeckling, Clelia De-la-Peña, Matthew R Lewis, Erick Greene, Ragan M Callaway, Lloyd W Sumner, Jorge M Vivanco. Plant neighbor identity influences plant biochemistry and physiology related to defense. BMC plant biology. 2010 Jun; 10(?):115. doi: 10.1186/1471-2229-10-115. [PMID: 20565801]
  • Berit Ebert, Daniela Zöller, Alexander Erban, Ines Fehrle, Jürgen Hartmann, Annette Niehl, Joachim Kopka, Joachim Fisahn. Metabolic profiling of Arabidopsis thaliana epidermal cells. Journal of experimental botany. 2010 Mar; 61(5):1321-35. doi: 10.1093/jxb/erq002. [PMID: 20150518]
  • Nurhan T Dunford, Jeff Edwards. Nutritional bioactive components of wheat straw as affected by genotype and environment. Bioresource technology. 2010 Jan; 101(1):422-5. doi: 10.1016/j.biortech.2009.08.009. [PMID: 19716291]
  • Anna Ringelmann, Michael Riedel, Markus Riederer, Ulrich Hildebrandt. Two sides of a leaf blade: Blumeria graminis needs chemical cues in cuticular waxes of Lolium perenne for germination and differentiation. Planta. 2009 Jun; 230(1):95-105. doi: 10.1007/s00425-009-0924-4. [PMID: 19352695]
  • Anna Lytovchenko, Romina Beleggia, Nicolas Schauer, Tal Isaacson, Jan E Leuendorf, Hanjo Hellmann, Jocelyn Kc Rose, Alisdair R Fernie. Application of GC-MS for the detection of lipophilic compounds in diverse plant tissues. Plant methods. 2009 Apr; 5(?):4. doi: 10.1186/1746-4811-5-4. [PMID: 19393072]
  • Angeles Fernández-Arche, Ana Marquez-Martín, Rocío de la Puerta Vazquez, Javier S Perona, Carmen Terencio, Carmen Perez-Camino, Valentina Ruiz-Gutierrez. Long-chain fatty alcohols from pomace olive oil modulate the release of proinflammatory mediators. The Journal of nutritional biochemistry. 2009 Mar; 20(3):155-62. doi: 10.1016/j.jnutbio.2008.01.007. [PMID: 18555679]
  • M A Ramadan, A S Ahmad, A M Nafady, A I Mansour. Chemical composition of the stem bark and leaves of Ficus pandurata Hance. Natural product research. 2009; 23(13):1218-30. doi: 10.1080/14786410902757899. [PMID: 19731141]
  • Shinichi Okada, Motoaki Saito, Emi Kazuyama, Takuya Hanada, Yasuo Kawaba, Atsushi Hayashi, Keisuke Satoh, Susumu Kanzaki. Effects of N-hexacosanol on nitric oxide synthase system in diabetic rat nephropathy. Molecular and cellular biochemistry. 2008 Aug; 315(1-2):169-77. doi: 10.1007/s11010-008-9804-7. [PMID: 18528636]
  • Maged S Abdel-Kader, Omer A Basudan, Mehtab Parveen, Masouda E Amer. A new 3-arylcoumarin from the roots of an Egyptian collection of Lotus polyphyllos. Natural product research. 2008 Mar; 22(5):448-52. doi: 10.1080/14786410701591812. [PMID: 18404565]
  • Yoshiji Ohta, Koji Ohashi, Tatsuya Matsura, Kenji Tokunaga, Akira Kitagawa, Kazuo Yamada. Octacosanol attenuates disrupted hepatic reactive oxygen species metabolism associated with acute liver injury progression in rats intoxicated with carbon tetrachloride. Journal of clinical biochemistry and nutrition. 2008 Mar; 42(2):118-25. doi: 10.3164/jcbn.2008017. [PMID: 18385828]
  • Teng Peng, Yong-qin Tu, Yun Deng, Xu Zhang. [Studies on chemical constituents of Primula sikkmensis]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2008 Jan; 31(1):44-6. doi: . [PMID: 18589747]
  • Vanessa Zabka, Michaela Stangl, Gerhard Bringmann, Gerd Vogg, Markus Riederer, Ulrich Hildebrandt. Host surface properties affect prepenetration processes in the barley powdery mildew fungus. The New phytologist. 2008; 177(1):251-263. doi: 10.1111/j.1469-8137.2007.02233.x. [PMID: 17937760]
  • Mark A Teece, Thomas Zengeya, Timothy A Volk, Lawrence B Smart. Cuticular wax composition of Salix varieties in relation to biomass productivity. Phytochemistry. 2008 Jan; 69(2):396-402. doi: 10.1016/j.phytochem.2007.08.015. [PMID: 17900636]
  • Nizar Nasri, Bruno Fady, Saïda Triki. Quantification of sterols and aliphatic alcohols in Mediterranean stone pine (Pinus pinea L.) populations. Journal of agricultural and food chemistry. 2007 Mar; 55(6):2251-5. doi: 10.1021/jf062911j. [PMID: 17309279]
  • Motoaki Saito, Yukako Kinoshita, Itaru Satoh, Chiko Shinbori, Hiroto Suzuki, Masashi Yamada, Takeshi Watanabe, Keisuke Satoh. Ability of cyclohexenonic long-chain fatty alcohol to reverse diabetes-induced cystopathy in the rat. European urology. 2007 Feb; 51(2):479-87; discussion 487. doi: 10.1016/j.eururo.2006.06.024. [PMID: 16842904]
  • Chiko Shinbori, Motoaki Saito, Yukako Kinoshita, Itaru Satoh, Tomoharu Kono, Takuya Hanada, Eiji Nanba, Kaori Adachi, Hiroto Suzuki, Masashi Yamada, Keisuke Satoh. N-hexacosanol reverses diabetic induced muscarinic hypercontractility of ileum in the rat. European journal of pharmacology. 2006 Sep; 545(2-3):177-84. doi: 10.1016/j.ejphar.2006.06.043. [PMID: 16872599]
  • Motoaki Saito, Yukako Kinoshita, Itaru Satoh, Chiko Shinbori, Tomoharu Kono, Takuya Hanada, Jiro Uemasu, Hiroto Suzuki, Masashi Yamada, Keisuke Satoh. N-hexacosanol ameliorates streptozotocin-induced diabetic rat nephropathy. European journal of pharmacology. 2006 Aug; 544(1-3):132-7. doi: 10.1016/j.ejphar.2006.06.001. [PMID: 16859672]
  • Hiroto Suzuki, Motoaki Saito, Yukako Kinoshita, Itaru Satoh, Tomoharu Kono, Chiko ShinBori, Sylakos Anastasios, Masashi Yamada, Keisuke Satoh. Preventive effects of cyclohexenonic long-chain fatty alcohol on diabetic cystopathy in the rat. Canadian journal of physiology and pharmacology. 2006 Feb; 84(2):195-201. doi: 10.1139/y05-114. [PMID: 16900945]
  • Takuya Hanada, Motoaki Saito, Susumu Kanzaki. Treatment with cyclohexenonic long-chain fatty alcohol reverses diabetes-induced tracheal dysfunction in the rat. Pharmacology. 2006; 78(2):51-60. doi: 10.1159/000095120. [PMID: 16912516]
  • Pilar López, José Martiń. Age related differences in lipophilic compounds found in femoral gland secretions of male spiny-footed lizards, Acanthodactylus erythrurus. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2005 Nov; 60(11-12):915-20. doi: 10.1515/znc-2005-11-1215. [PMID: 16402553]
  • Franka Gniwotta, Gerd Vogg, Vanessa Gartmann, Tim L W Carver, Markus Riederer, Reinhard Jetter. What do microbes encounter at the plant surface? Chemical composition of pea leaf cuticular waxes. Plant physiology. 2005 Sep; 139(1):519-30. doi: 10.1104/pp.104.053579. [PMID: 16113231]
  • I S R Punitha, K Rajendran, Arun Shirwaikar, Annie Shirwaikar. Alcoholic stem extract of Coscinium fenestratum regulates carbohydrate metabolism and improves antioxidant status in streptozotocin-nicotinamide induced diabetic rats. Evidence-based complementary and alternative medicine : eCAM. 2005 Sep; 2(3):375-81. doi: 10.1093/ecam/neh099. [PMID: 16136216]
  • David Nash, Rhys Leeming, Leigh Clemow, Murray Hannah, David Halliwell, David Allen. Quantitative determination of sterols and other alcohols in overland flow from grazing land and possible source materials. Water research. 2005 Aug; 39(13):2964-78. doi: 10.1016/j.watres.2005.04.063. [PMID: 15998530]
  • Sibel Irmak, Nurhan Turgut Dunford. Policosanol contents and compositions of wheat varieties. Journal of agricultural and food chemistry. 2005 Jul; 53(14):5583-6. doi: 10.1021/jf050508r. [PMID: 15998118]
  • I El-Gibaly, S K Abdel-Ghaffar. Effect of hexacosanol on the characteristics of novel sustained-release allopurinol solid lipospheres (SLS): factorial design application and product evaluation. International journal of pharmaceutics. 2005 Apr; 294(1-2):33-51. doi: 10.1016/j.ijpharm.2004.12.027. [PMID: 15814229]
  • Yuguang Lin, Mike Rudrum, Reggy P J van der Wielen, Elke A Trautwein, Gerald McNeill, Aafje Sierksma, Gert W Meijer. Wheat germ policosanol failed to lower plasma cholesterol in subjects with normal to mildly elevated cholesterol concentrations. Metabolism: clinical and experimental. 2004 Oct; 53(10):1309-14. doi: 10.1016/j.metabol.2004.05.006. [PMID: 15375787]
  • B Singh, S Singh. Antimicrobial activity of terpenoids from Trichodesma amplexicaule Roth. Phytotherapy research : PTR. 2003 Aug; 17(7):814-6. doi: 10.1002/ptr.1202. [PMID: 12916085]
  • Ji-ren Lii, Xiu-fen Gao, Tie-min Ai, Yu-ying Zhao. [Lipid compounds from Echinacea purpurea]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2002 Jan; 27(1):40-2. doi: ". [PMID: 12774354]
  • D Marrero Delange, L González Bravo. Trace determination of 1-octacosanol in rat plasma by solid-phase extraction with Tenax GC and capillary gas chromatography. Journal of chromatography. B, Biomedical sciences and applications. 2001 Oct; 762(1):43-9. doi: 10.1016/s0378-4347(01)00331-0. [PMID: 11589457]
  • J Borg, J Toazara, H Hietter, M Henry, G Schmitt, B Luu. Neurotrophic effect of naturally occurring long-chain fatty alcohols on cultured CNS neurons. FEBS letters. 1987 Mar; 213(2):406-10. doi: 10.1016/0014-5793(87)81531-4. [PMID: 3556588]