D-Malic acid (BioDeep_00000000728)

 

Secondary id: BioDeep_00000001119, BioDeep_00000400399, BioDeep_00000415844, BioDeep_00000419033

natural product human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


(2R)-2-HYDROXYBUTANEDIOIC ACID; 2-HYDROXY-SUCCINIC ACID

化学式: C4H6O5 (134.0215)
中文名称: D-(+)-苹果酸
谱图信息: 最多检出来源 Homo sapiens(otcml) 21.51%

分子结构信息

SMILES: C(C(C(=O)O)O)C(=O)O
InChI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/t2-/m1/s1

描述信息

(R)-malic acid is an optically active form of malic acid having (R)-configuration. It is a conjugate acid of a (R)-malate(2-). It is an enantiomer of a (S)-malic acid.
(R)-Malate is a metabolite found in or produced by Escherichia coli (strain K12, MG1655).
D-malate is a natural product found in Vaccinium macrocarpon, Pogostemon cablin, and other organisms with data available.
D-Malic acid is found in herbs and spices. This enantiomer of rare occurrence; reported from fruits and leaves of Hibiscus sabdariffa (roselle) although there are many more isolations of malic acid with no opt. rotn. given and some may be of the R-for
An optically active form of malic acid having (R)-configuration.
COVID info from PDB, Protein Data Bank
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Acquisition and generation of the data is financially supported in part by CREST/JST.
D-(+)-Malic acid (D-Malic acid), an active enantiomer of Malic acid, is a competitive inhibitor of L(--)malic acid transport[1].
D-(+)-Malic acid (D-Malic acid), an active enantiomer of Malic acid, is a competitive inhibitor of L(--)malic acid transport[1].

同义名列表

38 个代谢物同义名

(2R)-2-HYDROXYBUTANEDIOIC ACID; 2-HYDROXY-SUCCINIC ACID; D-(+)-Malic acid, unnatural form, >=97.0\\% (T); AAF7D69B-7713-4E35-92ED-EA50BA0FCDCE; BUTANEDIOIC ACID, 2-HYDROXY-, (2R)-; D-Malic acid, analytical standard; Butanedioic acid, hydroxy-, (2R)-; (R)-(+)-2-Hydroxysuccinic acid; (2R)-2-hydroxybutanedioic acid; (R)-2-hydroxybutanedioic acid; Hydroxy-(R)-Butanedioic acid; (r)-(+)-hydroxysuccinic acid; BJEPYKJPYRNKOW-UWTATZPHSA-N; (R)-Hydroxybutanedioic acid; (R)-2-Hydroxysuccinic acid; MALIC ACID D-(+)-FORM [MI]; (R)-2-Hydroxysuccinicacid; (R)-2-Hydroxybutanedioate; D-Hydroxybutanedioic acid; 2-HYDROXY-SUCCINIC ACID; Malic acid D-(+)-form; ApfelsA currencyure; 2-HYDROXY-succinate; Malic acid, L(+)-; D-(+)-Malic acid; D-(+)-Apple Acid; (+)-D-malic acid; D(+)-Malic acid; L(+)-Malic acid; .+-.-Malic acid; (R)-malic acid; Malic acid, D-; (+)-Malic acid; D-malic acid; (+)-D-Malate; R-Malic acid; (R)-malate; D-malate; (R)-Malate



数据库引用编号

26 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

8 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ARNT, EGFR, FH, HDAC1, HDAC6, RPL37A
Peripheral membrane protein 1 NDUFA5
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 1 EGFR
Nucleus 11 ARNT, CHD7, CS, EGFR, FH, HDAC1, HDAC6, MAFF, PMCH, RPL37A, SLC25A10
cytosol 5 FH, HDAC1, HDAC6, PHGDH, RPL37A
dendrite 2 HDAC6, TACR1
nuclear body 1 ARNT
centrosome 1 HDAC6
nucleoplasm 7 ARNT, CD2, CHD7, HDAC1, HDAC6, MAFF, SLC25A10
RNA polymerase II transcription regulator complex 2 ARNT, MAFF
Cell membrane 3 CD2, EGFR, TACR1
ruffle membrane 1 EGFR
Cell projection, axon 1 HDAC6
Early endosome membrane 1 EGFR
Multi-pass membrane protein 4 SLC22A6, SLC22A8, SLC25A10, TACR1
Synapse 1 PMCH
cell junction 1 EGFR
cell surface 3 CD2, EGFR, TACR1
glutamatergic synapse 1 EGFR
Golgi apparatus 1 CD2
Golgi membrane 1 EGFR
mitochondrial inner membrane 2 NDUFA5, SLC25A10
neuronal cell body 1 HDAC1
endosome 1 EGFR
plasma membrane 5 CD2, EGFR, SLC22A6, SLC22A8, TACR1
Membrane 5 CS, EGFR, SLC22A6, SLC25A10, VEGFB
apical plasma membrane 2 EGFR, SLC22A8
axon 1 HDAC6
basolateral plasma membrane 3 EGFR, SLC22A6, SLC22A8
caveola 2 HDAC6, SLC22A6
extracellular exosome 7 CS, FH, HBZ, PHGDH, RPL37A, SLC22A6, SLC22A8
extracellular space 2 EGFR, VEGFB
perinuclear region of cytoplasm 2 EGFR, HDAC6
mitochondrion 6 CS, D2HGDH, FH, MAFF, NDUFA5, SLC25A10
protein-containing complex 4 CD2, EGFR, HDAC1, SLC22A6
Single-pass type I membrane protein 2 CD2, EGFR
Secreted 1 VEGFB
extracellular region 3 CD2, PMCH, VEGFB
cytoplasmic side of plasma membrane 1 CD2
Mitochondrion matrix 1 CS
mitochondrial matrix 3 CS, D2HGDH, FH
transcription regulator complex 1 ARNT
Cell projection, cilium 1 HDAC6
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 HDAC6
nuclear membrane 1 EGFR
external side of plasma membrane 1 CD2
multivesicular body 1 HDAC6
perikaryon 1 HDAC6
nucleolus 1 CHD7
axon cytoplasm 1 HDAC6
cell-cell junction 1 CD2
postsynaptic membrane 1 TACR1
Mitochondrion inner membrane 1 NDUFA5
Matrix side 1 NDUFA5
heterochromatin 1 HDAC1
Membrane raft 1 EGFR
Cytoplasm, cytoskeleton 1 HDAC6
focal adhesion 2 EGFR, RPL37A
microtubule 1 HDAC6
intracellular vesicle 1 EGFR
lateral plasma membrane 1 SLC22A8
receptor complex 1 EGFR
ciliary basal body 1 HDAC6
chromatin 4 ARNT, CHD7, HDAC1, MAFF
cell leading edge 1 HDAC6
microtubule associated complex 1 HDAC6
Chromosome 1 FH
Cytoplasm, cytoskeleton, cilium basal body 1 HDAC6
sperm midpiece 1 TACR1
Basolateral cell membrane 2 SLC22A6, SLC22A8
site of double-strand break 1 FH
sperm flagellum 1 TACR1
aryl hydrocarbon receptor complex 1 ARNT
Cell projection, dendrite 1 HDAC6
cell body 1 TACR1
basal plasma membrane 2 EGFR, SLC22A6
synaptic membrane 1 EGFR
respiratory chain complex I 1 NDUFA5
transcription repressor complex 1 HDAC1
platelet alpha granule lumen 1 VEGFB
histone deacetylase complex 2 HDAC1, HDAC6
NuRD complex 1 HDAC1
aggresome 1 HDAC6
clathrin-coated endocytic vesicle membrane 1 EGFR
[Isoform 1]: Nucleus 1 CHD7
Basal cell membrane 1 SLC22A6
Sin3-type complex 1 HDAC1
cytosolic ribosome 1 RPL37A
hemoglobin complex 1 HBZ
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
haptoglobin-hemoglobin complex 1 HBZ
sperm head 1 TACR1
inclusion body 1 HDAC6
cytosolic large ribosomal subunit 1 RPL37A
[Isoform Mitochondrial]: Mitochondrion 1 FH
[Isoform Cytoplasmic]: Cytoplasm, cytosol 1 FH
nuclear aryl hydrocarbon receptor complex 1 ARNT
[Isoform 3]: Nucleus, nucleolus 1 CHD7


文献列表

  • Zhibing Lu, Xiaohua Feng, Ling Song, Ying Han, Alexander Kim, Osnat Herzberg, William R Woodson, Brian M Martin, Patrick S Mariano, Debra Dunaway-Mariano. Diversity of function in the isocitrate lyase enzyme superfamily: the Dianthus caryophyllus petal death protein cleaves alpha-keto and alpha-hydroxycarboxylic acids. Biochemistry. 2005 Dec; 44(50):16365-76. doi: 10.1021/bi051776l. [PMID: 16342929]